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WO2003106032A8 - Hybridisierungskammer - Google Patents

Hybridisierungskammer

Info

Publication number
WO2003106032A8
WO2003106032A8 PCT/EP2003/006253 EP0306253W WO03106032A8 WO 2003106032 A8 WO2003106032 A8 WO 2003106032A8 EP 0306253 W EP0306253 W EP 0306253W WO 03106032 A8 WO03106032 A8 WO 03106032A8
Authority
WO
WIPO (PCT)
Prior art keywords
microarray
hybridization chamber
space
cover
base
Prior art date
Application number
PCT/EP2003/006253
Other languages
English (en)
French (fr)
Other versions
WO2003106032A1 (de
Inventor
Ralph Mueller
Torsten Gerboth
Original Assignee
Axaron Bioscience Ag
Ralph Mueller
Torsten Gerboth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10254564A external-priority patent/DE10254564A1/de
Application filed by Axaron Bioscience Ag, Ralph Mueller, Torsten Gerboth filed Critical Axaron Bioscience Ag
Priority to AU2003238501A priority Critical patent/AU2003238501A1/en
Publication of WO2003106032A1 publication Critical patent/WO2003106032A1/de
Publication of WO2003106032A8 publication Critical patent/WO2003106032A8/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Die Hybridisierungskammer hat einen Boden (10) mit einer Aussparung (14) zur Aufnahme eines Microarrays (16). Ferner einen Deckel (12), der auf den Boden (10) auflegbar ist, wodurch ein hermetisch abgeschlossener Raum für das Microarray gebildet wird. Am Deckel (12) ist eine Deckfläche (18) ausgebildet, die einen Abstand von etwa 20 µm vom Microarray hat und parallel zu diesem verläuft. Dadurch wird eine Probenlösung (38) durch Kapillarkräfte in den Raum zwischen Microarray und Deckfläche gezogen und verteilt sich gleichmässig, ohne dass es irgendwelcher Pumpen bedarf. Die Hybridisierungskammer ermöglicht es, todvolumenfrei mit geringsten Probenmengen zu arbeiten.
PCT/EP2003/006253 2002-06-14 2003-06-13 Hybridisierungskammer WO2003106032A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003238501A AU2003238501A1 (en) 2002-06-14 2003-06-13 Hybridization chamber

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10226750 2002-06-14
DE10226750.2 2002-06-14
DE10254564.2 2002-11-21
DE10254564A DE10254564A1 (de) 2002-06-14 2002-11-21 Hybridisierungskammer

Publications (2)

Publication Number Publication Date
WO2003106032A1 WO2003106032A1 (de) 2003-12-24
WO2003106032A8 true WO2003106032A8 (de) 2004-02-26

Family

ID=29737606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006253 WO2003106032A1 (de) 2002-06-14 2003-06-13 Hybridisierungskammer

Country Status (2)

Country Link
AU (1) AU2003238501A1 (de)
WO (1) WO2003106032A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004046724B3 (de) * 2004-09-27 2006-02-02 Zell-Kontakt Gmbh Reaktionsgefäß und Verfahren zur Behandlung biologischen Materials
DE202007016855U1 (de) * 2007-11-30 2008-02-14 DKFZ Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inkubationsschale für Protein-Array-Inkubationen
DE202009008601U1 (de) 2009-06-19 2009-09-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inkubationsschale für Hochdurchsatzverfahren bei Protein-Array-Inkubationen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
WO1992007655A1 (en) * 1990-10-30 1992-05-14 Hypoguard (Uk) Limited Collection and display device
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE19610146C1 (de) * 1996-03-15 1997-06-12 Wolf Prof Dr Bertling Vorrichtung zur Untersuchung von biologischen und medizinischen Proben
WO2001041931A2 (en) * 1999-12-09 2001-06-14 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
DE10142788A1 (de) * 2001-08-31 2003-03-27 Advalytix Ag Vorrichtung und Verfahren zur Erzeugung dünner Flüssigkeitsfilme

Also Published As

Publication number Publication date
WO2003106032A1 (de) 2003-12-24
AU2003238501A8 (en) 2003-12-31
AU2003238501A1 (en) 2003-12-31

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