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WO2005056002A3 - Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria - Google Patents

Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria Download PDF

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Publication number
WO2005056002A3
WO2005056002A3 PCT/FR2004/003116 FR2004003116W WO2005056002A3 WO 2005056002 A3 WO2005056002 A3 WO 2005056002A3 FR 2004003116 W FR2004003116 W FR 2004003116W WO 2005056002 A3 WO2005056002 A3 WO 2005056002A3
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gram
homoserine lactone
butyrolactone
acyl
pathogenic bacteria
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Ceased
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PCT/FR2004/003116
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French (fr)
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WO2005056002A2 (en
Inventor
Denis Faure
Aurelien Carlier
Yves Dessaux
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Centre National de la Recherche Scientifique CNRS
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Centre National de la Recherche Scientifique CNRS
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Publication of WO2005056002A2 publication Critical patent/WO2005056002A2/en
Publication of WO2005056002A3 publication Critical patent/WO2005056002A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
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    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
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    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/742—Organic compounds containing oxygen
    • A23B2/754—Organic compounds containing oxygen containing carboxyl groups
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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Abstract

The invention relates to the use a η-butyrolactone degradation pathway inductor for increasing the enzymatic degradation of a N-acyl homoserine lactone of Gram-negative pathogenic bacteria sensitive to a N-acyl homoserine lactone apart from butyric and α-hydroxy-β-methylbutyric acids and to the application thereof, in particular for agriculture, the agri-food industry and human and animal medicine.
PCT/FR2004/003116 2003-12-04 2004-12-03 Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria Ceased WO2005056002A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0314231 2003-12-04
FR0314231A FR2863168A1 (en) 2003-12-04 2003-12-04 USE OF INDUCERS OF THE GAMMA-BUTYROLACTONE DEGRADATION PATH TO INACTIVATE THE N-ACY SIGNAL HOMOSERIN LACTONE.

Publications (2)

Publication Number Publication Date
WO2005056002A2 WO2005056002A2 (en) 2005-06-23
WO2005056002A3 true WO2005056002A3 (en) 2006-02-23

Family

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PCT/FR2004/003116 Ceased WO2005056002A2 (en) 2003-12-04 2004-12-03 Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria

Country Status (2)

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FR (1) FR2863168A1 (en)
WO (1) WO2005056002A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603518B2 (en) 2006-05-01 2013-12-10 Universiteit Gent Hydroxybutyrate and poly-hydroxybutyrate as components of animal feed or feed additives
JP2010516667A (en) 2007-01-19 2010-05-20 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク Chemicals that promote the growth of N-acyl homoserine lactone-degrading bacteria
WO2013184602A2 (en) 2012-06-04 2013-12-12 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN110563996B (en) * 2019-09-10 2021-12-21 大连民族大学 Gram-negative bacterium quorum sensing quenching polymer

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US3629451A (en) * 1969-03-03 1971-12-21 Stanley Drug Products Inc Method of treating bacterial infections
US3895116A (en) * 1971-11-29 1975-07-15 Eastman Kodak Co Mixtures of volatile fatty acids having anti-fungal and anti-bacterial activity
US4179522A (en) * 1975-11-27 1979-12-18 Bp Chemicals Limited Certain complex salts of mono carboxylic acids used as preservatives
JPS5758651A (en) * 1980-09-25 1982-04-08 Kayaku:Kk Preparation of diamino acid derivative
US4550026A (en) * 1983-02-15 1985-10-29 Yosuke Akiba Method for preserving food using a preservative gas atmosphere
JPH0255794A (en) * 1988-08-22 1990-02-26 Asahi Denka Kogyo Kk Antibacterial lubricating agent composition
US5462714A (en) * 1992-09-22 1995-10-31 Arda Technologies Antimicrobial composition and methods of use
RU2048807C1 (en) * 1993-10-10 1995-11-27 Научно-исследовательская фирма "Ультрасан" Antibacterial and antiinflammatory preparation
WO1995015684A1 (en) * 1993-12-12 1995-06-15 Agrogene, Ltd. A novel method to protect plants from fungal infection
CA2144021A1 (en) * 1994-05-10 1995-11-11 V. Gerold Luss Non-toxic, non-corrosive microbicidal composition
WO1996011572A1 (en) * 1994-10-14 1996-04-25 Sven Moberg Antimicrobial composition
WO1996029392A1 (en) * 1995-03-23 1996-09-26 Unisearch Limited Methods for microbial regulation
WO1997000676A1 (en) * 1995-06-21 1997-01-09 Oy Extracta Ltd. Antimicrobial and anti-inflammatory compounds
WO1997027851A1 (en) * 1996-02-01 1997-08-07 The Johns-Hopkins University L-homoserine and l-homoserine lactone as bacteriostatic agents for m. tuberculosis and m. bovis
WO1999059574A1 (en) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. A method for stimulation of defensin production by exposure to isoleucin
DE19826499A1 (en) * 1998-06-13 1999-12-16 Beiersdorf Ag Use of lactone, thiolactone and/or dithiolactone derivatives
US20030060457A1 (en) * 1998-07-31 2003-03-27 Schaffer Priscilla A. Cellular proteins as targets for the treatment of pathogens resistant to drugs that target pathogen-encoded proteins
JP2001206811A (en) * 2000-01-25 2001-07-31 Kagome Co Ltd Plant disease controlling agent and plant epidemic- controlling method
WO2001057174A1 (en) * 2000-02-01 2001-08-09 Reckitt Benckiser Inc. Hard surface cleaning composition
US20020183387A1 (en) * 2001-06-04 2002-12-05 Bogart Mark H. Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
WO2003018049A2 (en) * 2001-08-23 2003-03-06 Westgate Biological Limited Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection

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Title
CARLIER A ET AL: "The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activity.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 69, no. 8, August 2003 (2003-08-01), pages 4989 - 4993, XP002288910, ISSN: 0099-2240 *
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UROZ STÉPHANE ET AL: "Novel bacteria degrading N-acylhomoserine lactones and their use as quenchers of quorum-sensing-regulated functions of plant-pathogenic bacteria.", MICROBIOLOGY (READING, ENGLAND) AUG 2003, vol. 149, no. Pt 8, August 2003 (2003-08-01), pages 1981 - 1989, XP002288909, ISSN: 1350-0872 *

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WO2005056002A2 (en) 2005-06-23
FR2863168A1 (en) 2005-06-10

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