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WO2005018711A2 - Autopiqueur muni d'un chargeur a plusieurs lancettes - Google Patents

Autopiqueur muni d'un chargeur a plusieurs lancettes Download PDF

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Publication number
WO2005018711A2
WO2005018711A2 PCT/US2004/026982 US2004026982W WO2005018711A2 WO 2005018711 A2 WO2005018711 A2 WO 2005018711A2 US 2004026982 W US2004026982 W US 2004026982W WO 2005018711 A2 WO2005018711 A2 WO 2005018711A2
Authority
WO
WIPO (PCT)
Prior art keywords
lancet
lancets
lancing device
magazine
travel
Prior art date
Application number
PCT/US2004/026982
Other languages
English (en)
Other versions
WO2005018711A3 (fr
Inventor
Richard W. Levaughn
Gwenn E. Kennedy
Stephen Flynn
Carl E. Griffin
John C. Irwin
Mary Kate Pynes
Stephanie J. Campbell
Christoppher J. Ruf
Mitchell A. Solis
Avi M. Robbins
Jason R. Heath
Ray Lathrop
Venkat Katragadda
Original Assignee
Facet Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Facet Technologies, Llc filed Critical Facet Technologies, Llc
Priority to EP04781632A priority Critical patent/EP1663023A4/fr
Priority to US10/569,031 priority patent/US20060264996A1/en
Publication of WO2005018711A2 publication Critical patent/WO2005018711A2/fr
Publication of WO2005018711A3 publication Critical patent/WO2005018711A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150175—Adjustment of penetration depth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150541—Breakable protectors, e.g. caps, shields or sleeves, i.e. protectors separated destructively, e.g. by breaking a connecting area
    • A61B5/150564—Protectors removed by pulling or pushing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058—Joining techniques used for protective means
    • A61B5/150618—Integrally moulded protectors, e.g. protectors simultaneously moulded together with a further component, e.g. a hub, of the piercing element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150725—Procedure for removing protection means at the time of piercing removal procedure linked to further actions, e.g. cocking of the piercing device, which indicate that the piercing device is used or tempered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150885—Preventing re-use
    • A61B5/150916—Preventing re-use by blocking components, e.g. piston, driving device or fluid passageway
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15126—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides
    • A61B5/1513—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides comprising linear sliding guides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
    • A61B5/15149—Arrangement of piercing elements relative to each other
    • A61B5/15155—Piercing elements which are specially shaped or are provided with fittings or attachments to facilitate nesting, stacking or joining together end-to-end or side-by-side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
    • A61B5/15157—Geometry of stocking means or arrangement of piercing elements therein
    • A61B5/15159—Piercing elements stocked in or on a disc
    • A61B5/15163—Characterized by propelling the piercing element in an axial direction relative to the disc
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
    • A61B5/15157—Geometry of stocking means or arrangement of piercing elements therein
    • A61B5/15174—Piercing elements stocked in the form of a stack or pile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
    • A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
    • A61B5/15176—Stocking means comprising cap, cover, sheath or protection for aseptic stocking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B50/3001—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for sharps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
    • A61B2050/3013—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments having means for automatically ejecting the stored article

Definitions

  • the present invention relates generally to medical devices and procedures, and more particularly to lancing devices and multi-lancet cartridge assemblies for the collection and/or analysis of samples of blood or other bodily fluids.
  • a sharp lancet tip is commonly used to puncture the subject's skin at a lancing site to obtain a sample of blood, interstitial fluid or other body fluid, as for example in blood glucose monitoring by diabetics, and in blood typing and screening applications.
  • a person must periodically sample their blood for multiple testing throughout the day or week. Because re-use of a lancet can result in infection or spread of bloodbome contaminants, persons requiring repeated testing often must carry multiple lancets with them. This can be inconvenient and lead to reduced compliance with a prescribed test regimen. Accordingly, it can be seen that needs exist for a convenient, compact multi-use lancing device.
  • U.S. Patent No. 5,971,941 is understood to show a cassette with test strips for placement by a slider.
  • a lancet pierces the skin surface so that blood can be obtained for analysis.
  • the lancets are integrated on a test strip, and are positioned together with the test strip.
  • Another embodiment is understood to show a disposable cylindrical insert having a lancet and a test membrane with an aperture for the lancet. The insert is inserted in a mounting cavity of a plunger or piston, which forces the lancet outward for blood withdrawal.
  • DE 198 19407 A1 is understood to show a multiplicity of test strips with integrated lancets for insertion into an analysis device.
  • U.S. Patent No. 4,787,398 is understood to show a device with a plunger for directing a lancet outward, and has an evaluation system and a display system.
  • a replaceable unit is applied to the device for each measurement.
  • the replaceable unit comprises the lancet and a test strip, which is wetted with blood. This replaceable unit is thrr.vn away after each use.
  • EP 0449 525 A1 is understood to show a blood withdrawal system wherein a new lancet is inserted manually into a release device before each use. A test strip is then inserted into the device.
  • U.S. Patent No.4,627,445 is understood to show a device for measuring blood sugar, with an integrated blood withdrawal unit.
  • U.S. Patent No. 5,951 ,492 is understood to show a disposable unit with a capillary tube and a test strip, to which sampled blood taken is applied.
  • the capillary tube includes a lancet.
  • a new disposable unit is attached and removed before and after each measurement.
  • EP 0877250 A2, EP 0949506 A2 and EP 811843 A2 are understood to show devices having a multiplicity of test elements arranged on a rotatable disk carrier. The test elements are brought successively into a working position and pushed out of the housing to be wetted with blood.
  • U.S. Patent No. 6,228,100 and U.S. Patent No. 4,794,926 are understood to show lancets arranged on a carrier, which is rotated with respect to a housing.
  • German Application DE 100 57 832 C1 is understood to show a lancing device of a known form.
  • Other lancing devices understood to include multiple lancets are shown, for example, in U.S. Patent App. Serial No. 2002/0087056 A1 and WO 02/36010 A1.
  • EP 0589186 B1 is understood to show a lancet with a removable protective cap.
  • WO 01/66010 A1 is understood to include a multiplicity of lancets in a magazine, with an opening of the chamber closed by an elastic material, which is penetrated in the puncture process.
  • the present invention is a lancing device having an outer housing for receiving a replaceable multi-lancet cartridge or magazine.
  • the lancet cartridge or magazine remains stationary relative to the housing and drive mechanism of the lancing device, and the drive mechanism is advanced sequentially along the cartridge or magazine within the outer housing for carrying out multiple lancing procedures.
  • the drive mechanism is stationary and the cartridge or magazine advances sequential lancets through the drive mechanism.
  • the cartridge or magazine preferably includes a top and bottom for retaining the array of lancets sequentially mounted within the cartridge and for constraining the active lancet along a controlled and pre-defined path of travel during the lancing stroke.
  • the cartridge or magazine preferably also includes a mechanism for retaining protective endcaps that have been removed from the lancets in a position out of the path of travel of the lancets and for preventing the caps from rattling within the housing.
  • the invention is a lancing device having a housing for receiving a plurality of lancets, and a drive mechanism translationally mounted within the housing for traversing the plurality of lancets and sequentially engaging individual lancets from the plurality of lancets, and driving the engaged lancet along a path of travel.
  • the present invention is a lancing device including a drive mechanism for sequentially engaging individual lancets from a multi-lancet cartridge, retracting the engaged lancet along a first path of travel, and advancing the lancet along a second path of travel, wherein the drive mechanism preferably includes a coupling allowing the engaged lancet to pivot between the first and second paths of travel.
  • the invention is a lancing device including a plurality of lancets, wherein the plurality of lancets are initially joined together in an attached array, and wherein the lancing device preferably further includes a separating member for sequentially detaching individual lancets from the attached array.
  • the invention is a magazine for a lancing device, the magazine preferably including a plurality of lancets, and guide surfaces defining a storage position and a firing position for each of the plurality of lancets.
  • the invention is a magazine for a lancing device, the magazine including a lancet having a sharp tip portion, and being movable between a retracted position and a lancing position.
  • the magazine preferably further includes a window through which the sharp tip portion of the lancet projects in its lancing position, and a shutter movable between an open position allowing passage of the sharp tip portion of the lancet through the window and a closed position blocking the window.
  • the invention is a lancet cartridge including a plurality of lancets, each lancet having a body and a sharp tip projecting from the body.
  • the lancet cartridge preferably further includes a common sterility block into which the sharp tips of each of the plurality of lancets is removably embedded.
  • the invention is a lancet cartridge including a plurality of lancets, each of the plurality of lancets being joined to at least one adjacent lancet by a separable segment.
  • the invention is a lancet including a body having first and second ends, and a sharp tip projecting axially from a first end of the lancet body, wherein the second end of the lancet body is flared and comprises an arcuate distal surface.
  • Example embodiments of the present invention include an improved sampling device that is convenient, compact, and includes multiple lancets in a single cassette or cartridge.
  • the present invention preferably increases convenience for the user, thereby encouraging more frequent testing and insuring compliance with the subject's prescribed testing regimen.
  • FIGURE 1 is a perspective view of a lancing device according to an example embodiment of the present invention, with the drive mechanism in a first position.
  • FIGURE 2 is a perspective view of the device of FIG. 1 , after advancement of the drive mechanism to a subsequent position, with a top cover portion removed to show the lancet magazine and internal workings including the drive mechanism.
  • FIGURES 3a - 3d are perspective, side, top and end views of a lancet cartridge according to an example embodiment of the present invention.
  • FIGURES 4a - 4c are perspective, end, and partial cutaway top views of a lancet magazine according to an example embodiment of the present invention
  • FIGURES 5-7 show a sequence of operation of a lancing device and lancet magazine according to an example embodiment of the present invention.
  • FIGURE 8 shows a lancing device according to another example embodiment of the present invention.
  • FIGURE 9 shows another embodiment of a lancet magazine or cartridge according to the present invention.
  • FIGURE 10 is a detailed view of a single lancet of the lancet magazine of
  • FIGURES 11a - 11c show a sequence of operation of a lancing device and lancet according to FIG.10.
  • Ranges may be expressed herein as from “about” or “approximately” one particular value and/or to “about” or “approximately” another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent "about,” it will be understood that the particular value forms another embodiment.
  • FIGURES 1 and 2 show a lancing device 10 according to an example embodiment of the present invention.
  • the lancing device 10 preferably generally comprises a housing 12 and a drive mechanism 14.
  • a multi-lancet magazine 16 for example as shown in FIG. 4, is preferably removably loaded into the lancing device 10 for sequential engagement of the lancets with the drive mechanism.
  • the housing 12 and drive mechanism 14 are preferably re-usable, and the lancet magazine 16 is preferably a disposable component, so that spent magazines can be removed for disposal and replaced with new lancet magazines.
  • a lancet cartridge portion 17 of the magazine 16, as shown in FIG. 3 is removable from the magazine, and the magazine is reusable with replacement lancet cartridges.
  • the drive mechanism 14 preferably includes a piston with a coupling 34 for sequentially engaging individual lancets of the magazine or cartridge.
  • the coupling of the piston 34 preferably comprises a C-shaped channel or other configuration having a narrow mouth portion and a wider arcuate distal portion, so that the coupling can slide translationally into and out of engagement with sequential lancets of the magazine or cartridge, and securely engage flared end portions of the lancets for axial advancement and return of the lancets through their path of travel along a lancing stroke.
  • the engagement of the coupling 34 with the flared end of the lancet permits a degree of pivotal motion of the lancet within the coupling, thereby allowing the lancet to rotate between angularly-offset first and second travel paths as described below.
  • the drive mechanism 14 preferably further comprises an activation mechanism coupled to the piston 34 for driving the piston and an active lancet engaged within the coupling of the piston through the path of travel of the lancing stroke, from a first "retracted” position shielded within the housing, through a second "lancing" position wherein a tip portion of the active lancet projects outwardly of the housing for lancing the subject's skin at a sampling site, and back to a third "return” position shielded within the housing.
  • the activation mechanism can drive the piston and active lancet via spring-driven or other biasing means, a ratchet system, manual advancement mechanism, a screw type drive, or other means of propulsion.
  • the drive mechanism 14 preferably also comprises an actuator or trigger 18 for allowing the user to selectively actuate the activation mechanism to drive the active lancet through the lancing stroke.
  • the housing 12 is preferably a generally rigid shell serving to house and pro j ect the drive mechanism 14 and the magazine 16.
  • the housing 12 can be integrally formed or can comprise multiple pieces that are adjoined together.
  • the housing is preferably fabricated from plastic, metal or other substantially rigid and durable material of construction.
  • the housing comprises a base portion to which the drive mechanism is mounted, and a top cover portion that is permanently or releasably secured to the base portion.
  • the housing is a generally rectangular box having a top panel, a bottom panel, a front panel, a back panel, and first and second side panels.
  • the front panel preferably comprises a least one lancet opening through which the tip of the active lancet projects in its lancing position.
  • a plurality of lancet openings or an elongate slotted lancet opening is provided.
  • the top panel preferably comprises an opening through which the actuator 18 projects.
  • One or both side panels preferably comprise access ports for inserting and/or removing lancet magazines or cartridges into and out of the lancing device.
  • the drive mechanism 14 traverses a path from one side of the housing to the other, for sequentially engaging individual lancets of a lancet magazine 16, which is fixed in position relative to the housing 12.
  • FIG. 1 shows the drive mechanism 14 in a first position toward a first side of the housing, for engagement with a lancet toward the first side of the magazine 16; and
  • FIG. 2 shows the drive mechanism in a second position toward the second side of the housing, for engagement with another lancet toward the second side of the magazine.
  • the drive mechanism 14 can be manually or automatically advanced along its path of traverse.
  • a forward portion of the drive mechanism 14 preferably extends through the lancet opening in the front panel of the housing, and defines a contact ring surrounding a central opening for contact against the skin at the lancing site.
  • the forward portion of the drive mechanism traverses the lancet opening in the front panel of the housing as the remainder of the drive mechanism traverses the housing to engage sequential lancets.
  • the drive mechanism 14 remains stationary within the housing, and the lancet magazine 16 is manually or automatically advanced through the drive mechanism 14 to engage sequential lancets of the cartridge with the drive mechanism.
  • a linear array of lancets in a belt-like cartridge can be fed in through the access port in one side of the housing and discharged out of the access port in the other side, as the cartridge is advanced through the stationary drive mechanism.
  • FIGURES 3a - 3d show a linear array of lancets 20 in a belt-like cartridge.
  • the lancets of a cartridge are preferably oriented with their sharp tips aligned generally in the same direction, in a planar linear array.
  • the lancets of a cartridge are arranged in a conical array, as described below, or in a curved or otherwise configured array.
  • the lancet body 21 is formed of plastic and is injection-molded around a piercing element 23 having a sharp needle or blade tip projecting from its proximal end.
  • Each lancet preferably comprises a flared distal end, having a D-shaped profile with an arcuate distal face, for engagement with the coupling of the drive mechanism, and a sharp tip projecting from its proximal end.
  • One or more protective endcap members 22 are preferably provided for covering the sharp tips of the lancets to maintain sterility and prevent inadvertent needle sticks during loading and unloading.
  • a single unitary or common sterility block 22 forms the endcap member for all of the lancets 20 of the cartridge.
  • each lancet has a separate, individual sterility cap.
  • the capacity of a linear magazine or cartridge can optionally be doubled by attaching two such magazines together end-to-end, either mechanically or in design, into an adjoined magazine. For example, after all lancets on a first end portion of the adjoined magazine are used, the magazine is ejected, turned over and lancets on a second end portion are used.
  • FIGURES 5-7 show a sequence of operation of a multi-lancet magazine assembly 16 and a lancing device according to the present invention.
  • the magazine preferably comprises a cartridge having a linear array of lancets 20 therein, the lancets initially being positioned in an inclined storage position with their sharp tips embedded in a sterility cap 22.
  • the magazine preferably further comprises a magazine top 24 and a magazine bottom 26, defining first and second travel paths for each lancet 20.
  • the cartridge preferably also includes one or more cantilevered leaf springs or other biasing element(s) 28, for moving an active lancet from its initially inclined storage position (see FIG. 4) into a firing position (see FIGS. 6 and 7).
  • the storage position is preferably oriented at an acute angle relative to the firing position, most preferably at an angle of between about 5° to about 30° beneath the firing position.
  • FIGURE 5 shows engagement of an active lancet 20 with the coupling of the drive mechanism piston 34, to retract the lancet from the sterility block 22 along the first travel path.
  • the biasing element 28 pushes the top of the lancet body 21 against a shelf 36 on the underside of the magazine top 24.
  • the shelf 36 preferably comprises an angled surface extending rearwardly from the sterility block 22, a distance approximately equal to or slightly greater than the length of the lancet tip 23 extending from the lancet body 21 , constraining movement of the lancet to linear translation along the first travel path as the lancet is axially (i.e., in the direction of the lengthwise axis of the lancet needle) withdrawn from the sterility block.
  • the shelf 36 prevents bending damage to the lancet tip 23 by holding the active lancet 20 in its downward (storage/pre-fire) position until the lancet tip is completely withdrawn from the sterility block 22, at which point the edge of the lancet body 21 clears the end of the shelf 36, allowing the biasing element 28 to rotate the active lancet 20 into its generally horizontal firing position, shown in FIG. 6.
  • the lancet tip 23 preferably passes through a slot 38 formed in the shelf 36 as the lancet moves from the storage position to the firing position.
  • the second travel path preferably being offset at an acute angle, and more preferably at an angle of between about 5° to about 30°, above the first travel path.
  • the lancet preferably then returns along the second travel path, from its lancing position to its return position.
  • the second travel path is preferably generally horizontal (i.e., generally parallel to the magazine bottom and the bottom panel of the housing, and is defined by a channel or pathway along a bottom surface of the magazine top 24.
  • the magazine comprises one or more stops adjacent the opening 30 for contacting a cooperating surface feature of the lancet to limit its travel and thereby control lancing penetration depth.
  • a door or shutter 32 preferably extends from the magazine adjacent the opening 30, and is hingedly movable from an initial open position allowing passage of the lancet tip to a closed position blocking the opening 30 to prevent inadvertent contact with a used lancet.
  • the door 32 includes one-way locking features such as a barb for engagement with a cooperating detent formed in the magazine adjacent the opening 30 to prevent re-opening the door after closure, and thereby prevent re-use of a lancet.
  • the user preferably opens an access port in the housing of the lancing device, loads a preassembled multi-lancet cartridge into the lancing device, and closes the housing.
  • a first unused lancet is engaged with the drive mechanism to become the active lancet.
  • the drive mechanism is cocked or otherwise energized, if necessary, and the lancet is withdrawn along its first travel path to retract its tip from the protective endcap or sterility block.
  • the biasing element applies force to rotate the lancet from its storage position to its firing position.
  • the lancing device is positioned against a finger or other lancing site on the subject's body, and the drive mechanism is actuated to propel the lancet along its second travel path to lance the skin at the lancing site.
  • the lancet then retracts along the second travel path to its returned position.
  • the lancing device is advanced to release the used lancet and bring another lancet into the active position in engagement with the drive mechanism. After all lancets of a cartridge have been used, the spent cartridge is removed from the lancing device, and a fresh cartridge is installed.
  • FIGURE 8 shows a blood sampling device 110 according to another example embodiment of the invention.
  • the device includes a reusable housing 112, an actuator and drive mechanism 114, and a removable and replaceable lancet cartridge 116.
  • the cartridge preferably comprises a linear array of attached lancets 18 for sequential firing. Adjacent individual lancets of the cartridge are preferably attached to one another by intermediate webs, or are integrally formed and directly attached to one another by separable neck segments.
  • An active lancet of the cartridge is preferably advanced into a firing position by an advancing arm 124, into engagement with the drive mechanism.
  • a blade or other inclined separating member 120 is driven between the active lancet and the adjacent lancet to separate the active lancet from the cartridge.
  • the actuation of the separating member also serves to simultaneously or sequentially energize the drive mechanism, as by compressing a drive spring and engaging a trigger mechanism.
  • the trigger mechanism is released, whereupon the drive mechanism propels the active lancet through its travel path, between a retracted position within the housing to a lancing position wherein at least a tip portion of the lancet extends out of the housing to lance the subject's skin at a lancing site, and preferably back to a returned position within the housing.
  • the advancing mechanism can then be actuated to eject the used lancet from an ejection port 122 of the housing, and bring the next lancet of the cartridge into the active position for subsequent use.
  • FIG. 9 shows a generally conical arrangement of lancets 50 for a lancet cartridge.
  • each individual lancet 50 preferably comprises a lancet body 51 , a sharp tip 53 such as a needle or blade extending axially from a first end of the lancet body, a biasing arm 52 extending transversely from a side of the lancet body generally perpendicular to the lengthwise axis of the lancet body, and a flared second end preferably having a distal face with an arcuate profile.
  • the lancets are preferably assembled in a circular array within a housing, with their axes inclined inwardly so that their tips are directed toward the central axis of the circular array, to form a conical magazine or cartridge.
  • FIGURES 11a, 11b and 11c show a sequence of operation of a lancet 50 of the type shown in FIG. 10.
  • the lancet 50 is initially disposed in a storage position, with its lengthwise axis aligned in a first angular orientation, preferably within a storage channel 56 or other guide surface(s) of the cartridge or lancing device.
  • the lancet 50 is engaged by the drive mechanism of the lancing device, and is translationally retracted along a first travel path defined by the storage channel 56, as shown in FIG. 11a, into a retracted position.
  • the biasing arm 52 engages a biasing surface of the cartridge or lancing device, as shown in FIG.
  • a shelf positioned between the storage channel 56 and the firing channel 58 preferably constrains the lancet to translational motion along its first travel path, until the lancet body is retracted clear of the shelf.
  • the shelf preferably defines a slot 60, through which the lancet tip 53 passes as the lancet rotates into its second angular orientation under the influence of the biasing arm 52.
  • the drive mechanism is then actuated to translationally propel the lancet 50 in its axial direction, along a second travel path defined by the firing channel 58, from the retracted position to a lancing position wherein the lancet tip projects from the lancing device to lance the subject's skin at a lancing site, and preferably back again to a return position within the lancing device.
  • the first and second travel paths are preferably offset from one another at an acute angle, and more preferably at an angle of between about 5° to about 30°.

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Abstract

L'invention concerne un autopiqueur et une cartouche remplaçable à plusieurs lancettes destinée à être utilisée dans l'échantillonnage de fluides corporels. On retire les lancettes séquentielles de la cartouche par translation le long d'une voie de rangement, on les fait pivoter dans une voie de déclenchement à angle décalé et on les propulse par translation au moyen d'un mécanisme d'entraînement en vue de piquer la peau du sujet.
PCT/US2004/026982 2003-08-20 2004-08-19 Autopiqueur muni d'un chargeur a plusieurs lancettes WO2005018711A2 (fr)

Priority Applications (2)

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EP04781632A EP1663023A4 (fr) 2003-08-20 2004-08-19 Autopiqueur muni d'un chargeur a plusieurs lancettes
US10/569,031 US20060264996A1 (en) 2003-08-20 2004-08-19 Lancing device with multi-lancet magazine

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US49702303P 2003-08-20 2003-08-20
US60/497,023 2003-08-20

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WO2005018711A3 WO2005018711A3 (fr) 2005-04-28

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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1903942A2 (fr) 2005-07-19 2008-04-02 IHQ Innovation Headquarters OY Dispositif de controle de l'etat de sante, modules du dispositif et procede
WO2008052172A2 (fr) * 2006-10-26 2008-05-02 Facet Technologies, Llc Lancette rétractable et mécanisme de rétraction à utiliser avec celle-ci
WO2009022138A1 (fr) 2007-08-14 2009-02-19 Owen Mumford Limited Dispositifs autopiqueurs
EP2030566A1 (fr) * 2007-08-31 2009-03-04 Roche Diagnostics GmbH Système d'analyse pour déterminer une analyse dans un fluide corporel, magazine pour système d'analyse, acquisition d'échantillon intégré et élément d'analyse, et procédé d'analyse d'un liquide corporel
US7678127B2 (en) 2003-08-20 2010-03-16 Facet Technologies, Llc Multi-lancet device with sterility cap repositioning mechanism
EP2218399A1 (fr) * 2009-02-17 2010-08-18 Roche Diagnostics GmbH Protection contre la réutilisation pour système de lancettes
US8945022B2 (en) 2007-04-12 2015-02-03 Roche Diagnostics Operations, Inc. Puncturing system
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9072842B2 (en) 2002-04-19 2015-07-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9517027B2 (en) 2009-07-10 2016-12-13 Facet Techonologies, Llc Advancement mechanism for cartridge-based devices
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9694144B2 (en) 2001-06-12 2017-07-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US9724021B2 (en) 2002-04-19 2017-08-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US10034628B2 (en) 2003-06-11 2018-07-31 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE10057832C1 (de) 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
EP1404234B1 (fr) 2001-06-12 2011-02-09 Pelikan Technologies Inc. Dispositif permettant d'ameliorer le rendement du prelevement de sang capillaire au bout du doigt
ATE450210T1 (de) 2001-06-12 2009-12-15 Pelikan Technologies Inc Selbstoptimierende lanzettenvorrichtung mit adaptationsmittel für zeitliche schwankungen von hauteigenschaften
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
CA2448790C (fr) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Actionneur electrique de lancette
CA2448681C (fr) 2001-06-12 2014-09-09 Pelikan Technologies, Inc. Systeme integre de prelevement et d'analyse d'echantillons sanguins avec module de prelevement a utilisation multiple
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
DE10208575C1 (de) 2002-02-21 2003-08-14 Hartmann Paul Ag Blutanalysegerät zur Bestimmung eines Analyten
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
EP1633235B1 (fr) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Appareil d'echantillonnage de fluides anatomiques et d'examen de l'analysat
EP1635700B1 (fr) 2003-06-13 2016-03-09 Sanofi-Aventis Deutschland GmbH Appareil pour dispositif d'analyse sur le lieu de soin
WO2005033659A2 (fr) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Procede et appareil permettant d'obtenir un dispositif de capture d'echantillons ameliore
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7604118B2 (en) * 2003-12-15 2009-10-20 Panasonic Corporation Puncture needle cartridge and lancet for blood collection
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
ATE468142T1 (de) 2004-03-31 2010-06-15 Lilly Co Eli Injektionsgerät mit einer nadelkassette zur abgabe einer pharmazeutischen flüssigkeit
GB2414734B (en) * 2004-06-01 2010-09-08 Rosti As Devices for retaining and presenting for use a plurality of components
GB0420256D0 (en) 2004-09-13 2004-10-13 Cassells John M Method and apparatus for sampling and analysis of fluids
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
JP5147702B2 (ja) 2005-09-30 2013-02-20 インテュイティ メディカル インコーポレイテッド 完全に統合された、ウエアラブル又はハンドヘルドモニタ
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
GB0605003D0 (en) * 2006-03-13 2006-04-19 Microsample Ltd Method and apparatus for piercing the skin and delivery or collection of liquids
WO2008064333A2 (fr) * 2006-11-21 2008-05-29 Stat Medical Devices, Inc. Dispositif de lancette utilisant une cartouche de type révolver, et procédé de fabrication et/ou d'utilisation de la cartouche et du dispositif de lancette
CA2675275C (fr) 2007-01-12 2013-06-25 Facet Technologies, Llc Cartouche a lancettes multiples et autopiqueur
ATE534328T1 (de) * 2007-05-29 2011-12-15 Hoffmann La Roche Flexible lanzette in einem lanzettensystem
CA2682328A1 (fr) * 2007-05-30 2008-12-11 Eli Lilly And Company Cartouche avec aiguilles d'injection multiples pour un dispositif d'injection d'un medicament
EP2042098A1 (fr) * 2007-09-26 2009-04-01 Roche Diagnostics GmbH Magasin de lancettes
US9392968B2 (en) * 2008-01-23 2016-07-19 Stat Medical Devices, Inc. Lancet needle cartridge, cartridge lancet device, and method of using and making the same
WO2009116289A1 (fr) * 2008-03-18 2009-09-24 パナソニック株式会社 Dispositif de prélèvement d'échantillons de sang et chargeur associé
JP2009225936A (ja) * 2008-03-21 2009-10-08 Nitto Denko Corp 体液採取用回路基板、その製造方法、その使用方法およびバイオセンサ
WO2009126900A1 (fr) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Procédé et appareil pour dispositif de détection d’analyte
EP2293719B1 (fr) 2008-05-30 2015-09-09 Intuity Medical, Inc. Dispositif de prélèvement de liquide organique et interface de site de prélèvement
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
EP2375985B1 (fr) 2008-12-18 2013-06-19 Facet Technologies, LLC Autopiqueur
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010094427A2 (fr) 2009-02-19 2010-08-26 Roche Diagnostics Gmbh Stockage peu encombrant de moyens d'analyse
EP2226008A1 (fr) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Procédé de fabrication d'un chargeur analytique
EP2226007A1 (fr) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Chargeur d'éléments de test doté de champs de test recouverts
WO2011050142A1 (fr) * 2009-10-22 2011-04-28 Facet Technologies, Llc. Autopiqueur à ensemble de guidage amélioré
EP2316338A1 (fr) * 2009-11-02 2011-05-04 Roche Diagnostics GmbH Système de saisie de lancette pour dispositif de lancettes
CA2782047C (fr) 2009-11-30 2019-10-29 Intuity Medical, Inc. Dispositif et procede de fourniture de materiau d'etalonnage
USD634426S1 (en) 2010-04-08 2011-03-15 Facet Technologies, Llc Lancing device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CN104888314A (zh) 2010-11-19 2015-09-09 伊莱利利公司 用于药物注射装置的针盒
EP3750480B1 (fr) 2011-08-03 2022-02-02 Intuity Medical, Inc. Dispositifs de prélèvement de fluide corporel
CA2857503C (fr) 2011-12-15 2020-10-27 Facet Technologies, Llc Mecanisme de loquet destine a empecher l'oscillation d'une lancette dans un autopiqueur
US10085681B2 (en) 2012-04-11 2018-10-02 Facet Technologies, Llc Lancing device with moving pivot depth adjust
CA2869345C (fr) 2012-04-12 2018-08-21 Facet Technologies, Llc Dispositif autopiqueur a activation laterale de charge et mecanismes d'ejection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5971941A (en) 1997-12-04 1999-10-26 Hewlett-Packard Company Integrated system and method for sampling blood and analysis

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4627445A (en) * 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US5279294A (en) * 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
US4787398A (en) * 1985-04-08 1988-11-29 Garid, Inc. Glucose medical monitoring system
IL80628A0 (en) * 1985-11-18 1987-02-27 Bajada Serge Apparatus for testing the sensory system in humans or animals
US4794926A (en) * 1986-11-24 1989-01-03 Invictus, Inc. Lancet cartridge
GB8710470D0 (en) * 1987-05-01 1987-06-03 Mumford Ltd Owen Blood sampling devices
US5035704A (en) * 1989-03-07 1991-07-30 Lambert Robert D Blood sampling mechanism
DE4212315A1 (de) * 1992-04-13 1993-10-14 Boehringer Mannheim Gmbh Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke
US5514152A (en) * 1994-08-16 1996-05-07 Specialized Health Products, Inc. Multiple segment encapsulated medical lancing device
US5628765A (en) * 1994-11-29 1997-05-13 Apls Co., Ltd. Lancet assembly
ES2121564B1 (es) * 1996-05-17 2001-02-01 Mercury Diagnostics Inc Metodos y aparatos para extraer fluido corporal desde una incision.
US5951492A (en) * 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
US5741288A (en) * 1996-06-27 1998-04-21 Chemtrak, Inc. Re-armable single-user safety finger stick device having reset for multiple use by a single patient
US5984940A (en) * 1997-05-29 1999-11-16 Atrion Medical Products, Inc. Lancet device
US6071294A (en) * 1997-12-04 2000-06-06 Agilent Technologies, Inc. Lancet cartridge for sampling blood
US5871494A (en) * 1997-12-04 1999-02-16 Hewlett-Packard Company Reproducible lancing for sampling blood
US6036924A (en) * 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6228100B1 (en) * 1999-10-25 2001-05-08 Steven Schraga Multi-use lancet device
DE19963809C2 (de) * 1999-12-30 2002-01-17 Osram Opto Semiconductors Gmbh Optischer Encoder mit dreifacher Photodiode
DE10010694A1 (de) * 2000-03-04 2001-09-06 Roche Diagnostics Gmbh Blutlanzette mit hygienischen Spitzenschutz
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
DE10053974A1 (de) * 2000-10-31 2002-05-29 Roche Diagnostics Gmbh System zur Blutentnahme
DE10057832C1 (de) * 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US6530892B1 (en) * 2001-03-07 2003-03-11 Helen V. Kelly Automatic skin puncturing system
US6766817B2 (en) * 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7491178B2 (en) * 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) * 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) * 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7244265B2 (en) * 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) * 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7717863B2 (en) * 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2003088824A2 (fr) * 2002-04-19 2003-10-30 Pelikan Technologies, Inc. Dispositif et procede pour utiliser une lancette a vitesse variable
US7175642B2 (en) * 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7674232B2 (en) * 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) * 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7410468B2 (en) * 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7485128B2 (en) * 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) * 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7547287B2 (en) * 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) * 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7563232B2 (en) * 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7198606B2 (en) * 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US7141058B2 (en) * 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7481776B2 (en) * 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) * 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) * 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) * 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) * 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) * 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8034057B2 (en) * 2002-11-07 2011-10-11 Penenberg Brad L Apparatus for, and method of, preparing for and inserting hip joint prosthesis using computer guidance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5971941A (en) 1997-12-04 1999-10-26 Hewlett-Packard Company Integrated system and method for sampling blood and analysis

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9802007B2 (en) 2001-06-12 2017-10-31 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9694144B2 (en) 2001-06-12 2017-07-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US9724021B2 (en) 2002-04-19 2017-08-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9498160B2 (en) 2002-04-19 2016-11-22 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US9072842B2 (en) 2002-04-19 2015-07-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9186468B2 (en) 2002-04-19 2015-11-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US10034628B2 (en) 2003-06-11 2018-07-31 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US7678127B2 (en) 2003-08-20 2010-03-16 Facet Technologies, Llc Multi-lancet device with sterility cap repositioning mechanism
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1903942A2 (fr) 2005-07-19 2008-04-02 IHQ Innovation Headquarters OY Dispositif de controle de l'etat de sante, modules du dispositif et procede
US9375177B2 (en) 2005-07-19 2016-06-28 Ihq Innovation Headquarters Oy Health monitoring device, device modules and method
EP1903942B2 (fr) † 2005-07-19 2021-11-24 i-SENS inc. Dispositif de controle de l'etat de sante et procede
WO2008052172A2 (fr) * 2006-10-26 2008-05-02 Facet Technologies, Llc Lancette rétractable et mécanisme de rétraction à utiliser avec celle-ci
WO2008052172A3 (fr) * 2006-10-26 2008-08-21 Facet Technologies Llc Lancette rétractable et mécanisme de rétraction à utiliser avec celle-ci
US8945022B2 (en) 2007-04-12 2015-02-03 Roche Diagnostics Operations, Inc. Puncturing system
US8460330B2 (en) 2007-08-14 2013-06-11 Owen Mumford Limited Lancing devices
WO2009022138A1 (fr) 2007-08-14 2009-02-19 Owen Mumford Limited Dispositifs autopiqueurs
WO2009027010A2 (fr) * 2007-08-31 2009-03-05 Roche Diagniostics Gmbh Système d'analyse pour déterminer la présence d'un analyte dans un liquide corporel, magasin pour système d'analyse, élément intégré d'acquisition et d'analyse d'échantillon, et méthode d'analyse d'un liquide corporel
EP2030566A1 (fr) * 2007-08-31 2009-03-04 Roche Diagnostics GmbH Système d'analyse pour déterminer une analyse dans un fluide corporel, magazine pour système d'analyse, acquisition d'échantillon intégré et élément d'analyse, et procédé d'analyse d'un liquide corporel
US8888715B2 (en) 2007-08-31 2014-11-18 Roche Diagnostics Operations, Inc. Analysis system and method for determining an analyte in a body fluid with a magazine comprising integrated sample acquisition and analyzing elements
WO2009027010A3 (fr) * 2007-08-31 2009-04-23 Roche Diagnostics Gmbh Système d'analyse pour déterminer la présence d'un analyte dans un liquide corporel, magasin pour système d'analyse, élément intégré d'acquisition et d'analyse d'échantillon, et méthode d'analyse d'un liquide corporel
US8845669B2 (en) 2009-02-17 2014-09-30 Roche Diagnostics Operations, Inc. Reuse protection for lancet system
CN103919563A (zh) * 2009-02-17 2014-07-16 霍夫曼-拉罗奇有限公司 用于刺血针系统的重新使用保护
CN102316803A (zh) * 2009-02-17 2012-01-11 霍夫曼-拉罗奇有限公司 用于刺血针系统的重新使用保护
WO2010094435A1 (fr) * 2009-02-17 2010-08-26 Roche Diagnostics Gmbh Protection contre une réutilisation d'un système de lancettes
US9895093B2 (en) 2009-02-17 2018-02-20 Roche Diabetes Care, Inc. Reuse protection for lancet system
EP2218399A1 (fr) * 2009-02-17 2010-08-18 Roche Diagnostics GmbH Protection contre la réutilisation pour système de lancettes
US10602969B2 (en) 2009-02-17 2020-03-31 Roche Diabetes Care, Inc. Method of reuse protection for lancet system
US9517027B2 (en) 2009-07-10 2016-12-13 Facet Techonologies, Llc Advancement mechanism for cartridge-based devices
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation

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US20060264996A1 (en) 2006-11-23
EP1663023A4 (fr) 2010-01-27

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