WO2004105821A1 - Scar management composition comprising silicone - Google Patents
Scar management composition comprising silicone Download PDFInfo
- Publication number
- WO2004105821A1 WO2004105821A1 PCT/GB2004/002325 GB2004002325W WO2004105821A1 WO 2004105821 A1 WO2004105821 A1 WO 2004105821A1 GB 2004002325 W GB2004002325 W GB 2004002325W WO 2004105821 A1 WO2004105821 A1 WO 2004105821A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- silicone
- composition
- composition according
- elastomer
- skin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 85
- 231100000241 scar Toxicity 0.000 title claims abstract description 25
- 229920001296 polysiloxane Polymers 0.000 title claims description 70
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 27
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 238000009472 formulation Methods 0.000 claims description 16
- 239000000499 gel Substances 0.000 claims description 13
- 229920006037 cross link polymer Polymers 0.000 claims description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 229920001971 elastomer Polymers 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000806 elastomer Substances 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 239000004519 grease Substances 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000013003 healing agent Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 239000013464 silicone adhesive Substances 0.000 claims description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 3
- -1 cetyl hydroxyethyl Chemical group 0.000 claims description 3
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229940086555 cyclomethicone Drugs 0.000 claims description 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 239000010773 plant oil Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
- 229940022682 acetone Drugs 0.000 claims 1
- 229960004756 ethanol Drugs 0.000 claims 1
- 229960004592 isopropanol Drugs 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000004078 waterproofing Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 description 5
- 239000004945 silicone rubber Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000008240 homogeneous mixture Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940049657 cyclomethicone 5 Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Definitions
- the present invention relates to a composition which finds particular utility in scar management.
- the first silicone-containing sheets used in order to reduce the visual severity of tissue scarring were developed approximately 25 years ago and met with limited success since they were difficult to use. These silicone rubber sheets were secured on the skin surface with adhesive tape thereby forming a sealed enclosure. Typically, the silicone rubber sheet would be secured in place for 30 days during which time the skin would 'remodel' itself to a large degree giving rise to a decrease in the cosmetic severity of the scar tissue.
- liquid silicone compositions which are predominantly composed of water, have been introduced. These are supplied in a tube and are specifically designed to be applied to awkward areas ,of the skins surface. Examples of said compositions include KELO-COTE (TM) or with a roller ball applicator, CICACARE (TM). Unlike the previously described sheets, which are intended to be worn for a period of approximately 30 days, these liquid silicone compositions require re-application every few hours as the silicone layer located over the wound is thinner. However, these compositions remain sticky and tacky after application, some fail to dry, whilst others take 10 to 30 minutes to dry.
- a scar management composition in the form of a liquid gel wherein the composition is substantially watef- free and comprises at least one silicone elastomer and/or gum.
- composition of the present invention is in the form of a surprisingly stable gel which is easy to manufacture and as such is suitable for application to all skin areas, but it is particularly useful for the application, to areas to which it is
- liquid gel it is meant a composition having a viscosity in the range from 0.01
- substantially water-free it is meant that the composition does not contain more than 3% water.
- a further advantage of the composition of the present invention lies with its longer wear time, typically in excess of 8 hours. The longer wear time means that the composition can be worn for sufficiently long periods to enable moisture to develop under the sheet thus giving a skin softening and moisturising effect.
- a still further advantage of the composition of the present invention is its rapid drying time, typically of about 2 minutes, thereby eliminating the undesirable tack of previously used liquid compositions which have a much longer drying time, typically in the order of 10 to 30 minutes.
- composition of the present invention results in a greater reduction in the visual severity of a scar than that seen with previous methods of scar management.
- composition of the present invention is not only much easier and quicker to use than its predecessors but results in a greater reduction in the visual severity of scar tissue.
- Preliminary results obtained from an ongoing clinical study show that 100% of users reported that the appearance of their scars had improved during 6 weeks of treatment.
- the silicone elastomer and/or gum preferably constitutes from 0.01% to 80%, by weight, of the total composition of the present invention.
- Silicone elastomers suitable for use with the composition of the present invention include any of the following either alone or in combination:- silicone elastomers, silicone crosspolymers, dimethicone crosspolymer, elastomer 10 (Dow Corning),
- Elastomer 40 (Dow Corning), silicone elastomer copolymers and partially reacted silicone elastomer (silicone elastomer prepolymers which will when reacted further give rise to silicone elastomers or crosspolymers).
- Silicone gums suitable for use with the present invention include any of the following either alone or in combination:- silicone gum, dimethiconols, dimethiconol esters, dimethiconol copolymers, dimethiconol crosspolymers, dimethiconol blends, dimethiconol blend 20 (Dow Corning) and partial reacted silicone gums (prepolymers which will wne further reacted guve rise to silicone gums).
- composition of the present invention may comprise additional silicone components.
- Additional silicone components suitable for use with the present invention include any of the following either alone or in combination:-silicone oils, silicone fluids, silicone solvents, silicone gels, silicone wax, silicone grease, silicone crosspolymers, silicone adhesives, silicone emulsifier, silicone wax emulsifier, silicone copolymer, silicone
- composition of the present invention shall contain at least one volatile solvent and most preferably at least one volatile organic solvent, for example isopropyl alcohol (IPA), ethanol, methanol, low molecular weight silicone, cyclomethicone, volatile silicone fluids, ethoxydiglycol, hexane or any other skin compatible organic solvent.
- volatile solvent for example isopropyl alcohol (IPA), ethanol, methanol, low molecular weight silicone, cyclomethicone, volatile silicone fluids, ethoxydiglycol, hexane or any other skin compatible organic solvent.
- IPA isopropyl alcohol
- ethanol ethanol
- methanol low molecular weight silicone
- cyclomethicone volatile silicone fluids
- ethoxydiglycol ethoxydiglycol
- hexane hexane or any other skin compatible organic solvent.
- composition of the present invention comprises at least one thickening agent.
- the said solvent may constitute from 0 % to 80%, by weight, of the total composition of the present invention.
- the thickening agent preferably comprises from 0 to 50 % by weight of the total composition.
- Thickening agents suitable for use with the present invention include any of the following either alone or in combination:- high viscosity silicone fluids, silicone gels, silicone grease, silicone elastomer or cross polymer, silicone gum, silicone adhesive, silicone emulsifier, silicone wax emulsifier, reactive silicone component, silicone , prepolymer and silicone co-polymer, hydroxypropyl cellulose, ethyl cellulose, cetyl hydroxyethyl cellulose, polyurethane, polyurethane copolymers, or any other polymer which is soluble or partial soluble in organic solvents.
- composition of the present invention may also comprise any of the following, either alone or in combination:- active agents such as antibacterial agents, surfactants, antimicrobial agents, essential oil skin occlusion agents, copolymers and skin moisturisers, skin healing agents, scar healing agents, growth factors, or any compound which effects the level of growth factors in the skin, wound or scar, herbal agents, plant oils, essential oils or other plant extracts.
- active agents such as antibacterial agents, surfactants, antimicrobial agents, essential oil skin occlusion agents, copolymers and skin moisturisers, skin healing agents, scar healing agents, growth factors, or any compound which effects the level of growth factors in the skin, wound or scar, herbal agents, plant oils, essential oils or other plant extracts.
- a scar management composition as hereinbefore described to apply a coating of silicone elastomer and/or gum to human skin.
- a method for forming a scar management coating of at least one silicone elastomer and/or gum to human skin comprising the step of applying the composition as hereinbefore described to
- a method of preparing a scar management composition as hereinbefore described comprising the steps:- mixing together at least a first and a second two formulation wherein at least one of the first and second formulations comprises at least one silicone component.
- the first formulation may be added to the second formulation with vigorous mixing, again until a homogeneous gel ensues.
- Cyclomethicone 5 and isopropyl Myristate were pre-mixed to form the first formulation as a homogenous mixture.
- the first formulation was then added to Elastomer 10 (the second formulation) with vigorous stirring to furnish a surprisingly stable clear gel.
- Simogen carrier and isopropyl Myristate were pre-mixed to form the first formulation as a homogenous mixture.
- the first formulation was then added to Elastomer 10 (the second formulation) with vigorous stirring to furnish a surprisingly stable clear gel.
- the first formulation as a homogenous mixture.
- the first formulation was then added to a mixture comprising Elastomer 10 and dimethicone blend 20 (the second formulation) with vigorous stirring to furnish a
- test scar management composition 0.07g was applied to a 5 cm 2 area of the skin. The area was wetted with water after Ih, 2hrs, 4hrs and every 2hrs thereafter.
- the scar management composition 'passes' if the water forms an elevated bubble indicating that a significant amount of silicone is still present on the skin.
- the scar management composition 'fails' if the water does not form an elevated bubble indicating that little, if any, of the composition is still present on the skin.
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- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Cosmetics (AREA)
Abstract
A substantially water-free scar management composition in the form of a liquid gel. The composition comprises at least one silicone elastomer and/or gum.
Description
SCAR MANAGEMENT COMPOSITION COMPRISING SILICONE
The present invention relates to a composition which finds particular utility in scar management.
It has been known for some years that the cosmetic severity of tissue scarring as a result of medical treatment and/or injury can be greatly reduced by the application of a silicone-containing sheet to the skin's surface. The mode of action remains unclear.
The first silicone-containing sheets used in order to reduce the visual severity of tissue scarring, based on a rubber containing formulation, were developed approximately 25 years ago and met with limited success since they were difficult to use. These silicone rubber sheets were secured on the skin surface with adhesive tape thereby forming a sealed enclosure. Typically, the silicone rubber sheet would be secured in place for 30 days during which time the skin would 'remodel' itself to a large degree giving rise to a decrease in the cosmetic severity of the scar tissue.
Several theories have been postulated regarding the mode of action of the silicone layers. These include the moisture barrier properties of silicone, the leaching of low molecular weight silicone into the skin and the effect of the ionic content of the silicone.
Despite these silicone rubber sheets being expensive, they were widely used even though the location of their use on the skin surface was limited by their lack of flexibility.
The aforesaid silicone rubber sheets have since been replaced with softer self- adhesive silicone gel sheets, which possess a greater degree of flexibility by virtue of their polymeric oil-containing network structure. Therefore, although easier to apply, their use remains limited as a result of their sheet-like nature.
More recently liquid silicone compositions, which are predominantly composed of water, have been introduced. These are supplied in a tube and are specifically
designed to be applied to awkward areas ,of the skins surface. Examples of said compositions include KELO-COTE (TM) or with a roller ball applicator, CICACARE (TM). Unlike the previously described sheets, which are intended to be worn for a period of approximately 30 days, these liquid silicone compositions require re-application every few hours as the silicone layer located over the wound is thinner. However, these compositions remain sticky and tacky after application, some fail to dry, whilst others take 10 to 30 minutes to dry.
Surprisingly, it has been found that it is now possible to provide a composition which delivers the aforesaid cosmetic scar severity reduction which is substantially ater- free, but which is more convenient to use than prdviously available compositions as it dries quickly to a non-sticky film and has a substantially longer wear time than existing products such that it needs to be reapplied considerably less often .
According to the present invention there is provided a scar management composition in the form of a liquid gel wherein the composition is substantially watef- free and comprises at least one silicone elastomer and/or gum.
Advantageously, the composition of the present invention is in the form of a surprisingly stable gel which is easy to manufacture and as such is suitable for application to all skin areas, but it is particularly useful for the application, to areas to which it is
difficult to apply sheet material. By liquid gel it is meant a composition having a viscosity in the range from 0.01
cps to 500 000 cps when measured at 20°C.
By substantially water-free it is meant that the composition does not contain more than 3% water.
A further advantage of the composition of the present invention lies with its longer wear time, typically in excess of 8 hours. The longer wear time means that the composition can be worn for sufficiently long periods to enable moisture to develop under the sheet thus giving a skin softening and moisturising effect. A still further advantage of the composition of the present invention is its rapid drying time, typically of about 2 minutes, thereby eliminating the undesirable tack of previously used liquid compositions which have a much longer drying time, typically in the order of 10 to 30 minutes.
Surprisingly, the composition of the present invention results in a greater reduction in the visual severity of a scar than that seen with previous methods of scar management.
Accordingly, the composition of the present invention is not only much easier and quicker to use than its predecessors but results in a greater reduction in the visual severity of scar tissue. Preliminary results obtained from an ongoing clinical study show that 100% of users reported that the appearance of their scars had improved during 6 weeks of treatment.
The silicone elastomer and/or gum preferably constitutes from 0.01% to 80%, by weight, of the total composition of the present invention.
Silicone elastomers suitable for use with the composition of the present invention include any of the following either alone or in combination:- silicone elastomers, silicone crosspolymers, dimethicone crosspolymer, elastomer 10 (Dow Corning),
Elastomer 40 (Dow Corning), silicone elastomer copolymers and partially reacted silicone elastomer (silicone elastomer prepolymers which will when reacted further give
rise to silicone elastomers or crosspolymers).
Silicone gums suitable for use with the present invention include any of the following either alone or in combination:- silicone gum, dimethiconols, dimethiconol esters, dimethiconol copolymers, dimethiconol crosspolymers, dimethiconol blends, dimethiconol blend 20 (Dow Corning) and partial reacted silicone gums (prepolymers which will wne further reacted guve rise to silicone gums).
In addition to silicone elastomers and gums the composition of the present invention may comprise additional silicone components.
Additional silicone components suitable for use with the present invention include any of the following either alone or in combination:-silicone oils, silicone fluids, silicone solvents, silicone gels, silicone wax, silicone grease, silicone crosspolymers, silicone adhesives, silicone emulsifier, silicone wax emulsifier, silicone copolymer, silicone
PSA's and other curing or partially cured silicone cotøpounds.
Preferably the composition of the present invention shall contain at least one volatile solvent and most preferably at least one volatile organic solvent, for example isopropyl alcohol (IPA), ethanol, methanol, low molecular weight silicone, cyclomethicone, volatile silicone fluids, ethoxydiglycol, hexane or any other skin compatible organic solvent.
Preferably the composition of the present invention comprises at least one thickening agent.
The said solvent may constitute from 0 % to 80%, by weight, of the total composition of the present invention.
The thickening agent preferably comprises from 0 to 50 % by weight of the total
composition.
Thickening agents suitable for use with the present invention include any of the following either alone or in combination:- high viscosity silicone fluids, silicone gels, silicone grease, silicone elastomer or cross polymer, silicone gum, silicone adhesive, silicone emulsifier, silicone wax emulsifier, reactive silicone component, silicone , prepolymer and silicone co-polymer, hydroxypropyl cellulose, ethyl cellulose, cetyl hydroxyethyl cellulose, polyurethane, polyurethane copolymers, or any other polymer which is soluble or partial soluble in organic solvents.
In addition to the foregoing the composition of the present invention may also comprise any of the following, either alone or in combination:- active agents such as antibacterial agents, surfactants, antimicrobial agents, essential oil skin occlusion agents, copolymers and skin moisturisers, skin healing agents, scar healing agents, growth factors, or any compound which effects the level of growth factors in the skin, wound or scar, herbal agents, plant oils, essential oils or other plant extracts.
According to a second aspect of the present invention there is provided the use of a scar management composition as hereinbefore described to apply a coating of silicone elastomer and/or gum to human skin.
According to a further aspect of the present invention there is provided a method for forming a scar management coating of at least one silicone elastomer and/or gum to human skin comprising the step of applying the composition as hereinbefore described to
a desired area of the skin.
According to a still further aspect of the present invention therefore there is provided a method of preparing a scar management composition as hereinbefore
described comprising the steps:- mixing together at least a first and a second two formulation wherein at least one of the first and second formulations comprises at least one silicone component.
During preparation of the composition of the present invention the first formulation may be added to the second formulation with vigorous mixing, again until a homogeneous gel ensues.
In order that the present invention be more readily understood the composition of the present invention will now be described further by way of example only with relation to the following examples :-
Example 1
Cyclomethicone 5 and isopropyl Myristate were pre-mixed to form the first formulation as a homogenous mixture.
The first formulation was then added to Elastomer 10 (the second formulation) with vigorous stirring to furnish a surprisingly stable clear gel.
NB: Drying time 485 seconds
Example 2
Simogen carrier and isopropyl Myristate were pre-mixed to form the first
formulation as a homogenous mixture.
The first formulation was then added to Elastomer 10 (the second formulation) with vigorous stirring to furnish a surprisingly stable clear gel.
NB: Drying time 123 seconds
Example 3
Cetyl hydroxyl cellulose, propylene glycol and ethanol were pre-mixed to form
the first formulation as a homogenous mixture.
The first formulation was then added to a mixture comprising Elastomer 10 and dimethicone blend 20 (the second formulation) with vigorous stirring to furnish a
surprisingly stable clear gel
Drying time : 525 seconds
Wear Time Experiments
0.07g of the test scar management composition was applied to a 5 cm2 area of the skin. The area was wetted with water after Ih, 2hrs, 4hrs and every 2hrs thereafter.
The scar management composition 'passes' if the water forms an elevated bubble indicating that a significant amount of silicone is still present on the skin.
The scar management composition 'fails' if the water does not form an elevated bubble indicating that little, if any, of the composition is still present on the skin.
Comparative example 2
It is of course to be understood that the invention is not intended to be restricted to the details of the above embodiments which are described by way of example only.
Claims
1. A scar management composition in the form of a liquid gel wherein the . composition is substantially water-free and comprises at least one silicone elastomer and /or gum.
2. A composition according to claim 1, wherein the silicone elastomer or gum constitutes from 0.01% to 80% by weight of the total composition.
3. A composition according to claim 1 or claim 2, wherein the silicone elastomer is selected from any of the following either alone or in combination:- silicone elastomers, silicone crosspolymers, dimethicone crosspolymer, Elastomer 10, Elastomer 40, silicone elastomer copolymers, partially reacted silicone elastomers (prepolymers which when reacted further will give rise to silicone elastomer).
4. A composition according to claim 1 or claim 2, wherein the silicone gum component is selected from any of the following either alone or in combination:- silicone
gum, dimethiconols, dimethiconol esters, dimethiconol copolymers, dimethiconol
crosspolymers, Dimethiconol blends, Dimethicinol blend 20, partially reacted silicone gums (prepolymers which when reacted further will give rise to silicone gum).
5. A composition according to any one of claims 1 to 4 wherein the additional silicone component is selected from any of the following either alone or in combination; silicone oil, silicone fluids, silicone solvents, silicone gels, silicone wax, silicone grease, or silicone cross polymer, silicone adhesive, silicone emulsifier, silicone wax emulsifier, silicone co-polymer, silicone PSAs.
6. A composition according to any one of claims 1 to 5 wherein the composition comprises at least one volatile solvent.
7. A composition according to claim 6, wherein the volatile solvent is organic.
8. A composition according to claim 6 or claim 7, wherein the solvent constitutes from 0% to 80% by weight of the total composition.
9. A composition according to any one of claims 1 to 8 wherein the solvent is selected from any of the following either alone or in combination:- volatile silicone fluids, cyclomethicone, ethanol, acetone, iso propyl alcohol, methanol, ethoxydiglycol, hexane or other organic skin compatible solvent.
10. A composition according to any one of claims 1 to 9 wherein the composition comprises a thickening agent.
11. A composition according to claim 10, wherein the thickening agent constitutes from 0 to 50%) by weight of the total composition.
12. A composition according to any one of claims 1 to 12 wherein the thickening agent is selected from any of the following either alone or in combination:- high viscosity silicone fluids, silicone gels, silicone grease, silicone elastomer or cross polymer, silicone gum, silicone adhesive, silicone emulsifier, silicone wax emulsifier, reactive silicone component, silicone prepolymer and silicone co-polymer, hydroxypropyl cellulose, ethyl cellulose, cetyl hydroxyethyl cellulose, polyurethane, polyurethane copolymers, or any other polymer which is soluble or partially soluble in organic
solvents.
13. A composition according to any one of claims 1 to 12 wherein the composition further comprises active agents such as antibacterial agents, surfactants, antimicrobial
agents, waterproofing agents, essential oils, skin occlusion agents, copolymers and skin moisturisers, skin healing agents, scar healing agents, growth factors, or any compound which effects the level of growth factors in the skin, wound or scar, herbal agents, plant oils, pharmaceutical agent or other plant extracts.
14. The use of a scar management composition as described in claim 1 to apply a coating of silicone elastomer and/or gum to human skin.
15. A method of forming a coating of silicone elastomer and/or gum upon human skin comprising the step of applying a scar management composition as described in claim 1 to a desired area of the skin.
16. A method for the preparation of a scar management composition wherein the composition is substantially free of water comprising the steps: mixing together at least a first and second formulation wherein at least one of the first and second formulations comprises at least one silicone component.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0312428.6A GB0312428D0 (en) | 2003-05-30 | 2003-05-30 | Scar management composition |
| GB0312428.6 | 2003-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2004105821A1 true WO2004105821A1 (en) | 2004-12-09 |
Family
ID=9959037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2004/002325 WO2004105821A1 (en) | 2003-05-30 | 2004-06-01 | Scar management composition comprising silicone |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB0312428D0 (en) |
| WO (1) | WO2004105821A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009545559A (en) * | 2006-07-31 | 2009-12-24 | ラボラトワール・ベザン・ザンテルナショナル | Treatment and prevention of excessive scarring |
| WO2012113604A2 (en) | 2011-02-23 | 2012-08-30 | Unilever Plc | Improvements relating to the skin feel of products |
| US8758404B2 (en) | 2004-10-18 | 2014-06-24 | Covidien Lp | Surgical fasteners coated with wound treatment materials |
| US9511034B1 (en) | 2013-12-09 | 2016-12-06 | Bio-Silicote, Inc. | Method for applying a skin treatment |
| CN108403623A (en) * | 2018-05-29 | 2018-08-17 | 南京华开生物科技有限公司 | silicone scar gel |
| CN115957370A (en) * | 2022-11-18 | 2023-04-14 | 振德医疗用品股份有限公司 | Scar repairing silica gel and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160539A (en) * | 1996-03-28 | 1997-10-01 | 陆达人 | Scar inhibitor and its compounding process |
| WO2001023011A1 (en) * | 1999-09-27 | 2001-04-05 | Smith & Nephew Plc | Topical scar treatment using a mixture of silicones |
| US6284941B1 (en) * | 1999-03-09 | 2001-09-04 | Craig M. Cox | Bandage having a scar treatment pad for scar management and scar repair |
| WO2002045698A2 (en) * | 2000-12-04 | 2002-06-13 | Den Heede Marie Therese Van | Silicone gel sheet for treatment of scar tissue |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0007140D0 (en) * | 1999-09-27 | 2000-05-17 | Dow Corning Sa | Scar treatment composition |
| US6337076B1 (en) * | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
-
2003
- 2003-05-30 GB GBGB0312428.6A patent/GB0312428D0/en not_active Ceased
-
2004
- 2004-06-01 WO PCT/GB2004/002325 patent/WO2004105821A1/en active Application Filing
- 2004-06-01 GB GB0412170A patent/GB2402878A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160539A (en) * | 1996-03-28 | 1997-10-01 | 陆达人 | Scar inhibitor and its compounding process |
| US6284941B1 (en) * | 1999-03-09 | 2001-09-04 | Craig M. Cox | Bandage having a scar treatment pad for scar management and scar repair |
| WO2001023011A1 (en) * | 1999-09-27 | 2001-04-05 | Smith & Nephew Plc | Topical scar treatment using a mixture of silicones |
| WO2002045698A2 (en) * | 2000-12-04 | 2002-06-13 | Den Heede Marie Therese Van | Silicone gel sheet for treatment of scar tissue |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Section Ch Week 200309, Derwent World Patents Index; Class A96, AN 2003-094245, XP002294658 * |
| WILLIAMS C: "CICA-CARE: ADHESIVE GEL SHEET", BRITISH JOURNAL OF NURSING,, ALLEN, LONDON, GB, vol. 5, no. 14, 1996, pages 875 - 876, XP000670985, ISSN: 0966-0461 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8758404B2 (en) | 2004-10-18 | 2014-06-24 | Covidien Lp | Surgical fasteners coated with wound treatment materials |
| JP2009545559A (en) * | 2006-07-31 | 2009-12-24 | ラボラトワール・ベザン・ザンテルナショナル | Treatment and prevention of excessive scarring |
| WO2012113604A2 (en) | 2011-02-23 | 2012-08-30 | Unilever Plc | Improvements relating to the skin feel of products |
| US9511034B1 (en) | 2013-12-09 | 2016-12-06 | Bio-Silicote, Inc. | Method for applying a skin treatment |
| CN108403623A (en) * | 2018-05-29 | 2018-08-17 | 南京华开生物科技有限公司 | silicone scar gel |
| CN115957370A (en) * | 2022-11-18 | 2023-04-14 | 振德医疗用品股份有限公司 | Scar repairing silica gel and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0312428D0 (en) | 2003-07-09 |
| GB0412170D0 (en) | 2004-06-30 |
| GB2402878A (en) | 2004-12-22 |
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