[go: up one dir, main page]

WO2003053422A3 - Methodes et compositions pour le traitement de pathologies respiratoires - Google Patents

Methodes et compositions pour le traitement de pathologies respiratoires Download PDF

Info

Publication number
WO2003053422A3
WO2003053422A3 PCT/FR2002/004506 FR0204506W WO03053422A3 WO 2003053422 A3 WO2003053422 A3 WO 2003053422A3 FR 0204506 W FR0204506 W FR 0204506W WO 03053422 A3 WO03053422 A3 WO 03053422A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
treating respiratory
pathologies
respiratory pathologies
Prior art date
Application number
PCT/FR2002/004506
Other languages
English (en)
Other versions
WO2003053422A2 (fr
Inventor
Lionel Bueno
Original Assignee
Rytek
Lionel Bueno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0116706A external-priority patent/FR2833839A1/fr
Application filed by Rytek, Lionel Bueno filed Critical Rytek
Priority to CA002470442A priority Critical patent/CA2470442A1/fr
Priority to AU2002364679A priority patent/AU2002364679A1/en
Priority to US10/498,094 priority patent/US20050019314A1/en
Priority to EP02805413A priority patent/EP1455767A2/fr
Publication of WO2003053422A2 publication Critical patent/WO2003053422A2/fr
Publication of WO2003053422A3 publication Critical patent/WO2003053422A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente demande concerne des compositions et méthodes pour letraitement de pathologies respiratoires. Elle concerne également des compositions et méthodes permettant de réguler la perméabilité paracellulaire de l'épithélium pulmonaire. Les compositions et méthodes de l'invention reposent notamment sur l'utilisation d'agents ou de conditions modulant la tension du cytosquelette, plus particulièrement des composés inhibant la contraction de la chaîne légère de la myosine des cellules épithéliales pulmonaires, notamment des entérocytes. L'invention est utilisable pour le traitement préventif ou curatif de pathologies variées, telles que asthme, allergies, maladies obstructives, etc., chez les mammifères, notamment les humains.
PCT/FR2002/004506 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires WO2003053422A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002470442A CA2470442A1 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires
AU2002364679A AU2002364679A1 (en) 2001-12-21 2002-12-20 Method and compositions for treating respiratory pathologies
US10/498,094 US20050019314A1 (en) 2001-12-21 2002-12-20 Method and compositions for treating respiratory pathologies
EP02805413A EP1455767A2 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0116706A FR2833839A1 (fr) 2001-12-21 2001-12-21 Methodes et compositions pour le traitement de pathologies respiratoires
FR01/16706 2001-12-21
FR0208606A FR2833840B1 (fr) 2001-12-21 2002-07-09 Methodes et compositions pour le traitement de pathologies respiratoires
FR02/08606 2002-07-09

Publications (2)

Publication Number Publication Date
WO2003053422A2 WO2003053422A2 (fr) 2003-07-03
WO2003053422A3 true WO2003053422A3 (fr) 2004-04-15

Family

ID=26213306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004506 WO2003053422A2 (fr) 2001-12-21 2002-12-20 Methodes et compositions pour le traitement de pathologies respiratoires

Country Status (12)

Country Link
US (2) US20050019314A1 (fr)
EP (1) EP1455767A2 (fr)
AR (1) AR038042A1 (fr)
AU (1) AU2002364679A1 (fr)
CA (1) CA2470442A1 (fr)
FR (1) FR2833840B1 (fr)
PA (1) PA8562701A1 (fr)
PE (1) PE20030853A1 (fr)
SV (1) SV2003001439A (fr)
TW (1) TW200305447A (fr)
UY (1) UY27589A1 (fr)
WO (1) WO2003053422A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20050129679A1 (en) * 2003-12-15 2005-06-16 Nastech Pharmaceutical Company Inc. Method for opening tight junctions
KR101158147B1 (ko) * 2003-12-17 2012-07-17 와이어쓰 엘엘씨 Ａβ 면역원성 펩티드 캐리어 컨쥬게이트 및 이의 제조방법
EP1778652A2 (fr) * 2004-08-20 2007-05-02 EntreMed, Inc. Compositions et procedes comportant des antagonistes de recepteur active par la proteinase
FR2879100B1 (fr) * 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
WO2008073627A2 (fr) * 2006-11-03 2008-06-19 Alba Therapeutics Corporation Procédé de diagnostic et de traitement de l'asthme
US20150038674A1 (en) * 2013-08-05 2015-02-05 Bayrak Bertan Boran Use of glp-2 analogues in pulmonary diseases for therapeutic purpose
FR3145744A1 (fr) 2023-02-11 2024-08-16 Marc Grosman Drone comportant au moins une pile à combustible, un calculateur dont un élément quantique ou supraconducteur, capable de réaliser plusieurs tâches au cours d’un vol sur zone difficile d’accès.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0638564A1 (fr) * 1993-02-19 1995-02-15 Asahi Kasei Kogyo Kabushiki Kaisha Derive de benzothiazolesulfonamide, procede de production et application de ce derive
US5883114A (en) * 1992-05-30 1999-03-16 Goedecke Aktiengesellschaft Indolocarbazole imides and the use thereof
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748A (en) * 1844-09-17 Improvement in ratoon and cane cutters
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
FR2674434B1 (fr) * 1991-03-27 1993-06-18 Nativelle Sa Ets Nouvelle composition pharmaceutique a base de taurine pour l'administration par inhalation.
US5336503A (en) * 1992-03-31 1994-08-09 Daiichi Pharmaceutical Co., Ltd. Anti-peptic ulcer agent
AU703540B2 (en) * 1996-03-26 1999-03-25 Meddiss, Incorporated Methods for inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general
ES2286834T5 (es) * 1996-08-12 2011-01-31 Mitsubishi Tanabe Pharma Corporation Medicamentos que comprenden un inhibidor de la rho quinasa.
WO1999014242A2 (fr) * 1997-09-19 1999-03-25 Magainin Pharmaceuticals Inc. Facteurs associes a l'asthme comme cibles pour traiter les allergies atopiques y compris l'asthme et les troubles apparentes
WO2002014499A2 (fr) * 2000-08-15 2002-02-21 Immunex Corporation Polypeptides de claudines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883114A (en) * 1992-05-30 1999-03-16 Goedecke Aktiengesellschaft Indolocarbazole imides and the use thereof
EP0638564A1 (fr) * 1993-02-19 1995-02-15 Asahi Kasei Kogyo Kabushiki Kaisha Derive de benzothiazolesulfonamide, procede de production et application de ce derive
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
AHDIEH M ET AL: "LUNG EPITHELIAL BARRIER FUNCTION AND WOUND HEALING ARE DECREASED BY IL-4 AND IL-13 ENHANCED BY IFN-GAMMA", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 281, no. 6, December 2001 (2001-12-01), pages C2029 - C2038, XP008007756, ISSN: 0363-6143 *
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 11, no. 6, 1994, pages 676 - 681, ISSN: 1044-1549 *
ARERUGI = [ALLERGY]. JAPAN NOV 1990, vol. 39, no. 11, November 1990 (1990-11-01), pages 1541 - 1545, ISSN: 0021-4884 *
CITI S ET AL: "CYTOSKELETAL INVOLVEMENT IN THE MODULATION OF CELL-CELL JUNCTIONS BY THE PROTEIN KINASE INHIBITOR H-7", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 107, no. 3, 1994, pages 683 - 692, XP002040798 *
CITI S: "PROTEIN KINASE INHIBITORS PREVENT JUNCTIONS DISSOCIATION INDUCED BY LOW EXTRACELLULAR CALCIUM IN MDCK EPITHELIAL CELLS", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 117, no. 1, April 1992 (1992-04-01), pages 169 - 178, XP008007882, ISSN: 0021-9525 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, LIU XUELIANG ET AL: "Myosin Light Chain Phosphatase Activity in Ragweed Pollen-Sensitized Canine Tracheal Smooth Muscle", XP002256897, Database accession no. PREV199598078691 *
DATABASE MEDLINE [online] November 1990 (1990-11-01), OHASHI Y ET AL: "[Relationship between bronchial reactivity to inhaled acetylcholine, eosinophil infiltration and a widening of the intercellular space in patients with asthma]", XP002216574, Database accession no. NLM2288500 *
GARCIA J G ET AL: "Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES MAY 1998, vol. 84, no. 5, May 1998 (1998-05-01), pages 1817 - 1821, XP001165792, ISSN: 8750-7587 *
GARCIA J G ET AL: "Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src).", THE AMERICAN JOURNAL OF PHYSIOLOGY. UNITED STATES JUN 1999, vol. 276, no. 6 Pt 1, June 1999 (1999-06-01), pages L989 - L998, XP002256896, ISSN: 0002-9513 *
GODFREY R W A: "HUMAN AIRWAY EPITHELIAL TIGHT JUNCTIONS", MICROSCOPY RESEARCH AND TECHNIQUE, WILEY-LISS, CHICHESTER, GB, vol. 38, no. 5, 1 September 1997 (1997-09-01), pages 488 - 499, XP008007862, ISSN: 1059-910X *
KOBAYASHI K ET AL: "MECHANISM OF HYDROGEN PEROXIDE-INDUCED INHIBITION OF SHEEP AIRWAY CILIA", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 6, no. 6, 1992, pages 667 - 673, XP008022800, ISSN: 1044-1549 *
KOBAYASHI N ET AL: "IMMUNOHISTOCHEMICAL STUDY OF E-CADHERIN AND ZO-1 IN ALLERGIC NASAL EPITHELIUM OF THE GUINEA PIG", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, XX, XX, vol. 116, no. 3, July 1998 (1998-07-01), pages 196 - 205, XP008007809, ISSN: 1018-2438 *
LEFF A R: "Pharmacologic management of asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1998 UNITED STATES, vol. 101, no. 2 II, 1998, pages S397 - S399, XP008022810, ISSN: 0091-6749 *
MARUOKA ET AL.: "Involvement of Rho and Myosin Light Chain Kinase in neutrophil elastase-induced morphological changes in airway epithelial cells", AM. J. RESPIR. CRITICAL CARE MED., vol. 159, no. 3suppl., 1999, pages a187, XP008022808 *
PARKER J C: "Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES DEC 2000, vol. 89, no. 6, December 2000 (2000-12-01), pages 2241 - 2248, XP001165791, ISSN: 8750-7587 *
PETRACHE I ET AL: "DIFFERENTIAL EFFECT OF MLC KINASE IN TNF-ALPHA-INDUCED ENDOTHELIAL CELL APOPTOSIS AND BARRIER DYSFUNCTION", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, XX, XX, vol. 280, no. 6, June 2001 (2001-06-01), pages L1168 - L1178, XP001128712, ISSN: 1040-0605 *
See also references of EP1455767A2 *
VOLBERG T ET AL: "Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.", CELL MOTILITY AND THE CYTOSKELETON. UNITED STATES 1994, vol. 29, no. 4, 1994, pages 321 - 338, XP008022805, ISSN: 0886-1544 *
WYATT T A ET AL: "Stimulation of protein kinase C activity by tumor necrosis factor-[alpha] in bovine bronchial epithelial cells", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1997 UNITED STATES, vol. 273, no. 5 17-5, 1997, pages L1007 - L1012, XP001165793, ISSN: 1040-0605 *

Also Published As

Publication number Publication date
AR038042A1 (es) 2004-12-22
WO2003053422A2 (fr) 2003-07-03
FR2833840B1 (fr) 2010-06-18
US20030125321A1 (en) 2003-07-03
EP1455767A2 (fr) 2004-09-15
CA2470442A1 (fr) 2003-07-03
US20050019314A1 (en) 2005-01-27
PE20030853A1 (es) 2003-10-28
UY27589A1 (es) 2003-05-30
SV2003001439A (es) 2003-11-04
PA8562701A1 (es) 2004-02-16
AU2002364679A1 (en) 2003-07-09
AU2002364679A8 (en) 2003-07-09
FR2833840A1 (fr) 2003-06-27
TW200305447A (en) 2003-11-01

Similar Documents

Publication Publication Date Title
ATE183647T1 (de) Methode zur behandlung von entzündungen der lunge
WO2003000241A3 (fr) Nouvelles compositions de medicament a base d'anticholinergiques, de corticosteroides et d'agents beta-mimetiques
BR0112799A (pt) Composição farmacêutica, processo para preparação e utilização da mesma, conjunto e processo para tratamento de obesidade, utilização de um inibidor de lìpase e de um sequestrante de ácido de bìlis e processo de tratamento ou prevencão de efeitos colaterais gastrointestinais
WO2003099207A3 (fr) Lactoferrine par voie orale dans le traitement des troubles respiratoires
IL164795A0 (en) Treatment and prevention of pulmonary conditions
WO2007092622A3 (fr) Compositions et méthodes pour le traitement d'os
WO2003053422A3 (fr) Methodes et compositions pour le traitement de pathologies respiratoires
WO2007057858A3 (fr) Compositions utiles dans la prevention et le traitement du rhume et des symptomes grippaux
ATE276749T1 (de) Zusammensetzungen zur vorbeugung und behandlung der erkältung und grippe-artiger symptome und ihre verwendung
WO2007089548A3 (fr) Composés et procédés de modulation du trafic de protéines
WO2007079214A3 (fr) Antagonistes du recepteur de la prokineticine 2
WO2008021210A3 (fr) Méthodes et compositions pour le traitement de troubles neurodégénératifs
WO2004021989A3 (fr) Imidazolopyridines, procedes de fabrication et methodes d'utilisation
RS95904A (en) Tri -substituted heteroaryls and methods for making and using the same
WO2003072593A3 (fr) Peptides ciblant les os
WO2006024018A3 (fr) Methodes et compositions pour le traitement de la douleur nociceptive
WO2004030620A3 (fr) Inhibiteurs de tyrosine kinase
PL1633376T3 (pl) Środki do profilaktyki i leczenia objawów przeziębienia i grypopodobnych zawierające chelatowany cynk
WO2007005672A3 (fr) Traitement et prevention de maladies et de situations respiratoires
MXPA04004300A (es) Analogos de lipoxina a4.
NO20053972L (no) Aminosyre-avledede prodrug av propofol, sammensetninger og anvendelse derav.
BR0316163A (pt) Inibidores de histona desacetilase para tratamento de doenças degenerativas do olho
TW200621753A (en) Pyrimidinylimidazoles and methods of making and using the same
MXPA03011702A (es) Composicion que comprende un inhibidor de fosodiesterasa 4 y un antagonista de receptor h1 y el uso de los mismos para la elaboracion de un medicamento para el tratamiento de enfermedades respiratorias.
WO2003020213A3 (fr) Procedes et compositions pour le traitement de troubles inflammatoires

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002805413

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10498094

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2470442

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 2002805413

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP