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WO2004078916A3 - In vitro micro-organs, and uses related thereto - Google Patents

In vitro micro-organs, and uses related thereto Download PDF

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Publication number
WO2004078916A3
WO2004078916A3 PCT/IL2004/000202 IL2004000202W WO2004078916A3 WO 2004078916 A3 WO2004078916 A3 WO 2004078916A3 IL 2004000202 W IL2004000202 W IL 2004000202W WO 2004078916 A3 WO2004078916 A3 WO 2004078916A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
micro
organ
organ cultures
cultures
Prior art date
Application number
PCT/IL2004/000202
Other languages
French (fr)
Other versions
WO2004078916A2 (en
Inventor
Eduardo N Mitrani
Original Assignee
Yissum Res Dev Co
Eduardo N Mitrani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/376,506 external-priority patent/US20030152562A1/en
Application filed by Yissum Res Dev Co, Eduardo N Mitrani filed Critical Yissum Res Dev Co
Publication of WO2004078916A2 publication Critical patent/WO2004078916A2/en
Publication of WO2004078916A3 publication Critical patent/WO2004078916A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation.
PCT/IL2004/000202 2003-03-03 2004-03-02 In vitro micro-organs, and uses related thereto WO2004078916A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/376,506 2003-03-03
US10/376,506 US20030152562A1 (en) 2001-10-23 2003-03-03 Vitro micro-organs, and uses related thereto

Publications (2)

Publication Number Publication Date
WO2004078916A2 WO2004078916A2 (en) 2004-09-16
WO2004078916A3 true WO2004078916A3 (en) 2005-02-10

Family

ID=32961225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000202 WO2004078916A2 (en) 2003-03-03 2004-03-02 In vitro micro-organs, and uses related thereto

Country Status (1)

Country Link
WO (1) WO2004078916A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155749B2 (en) 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
IL196820A0 (en) 2009-02-01 2009-11-18 Yissum Res Dev Co Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells
US20150166961A1 (en) * 2012-06-14 2015-06-18 Fred Hutchinson Cancer Research Center Ex vivo expansion of myogenic stem cells by notch activation
CN113604446B (en) * 2021-08-16 2023-04-07 重庆大学 Mutant R16Q of 7α-hydroxysteroid dehydrogenase St-2-2
CN113813437B (en) * 2021-09-28 2022-07-01 振德医疗用品股份有限公司 Anti-infection anti-adhesion wound dressing based on bacteria non-specific adhesion
CN115721716B (en) * 2022-07-13 2024-06-14 苏州翊鹏医药科技有限公司 Use of MDH2 inhibitors in the treatment of androgenetic alopecia
CN116358954B (en) * 2023-02-22 2024-08-09 深圳市昭蓝生物科技有限公司 Composite quality control product, preparation method thereof and prenatal screening kit
CN117618540B (en) * 2023-12-05 2025-01-03 中南大学 Chemokine CCL28 immunomodulator locally injected in tissue cell transplantation rejection reaction and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030833A (en) * 1995-08-04 2000-02-29 The General Hospital Transgenic swine and swine cells having human HLA genes
US20020012661A1 (en) * 1999-12-10 2002-01-31 Norimitsu Saito Methods for introducing genes into mammalian subjects

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030833A (en) * 1995-08-04 2000-02-29 The General Hospital Transgenic swine and swine cells having human HLA genes
US20020012661A1 (en) * 1999-12-10 2002-01-31 Norimitsu Saito Methods for introducing genes into mammalian subjects

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155749B2 (en) 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations

Also Published As

Publication number Publication date
WO2004078916A2 (en) 2004-09-16

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