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WO2005007104A3 - Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease - Google Patents

Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease Download PDF

Info

Publication number
WO2005007104A3
WO2005007104A3 PCT/US2004/022066 US2004022066W WO2005007104A3 WO 2005007104 A3 WO2005007104 A3 WO 2005007104A3 US 2004022066 W US2004022066 W US 2004022066W WO 2005007104 A3 WO2005007104 A3 WO 2005007104A3
Authority
WO
WIPO (PCT)
Prior art keywords
prevention
treatment
methods
heart disease
compositions
Prior art date
Application number
PCT/US2004/022066
Other languages
French (fr)
Other versions
WO2005007104A2 (en
Inventor
Jason P Mcdevitt
Original Assignee
Univ Emory
Jason P Mcdevitt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Jason P Mcdevitt filed Critical Univ Emory
Publication of WO2005007104A2 publication Critical patent/WO2005007104A2/en
Publication of WO2005007104A3 publication Critical patent/WO2005007104A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides the following formula (I) and uses thereof: wherein each Ak is independently selected from the group consisting of alkyl; Cy is selected from the group consisting of cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle; and A is selected from the group consisting of alkyl, substituted alkyl, C(O)R, and C(O)NHR.
PCT/US2004/022066 2003-07-07 2004-07-07 Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease WO2005007104A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48518303P 2003-07-07 2003-07-07
US60/485,183 2003-07-07

Publications (2)

Publication Number Publication Date
WO2005007104A2 WO2005007104A2 (en) 2005-01-27
WO2005007104A3 true WO2005007104A3 (en) 2005-06-23

Family

ID=34079099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022066 WO2005007104A2 (en) 2003-07-07 2004-07-07 Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease

Country Status (1)

Country Link
WO (1) WO2005007104A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives

Also Published As

Publication number Publication date
WO2005007104A2 (en) 2005-01-27

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