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WO2005051320A3 - Gcks as modifiers of branching morphogenesis and methods of use - Google Patents

Gcks as modifiers of branching morphogenesis and methods of use Download PDF

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Publication number
WO2005051320A3
WO2005051320A3 PCT/US2004/039550 US2004039550W WO2005051320A3 WO 2005051320 A3 WO2005051320 A3 WO 2005051320A3 US 2004039550 W US2004039550 W US 2004039550W WO 2005051320 A3 WO2005051320 A3 WO 2005051320A3
Authority
WO
WIPO (PCT)
Prior art keywords
branching morphogenesis
methods
gcks
modifiers
gck
Prior art date
Application number
PCT/US2004/039550
Other languages
French (fr)
Other versions
WO2005051320A2 (en
Inventor
Hinrich Alexander Habeck
Felix D Karim
Thomas I Koblizek
Ulrike Langheinrich
Gregory D Plowman
Merker Staefan Schulte
Gordon Mark Stott
Candace Swimmer
Original Assignee
Exelixis Inc
Trowe Torsten
Vogel Andreas Michael
Jin Yisheng
Odenthal Jorg Hinrich
Scheel Jochen Konrad
Will Torsten Tilmann
Hinrich Alexander Habeck
Felix D Karim
Thomas I Koblizek
Ulrike Langheinrich
Gregory D Plowman
Merker Staefan Schulte
Gordon Mark Stott
Candace Swimmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Trowe Torsten, Vogel Andreas Michael, Jin Yisheng, Odenthal Jorg Hinrich, Scheel Jochen Konrad, Will Torsten Tilmann, Hinrich Alexander Habeck, Felix D Karim, Thomas I Koblizek, Ulrike Langheinrich, Gregory D Plowman, Merker Staefan Schulte, Gordon Mark Stott, Candace Swimmer filed Critical Exelixis Inc
Publication of WO2005051320A2 publication Critical patent/WO2005051320A2/en
Publication of WO2005051320A3 publication Critical patent/WO2005051320A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human GCK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of GCK are provided.
PCT/US2004/039550 2003-11-24 2004-11-23 Gcks as modifiers of branching morphogenesis and methods of use WO2005051320A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52455003P 2003-11-24 2003-11-24
US60/524,550 2003-11-24

Publications (2)

Publication Number Publication Date
WO2005051320A2 WO2005051320A2 (en) 2005-06-09
WO2005051320A3 true WO2005051320A3 (en) 2006-10-12

Family

ID=34632906

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2004/039790 WO2005052132A2 (en) 2003-11-24 2004-11-22 Mbms as modifiers of branching morphogenesis and methods of use
PCT/US2004/039550 WO2005051320A2 (en) 2003-11-24 2004-11-23 Gcks as modifiers of branching morphogenesis and methods of use
PCT/US2004/039408 WO2005051314A2 (en) 2003-11-24 2004-11-23 Iraks as modifiers of branching morphogenesis and methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039790 WO2005052132A2 (en) 2003-11-24 2004-11-22 Mbms as modifiers of branching morphogenesis and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039408 WO2005051314A2 (en) 2003-11-24 2004-11-23 Iraks as modifiers of branching morphogenesis and methods of use

Country Status (1)

Country Link
WO (3) WO2005052132A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
NZ589084A (en) 2008-05-16 2012-06-29 Takeda San Diego Inc Glucokinase activators
NZ593893A (en) * 2009-01-07 2013-02-22 Haidong Huang Gene encoding human glucokinase mutant, enzyme encoded by the same, recombinant vectors and hosts, pharmaceutical compositions and uses thereof, methods for treating and preventing diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654397A (en) * 1985-06-23 1997-08-05 Tularik, Inc. Interleukin-1 receptor-associated protein kinase and assays
JPH06506596A (en) * 1991-04-10 1994-07-28 ザ　トラスティーズ　オブ　ボストン　ユニバーシティー Interleukin-8 receptor and related molecules and methods
US20020026037A1 (en) * 1995-06-06 2002-02-28 Jing-Shan Hu Vascular endothelial growth factor 3 antibodies
AU702844B2 (en) * 1995-06-23 1999-03-04 Tularik Inc. Interleukin-1 receptor-associated protein kinase and assays
US20030064917A1 (en) * 1998-07-23 2003-04-03 Crawford Susan E. Methods and compositions for inhibiting angiogenesis
US6365356B1 (en) * 1999-03-17 2002-04-02 Cornell Research Foundation, Inc. Receptors that regulate cell signaling relating to chemokines
US6818419B2 (en) * 2000-01-13 2004-11-16 Tularik Inc. IRAK-4: compositions and methods of use
WO2002099083A2 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Gfats as modifiers of the p53 pathway and methods of use
US20030100005A1 (en) * 2001-11-26 2003-05-29 Karim Felix D. CRBs as modifiers of branching morphogenesis and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RIZZO M.A.: "A Funtional Link Between Glucokinase Binding to Insulin Granules and Conformational Alterations in Response to Glucose and Insulin", J.BIOL.CHEM., vol. 277, no. 37, September 2002 (2002-09-01), pages 34168 - 34175 *

Also Published As

Publication number Publication date
WO2005052132A2 (en) 2005-06-09
WO2005051314A2 (en) 2005-06-09
WO2005051320A2 (en) 2005-06-09
WO2005051314A3 (en) 2007-04-26
WO2005052132A3 (en) 2007-06-07

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