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WO2006066247A3 - Methods and compositions for extending telomere length and increasing cell lifespan - Google Patents

Methods and compositions for extending telomere length and increasing cell lifespan Download PDF

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Publication number
WO2006066247A3
WO2006066247A3 PCT/US2005/046134 US2005046134W WO2006066247A3 WO 2006066247 A3 WO2006066247 A3 WO 2006066247A3 US 2005046134 W US2005046134 W US 2005046134W WO 2006066247 A3 WO2006066247 A3 WO 2006066247A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
telomere length
increasing cell
cell
Prior art date
Application number
PCT/US2005/046134
Other languages
French (fr)
Other versions
WO2006066247A2 (en
Inventor
Gary Alan Suttle
Original Assignee
Exvivo Technologies
Gary Alan Suttle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exvivo Technologies, Gary Alan Suttle filed Critical Exvivo Technologies
Publication of WO2006066247A2 publication Critical patent/WO2006066247A2/en
Publication of WO2006066247A3 publication Critical patent/WO2006066247A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods of elongating a telomere of a cell, the methods comprising enhancing hTERT expression in the cell and increasing telomerase processivity. Telomerized cells which comprise a cell having a telomere, the telomere being elongated by enhancing hTERT expression in the cell and by increasing the processivity of telomerase in the cell.
PCT/US2005/046134 2004-12-17 2005-12-19 Methods and compositions for extending telomere length and increasing cell lifespan WO2006066247A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63705904P 2004-12-17 2004-12-17
US60/637,059 2004-12-17

Publications (2)

Publication Number Publication Date
WO2006066247A2 WO2006066247A2 (en) 2006-06-22
WO2006066247A3 true WO2006066247A3 (en) 2006-08-31

Family

ID=36588655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046134 WO2006066247A2 (en) 2004-12-17 2005-12-19 Methods and compositions for extending telomere length and increasing cell lifespan

Country Status (1)

Country Link
WO (1) WO2006066247A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7320302B2 (en) 2018-10-02 2023-08-03 ステムオン インコーポレーテッド Composition for elongating cell telomeres and method for producing the same

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102232319B1 (en) * 2014-05-09 2021-03-26 주식회사 젬백스앤카엘 Composition for preventing or treating cerebrovascular diseases comprising a telomerase peptide as an active ingredient
CN105582525B (en) * 2014-10-24 2019-08-06 佛山市龙杰生物科技有限公司 Application of the CIRP in terms of preparing Telomerase bonding agent or telomerase activation adjusting control agent
WO2018112378A1 (en) 2016-12-15 2018-06-21 Synploid Biotek, Llc Methods of cell renewal
KR102209234B1 (en) * 2018-10-02 2021-02-01 주식회사 스템온 Methods for lengthening telomeres in cells
US12241056B2 (en) * 2018-10-02 2025-03-04 Stemon Inc. Method for extending telomere of cell
EP3886891B1 (en) * 2018-11-28 2024-11-20 University Of The Witwatersrand, Johannesburg Laminin receptor precursor/ high affinity laminin receptor (lrp/lr) for use in the treatment of parkinson's disease
CN112063655A (en) * 2019-09-24 2020-12-11 刘玉文 Telomere gene therapy product and application of mammal broad promoter
WO2021167879A1 (en) * 2020-02-17 2021-08-26 Spinalcyte, Llc Telomere length modulation using fibroblasts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AKIYAMA M. ET AL.: "Telomerase Overexpression in K562 Leukemia Cells Protects Against Apoptosis by Serum Deprivation and Double-Stranded DNA Break Inducing Agents, But Not Against DNA Synthesis Inhibitors", CANCER LETTERS, vol. 178, 2002, pages 187 - 197 *
ZIMMERMANN S. ET AL.: "Telemere Elongation in Hematopoietic Progenitor Cells", BLOOD, vol. 98, no. 11 PART 1, 16 November 2001 (2001-11-16), pages 276A *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7320302B2 (en) 2018-10-02 2023-08-03 ステムオン インコーポレーテッド Composition for elongating cell telomeres and method for producing the same

Also Published As

Publication number Publication date
WO2006066247A2 (en) 2006-06-22

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