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WO2006079896A3 - Stable polyol formulations of oxazolidinone antibacterial agents - Google Patents

Stable polyol formulations of oxazolidinone antibacterial agents Download PDF

Info

Publication number
WO2006079896A3
WO2006079896A3 PCT/IB2006/000117 IB2006000117W WO2006079896A3 WO 2006079896 A3 WO2006079896 A3 WO 2006079896A3 IB 2006000117 W IB2006000117 W IB 2006000117W WO 2006079896 A3 WO2006079896 A3 WO 2006079896A3
Authority
WO
WIPO (PCT)
Prior art keywords
gel formulations
oxazolidinone
antibacterial agents
present
oxazolidinone antibacterial
Prior art date
Application number
PCT/IB2006/000117
Other languages
French (fr)
Other versions
WO2006079896A2 (en
Inventor
Lorraine Elisabeth Pena
Pamela Jean Secreast
Original Assignee
Pharmacia & Upjohn Co Llc
Lorraine Elisabeth Pena
Pamela Jean Secreast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc, Lorraine Elisabeth Pena, Pamela Jean Secreast filed Critical Pharmacia & Upjohn Co Llc
Publication of WO2006079896A2 publication Critical patent/WO2006079896A2/en
Publication of WO2006079896A3 publication Critical patent/WO2006079896A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Stable gel formulations of oxazolidinone antibiotic drugs, such as linezolid, are provided which are suitable for topical administration. Gel formulations of the present invention comprise an oxazolidinone antibiotic drug solubilized in a polyol solvent system including a polyol solvent, a thickening agent, and water. The oxazolidinone drug remains solubilized in gel formulations of the present formulation for at least 3 hours at a temperature from 15°C to 30°C. Also provided are methods of topically administering gel formulations of the present invention to treat or prevent infection by gram-positive bacteria.
PCT/IB2006/000117 2005-01-27 2006-01-17 Stable polyol formulations of oxazolidinone antibacterial agents WO2006079896A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64756105P 2005-01-27 2005-01-27
US60/647,561 2005-01-27

Publications (2)

Publication Number Publication Date
WO2006079896A2 WO2006079896A2 (en) 2006-08-03
WO2006079896A3 true WO2006079896A3 (en) 2007-01-11

Family

ID=36740872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/000117 WO2006079896A2 (en) 2005-01-27 2006-01-17 Stable polyol formulations of oxazolidinone antibacterial agents

Country Status (1)

Country Link
WO (1) WO2006079896A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275061A1 (en) 2009-07-15 2011-01-19 Otos Tech Co., Ltd. Welding helmet including anti-blinding device to selectively and conveniently control welding operation and grinding operation
GB2487773B (en) * 2011-02-04 2014-09-17 Aidance Skincare & Topical Solutions Llc Topical antibiotic formulations
WO2021184339A1 (en) * 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007436A1 (en) * 1988-02-18 1989-08-24 The Upjohn Company Minoxidil gel
WO1994007478A1 (en) * 1992-10-06 1994-04-14 The Upjohn Company Topical pharmaceutical compositions
WO2002030395A1 (en) * 2000-10-10 2002-04-18 Pharmacia & Upjohn Company Topical antibiotic composition for treatment of eye infection
WO2003030906A1 (en) * 2001-10-11 2003-04-17 Pharmacia & Upjohn Company Treating infections by administration of oxazolidinones to the skin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007436A1 (en) * 1988-02-18 1989-08-24 The Upjohn Company Minoxidil gel
WO1994007478A1 (en) * 1992-10-06 1994-04-14 The Upjohn Company Topical pharmaceutical compositions
WO2002030395A1 (en) * 2000-10-10 2002-04-18 Pharmacia & Upjohn Company Topical antibiotic composition for treatment of eye infection
WO2003030906A1 (en) * 2001-10-11 2003-04-17 Pharmacia & Upjohn Company Treating infections by administration of oxazolidinones to the skin

Also Published As

Publication number Publication date
WO2006079896A2 (en) 2006-08-03

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Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase

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