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WO2006094210A3 - Tetrahydroquinoxalinone sirtuin modulators - Google Patents

Tetrahydroquinoxalinone sirtuin modulators Download PDF

Info

Publication number
WO2006094210A3
WO2006094210A3 PCT/US2006/007656 US2006007656W WO2006094210A3 WO 2006094210 A3 WO2006094210 A3 WO 2006094210A3 US 2006007656 W US2006007656 W US 2006007656W WO 2006094210 A3 WO2006094210 A3 WO 2006094210A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
sirtuin
disorders
tetrahydroquinoxalinone
modulating compounds
Prior art date
Application number
PCT/US2006/007656
Other languages
French (fr)
Other versions
WO2006094210A2 (en
Inventor
Jill Milne
Karl D Normington
Michael Milburn
Original Assignee
Sirtris Pharmaceuticals Inc
Jill Milne
Karl D Normington
Michael Milburn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc, Jill Milne, Karl D Normington, Michael Milburn filed Critical Sirtris Pharmaceuticals Inc
Publication of WO2006094210A2 publication Critical patent/WO2006094210A2/en
Publication of WO2006094210A3 publication Critical patent/WO2006094210A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
PCT/US2006/007656 2005-03-03 2006-03-03 Tetrahydroquinoxalinone sirtuin modulators WO2006094210A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65895005P 2005-03-03 2005-03-03
US60/658,950 2005-03-03
US71031305P 2005-08-22 2005-08-22
US60/710,313 2005-08-22

Publications (2)

Publication Number Publication Date
WO2006094210A2 WO2006094210A2 (en) 2006-09-08
WO2006094210A3 true WO2006094210A3 (en) 2007-03-29

Family

ID=36941869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/007656 WO2006094210A2 (en) 2005-03-03 2006-03-03 Tetrahydroquinoxalinone sirtuin modulators

Country Status (1)

Country Link
WO (1) WO2006094210A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616919B (en) * 2006-12-28 2012-10-10 雅培制药有限公司 Inhibitors of poly(adp-ribose)polymerase
MX2010012010A (en) 2008-05-01 2010-11-30 Sirtris Pharmaceuticals Inc Quenolines and related analogs as sirtuin modulators.
CN102143957B (en) 2008-07-03 2014-08-20 西特里斯药业公司 Benzimidazoles and related analogs as sirtuin modulators
MX2011003372A (en) 2008-09-29 2011-06-09 Sirtris Pharmaceuticals Inc Chromenone analogs as sirtuin modulators.
CA2746506A1 (en) 2008-12-08 2010-07-08 Northwestern University Method of modulating hsf-1
AR077958A1 (en) 2009-08-27 2011-10-05 Vifor Int Ag ANTOGONIST QUINOXALINONES OF HEPCIDINE
ES2574927T3 (en) * 2009-10-29 2016-06-23 Glaxosmithkline Llc Bicyclic pyridines and the like as modulators of sirtuin
US8916528B2 (en) 2011-11-16 2014-12-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
EP2997029B1 (en) * 2013-05-13 2019-01-09 GlaxoSmithKline LLC Substituted bridged urea analogs as sirtuin modulators
RU2720237C2 (en) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Compositions containing benzopiperazine as bromodomain bet inhibitors
SI3071203T1 (en) 2013-11-18 2021-07-30 Forma Therapeutics, Inc. Tetrahydroquinoline compositions as bet bromodomain inhibitors
CA2968029A1 (en) * 2014-11-19 2016-05-26 Glaxosmithkline Intellectual Property (No.2) Limited Substituted bridged urea analogs as sirtuin modulators
CN106146416B (en) * 2016-08-01 2019-02-19 河南大学 Nitrogen-substituted 3-oxo-6-substituted tetrahydroquinoxaline structure compound, its preparation method and its medical use
GB201713019D0 (en) * 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for controlling deposits
GB201713009D0 (en) * 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for reducing oxidation
GB201713023D0 (en) * 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for blending fuels
GB2574862A (en) * 2018-06-21 2019-12-25 Curadev Pharma Ltd Azaheterocyclic small molecule modulators of human STING
WO2021252775A1 (en) 2020-06-11 2021-12-16 Chdi Foundation, Inc. Heterocyclic compounds and imaging agents for imaging huntingtin protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002555A2 (en) * 2003-07-01 2005-01-13 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002555A2 (en) * 2003-07-01 2005-01-13 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
US20050096256A1 (en) * 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PORCU M ET AL: "The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 26, no. 2, February 2005 (2005-02-01), pages 94 - 103, XP004727629, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
WO2006094210A2 (en) 2006-09-08

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