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WO2003066832A3 - Generation of new insulin cells from progenitor cells present in adult pancreatic islets - Google Patents

Generation of new insulin cells from progenitor cells present in adult pancreatic islets Download PDF

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Publication number
WO2003066832A3
WO2003066832A3 PCT/US2003/003859 US0303859W WO03066832A3 WO 2003066832 A3 WO2003066832 A3 WO 2003066832A3 US 0303859 W US0303859 W US 0303859W WO 03066832 A3 WO03066832 A3 WO 03066832A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
producing cells
generation
cells
pancreatic islets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/003859
Other languages
French (fr)
Other versions
WO2003066832A2 (en
Inventor
Teitelman Gladys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Priority to AU2003217357A priority Critical patent/AU2003217357A1/en
Publication of WO2003066832A2 publication Critical patent/WO2003066832A2/en
Publication of WO2003066832A3 publication Critical patent/WO2003066832A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention is directed to an in vitro method for converting non­insulin producing cells to insulin-producing cells. A continuous source of insulin-­producing cells is obtained. Insulin from these insulin-producing cells may be collected and administered to a mammal, or the insulin-producing cells may themselves be transplanted into a mammal. Also provided are insulin-producing cells made by the methods of the invention, methods for culturing insulin-producing cells, and methods for treating diabetes with the insulin-producing cells.
PCT/US2003/003859 2002-02-07 2003-02-07 Generation of new insulin cells from progenitor cells present in adult pancreatic islets Ceased WO2003066832A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003217357A AU2003217357A1 (en) 2002-02-07 2003-02-07 Generation of new insulin cells from progenitor cells present in adult pancreatic islets

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35571502P 2002-02-07 2002-02-07
US60/355,715 2002-02-07

Publications (2)

Publication Number Publication Date
WO2003066832A2 WO2003066832A2 (en) 2003-08-14
WO2003066832A3 true WO2003066832A3 (en) 2003-12-24

Family

ID=27734554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003859 Ceased WO2003066832A2 (en) 2002-02-07 2003-02-07 Generation of new insulin cells from progenitor cells present in adult pancreatic islets

Country Status (2)

Country Link
AU (1) AU2003217357A1 (en)
WO (1) WO2003066832A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
AU2005322068B2 (en) 2004-12-23 2011-09-01 Ethicon Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
ES2642844T3 (en) 2005-12-16 2017-11-20 DePuy Synthes Products, Inc. Compositions and methods to inhibit an adverse immune response in histocompatibility transplantation that do not match
CN107028983A (en) 2008-12-19 2017-08-11 德普伊新特斯产品有限责任公司 The treatment of PUD D and illness
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
WO2010111663A1 (en) 2009-03-26 2010-09-30 Ethicon, Inc. Human umbilical cord tissue cells as therapy for alzheimer' s disease
AU2012358810B2 (en) 2011-12-23 2018-03-15 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
US5858973A (en) * 1994-02-23 1999-01-12 The General Hospital Corporation Transcription factor and uses therefor
US6020200A (en) * 1995-03-03 2000-02-01 Metabolex, Inc. Encapsulation compositions and methods
US6149907A (en) * 1994-04-13 2000-11-21 Research Corporation Technologies, Inc. Treatments using sertoli cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
US5858973A (en) * 1994-02-23 1999-01-12 The General Hospital Corporation Transcription factor and uses therefor
US6149907A (en) * 1994-04-13 2000-11-21 Research Corporation Technologies, Inc. Treatments using sertoli cells
US6020200A (en) * 1995-03-03 2000-02-01 Metabolex, Inc. Encapsulation compositions and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EIZIRIK ET AL.: "Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induced long-lasting functional impairment of beta-cells", BIOCHEMICAL PHARMACOLOGY, vol. 42, no. 12, 1991, pages 2275 - 2282, XP002967912 *
FISHER ET AL.: "Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase and a metal chelator", DIABETES, vol. 29, March 1980 (1980-03-01), pages 213 - 216, XP002967914 *
SUAREZ-PINZON ET AL.: "An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitric prevents diabetes development in NOD mice", JOURNAL OF AUTOIMMUNITY, vol. 16, 2001, pages 449 - 455, XP002967913 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9234172B2 (en) 2003-06-27 2016-01-12 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US9585918B2 (en) 2005-12-28 2017-03-07 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells

Also Published As

Publication number Publication date
WO2003066832A2 (en) 2003-08-14
AU2003217357A1 (en) 2003-09-02
AU2003217357A8 (en) 2003-09-02

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