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WO2005054174A3 - Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes - Google Patents

Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes Download PDF

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Publication number
WO2005054174A3
WO2005054174A3 PCT/DE2004/002691 DE2004002691W WO2005054174A3 WO 2005054174 A3 WO2005054174 A3 WO 2005054174A3 DE 2004002691 W DE2004002691 W DE 2004002691W WO 2005054174 A3 WO2005054174 A3 WO 2005054174A3
Authority
WO
WIPO (PCT)
Prior art keywords
complex
compounds
modulating
transaminase
glycolysis enzyme
Prior art date
Application number
PCT/DE2004/002691
Other languages
English (en)
French (fr)
Other versions
WO2005054174A2 (de
Inventor
Hans Scheefers
Original Assignee
Schebo Biotech Ag
Hans Scheefers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schebo Biotech Ag, Hans Scheefers filed Critical Schebo Biotech Ag
Priority to US10/581,842 priority Critical patent/US20090149415A1/en
Priority to EP04802899A priority patent/EP1735271A2/de
Publication of WO2005054174A2 publication Critical patent/WO2005054174A2/de
Publication of WO2005054174A3 publication Critical patent/WO2005054174A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/22—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups esterified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/17—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and doubly-bound oxygen atoms bound to the same acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung betrifft Verbindungen zur Modulation des Glykolyse Enzym-Komplexes und des Transaminase­-Komplexes, pharmazeutische Zusammensetzungen enthal­tend solche Verbindungen sowie Verwendungen von sol­chen Verbindungen zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung verschiedener Krankheiten.
PCT/DE2004/002691 2003-12-05 2004-12-06 Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes WO2005054174A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/581,842 US20090149415A1 (en) 2003-12-05 2004-12-06 Compounds for modulating the glycolysis enzyme complex and/or the transaminase complex
EP04802899A EP1735271A2 (de) 2003-12-05 2004-12-06 Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10357301.1 2003-12-05
DE10357301A DE10357301A1 (de) 2003-12-05 2003-12-05 Verbindungen zur Modulation des Glykolyse-Enzym- und/oder Transaminase-Komplexes

Publications (2)

Publication Number Publication Date
WO2005054174A2 WO2005054174A2 (de) 2005-06-16
WO2005054174A3 true WO2005054174A3 (de) 2005-08-11

Family

ID=34638486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/002691 WO2005054174A2 (de) 2003-12-05 2004-12-06 Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes

Country Status (4)

Country Link
US (1) US20090149415A1 (de)
EP (1) EP1735271A2 (de)
DE (1) DE10357301A1 (de)
WO (1) WO2005054174A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3613417A4 (de) * 2017-04-22 2021-06-09 Caidong Qin Verfahren zur hemmung des zellularen glykolyseprozesses und anwendung davon

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971164A (en) * 1960-02-03 1964-09-30 Upjohn Co Therapeutic compositions comprising ª‡-aminoxy-alkanoic acids and derivatives thereof
FR2150778A1 (de) * 1971-08-12 1973-04-13 Richter Gedeon Vegyeszet
WO2004024676A1 (de) * 2002-09-06 2004-03-25 Schebo®Biotech Ag Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435744C2 (de) * 1984-09-28 1986-08-07 Organogen Medizinisch-Molekularbiologische Forschungsgesellschaft mbH, 6900 Heidelberg Trägermaterial zur Verwendung für Immunbestimmungen
DE10112926B4 (de) * 2001-03-13 2005-11-10 Schebo Biotech Ag Verwendung von Aminooxyacetat zur Tumorbehandlung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971164A (en) * 1960-02-03 1964-09-30 Upjohn Co Therapeutic compositions comprising ª‡-aminoxy-alkanoic acids and derivatives thereof
FR2150778A1 (de) * 1971-08-12 1973-04-13 Richter Gedeon Vegyeszet
WO2004024676A1 (de) * 2002-09-06 2004-03-25 Schebo®Biotech Ag Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
ACS SYMPOSIUM SERIES , 356(SITES ACTION NEUROTOXIC PESTIC.), 122-34 CODEN: ACSMC8; ISSN: 0097-6156, 1987 *
ACTA VITAMINOLOGICA , 18(1), 7-12 CODEN: ACVIA9; ISSN: 0001-7248, 1964 *
AMAGASA, TADASHI ET AL: "Effects of aminooxyacetic acid and its derivatives on flowering in Pharbitis nil", PLANT AND CELL PHYSIOLOGY , 33(7), 1025-9 CODEN: PCPHA5; ISSN: 0032-0781, 1992, XP009049386 *
BIOKHIMIYA (MOSCOW) , 34(1), 66-72 CODEN: BIOHAO; ISSN: 0320-9725, 1969 *
BIOKHIMIYA (MOSCOW) , 39(6), 1146-56 CODEN: BIOHAO; ISSN: 0320-9725, 1974 *
BRIGGS, M.T. ET AL, J.CHEM.SOC. PERKIN TRANS. 1, 1979, pages 2138 - 2143 *
BYULLETEN EKSPERIMENTAL'NOI BIOLOGII I MEDITSINY , 47(NO. 8), 52-5 CODEN: BEBMAE; ISSN: 0365-9615, 1959 *
BYULLETEN EKSPERIMENTAL'NOI BIOLOGII I MEDITSINY , 51, 76-90 CODEN: BEBMAE; ISSN: 0365-9615, 1961 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FÖRDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; XP002332749 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FÖRDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; XP002332750 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FÖRDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; XP002332751 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FÖRDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE; XP002332752 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BUKIN, YU. V. ET AL: "Induction and inhibition of tyrosine aminotransferase in liver of mice and rats by vitamin B6 antagonists and by inhibitors of pyridoxal enzymes", XP002332742, retrieved from STN Database accession no. 82:149942 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GAMMON, D. W. ET AL: "GABA transaminase and glutamic acid decarboxylase as targets for insecticides. Biochemical and toxicological assessment", XP002332748, retrieved from STN Database accession no. 1988:89431 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SEVERIN, E. S. ET AL: "Reaction of hydroxylamine derivatives with transaminases of aromatic amino acids", XP002332741, retrieved from STN Database accession no. 70:111815 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BONOMI, U. ET AL: "Activity of aminoxy and hydroxylamino analogs of phenylalanine and glycine in some pyridoxal phosphate-dependent enzymic reactions", XP002332747, retrieved from STN Database accession no. 1964:450468 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KHOMUTOV, R. M. ET AL: "Hydroxylamine derivatives. IV. Synthesis of cyclocanaline (homocycloserine) and related compounds", XP002332746, retrieved from STN Database accession no. 1963:81505 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; POLYANOVSKII, O. L. ET AL: "Action of cycloserine and related compounds on activity of glutamic-oxalacetic transaminase and glutamic-pyruvic transaminase of pig heart", XP002332745, retrieved from STN Database accession no. 1962:55263 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VISHEPAN, E. D. ET AL: "Inhibition of glutamic-pyruvic transaminase activity with DL-cycloserine and other compounds", XP002332744, retrieved from STN Database accession no. 1962:3543 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VYSHEPAN, E. D. ET AL: "The effect of DL-cycloserine upon the process of transamination", XP002332743, retrieved from STN Database accession no. 1961:60946 *
DOKLADY AKADEMII NAUK SSSR , 141, 488-91 CODEN: DANKAS; ISSN: 0002-3264, 1961 *
GARRETT, EDWARD R.: "Characterization and mode of degradation of the neurophysiologically important transaminase inhibitors, the aminooxyalkanoic acids", JOURNAL OF PHARMACEUTICAL SCIENCES , 51, 572-6 CODEN: JPMSAE; ISSN: 0022-3549, 1962, XP009049393 *
IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA 2161-6 CODEN: IASKA6; ISSN: 0002-3353, 1962 *
KAUPPINEN R A ET AL: "AMINOOXYACETIC ACID INHIBITS THE MALATE-ASPARTATE SHUTTLE IN ISOLATED NERVE TERMINALS AND PREVENTS THE MITOCHONDIRA FROM UTILIZING GLYCOLYTIC SUBSTRATES", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 930, no. 2, 1987, pages 173 - 178, XP008024638, ISSN: 0006-3002 *
KHOMUTOV, R.M. ET AL, BULL.ACAD.SCI.USSR DIV.CHEM.SCI, 1967, pages 1743 - 1745 *
KORNOWSKI, H ET AL, BULL.SOC.CHIM.FR., 1966, pages 679 - 682 *
SCHUMANN, E. L. ET AL: "The synthesis and .gamma.-aminobutyric acid transaminase inhibition of aminooxy acids and related compounds", JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY , 5, 464-77 CODEN: JMPCAS; ISSN: 0095-9065, 1962, XP009049392 *
TOMASIAK M: "Importance of the malate-aspartate shuttle for the reoxidation of glycolytically produced NADH annd for cell aggregation in procine blood platelets", ACTA BIOCHIMICA POLONICA, POLISH SCIENTIFIC PUBLISHERS, WARSAW, PO, vol. 34, no. 3, 1987, pages 269 - 284, XP008024646, ISSN: 0001-527X *
YANG, D. ET AL, J.ORG.CHEM., vol. 66, no. 22, 2001, pages 7303 - 7312 *

Also Published As

Publication number Publication date
US20090149415A1 (en) 2009-06-11
EP1735271A2 (de) 2006-12-27
DE10357301A1 (de) 2005-07-07
WO2005054174A2 (de) 2005-06-16

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