[go: up one dir, main page]

WO2003105765A3 - PHOSPHOLIPIDIC MICELLES IN LIPOSOMES AS SOLUBILIZING AGENTS FOR WATER-INSOLUBLE COMPOUNDS - Google Patents

PHOSPHOLIPIDIC MICELLES IN LIPOSOMES AS SOLUBILIZING AGENTS FOR WATER-INSOLUBLE COMPOUNDS Download PDF

Info

Publication number
WO2003105765A3
WO2003105765A3 PCT/US2003/018686 US0318686W WO03105765A3 WO 2003105765 A3 WO2003105765 A3 WO 2003105765A3 US 0318686 W US0318686 W US 0318686W WO 03105765 A3 WO03105765 A3 WO 03105765A3
Authority
WO
WIPO (PCT)
Prior art keywords
micelles
water
phospholipidic
liposomes
solubilizing agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/018686
Other languages
French (fr)
Other versions
WO2003105765A2 (en
Inventor
Hayat Onyuksel
Israel Rubinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Priority to AU2003253645A priority Critical patent/AU2003253645A1/en
Publication of WO2003105765A2 publication Critical patent/WO2003105765A2/en
Publication of WO2003105765A3 publication Critical patent/WO2003105765A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des micelles dans des compositions liposomiques pour l'administration de médicaments insolubles dans l'eau et de composés amphiphiles, des procédés de préparation desdites compositions, ainsi que des procédés de traitement de différentes maladies et de différents troubles au moyen desdites compositions de l'invention.The invention relates to micelles in liposomal compositions for the administration of water-insoluble drugs and amphiphilic compounds, methods of preparing the compositions, and methods of treating different diseases and disorders using the compositions. of the invention.

PCT/US2003/018686 2002-06-12 2003-06-12 Phospholipid micelles in liposomes as solubilizers for water-insoluble compounds Ceased WO2003105765A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003253645A AU2003253645A1 (en) 2002-06-12 2003-06-12 Phospholipid micelles in liposomes as solubilizers for water-insoluble compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38798202P 2002-06-12 2002-06-12
US60/387,982 2002-06-12

Publications (2)

Publication Number Publication Date
WO2003105765A2 WO2003105765A2 (en) 2003-12-24
WO2003105765A3 true WO2003105765A3 (en) 2004-04-08

Family

ID=29736397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018686 Ceased WO2003105765A2 (en) 2002-06-12 2003-06-12 Phospholipid micelles in liposomes as solubilizers for water-insoluble compounds

Country Status (2)

Country Link
AU (1) AU2003253645A1 (en)
WO (1) WO2003105765A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2596131A1 (en) * 2005-01-28 2006-08-03 Bc Cancer Agency Liposomal compositions for parenteral delivery of agents
EP1871343A2 (en) * 2005-04-12 2008-01-02 Wisconsin Alumni Research Foundation Micelle composition of polymer and passenger drug
EP2111218B1 (en) * 2007-01-24 2014-07-02 Syddansk Universitet Dna controlled assembly of lipid membranes
WO2009042114A2 (en) 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
DK2349320T3 (en) * 2008-10-17 2016-09-26 Vectus Biosystems Ltd Compositions and methods for the treatment of renal disorders
EP2480207B1 (en) 2009-09-25 2016-11-09 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
US8895069B2 (en) * 2011-05-16 2014-11-25 Postech Academy-Industry Foundation Drug delivery system using hyaluronic acid-peptide conjugate micelle
WO2016167730A1 (en) * 2015-04-13 2016-10-20 Özen Oğuz Aslan Nanomicelles for the treatment of cancer
CA2997286A1 (en) 2015-09-14 2017-03-23 Vgsk Technologies, Inc. A sterically stabilized carrier for subcutaneous, sublingual and oral therapeutics, compositions and methods for treating a mammal
CN114073675A (en) * 2020-08-10 2022-02-22 复旦大学 A kind of propofol mixed micelle and preparation method thereof
AU2022270670A1 (en) 2021-05-05 2023-11-30 Nejat Duzgunes Liposome-encapsulated corticosteriods inhibit sars-cov-2 replication and reduces lung inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217886B1 (en) * 1997-07-14 2001-04-17 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
US6322810B1 (en) * 1997-07-14 2001-11-27 Hayat Alkan-Onyuksel Materials and methods for making improved micelle compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217886B1 (en) * 1997-07-14 2001-04-17 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
US6322810B1 (en) * 1997-07-14 2001-11-27 Hayat Alkan-Onyuksel Materials and methods for making improved micelle compositions

Also Published As

Publication number Publication date
AU2003253645A1 (en) 2003-12-31
WO2003105765A2 (en) 2003-12-24
AU2003253645A8 (en) 2003-12-31

Similar Documents

Publication Publication Date Title
DE69715786D1 (en) COMPOSITIONS WITH CATIONIC AMPHIPHILES AND COLIPIDES FOR THE INTRACELLULAR ADMINISTRATION OF THERAPEUTIC MOLECULES
WO2003105765A3 (en) PHOSPHOLIPIDIC MICELLES IN LIPOSOMES AS SOLUBILIZING AGENTS FOR WATER-INSOLUBLE COMPOUNDS
ATE355374T1 (en) THERAPEUTIC AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF AMYLOIDOGENIC DISEASES
EP1478371A4 (en) METHODS AND PRODUCTS FOR ENHANCING IMMUNE RESPONSES USING IMIDAZOQUINOLINE COMPOUND
MA28009A1 (en) PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
EP1467724B1 (en) Orodispersible pharmaceutical composition comprising agomelatine
MA28011A1 (en) PIPERAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
MA24694A1 (en) THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS, AND COMPOSITIONS CONTAINING THEM.
MA31283B1 (en) SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR THE TREATMENT OF HYPERLIFERATIVE DISORDERS AND ANGIOGENESIS RELATED DISEASES
MA28008A1 (en) PYRIDYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
TNSN00093A1 (en) NEW MODULATORS OF GLUCOCORTICOID RECEPTORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ATE398998T1 (en) MICELLAR MEDICINAL PRODUCTS FOR BUCCAL AND PULMONARY USE
TNSN99252A1 (en) NOVEL MODULATORS OF CHIMIOKINE CCR5 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN00252A1 (en) PHARMACEUTICAL COMPOSITIONS GENERATING INCREASED CONCENTRATIONS OF DRUGS
EP0783299A4 (en) COMPOUNDS AND COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
FR2411821A1 (en) NEW 1,9-DIHYDROXYOCTAHYDROPHENANTHRENES AND 1-HYDROXYOCTAHYDROPHENANTHRENE-9-ONES AND MEDICINAL PRODUCTS CONTAINING THEM
CA2431606A1 (en) Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providing enhanced therapeutic activity
FR2727015B1 (en) ONDANSETRON LIQUID PHARMACEUTICAL COMPOSITIONS
TNSN97044A1 (en) QUINOXALINEDONE DERIVATIVES, METHODS AND INTERMEDIATES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
NO306894B1 (en) Use of galanthamine for the preparation of a pharmaceutical formulation for the treatment of nicotine addiction
TNSN98024A1 (en) 2-AMINO-6- (2-SUBSTITUE-4-PHENOXY) -SUBSTITUE-PYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
CA2266622A1 (en) Hyaluronic drug delivery system
TNSN98127A1 (en) AZETIDINYLPROPYLPIPERIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TNSN97164A1 (en) NOVEL HORMONAL COMPOSITION AND ITS USE
EP0711169A4 (en) ANDROSTANE STEROIDS FOR USE AS NEUROCHEMICAL INITIATORS OF MODIFYING HUMAN HYPOTHALAMIC FUNCTION, PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP