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WO2004013100A3 - Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique Download PDF

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Publication number
WO2004013100A3
WO2004013100A3 PCT/FR2003/002355 FR0302355W WO2004013100A3 WO 2004013100 A3 WO2004013100 A3 WO 2004013100A3 FR 0302355 W FR0302355 W FR 0302355W WO 2004013100 A3 WO2004013100 A3 WO 2004013100A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
alkyl
phenyl
optionally substituted
piperidin
Prior art date
Application number
PCT/FR2003/002355
Other languages
English (en)
Other versions
WO2004013100A2 (fr
Inventor
Emmanuelle Dachary
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Benoit Marabout
Nathalie Rakotoarisoa
Pierre Roger
Mireille Sevrin
Original Assignee
Sanofi Synthelabo
Emmanuelle Dachary
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Benoit Marabout
Nathalie Rakotoarisoa
Pierre Roger
Mireille Sevrin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo, Emmanuelle Dachary, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Benoit Marabout, Nathalie Rakotoarisoa, Pierre Roger, Mireille Sevrin filed Critical Sanofi Synthelabo
Priority to AU2003273474A priority Critical patent/AU2003273474A1/en
Publication of WO2004013100A2 publication Critical patent/WO2004013100A2/fr
Publication of WO2004013100A3 publication Critical patent/WO2004013100A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de formule générale (I) où R1 représente H ou un alkyle, cycloalkylalkyle, phénylalkyle, alcényle ou alcynyle, X représente soit H ou un ou plusieurs atomes d'halogènes, alkyle ou alcoxy, R2 représente H ou un ou plusieurs atomes d'halogènes ou groupes alcoxy, ou amino éventuellement substitué, R3 représente soit un groupe aminosulfonyle éventuellement substitué, soit un groupe cyano ou un groupe de formule S-alkyle, soit un groupe alkylsulfonyle, soit un groupe carboxy ou alcoxycabonyle, soit un groupe carbamoyle éventuellement substitué, soit un groupe acétyle ou benzoyle, soit un groupe alkyle, cycloalkyle, alcényle, phényle, thiényle ou thianthrényle. Application en thérapeutique.
PCT/FR2003/002355 2002-07-29 2003-07-25 Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique WO2004013100A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003273474A AU2003273474A1 (en) 2002-07-29 2003-07-25 Less thanigreater thannless than/igreater than-(phenyl(piperidin-2-yl)methyl)benzamide derivatives, preparation thereof, and use thereof in therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/09589 2002-07-29
FR0209589A FR2842805A1 (fr) 2002-07-29 2002-07-29 Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide,leur preparation et leur application et therapeutique

Publications (2)

Publication Number Publication Date
WO2004013100A2 WO2004013100A2 (fr) 2004-02-12
WO2004013100A3 true WO2004013100A3 (fr) 2004-04-15

Family

ID=30011557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002355 WO2004013100A2 (fr) 2002-07-29 2003-07-25 Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique

Country Status (3)

Country Link
AU (1) AU2003273474A1 (fr)
FR (1) FR2842805A1 (fr)
WO (1) WO2004013100A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9227930B2 (en) 2010-08-13 2016-01-05 Abbvie Inc. Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9238619B2 (en) 2010-08-13 2016-01-19 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0408774D0 (en) * 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
AU2006205796B2 (en) * 2005-01-14 2010-09-02 Merck Sharp & Dohme B.V. Glycine reuptake inhibitors for treating drug and alcohol dependence
ES2536351T3 (es) 2005-06-13 2015-05-22 Merck Sharp & Dohme Limited Agentes terapéuticos
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
EP2271625B1 (fr) 2008-04-01 2012-09-12 Abbott GmbH & Co. KG Tétrahydroisoquinoléines, compositions pharmaceutiques les contenant et leur utilisation en thérapie
WO2010087761A1 (fr) * 2009-01-28 2010-08-05 Astrazeneca Ab Composés 2-aza-bicyclo[2.2.2]octane et leurs utilisations
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
AR075837A1 (es) * 2009-03-16 2011-04-27 Sanofi Aventis Derivados de n[(2-aza-biciclo[2,1,1]hex-1-il)-aril-metil] heterobenzamida, su preparacion, composiciones farmaceuticas y su uso en el tratamiento de enfermedades neurodegenerativas
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2014527511A (ja) 2011-06-24 2014-10-16 アムジエン・インコーポレーテツド Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用
CA2839703A1 (fr) 2011-06-24 2012-12-27 Amgen Inc. Antagonistes de trpm8 et leur utilisation dans le cadre therapeutique
CA2844275A1 (fr) 2011-08-05 2013-02-14 AbbVie Deutschland GmbH & Co. KG Derives d'aminochromane, d'aminothiochromane et d'amino-1,2,3,4-tetrahydroquinoleine, compositions pharmaceutiques contenant ceux-ci et leur utilisation therapeutique
WO2013072520A1 (fr) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG Dérivés aminobenzocycloheptène, aminotétraline, aminoindane et phénalkylamine n-substitués, composition pharmaceutiques les contenant, et leur application thérapeutique
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
O. FRIELICH ET AL.: "Asymmetric synthesis. 39. Synthesis of 2-(1-aminoalkyl)piperidines via 2-cyano-6-phenyl oxazolopiperidine", J. ORG. CHEM., vol. 61, 1996, pages 6700 - 6705, XP002235079 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9227930B2 (en) 2010-08-13 2016-01-05 Abbvie Inc. Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9238619B2 (en) 2010-08-13 2016-01-19 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy

Also Published As

Publication number Publication date
AU2003273474A1 (en) 2004-02-23
WO2004013100A2 (fr) 2004-02-12
AU2003273474A8 (en) 2004-02-23
FR2842805A1 (fr) 2004-01-30

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