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WO2004056326A2 - Compositions a base de bi-amidon a usage topique - Google Patents

Compositions a base de bi-amidon a usage topique Download PDF

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Publication number
WO2004056326A2
WO2004056326A2 PCT/IB2003/006092 IB0306092W WO2004056326A2 WO 2004056326 A2 WO2004056326 A2 WO 2004056326A2 IB 0306092 W IB0306092 W IB 0306092W WO 2004056326 A2 WO2004056326 A2 WO 2004056326A2
Authority
WO
WIPO (PCT)
Prior art keywords
starch
topical compositions
compositions according
topical
mpa
Prior art date
Application number
PCT/IB2003/006092
Other languages
English (en)
Italian (it)
Other versions
WO2004056326A3 (fr
Inventor
Giuliano Albasi
Original Assignee
Natu Raw Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natu Raw Ltd. filed Critical Natu Raw Ltd.
Priority to AU2003303190A priority Critical patent/AU2003303190A1/en
Publication of WO2004056326A2 publication Critical patent/WO2004056326A2/fr
Publication of WO2004056326A3 publication Critical patent/WO2004056326A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Definitions

  • the present invention relates to topical compositions comprising a bi-starch as excipient. STATE OF THE ART
  • starch There exist many different types of starch according to the source, for example wheat, maize, rice, potatoes, tapioca, peas, according to the variety thereof, and according to the different percentage of amylopectin and amylose. Starches are used both as such and modified by means of various physical or chemical methods.
  • One of the physical methods is pre-gelatinization, whereby the starch undergoes a thermal treatment in the presence of water, thus losing its granular form and becoming soluble in cold water.
  • chemical methods it is possible to cite oxidation, esterification, etherification, and cross-linking.
  • esterification is generally obtained, by reaction, for example, of an anhydride of a mono or dicarboxylic acid or a salt of an inorganic acid, such as, for instance, phosphoric acid.
  • a more complex molecule is obtained, i.e., a bi-starch in which each amide molecule is connected to the other molecule via a chain spacer represented by the residue of phosphoric acid or of the aforesaid dicarboxylic acid, which forms an ester with each of said amide molecules.
  • Starch modified physically and chemically has multiple applications in industry, and above all in the food industry as thickening agent. It is moreover used in the cosmetics industry, once again as thickening agent.
  • US 6.391.260 describes formulations for cosmetic use in the form of emulsions consisting of an aqueous phase, an oily phase, an emulsifier and a glyceryl starch cross-linked by reaction with epichlorohydrin.
  • EP 689829 describes formulations for cosmetic use containing a starch modified with an amino multicarboxylate group.
  • the presence of the oily component is indispensable in addition to the starch, said oily component in general being made up of paraffins, mineral oils, castor oil, etc., i.e., non-biodegradable materials.
  • the present invention relates to water-based topical compositions which have a creamy consistency or are in the form of gels, are substantially free from oily substances, and contain a bi-starch as excipient.
  • a further subject of the present invention are the aforesaid topical compositions for cosmetic use.
  • Yet another subject of the present invention are the aforesaid topical compositions according to the present invention for pharmaceutical use, and hence containing at least one active pharmaceutical ingredient.
  • Yet a further subject of the present invention are the aforesaid topical compositions for veterinary use, hence containing at least one active principle for veterinary use.
  • compositions capable of enabling adsorption of an active cosmetic, veterinary, or pharmaceutical principle via topical route, through the skin, the scalp, and the oral and vaginal mucosae.
  • the topical compositions that form the subject of the present invention have a biodegradablity of 100%.
  • creamy consistency or in the form of gels is meant a composition for topical use having a Brookfield viscosity measured at 23°C and at 20 rpm comprised between 1000 mPa.s and 180,000 mPa.s.
  • the topical compositions forming the subject of the present invention have a Brookfield viscosity of between 3000 mPa.s and 150,000 mPa.s, and even more preferably between 11 ,000 mPa.s and 60,000 mPa.s.
  • each starch molecule is connected to the second starch molecule by means of a chain spacer, which is preferably chosen between:
  • bi-starch is chosen in the class consisting of phosphate bi-starch, phosphate acetylated bi-starch , adipate acetylated bi-starch, phosphate hydroxypropylated bi-starch, and phosphate phosphated bi-starch.
  • adipate acetylated bi-starch is used.
  • bi-starch As likewise the other bi-starches mentioned above, are prepared according to the chemical reactions described in "STARCH: CHEMISTRY AND TECHNOLOGY R" chap. 10, Whistler et a/., 2nd edition, 1984.
  • the bi-starch used in the preparation of the topical compositions forming the subject of the present invention is preferably pre-gelatinized i.e., it has undergone a thermal treatment in the presence of water, according to methods known to any person skilled in the art.
  • this starch thus modified is dispersed in an aqueous solution, which is poured onto a rotating drum heated to a temperature of between 100°C and 130°C, operating at pressures of between 2 and 6 bar, so that, in contact with the surface of the drum, the dispersion "explodes", with consequent evaporation of the water in time intervals ranging from 30 seconds to 3 minutes.
  • the bi-starch used in the preparation of the topical compositions forming the subject of the present invention has an amount of amylopectin higher than 50 wt%, and preferably higher than 90 wt%.
  • the bi-starch is that of maize.
  • a particularly preferred embodiment envisages that pre-gelatinized adipate acetylated bi-starch of maize is used for the preparation of the topical compositions forming the subject of the present invention.
  • the topical compositions forming the subject of the present invention preferably contain the bi-starch in concentrations of between 4 wt% and 20 wt%, more preferably between 5 wt% and 11 wt%, and even more preferably between 6 wt% and 9 wt% calculated on the total Weight of said formulation.
  • the topical compositions forming the subject of the present invention moreover contain emollients chosen in the class of the polyols and in particular are chosen from glycerine, sorbitol and corresponding analogues, such as for example mannitol, maltit ⁇ l, xylitol etc., or mixtures of said polyols.
  • compositions forming the subject of the present invention consequently have a creamy consistency and appearance or are in the form of gels.
  • Compositions for cosmetic use, which form a further subject of the present invention may possibly contain a further active ingredient suitable for cosmetic use, in addition to glycerine and sorbitol.
  • topical compositions forming the subject of the present invention for cosmetic use mention may be made, for example, of hair gel containing in particular 20 wt% of glycerine, 20 wt% of sorbitol preferably in the form of a 70 wt% aqueous dispersion, between 6 wt% and 9 wt% of pre-gelatinized adipate acetylated bi-starch adipate of maize, and the remainder to reach 100 wt% is represented by water.
  • topical compositions forming the subject of the present invention and in particular the topical compositions containing as further excipients glycerine and sorbitol are preferably prepared according to the following operating conditions: a) mixing glycerine and bi-starch, while adding gradually water during said mixing; b) adding, finally, sorbitol to the mixture coming from stage (a).
  • topical composition forming the subject of the present invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne les compositions topiques à base d'eau à usages cosmétique, pharmaceutique ou vétérinaire présentant une consistance crémeuse. Les compositions de cette invention sont sensiblement exemptes de composants huileux et contiennent un bi-amidon tenant lieu d'excipient.
PCT/IB2003/006092 2002-12-23 2003-12-19 Compositions a base de bi-amidon a usage topique WO2004056326A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003303190A AU2003303190A1 (en) 2002-12-23 2003-12-19 Bi-starch based compositions for topical use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2002A002746 2002-12-23
ITMI20022746 ITMI20022746A1 (it) 2002-12-23 2002-12-23 Composizioni per uso topico a base di un diamido.

Publications (2)

Publication Number Publication Date
WO2004056326A2 true WO2004056326A2 (fr) 2004-07-08
WO2004056326A3 WO2004056326A3 (fr) 2004-09-10

Family

ID=32676861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/006092 WO2004056326A2 (fr) 2002-12-23 2003-12-19 Compositions a base de bi-amidon a usage topique

Country Status (3)

Country Link
AU (1) AU2003303190A1 (fr)
IT (1) ITMI20022746A1 (fr)
WO (1) WO2004056326A2 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4701096A (en) * 1995-01-18 1996-08-07 National Starch And Chemical Investment Holding Corporation Cosmetics containing thermally-inhibited starches
DE19627498A1 (de) * 1996-07-08 1998-01-15 Nat Starch Chem Invest Stärkehaltige Reinigungs- und Pflegemittel
NO991662L (no) * 1998-04-09 1999-10-11 Nat Starch Chem Invest Ikke-ionisk derivatiserte stivelser og deres anvendelse i polyakrylsyreinneholdende haarkosmetiske sammensetninger med lav VOC
CA2268467A1 (fr) * 1998-04-09 1999-10-09 National Starch And Chemical Investment Holding Corporation Empois obtenus sans ions et leurs applications dans des compositions de fixatifs aerosols
FR2779648B1 (fr) * 1998-06-15 2001-07-20 Oreal Composition cosmetique ou pharmaceutique se presentant sous forme de solide et pouvant etre deformable
AU7583200A (en) * 1999-09-15 2001-04-17 Avebe America, Inc. Shear thickening pregelatinized starch
DE10216500A1 (de) * 2002-04-11 2003-10-23 Beiersdorf Ag Haarpflegemittel

Also Published As

Publication number Publication date
WO2004056326A3 (fr) 2004-09-10
ITMI20022746A1 (it) 2004-06-24
AU2003303190A8 (en) 2004-07-14
AU2003303190A1 (en) 2004-07-14

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