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WO2003083046A3 - Novel proteins and nucleic acids encoding same - Google Patents

Novel proteins and nucleic acids encoding same Download PDF

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Publication number
WO2003083046A3
WO2003083046A3 PCT/US2003/010142 US0310142W WO03083046A3 WO 2003083046 A3 WO2003083046 A3 WO 2003083046A3 US 0310142 W US0310142 W US 0310142W WO 03083046 A3 WO03083046 A3 WO 03083046A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
nucleic acids
molecule target
therapeutic
methods
Prior art date
Application number
PCT/US2003/010142
Other languages
French (fr)
Other versions
WO2003083046A2 (en
Inventor
David W Anderson
Patricia Bento
Ferenc L Boldog
Catherine E Burgess
Stacie J Casman
Katarzyna Furtak
Linda Gorman
Bonnie E Gould-Rothberg
Erik Gunther
Melvyn P Heyes
Li Li
Kimberly A Spytek
David J Stone
Mei Zhong
Uriel M Malyankar
Shlomit R Edinger
Meera Patturajan
Mark E Rothenberg
Glennda Smithson
Original Assignee
Curagen Corp
David W Anderson
Patricia Bento
Ferenc L Boldog
Catherine E Burgess
Stacie J Casman
Katarzyna Furtak
Linda Gorman
Bonnie E Gould-Rothberg
Erik Gunther
Melvyn P Heyes
Li Li
Kimberly A Spytek
David J Stone
Mei Zhong
Uriel M Malyankar
Shlomit R Edinger
Meera Patturajan
Mark E Rothenberg
Glennda Smithson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/093,463 external-priority patent/US20030208039A1/en
Priority claimed from US10/115,479 external-priority patent/US20040006205A1/en
Priority claimed from US10/287,226 external-priority patent/US20040086875A1/en
Application filed by Curagen Corp, David W Anderson, Patricia Bento, Ferenc L Boldog, Catherine E Burgess, Stacie J Casman, Katarzyna Furtak, Linda Gorman, Bonnie E Gould-Rothberg, Erik Gunther, Melvyn P Heyes, Li Li, Kimberly A Spytek, David J Stone, Mei Zhong, Uriel M Malyankar, Shlomit R Edinger, Meera Patturajan, Mark E Rothenberg, Glennda Smithson filed Critical Curagen Corp
Priority to CA002481376A priority Critical patent/CA2481376A1/en
Priority to EP03726178A priority patent/EP1523322A4/en
Priority to AU2003228426A priority patent/AU2003228426A1/en
Publication of WO2003083046A2 publication Critical patent/WO2003083046A2/en
Publication of WO2003083046A3 publication Critical patent/WO2003083046A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
PCT/US2003/010142 2002-03-08 2003-04-01 Novel proteins and nucleic acids encoding same WO2003083046A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002481376A CA2481376A1 (en) 2002-04-02 2003-04-01 Novel proteins and nucleic acids encoding same
EP03726178A EP1523322A4 (en) 2002-04-02 2003-04-01 Novel proteins and nucleic acids encoding same
AU2003228426A AU2003228426A1 (en) 2002-04-02 2003-04-01 Novel proteins and nucleic acids encoding same

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US10/093,463 US20030208039A1 (en) 2001-03-08 2002-03-08 Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
US10/115,479 2002-04-02
US10/115,479 US20040006205A1 (en) 2001-04-03 2002-04-02 Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US37034902P 2002-04-05 2002-04-05
US60/370,349 2002-04-05
US37096902P 2002-04-08 2002-04-08
US60/370,969 2002-04-08
US37201902P 2002-04-12 2002-04-12
US60/372,019 2002-04-12
US37437902P 2002-04-22 2002-04-22
US60/374,379 2002-04-22
US38454302P 2002-05-30 2002-05-30
US60/384,543 2002-05-30
US16061902A 2002-06-03 2002-06-03
US10/160,619 2002-06-03
US40374802P 2002-08-15 2002-08-15
US60/403,748 2002-08-15
US10/287,226 2002-11-04
US10/287,226 US20040086875A1 (en) 2001-11-05 2002-11-04 Novel proteins and nucleic acids encoding same
US10/403,161 2003-03-31

Publications (2)

Publication Number Publication Date
WO2003083046A2 WO2003083046A2 (en) 2003-10-09
WO2003083046A3 true WO2003083046A3 (en) 2004-07-22

Family

ID=28679254

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/010142 WO2003083046A2 (en) 2002-03-08 2003-04-01 Novel proteins and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2003083046A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE493651T1 (en) 2002-07-03 2011-01-15 Illumigen Biosciences Inc METHODS AND COMPOSITIONS FOR DIAGNOSING HEPA CELL CARCINOMA
EP1718756B1 (en) * 2004-02-24 2011-11-16 Allergan, Inc. Botulinum toxin screening assays
WO2005104785A2 (en) * 2004-04-27 2005-11-10 Illumigen Biosciences, Inc. Methods and compositions for specifically targeting human hepatocellular carcinoma cells
WO2005118832A2 (en) * 2004-06-01 2005-12-15 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase-like protein (sgkl)
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
CA2587979A1 (en) * 2004-11-19 2006-05-26 Oy Jurilab Ltd Method and kit for detecting a risk of essential arterial hypertension
DE102004059781A1 (en) * 2004-12-10 2006-06-22 Sanofi-Aventis Deutschland Gmbh Use of serum / glucocorticoid-regulated kinase
GB0517916D0 (en) * 2005-09-02 2005-10-12 Paradigm Therapeutics Ltd Ion channel
US8187601B2 (en) 2008-07-01 2012-05-29 Aveo Pharmaceuticals, Inc. Fibroblast growth factor receptor 3 (FGFR3) binding proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863780A (en) * 1996-09-12 1999-01-26 Incyte Pharmaceuticals, Inc. Human Protein Kinases
US6326181B1 (en) * 1997-02-28 2001-12-04 Florian Lang Cell volume-regulated human kinase h-sgk

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863780A (en) * 1996-09-12 1999-01-26 Incyte Pharmaceuticals, Inc. Human Protein Kinases
US6326181B1 (en) * 1997-02-28 2001-12-04 Florian Lang Cell volume-regulated human kinase h-sgk

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE PIR_76 [online] R. WEBSTER: "Serum and Glucocorticoid-regulated Kinase-Rat", XP002977288, Database accession no. A48094 *
DATABASE PROTEIN [online] 15 March 1999 (1999-03-15), "Human SQK Protein", Database accession no. AAW90139 *
MOL. CELL. BIOL., 21 January 1994 (1994-01-21) *

Also Published As

Publication number Publication date
WO2003083046A2 (en) 2003-10-09

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