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WO2004058329A3 - Anesthesique local a base d'une combinaison d'ester - Google Patents

Anesthesique local a base d'une combinaison d'ester Download PDF

Info

Publication number
WO2004058329A3
WO2004058329A3 PCT/US2003/041219 US0341219W WO2004058329A3 WO 2004058329 A3 WO2004058329 A3 WO 2004058329A3 US 0341219 W US0341219 W US 0341219W WO 2004058329 A3 WO2004058329 A3 WO 2004058329A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
ester
present
local anesthetic
ester combination
Prior art date
Application number
PCT/US2003/041219
Other languages
English (en)
Other versions
WO2004058329A2 (fr
Inventor
Steven L Shafer
Original Assignee
Univ Leland Stanford Junior
Steven L Shafer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Steven L Shafer filed Critical Univ Leland Stanford Junior
Priority to BR0317519-7A priority Critical patent/BR0317519A/pt
Priority to JP2004564039A priority patent/JP2006513224A/ja
Priority to AU2003299885A priority patent/AU2003299885A1/en
Priority to EP03800157A priority patent/EP1572218A4/fr
Priority to MXPA05006771A priority patent/MXPA05006771A/es
Priority to CA002507511A priority patent/CA2507511A1/fr
Publication of WO2004058329A2 publication Critical patent/WO2004058329A2/fr
Publication of WO2004058329A3 publication Critical patent/WO2004058329A3/fr
Priority to NO20053203A priority patent/NO20053203L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions et des procédés permettant une anesthésie et/ou une analgésie locales améliorées, dans lesquels le délai d'action est bref, le risque de toxicité faible et l'effet prolongé. Plus spécifiquement, l'invention concerne une combinaison d'au moins deux anesthésiques d'ester destinée à être administrée à un sujet, au moins un anesthésique d'ester possédant un délai d'action bref et au moins un anesthésique d'ester présentant une activité prolongée. Les compositions de cette invention sont utiles pour l'analgésie et/ou l'anesthésie et sont plus spécifiquement utiles pour la prophylaxie et/ou le traitement de la douleur.
PCT/US2003/041219 2002-12-20 2003-12-18 Anesthesique local a base d'une combinaison d'ester WO2004058329A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR0317519-7A BR0317519A (pt) 2002-12-20 2003-12-18 Composição farmacêutica para anestesia local e uso da mesma
JP2004564039A JP2006513224A (ja) 2002-12-20 2003-12-18 エステル局所麻酔薬の組み合わせ
AU2003299885A AU2003299885A1 (en) 2002-12-20 2003-12-18 Ester combination local anesthetic
EP03800157A EP1572218A4 (fr) 2002-12-20 2003-12-18 Anesthesique local a base d'une combinaison d'ester
MXPA05006771A MXPA05006771A (es) 2002-12-20 2003-12-18 Anestesico local con combinacion de ester.
CA002507511A CA2507511A1 (fr) 2002-12-20 2003-12-18 Anesthesique local a base d'une combinaison d'ester
NO20053203A NO20053203L (no) 2002-12-20 2005-06-30 Kombinasjon av lokale esteranestetika.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32731002A 2002-12-20 2002-12-20
US10/327,310 2002-12-20

Publications (2)

Publication Number Publication Date
WO2004058329A2 WO2004058329A2 (fr) 2004-07-15
WO2004058329A3 true WO2004058329A3 (fr) 2004-12-29

Family

ID=32680753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041219 WO2004058329A2 (fr) 2002-12-20 2003-12-18 Anesthesique local a base d'une combinaison d'ester

Country Status (10)

Country Link
EP (1) EP1572218A4 (fr)
JP (1) JP2006513224A (fr)
KR (1) KR20050085736A (fr)
CN (1) CN1729004A (fr)
AU (1) AU2003299885A1 (fr)
BR (1) BR0317519A (fr)
CA (1) CA2507511A1 (fr)
MX (1) MXPA05006771A (fr)
NO (1) NO20053203L (fr)
WO (1) WO2004058329A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060062836A1 (en) * 2004-09-21 2006-03-23 Carter Stephen G Methods of device-assisted drug delivery
WO2006096914A1 (fr) 2005-03-15 2006-09-21 Animal Ethics Pty Ltd Composition analgesique locale
ITMI20051633A1 (it) * 2005-09-06 2007-03-07 Sint Sa Nuovo uso di una composizione comprendente cloroprocaina hcl nuova composizione comprendente cloroprocaina hcl e metodo per la sua fabbricazione
WO2008011539A2 (fr) * 2006-07-19 2008-01-24 Pharmacofore, Inc. Composés anesthésiques
US20080220062A1 (en) * 2006-10-23 2008-09-11 Psivida, Inc. Sustained release of agents for localized pain management
WO2009091546A1 (fr) * 2008-01-18 2009-07-23 Pharmacofore, Inc. Composés anesthésiques
ITMI20122120A1 (it) * 2012-12-12 2014-06-13 Sint Sa Composizione farmaceutica a base di cloroprocaina per la somministrazione intratecale ripetuta
ITCR20130004A1 (it) * 2013-02-05 2014-08-06 Vincenzo Vigna Farmaco salvavita
US10117847B2 (en) 2015-12-04 2018-11-06 Ventis Pharma Extended duration local anesthetic formulation
DE102016215037B4 (de) 2016-08-11 2024-10-24 Lamello Ag Federvorrichtung und Verbindungsvorrichtung
CU20200019A7 (es) * 2017-09-15 2020-11-30 Sintetica S A Formulaciones tópicas de cloroprocaína y métodos para preparar las mismas
WO2019226599A1 (fr) * 2018-05-22 2019-11-28 Alkalidx, Inc. Diagnostics et traitements de sujets insensibles à un anesthésique
JP6886551B1 (ja) * 2020-11-06 2021-06-16 医療法人祥和会 歯科用の局所麻酔液

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326020B1 (en) * 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US7273887B1 (en) * 1999-10-22 2007-09-25 Transdermatech, Inc. Topical anesthetic formulation
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326020B1 (en) * 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1572218A4 *

Also Published As

Publication number Publication date
BR0317519A (pt) 2005-11-16
AU2003299885A1 (en) 2004-07-22
EP1572218A4 (fr) 2007-05-16
JP2006513224A (ja) 2006-04-20
NO20053203L (no) 2005-09-19
CA2507511A1 (fr) 2004-07-15
CN1729004A (zh) 2006-02-01
NO20053203D0 (no) 2005-06-30
WO2004058329A2 (fr) 2004-07-15
EP1572218A2 (fr) 2005-09-14
KR20050085736A (ko) 2005-08-29
MXPA05006771A (es) 2005-09-08

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