[go: up one dir, main page]

WO2003104400A3 - Secretory signal sequences and uses thereof - Google Patents

Secretory signal sequences and uses thereof Download PDF

Info

Publication number
WO2003104400A3
WO2003104400A3 PCT/US2003/017661 US0317661W WO03104400A3 WO 2003104400 A3 WO2003104400 A3 WO 2003104400A3 US 0317661 W US0317661 W US 0317661W WO 03104400 A3 WO03104400 A3 WO 03104400A3
Authority
WO
WIPO (PCT)
Prior art keywords
signal sequences
secretory signal
fused
present
chimeric protein
Prior art date
Application number
PCT/US2003/017661
Other languages
French (fr)
Other versions
WO2003104400A2 (en
Inventor
Nicholas Fasel
Carole Beghdadi-Rais
Chantal Desponds
Gary Cohen
Roselyn Eisenberg
Original Assignee
Rmf Dictagene Sa
Univ Pennsylvania
Nicholas Fasel
Carole Beghdadi-Rais
Chantal Desponds
Gary Cohen
Roselyn Eisenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rmf Dictagene Sa, Univ Pennsylvania, Nicholas Fasel, Carole Beghdadi-Rais, Chantal Desponds, Gary Cohen, Roselyn Eisenberg filed Critical Rmf Dictagene Sa
Priority to AU2003238892A priority Critical patent/AU2003238892A1/en
Publication of WO2003104400A2 publication Critical patent/WO2003104400A2/en
Publication of WO2003104400A3 publication Critical patent/WO2003104400A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides polypeptide sequences which, when fused to a heterologous polypeptide, promote secretion of the resulting chimeric protein, and uses thereof.
PCT/US2003/017661 2002-06-07 2003-06-06 Secretory signal sequences and uses thereof WO2003104400A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003238892A AU2003238892A1 (en) 2002-06-07 2003-06-06 Secretory signal sequences and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38736502P 2002-06-07 2002-06-07
US60/387,365 2002-06-07

Publications (2)

Publication Number Publication Date
WO2003104400A2 WO2003104400A2 (en) 2003-12-18
WO2003104400A3 true WO2003104400A3 (en) 2004-02-12

Family

ID=29736303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017661 WO2003104400A2 (en) 2002-06-07 2003-06-06 Secretory signal sequences and uses thereof

Country Status (2)

Country Link
AU (1) AU2003238892A1 (en)
WO (1) WO2003104400A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7628993B2 (en) 2006-07-20 2009-12-08 Vical Incorporated Compositions and methods for vaccinating against HSV-2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814486A (en) * 1995-07-07 1998-09-29 Competitive Technologies, Inc. Herpes simplex virus glycoprotein D variants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814486A (en) * 1995-07-07 1998-09-29 Competitive Technologies, Inc. Herpes simplex virus glycoprotein D variants

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DEAN ET AL.: "Single amino acid substitution in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity", VIROLOGY, vol. 199, 1994, pages 67 - 80, XP002970336 *
HUBER ET AL.: "Herpes simplex virus with highly reduced gD levels can efficiently enter and spread between human keratinocytes", JOURNAL OF VIROLOGY, vol. 75, no. 21, November 2001 (2001-11-01), pages 10309 - 10318, XP002970339 *
JOHNSON ET AL.: "Soluble forms of herpes simplex virus glycoprotein D bind to a limited number of cell surface receptors and inhibit virus entry into cells", JOURNAL OF VIROLOGY, vol. 64, no. 6, June 1990 (1990-06-01), pages 2569 - 2576, XP000606350 *
RUX ET AL.: "Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator", JOURNAL OF VIROLOGY, vol. 72, no. 9, September 1998 (1998-09-01), pages 7091 - 7098, XP002970337 *
TERRY-ALLISON ET AL.: "Hve A (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5802 - 5810, XP002923344 *
WILLIS ET AL.: "Examination of the kinetics of herpes simplex virus glycoprotein D binding to the herpesvirus entry mediator, using surface plasmon resonance", JOURNAL OF VIROLOGY, vol. 72, no. 7, July 1998 (1998-07-01), pages 5937 - 5947, XP002970338 *

Also Published As

Publication number Publication date
AU2003238892A8 (en) 2003-12-22
AU2003238892A1 (en) 2003-12-22
WO2003104400A2 (en) 2003-12-18

Similar Documents

Publication Publication Date Title
DE60325892D1 (en) POSITIONING AND USE PROCEDURE
WO2005007818A3 (en) Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof
WO2004080148A3 (en) Novel nucleic acids and polypeptides
WO2003025148A3 (en) Novel nucleic acids and polypeptides
WO2003023013A3 (en) Novel nucleic acids and polypeptides
WO2002081731A3 (en) Novel nucleic acids and polypeptides
NO2011003I2 (en)
WO2001075067A3 (en) Novel nucleic acids and polypeptides
WO2001057188A3 (en) Novel nucleic acids and polypeptides
WO2001057190A3 (en) Novel nucleic acids and polypeptides
WO2001066689A3 (en) Novel nucleic acids and polypeptides
WO2002031111A3 (en) Novel nucleic acids and polypeptides
WO2001088088A3 (en) Novel nucleic acids and polypeptides
WO2002059260A3 (en) Nucleic acids and polypeptides
HK1114636A1 (en) 1l-17 homologous polypeptides and therapeutic uses thereof
DE69231001D1 (en) UBIQUIT-SPECIFIC PROTEASES
EP1487966A4 (en) Secretion of proteins with multiple disulfide bonds in bacteria and uses thereof
WO2003062370A3 (en) Multimeric proteins and methods of making and using same
WO2004043403A3 (en) Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
WO2004087874A3 (en) Novel nucleic acids and polypeptides
IL150676A0 (en) NOVEL STRa6 POLYPEPTIDES
WO2002018424A3 (en) Nucleic acids and polypeptides
WO2001079449A3 (en) Novel nucleic acids and polypeptides
WO2003080795A3 (en) Novel nucleic acids and secreted polypeptides
WO2003087128A3 (en) Secretory signal sequences and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP