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WO2003070760A3 - Anti-amyloid beta antibodies and their use - Google Patents

Anti-amyloid beta antibodies and their use Download PDF

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Publication number
WO2003070760A3
WO2003070760A3 PCT/EP2003/001759 EP0301759W WO03070760A3 WO 2003070760 A3 WO2003070760 A3 WO 2003070760A3 EP 0301759 W EP0301759 W EP 0301759W WO 03070760 A3 WO03070760 A3 WO 03070760A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
antibody molecules
molecules
hosts
seq
Prior art date
Application number
PCT/EP2003/001759
Other languages
French (fr)
Other versions
WO2003070760A2 (en
Inventor
Michael Bardroff
Bernd Bohrmann
Manfred Brockhaus
Walter Huber
Titus Kretzschmar
Corinna Loehning
Hansruedi Loetscher
Christer Nordstedt
Christine Rothe
Original Assignee
Hoffmann La Roche
Morphosys Ag
Michael Bardroff
Bernd Bohrmann
Manfred Brockhaus
Walter Huber
Titus Kretzschmar
Corinna Loehning
Hansruedi Loetscher
Christer Nordstedt
Christine Rothe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27741103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003070760(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020047013038A priority Critical patent/KR101038828B1/en
Priority to MXPA04008077A priority patent/MXPA04008077A/en
Priority to IL16356303A priority patent/IL163563A0/en
Priority to JP2003569667A priority patent/JP4383888B2/en
Priority to CA2477012A priority patent/CA2477012C/en
Priority to BRPI0307837A priority patent/BRPI0307837B8/en
Application filed by Hoffmann La Roche, Morphosys Ag, Michael Bardroff, Bernd Bohrmann, Manfred Brockhaus, Walter Huber, Titus Kretzschmar, Corinna Loehning, Hansruedi Loetscher, Christer Nordstedt, Christine Rothe filed Critical Hoffmann La Roche
Priority to EP03714751A priority patent/EP1481008A2/en
Priority to US10/505,313 priority patent/US7794719B2/en
Priority to NZ534522A priority patent/NZ534522A/en
Priority to BR122019025343A priority patent/BR122019025343B8/en
Priority to AU2003218995A priority patent/AU2003218995B2/en
Priority to CN038040336A priority patent/CN1630665B/en
Publication of WO2003070760A2 publication Critical patent/WO2003070760A2/en
Publication of WO2003070760A3 publication Critical patent/WO2003070760A3/en
Priority to CL200401122A priority patent/CL2004001122A1/en
Priority to HRP20040712AA priority patent/HRP20040712B1/en
Priority to IL163563A priority patent/IL163563A/en
Priority to ZA2004/06604A priority patent/ZA200406604B/en
Priority to NO20043891A priority patent/NO336112B1/en
Priority to US12/462,119 priority patent/US8216577B2/en
Priority to US13/472,781 priority patent/US8329886B2/en
Priority to NO20121017A priority patent/NO20121017L/en
Priority to US13/671,753 priority patent/US20130136747A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)

Abstract

The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
PCT/EP2003/001759 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use WO2003070760A2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
CN038040336A CN1630665B (en) 2002-02-20 2003-02-20 Anti-A beta antibodies and their use
BR122019025343A BR122019025343B8 (en) 2002-02-20 2003-02-20 nucleic acid molecule, vector and method for preparing an antibody molecule
IL16356303A IL163563A0 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use
JP2003569667A JP4383888B2 (en) 2002-02-20 2003-02-20 Anti-Aβ antibodies and uses thereof
CA2477012A CA2477012C (en) 2002-02-20 2003-02-20 Anti-a.beta. antibodies and their use
BRPI0307837A BRPI0307837B8 (en) 2002-02-20 2003-02-20 anti-beta-a-4 peptide antibody molecule, compositions and their uses
MXPA04008077A MXPA04008077A (en) 2002-02-20 2003-02-20 ANTI-Abeta ANTIBODIES AND THEIR USE.
EP03714751A EP1481008A2 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use
US10/505,313 US7794719B2 (en) 2002-02-20 2003-02-20 Anti-amyloid β antibodies
NZ534522A NZ534522A (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use
AU2003218995A AU2003218995B2 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use
KR1020047013038A KR101038828B1 (en) 2002-02-20 2003-02-20 Anti-Αβ Antibody and Uses thereof
CL200401122A CL2004001122A1 (en) 2002-02-20 2004-05-19 SPECIFIC ANTIBODIES FOR TWO REGIONS OF THE BETA AMYLOID PEPTIDE (BETA A4); NUCLEIC ACIDS THAT CODE THEM; COMPOSITION THAT UNDERSTANDS THEM; KIT THAT THE ANTIBODIES UNDERSTAND; PREPARATION PROCEDURE; USES TO PREVENT AND TREAT DISEASE
HRP20040712AA HRP20040712B1 (en) 2002-02-20 2004-08-04 Anti-amyloid beta antibodies and their use
IL163563A IL163563A (en) 2002-02-20 2004-08-16 Anti-amyloid beta antibodies and their use in medicine
ZA2004/06604A ZA200406604B (en) 2002-02-20 2004-08-19 Anti-amyloid beta antibodies and their use
NO20043891A NO336112B1 (en) 2002-02-20 2004-09-16 Anti-Aβ antibodies and method of preparation, as well as nucleic acid molecules encoding such antibodies, and vectors and host cells comprising said nucleic acid molecules, in addition to pharmaceutical and diagnostic preparations, as well as specific uses of the antibody molecules, the nucleic acid molecules or the vector acid molecules or
US12/462,119 US8216577B2 (en) 2002-02-20 2009-07-28 Anti-Aβ antibodies and their use
US13/472,781 US8329886B2 (en) 2002-02-20 2012-05-16 Nucleic acid molecules encoding anti-amyloid beta antibodies
NO20121017A NO20121017L (en) 2002-02-20 2012-09-10 Anti-Abeta antibodies and their use as well as method for optimizing and preparing a pharmaceutical composition
US13/671,753 US20130136747A1 (en) 2002-02-20 2012-11-08 Anti-amyloid beta antibodies and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02003844.4 2002-02-20
EP02003844 2002-02-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10505313 A-371-Of-International 2003-02-20
US12/462,119 Division US8216577B2 (en) 2002-02-20 2009-07-28 Anti-Aβ antibodies and their use

Publications (2)

Publication Number Publication Date
WO2003070760A2 WO2003070760A2 (en) 2003-08-28
WO2003070760A3 true WO2003070760A3 (en) 2004-03-04

Family

ID=27741103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/001759 WO2003070760A2 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use

Country Status (27)

Country Link
US (4) US7794719B2 (en)
EP (2) EP1481008A2 (en)
JP (2) JP4383888B2 (en)
KR (1) KR101038828B1 (en)
CN (4) CN1630665A (en)
AR (2) AR038568A1 (en)
AU (1) AU2003218995B2 (en)
BR (1) BRPI0307837B8 (en)
CA (1) CA2477012C (en)
CL (1) CL2004001122A1 (en)
CO (1) CO5601037A2 (en)
CY (1) CY1118037T1 (en)
DK (1) DK2368907T3 (en)
ES (1) ES2590684T3 (en)
HR (1) HRP20040712B1 (en)
HU (1) HUE030591T2 (en)
IL (2) IL163563A0 (en)
LT (1) LT2368907T (en)
MX (1) MXPA04008077A (en)
NO (2) NO336112B1 (en)
NZ (1) NZ534522A (en)
PL (1) PL216190B1 (en)
PT (1) PT2368907T (en)
RU (1) RU2341533C2 (en)
SI (1) SI2368907T1 (en)
WO (1) WO2003070760A2 (en)
ZA (1) ZA200406604B (en)

Cited By (9)

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US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
KR101605207B1 (en) 2006-07-14 2016-03-22 에이씨 이뮨 에스.에이. Humanized antibody against amyloid beta
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody

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