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WO2006125765A3 - Acylated insulin with high purity - Google Patents

Acylated insulin with high purity Download PDF

Info

Publication number
WO2006125765A3
WO2006125765A3 PCT/EP2006/062495 EP2006062495W WO2006125765A3 WO 2006125765 A3 WO2006125765 A3 WO 2006125765A3 EP 2006062495 W EP2006062495 W EP 2006062495W WO 2006125765 A3 WO2006125765 A3 WO 2006125765A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
acylated insulin
high purity
weight
acylated
Prior art date
Application number
PCT/EP2006/062495
Other languages
French (fr)
Other versions
WO2006125765A2 (en
Inventor
Jan Markussen
Svend Havelund
Jes Kristian Jacobsen
Aage Hvass
Ib Jonassen
Georg Wilhelm Jensen
Original Assignee
Novo Nordisk As
Jan Markussen
Svend Havelund
Jes Kristian Jacobsen
Aage Hvass
Ib Jonassen
Georg Wilhelm Jensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Jan Markussen, Svend Havelund, Jes Kristian Jacobsen, Aage Hvass, Ib Jonassen, Georg Wilhelm Jensen filed Critical Novo Nordisk As
Priority to EP06763218A priority Critical patent/EP1888104A2/en
Publication of WO2006125765A2 publication Critical patent/WO2006125765A2/en
Publication of WO2006125765A3 publication Critical patent/WO2006125765A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention is related to a highly purified pharmaceutical preparation comprising an acylated insulin where the acyl group is attached via a linker molecule to the ϵ- amino group of the B29Lys residue of the parent insulin moiety. The insulin pharmaceutical formulation comprises less than about 3% weight/weight of an isomer of the acylated insulin.
PCT/EP2006/062495 2005-05-26 2006-05-22 Acylated insulin with high purity WO2006125765A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06763218A EP1888104A2 (en) 2005-05-26 2006-05-22 Acylated insulin with high purity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500767 2005-05-26
DKPA200500767 2005-05-26

Publications (2)

Publication Number Publication Date
WO2006125765A2 WO2006125765A2 (en) 2006-11-30
WO2006125765A3 true WO2006125765A3 (en) 2007-02-15

Family

ID=37269816

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/062495 WO2006125765A2 (en) 2005-05-26 2006-05-22 Acylated insulin with high purity

Country Status (2)

Country Link
EP (1) EP1888104A2 (en)
WO (1) WO2006125765A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026156A (en) 2015-08-25 2018-05-11 诺和诺德股份有限公司 Novel insulin derivates and its medical usage
US20180244743A1 (en) 2015-08-25 2018-08-30 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
EP3856141A1 (en) * 2018-09-25 2021-08-04 Amphastar Pharmaceuticals, Inc. Highly purified recombinant human insulin (rhi) api and methods of producing the same
BR112021006315A2 (en) 2018-10-01 2021-07-06 Boehringer Ingelheim Vetmedica Gmbh peristaltic pump and analyzer to test a sample

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
WO1999021888A1 (en) * 1997-10-24 1999-05-06 Novo Nordisk A/S Aggregates of human insulin derivatives
US20040138099A1 (en) * 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
EP1132404A2 (en) * 1993-09-17 2001-09-12 Novo Nordisk A/S Acylated insulin
WO1999021888A1 (en) * 1997-10-24 1999-05-06 Novo Nordisk A/S Aggregates of human insulin derivatives
US20040138099A1 (en) * 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes

Also Published As

Publication number Publication date
WO2006125765A2 (en) 2006-11-30
EP1888104A2 (en) 2008-02-20

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