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WO2002102387A1 - Traitement de la douleur neuropathique - Google Patents

Traitement de la douleur neuropathique Download PDF

Info

Publication number
WO2002102387A1
WO2002102387A1 PCT/DK2002/000407 DK0200407W WO02102387A1 WO 2002102387 A1 WO2002102387 A1 WO 2002102387A1 DK 0200407 W DK0200407 W DK 0200407W WO 02102387 A1 WO02102387 A1 WO 02102387A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
compound
bond
spiro
piperidine
Prior art date
Application number
PCT/DK2002/000407
Other languages
English (en)
Inventor
Connie Sanchez
Ejner Knud Moltzen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of WO2002102387A1 publication Critical patent/WO2002102387A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/547—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame spiro-condensed or forming part of bridged ring systems

Definitions

  • R 4 to R 7 are independently selected from hydrogen, halogen, C ⁇ -C 6 alkyl, C ⁇ -C alkoxy, hydroxy, C ⁇ -C 6 alkylthio, C ⁇ -C 6 alkyl- or di(C ⁇ -C 6 )alkylamino, cyano, trifluoromethyl, or trifluoromethylthio; and
  • the present invention relates to the use as above of a compound wherein Z 3 is a bond, and Z 2 is "O" or "S" and Z 1 is CH 2 .
  • the present invention relates the use of such compounds wherein X is O, S or NR 10 wherein R 10 is C ⁇ -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, adamantyl or C 3 -C 8 cycloalkyl(C ⁇ -C 6 )alkyl, C 3 -C 8 cycloalkenyl or C 3 -C 8 cycloalkenyl(C ⁇ -C 6 )alkyl, C ⁇ -C 6 alkylcarbonyl, phenylcarbonyl, amino(C ⁇ -C 6 )alkyl, mono- or di(C ⁇ -C 6 )alkylamino(C ⁇ - C 6 )alkyl, C ⁇ -C 6 alkylsulfonyl,
  • C -8 -cycloalkyl designates a carbocyclic ring having 3-8 carbon, such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
  • Halogen means fluoro, chloro, bromo or iodo.
  • each of the dotted lines may or may not represent a bond, i.e. that the ring and the side chain respectively may or may not have a double bond in the positions of the dotted lines, provided that only two at a time indicate a bond and that adjacent dotted lines do not both indicate a bond.
  • organic salts are those with maleic, fumaric, benzoic, ascorbic, succinic, oxalic, bis-methylenesalicylic, methanesulfonic, ethane-disulfonic, acetic, propionic, tartaric, salicylic, citric, gluconic, lactic, malic, mandelic, cinnamic, citraconic, aspartic, stearic, palmitic, itaconic, glycolic, p- amino-benzoic, glutamic, benzene sulfonic and theophylline acetic acids, as well as the 8- halotheophyllines, for example 8-bromo-theophylline.
  • inorganic salts are those with hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric and nitric acids.
  • the compound is used as the base or the fumarate.
  • the acid addition salts according to the invention may be obtained by treatment of -[4-[l-(4-fluorophenyl)-lH-indole-3-yl]-l-butyl]-spiro[isobenzo-furan-l(3 ),4'- piperidine] with the acid in an inert solvent followed by precipitation, isolation and optionally re-crystallisation by known methods and if desired micronisation of the crystalline product by wet or dry milling or another convenient process, or preparation of particles from a solvent-emulsification process.
  • Precipitation of the salt is preferably carried out in an inert solvent, e.g. an inert polar solvent such as an alcohol (e.g. ethanol, 2-propanol and n-propanol).
  • WO 9924436 describes the hydrochloride of l'-[4-[l-(4-Fluoro ⁇ henyl)-3-indolyl]-l-butyl]- spiro [isobenzofuran- l(3H),4'-piperidine] which is a preferred compound according to the present invention.
  • the compounds of formula (I) or a pharmaceutically acceptable salt thereof may be administered in any suitable way e.g. orally or parenterally, and it may be presented in any suitable form for such administration, e.g. in the form of tablets, capsules, powders, syrups or solutions or dispersions for injection.
  • the compound of the invention is administered in the form of a solid pharmaceutical entity, suitably as a tablet or a capsule or in the form of a suspension, solution or dispersion for injection.
  • Tablets may thus be prepared by mixing the active ingredients with ordinary adjuvants and/or diluents and subsequently compressing the mixture in a convenient tabletting machine.
  • adjuvants or diluents comprise: corn starch, lactose, talcum, magnesium stearate, gelatine, lactose, gums, and the like. Any other adjuvant or additive such as colourings, aroma, preservatives, etc. may also be used provided that they are compatible with the active ingredients.
  • the compound of the invention is most conveniently administered orally in unit dosage forms such as tablets or capsules, containing the active ingredient in an amount from about 10 ⁇ g/kg to lOmg/kg body weight, preferably 25 ⁇ g/day/kg to 1.0 mg/day/kg, most preferably 0.1 mg/day/kg to 1.0 mg/day/kg body weight.
  • the formalin pain model is a well-established animal model of persistent somatic pain (Dubuisson, D. and Dennis, S.G. Pain 4, 1977, 161-174 ). It has been described as a model of clinical inflammatory pain (Tj ⁇ lsen, A. and Hole, K., In: Dickenson, A.H. and Besson, J-
  • phase 1 This is follow by inflammatory processes and nerve sensitisation (phase 2).
  • phase 2 The latter phase models the neuropathic pain condition.
  • drugs are active in the model, e.g. morphine and in particular antiepileptic drugs
  • NSAIDs non-steroid antiinflammatory drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne l'utilisation de composés de spiro-pipéridine pour la préparation d'un médicament destiné au traitement de la douleur neuropathique.
PCT/DK2002/000407 2001-06-18 2002-06-18 Traitement de la douleur neuropathique WO2002102387A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100946 2001-06-18
DKPA200100946 2001-06-18

Publications (1)

Publication Number Publication Date
WO2002102387A1 true WO2002102387A1 (fr) 2002-12-27

Family

ID=8160569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000407 WO2002102387A1 (fr) 2001-06-18 2002-06-18 Traitement de la douleur neuropathique

Country Status (1)

Country Link
WO (1) WO2002102387A1 (fr)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054249A1 (fr) * 2003-12-05 2005-06-16 Astrazeneca Ab Nouveaux composes
WO2005061499A1 (fr) * 2003-12-22 2005-07-07 Astrazeneca Ab Nouveaux spiroderives tricycliques en tant que modulateurs de l'activite des recepteurs de chimiokines
WO2006021463A1 (fr) * 2004-08-27 2006-03-02 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs de récepteurs sigma
WO2006021462A1 (fr) * 2004-08-27 2006-03-02 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs de récepteur sigma
EP1634872A1 (fr) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma
EP1634873A1 (fr) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs des récepteurs sigma
EP1787679A1 (fr) * 2005-07-29 2007-05-23 Laboratorios Del Dr. Esteve, S.A. Utilisation des composés attachés au sigma recepteur pour le traitement de la douleur associée avec diabète
WO2007025613A3 (fr) * 2005-07-15 2007-07-19 Esteve Labor Dr Utilisation de composes se liant au recepteur sigma pour traiter la douleur associee au diabete
EP1829867A1 (fr) 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Composés d'imidazole ayant une acitivité pharmaceutique vis-à-vis le recepteur sigma
EP1829866A1 (fr) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs des récepteurs sigma
EP1829875A1 (fr) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrazole comme inhibiteurs de récepteur Sigma
WO2007098953A1 (fr) * 2006-03-01 2007-09-07 Laboratorios Del Dr. Esteve, S.A. Derives pyrazole utilises en tant qu'inhibiteurs du recepteur sigma
US7449475B2 (en) 2002-07-08 2008-11-11 Astrazeneca Ab Tricyclic spiropiperidines or spiropyrrolidines
US7498338B2 (en) 2003-11-20 2009-03-03 Astrazeneca Ab Compounds
RU2417987C2 (ru) * 2004-08-27 2011-05-10 Лабораторьос Дель Др.Эстеве, С.А. Ингибиторы сигма-рецептора
WO2011147910A1 (fr) 2010-05-27 2011-12-01 Laboratorios Del Dr. Esteve, S.A. Composés pyrazole comme inhibiteurs du récepteur sigma
US8865727B2 (en) 2008-02-29 2014-10-21 Vm Therapeutics Llc Method for treating pain syndrome and other disorders
US9757358B2 (en) 2010-02-04 2017-09-12 Laboratorios Del Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
US9782483B2 (en) 2010-05-21 2017-10-10 Laboratories Del Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
US9789115B2 (en) 2010-08-03 2017-10-17 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
US9789117B2 (en) 2011-05-18 2017-10-17 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
US9844516B2 (en) 2010-02-04 2017-12-19 Laboratorios De Dr. Esteve Sigma ligands for use in the prevention and/or treatment of post-operative pain
US9914705B2 (en) 2008-04-25 2018-03-13 Laboratorios Del Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
US9931346B2 (en) 2013-12-17 2018-04-03 Laboratorios Del Dr. Esteve S.A. Serotonin-norepinephrine reuptake inhibitors (SNRIs) and Sigma receptor ligands combinations
US10085968B2 (en) 2009-12-04 2018-10-02 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US10780074B2 (en) 2017-08-02 2020-09-22 Sunovion Pharmaceuticals Inc. Compounds and uses thereof
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11077090B2 (en) 2016-07-29 2021-08-03 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

Citations (4)

* Cited by examiner, † Cited by third party
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EP0004952A1 (fr) * 1978-04-14 1979-10-31 Hoechst Aktiengesellschaft Spiro(dihydrobenzofuranne-pipéridines et -pyrrolidines) et leurs dérivés, procédés pour leur préparation et médicaments les contenant
US4521537A (en) * 1982-08-20 1985-06-04 Hoechst-Roussel Pharmaceuticals Incorporated Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents
US4524209A (en) * 1982-04-09 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
WO1992022554A1 (fr) * 1991-06-13 1992-12-23 H. Lundbeck A/S Derives de piperidine produisant un effet anxiolytique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004952A1 (fr) * 1978-04-14 1979-10-31 Hoechst Aktiengesellschaft Spiro(dihydrobenzofuranne-pipéridines et -pyrrolidines) et leurs dérivés, procédés pour leur préparation et médicaments les contenant
US4524209A (en) * 1982-04-09 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles
US4521537A (en) * 1982-08-20 1985-06-04 Hoechst-Roussel Pharmaceuticals Incorporated Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents
WO1992022554A1 (fr) * 1991-06-13 1992-12-23 H. Lundbeck A/S Derives de piperidine produisant un effet anxiolytique

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7449475B2 (en) 2002-07-08 2008-11-11 Astrazeneca Ab Tricyclic spiropiperidines or spiropyrrolidines
US7498338B2 (en) 2003-11-20 2009-03-03 Astrazeneca Ab Compounds
WO2005054249A1 (fr) * 2003-12-05 2005-06-16 Astrazeneca Ab Nouveaux composes
WO2005061499A1 (fr) * 2003-12-22 2005-07-07 Astrazeneca Ab Nouveaux spiroderives tricycliques en tant que modulateurs de l'activite des recepteurs de chimiokines
US7524856B2 (en) 2003-12-22 2009-04-28 Astrazeneca Ab Tricyclic spiroderivatives as modulators of chemokine receptor activity
US8470867B2 (en) 2004-08-27 2013-06-25 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
RU2404972C2 (ru) * 2004-08-27 2010-11-27 Лабораторьос Дель Др.Эстеве, С.А. Ингибиторы сигма-рецептора
CN101010302B (zh) * 2004-08-27 2013-11-06 埃斯蒂维实验室股份有限公司 σ受体抑制剂
WO2006021463A1 (fr) * 2004-08-27 2006-03-02 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs de récepteurs sigma
US8394797B2 (en) 2004-08-27 2013-03-12 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazole sigma receptor antagonists
US8314096B2 (en) 2004-08-27 2012-11-20 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
US8293740B2 (en) 2004-08-27 2012-10-23 Laboratories Del Dr. Esteve, S.A. Sigma receptor inhibitors
US7282499B2 (en) 2004-08-27 2007-10-16 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1634873A1 (fr) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs des récepteurs sigma
EP1634872A1 (fr) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma
WO2006021462A1 (fr) * 2004-08-27 2006-03-02 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs de récepteur sigma
US7696199B2 (en) 2004-08-27 2010-04-13 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
US7829559B2 (en) 2004-08-27 2010-11-09 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazole sigma receptor antagonists
EP2325174A1 (fr) 2004-08-27 2011-05-25 Laboratorios Del. Dr. Esteve, S.A. Inhibiteurs de recepteur sigma
AU2005276591B2 (en) * 2004-08-27 2011-03-31 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
RU2417987C2 (ru) * 2004-08-27 2011-05-10 Лабораторьос Дель Др.Эстеве, С.А. Ингибиторы сигма-рецептора
WO2007025613A3 (fr) * 2005-07-15 2007-07-19 Esteve Labor Dr Utilisation de composes se liant au recepteur sigma pour traiter la douleur associee au diabete
EP1787679A1 (fr) * 2005-07-29 2007-05-23 Laboratorios Del Dr. Esteve, S.A. Utilisation des composés attachés au sigma recepteur pour le traitement de la douleur associée avec diabète
US8202872B2 (en) 2006-03-01 2012-06-19 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
WO2007098953A1 (fr) * 2006-03-01 2007-09-07 Laboratorios Del Dr. Esteve, S.A. Derives pyrazole utilises en tant qu'inhibiteurs du recepteur sigma
EP1829875A1 (fr) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrazole comme inhibiteurs de récepteur Sigma
EP1829866A1 (fr) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs des récepteurs sigma
EP1829867A1 (fr) 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Composés d'imidazole ayant une acitivité pharmaceutique vis-à-vis le recepteur sigma
US9402848B2 (en) 2008-02-29 2016-08-02 Vm Therapeutics Llc Method for treating pain syndrome and other disorders
US8865727B2 (en) 2008-02-29 2014-10-21 Vm Therapeutics Llc Method for treating pain syndrome and other disorders
US8980900B2 (en) 2008-02-29 2015-03-17 VM Therapeutics, LLC. Method for treating pain syndrome and other disorders
US9834555B2 (en) 2008-02-29 2017-12-05 VM Therapeutics LLC. Method for treating pain syndrome and other disorders
US9914705B2 (en) 2008-04-25 2018-03-13 Laboratorios Del Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
US10894033B2 (en) 2009-12-04 2021-01-19 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
US10085968B2 (en) 2009-12-04 2018-10-02 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
US9757358B2 (en) 2010-02-04 2017-09-12 Laboratorios Del Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
US9844516B2 (en) 2010-02-04 2017-12-19 Laboratorios De Dr. Esteve Sigma ligands for use in the prevention and/or treatment of post-operative pain
US9782483B2 (en) 2010-05-21 2017-10-10 Laboratories Del Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
WO2011147910A1 (fr) 2010-05-27 2011-12-01 Laboratorios Del Dr. Esteve, S.A. Composés pyrazole comme inhibiteurs du récepteur sigma
EP2395003A1 (fr) 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Composés pyrazoliques en tant qu'inhibiteurs du récepteur sigma
US9181195B2 (en) 2010-05-27 2015-11-10 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
US9789115B2 (en) 2010-08-03 2017-10-17 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
US9789117B2 (en) 2011-05-18 2017-10-17 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
US9931346B2 (en) 2013-12-17 2018-04-03 Laboratorios Del Dr. Esteve S.A. Serotonin-norepinephrine reuptake inhibitors (SNRIs) and Sigma receptor ligands combinations
US11077090B2 (en) 2016-07-29 2021-08-03 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US10927124B2 (en) 2016-07-29 2021-02-23 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US10196403B2 (en) 2016-07-29 2019-02-05 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
US11958862B2 (en) 2016-07-29 2024-04-16 Sumitomo Pharma America, Inc. Compounds and compositions and uses thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
US10780074B2 (en) 2017-08-02 2020-09-22 Sunovion Pharmaceuticals Inc. Compounds and uses thereof
US11491133B2 (en) 2017-08-02 2022-11-08 Sunovion Pharmaceuticals Inc. Heteroaryl-isochroman compounds and uses thereof
US10815249B2 (en) 2018-02-16 2020-10-27 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11440921B2 (en) 2018-02-16 2022-09-13 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
US11987591B2 (en) 2018-02-16 2024-05-21 Sumitomo Pharma America, Inc. Salts, crystal forms, and production methods thereof
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US11738002B2 (en) 2020-04-14 2023-08-29 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders

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