WO2004067759A3 - Replication of nucleic acid arrays - Google Patents
Replication of nucleic acid arrays Download PDFInfo
- Publication number
- WO2004067759A3 WO2004067759A3 PCT/GB2004/000375 GB2004000375W WO2004067759A3 WO 2004067759 A3 WO2004067759 A3 WO 2004067759A3 GB 2004000375 W GB2004000375 W GB 2004000375W WO 2004067759 A3 WO2004067759 A3 WO 2004067759A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acids
- nucleic acid
- replication
- acid arrays
- hybridised
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Looms (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A method of producing arrays of nucleic acids corresponding to a first set of nucleic acids immobilised on a first solid support (master array) includes furnishing on said first set of nucleic acids a second set of nucleic acids, each nucleic acid of the second set having at least a portion which is complementary to at least a portion of respective nucleic acid of the first set and being hybridised to it thereby. This may involve contact with a solution containing a mixture of nucleic acids, or synthesis using the first nucleic acids as primers and templates. The second set of nucleic acids are immobilised to a second solid support, either before or while they are hybridised to the first set of nucleic acids. Separation of the first and second solid supports provides said first support bearing the master array and said second support bearing a complementary array.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0516777A GB2413555A (en) | 2003-01-29 | 2004-01-29 | Replication of nucleic acid arrays |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0302058.3A GB0302058D0 (en) | 2003-01-29 | 2003-01-29 | Replication of nucleic acid arrays |
| GB0302058.3 | 2003-01-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004067759A2 WO2004067759A2 (en) | 2004-08-12 |
| WO2004067759A3 true WO2004067759A3 (en) | 2004-11-18 |
Family
ID=9952050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2004/000375 Ceased WO2004067759A2 (en) | 2003-01-29 | 2004-01-29 | Replication of nucleic acid arrays |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB0302058D0 (en) |
| WO (1) | WO2004067759A2 (en) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006002934A1 (en) * | 2004-06-30 | 2006-01-12 | Rina Netzwerk Rna Technologien Gmbh | Blueprint biochips |
| GB2440209A (en) * | 2006-07-18 | 2008-01-23 | Univ Cranfield | Nucleic acid arrays replication |
| ITBO20070627A1 (en) * | 2007-09-14 | 2009-03-15 | Twof Inc | METHOD FOR THE PREPARATION OF MICROARRAY DNA WITH HIGH LINEAR DENSITY PROBES |
| WO2010003132A1 (en) | 2008-07-02 | 2010-01-07 | Illumina Cambridge Ltd. | Using populations of beads for the fabrication of arrays on surfaces |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| SI2556171T1 (en) | 2010-04-05 | 2016-03-31 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP2647426A1 (en) * | 2012-04-03 | 2013-10-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Replication of distributed nucleic acid molecules with preservation of their relative distribution through hybridization-based binding |
| EP3901280B1 (en) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| CN105849275B (en) | 2013-06-25 | 2020-03-17 | 普罗格诺西斯生物科学公司 | Method and system for detecting spatial distribution of biological targets in a sample |
| EP3077545B1 (en) | 2013-12-05 | 2020-09-16 | Centrillion Technology Holdings Corporation | Methods for sequencing nucleic acids |
| WO2015085268A1 (en) | 2013-12-05 | 2015-06-11 | Centrillion Technology Holdings Corporation | Modified surfaces |
| CN106460032B (en) * | 2013-12-05 | 2019-12-24 | 生捷科技控股公司 | Preparation of patterned arrays |
| US11060139B2 (en) | 2014-03-28 | 2021-07-13 | Centrillion Technology Holdings Corporation | Methods for sequencing nucleic acids |
| CA2982146A1 (en) | 2015-04-10 | 2016-10-13 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| WO2020047010A2 (en) * | 2018-08-28 | 2020-03-05 | 10X Genomics, Inc. | Increasing spatial array resolution |
| WO2020123309A1 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Resolving spatial arrays by proximity-based deconvolution |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| EP3891300B1 (en) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| WO2021133842A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| WO2021216708A1 (en) | 2020-04-22 | 2021-10-28 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| ES2981265T3 (en) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Methods for determining a surgical margin and methods of using it |
| EP4446430A3 (en) | 2020-06-10 | 2024-12-18 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| EP4450639B1 (en) | 2020-06-25 | 2025-10-15 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4428246B1 (en) | 2021-04-14 | 2025-12-24 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| EP4320271B1 (en) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| EP4582555A3 (en) * | 2021-06-03 | 2025-10-22 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
| EP4419707A1 (en) | 2021-11-10 | 2024-08-28 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996001836A1 (en) * | 1994-07-07 | 1996-01-25 | Nanogen, Inc. | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics |
| US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| WO1998044151A1 (en) * | 1997-04-01 | 1998-10-08 | Glaxo Group Limited | Method of nucleic acid amplification |
| WO2000027521A1 (en) * | 1998-11-06 | 2000-05-18 | Solexa Ltd. | A method for reproducing molecular arrays |
| WO2001032935A2 (en) * | 1999-11-02 | 2001-05-10 | Celine Hu | Molecular microarrays and methods for production and use thereof |
| WO2002010450A2 (en) * | 2000-08-02 | 2002-02-07 | Surmodics, Inc. | Replicable probe array |
| EP1180548A2 (en) * | 2000-07-31 | 2002-02-20 | Agilent Technologies, Inc. | Array based methods for synthesizing nucleic acid mixtures |
-
2003
- 2003-01-29 GB GBGB0302058.3A patent/GB0302058D0/en not_active Ceased
-
2004
- 2004-01-29 WO PCT/GB2004/000375 patent/WO2004067759A2/en not_active Ceased
- 2004-01-29 GB GB0516777A patent/GB2413555A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795714A (en) * | 1992-11-06 | 1998-08-18 | Trustees Of Boston University | Method for replicating an array of nucleic acid probes |
| WO1996001836A1 (en) * | 1994-07-07 | 1996-01-25 | Nanogen, Inc. | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics |
| WO1998044151A1 (en) * | 1997-04-01 | 1998-10-08 | Glaxo Group Limited | Method of nucleic acid amplification |
| WO2000027521A1 (en) * | 1998-11-06 | 2000-05-18 | Solexa Ltd. | A method for reproducing molecular arrays |
| WO2001032935A2 (en) * | 1999-11-02 | 2001-05-10 | Celine Hu | Molecular microarrays and methods for production and use thereof |
| EP1180548A2 (en) * | 2000-07-31 | 2002-02-20 | Agilent Technologies, Inc. | Array based methods for synthesizing nucleic acid mixtures |
| WO2002010450A2 (en) * | 2000-08-02 | 2002-02-07 | Surmodics, Inc. | Replicable probe array |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004067759A2 (en) | 2004-08-12 |
| GB0516777D0 (en) | 2005-09-21 |
| GB0302058D0 (en) | 2003-02-26 |
| GB2413555A (en) | 2005-11-02 |
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