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WO2002062803A1 - Derive de thienopyrimidine - Google Patents

Derive de thienopyrimidine Download PDF

Info

Publication number
WO2002062803A1
WO2002062803A1 PCT/JP2002/001008 JP0201008W WO02062803A1 WO 2002062803 A1 WO2002062803 A1 WO 2002062803A1 JP 0201008 W JP0201008 W JP 0201008W WO 02062803 A1 WO02062803 A1 WO 02062803A1
Authority
WO
WIPO (PCT)
Prior art keywords
thienopyrimidine derivative
derivative
thienopyrimidine
medicine
salt
Prior art date
Application number
PCT/JP2002/001008
Other languages
English (en)
Japanese (ja)
Inventor
Hirotsune Itahana
Takashi Kamikubo
Eisuke Nozawa
Hidetaka Kaku
Masamichi Okada
Takashi Toya
Atsushi Nakamura
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Publication of WO2002062803A1 publication Critical patent/WO2002062803A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention se rapporte à un nouveau dérivé de thiénopyrimidine ou à un sel de ce dérivé. Ce composé présente une activité de récepteur du glutamate métabotropique et s'avère utile en tant que médicament.
PCT/JP2002/001008 2001-02-08 2002-02-07 Derive de thienopyrimidine WO2002062803A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-32121 2001-02-08
JP2001032121 2001-02-08

Publications (1)

Publication Number Publication Date
WO2002062803A1 true WO2002062803A1 (fr) 2002-08-15

Family

ID=18896101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/001008 WO2002062803A1 (fr) 2001-02-08 2002-02-07 Derive de thienopyrimidine

Country Status (1)

Country Link
WO (1) WO2002062803A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029060A1 (fr) * 2002-09-26 2004-04-08 Nihon Nohyaku Co., Ltd. Nouveaux herbicides, leur utilisation, nouveaux derives de thienopyrimidine, leurs intermediaires, et methode de production desdits composes
WO2006002051A1 (fr) * 2004-06-15 2006-01-05 Schering Corporation Composes tricycliques et leur utilisation comme antagonistes du mglur1
WO2007024593A1 (fr) * 2005-08-19 2007-03-01 Schering Corporation Antagonistes mglur1 tricycliques fusionnes utilises en tant qu'agents therapeutiques
WO2007072090A1 (fr) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Derives de thienopyridine en tant que modulateurs de recepteurs metabotropiques du glutamate
US7482360B2 (en) 2005-09-23 2009-01-27 Schering Corporation Fused tetracyclic mGluR1 antagonists as therapeutic agents
US7598259B2 (en) 2004-06-15 2009-10-06 Schering Corporation mGluR1 antagonists as therapeutic agents
US7939657B2 (en) * 2003-10-29 2011-05-10 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
US8691833B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
WO2015056771A1 (fr) 2013-10-17 2015-04-23 アステラス製薬株式会社 Composé bicyclique contenant du soufre

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006724A1 (fr) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Agonistes du recepteur du glutamate metabotropique
JPH11189596A (ja) * 1997-12-25 1999-07-13 Yamanouchi Pharmaceut Co Ltd メタボトロピックグルタメート受容体作用薬及び新規イミダゾベンゾチアゾール誘導体
WO2000059913A1 (fr) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives de thiazolobenzimidazole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006724A1 (fr) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Agonistes du recepteur du glutamate metabotropique
JPH11189596A (ja) * 1997-12-25 1999-07-13 Yamanouchi Pharmaceut Co Ltd メタボトロピックグルタメート受容体作用薬及び新規イミダゾベンゾチアゾール誘導体
WO2000059913A1 (fr) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives de thiazolobenzimidazole

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029060A1 (fr) * 2002-09-26 2004-04-08 Nihon Nohyaku Co., Ltd. Nouveaux herbicides, leur utilisation, nouveaux derives de thienopyrimidine, leurs intermediaires, et methode de production desdits composes
US7939657B2 (en) * 2003-10-29 2011-05-10 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
WO2006002051A1 (fr) * 2004-06-15 2006-01-05 Schering Corporation Composes tricycliques et leur utilisation comme antagonistes du mglur1
US7989464B2 (en) 2004-06-15 2011-08-02 Schering Corporation mGluR1 antagonists as therapeutic agents
US7485648B2 (en) 2004-06-15 2009-02-03 Schering Corporation mGluR1 antagonists as therapeutic agents
US7598259B2 (en) 2004-06-15 2009-10-06 Schering Corporation mGluR1 antagonists as therapeutic agents
WO2007024593A1 (fr) * 2005-08-19 2007-03-01 Schering Corporation Antagonistes mglur1 tricycliques fusionnes utilises en tant qu'agents therapeutiques
US7767815B2 (en) 2005-08-19 2010-08-03 Schering Corporation Fused tricyclic mGluR1 antagonists as therapeutic agents
US7482360B2 (en) 2005-09-23 2009-01-27 Schering Corporation Fused tetracyclic mGluR1 antagonists as therapeutic agents
WO2007072090A1 (fr) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Derives de thienopyridine en tant que modulateurs de recepteurs metabotropiques du glutamate
US8691833B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
US8691831B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
WO2015056771A1 (fr) 2013-10-17 2015-04-23 アステラス製薬株式会社 Composé bicyclique contenant du soufre
US9051339B2 (en) 2013-10-17 2015-06-09 Astellas Pharma Inc. Sulfur-containing bicyclic compound
CN105636965A (zh) * 2013-10-17 2016-06-01 安斯泰来制药株式会社 含硫二环式化合物
KR20160071408A (ko) 2013-10-17 2016-06-21 아스텔라스세이야쿠 가부시키가이샤 황 함유 이환식 화합물
US9642852B2 (en) 2013-10-17 2017-05-09 Astellas Pharma Inc. Sulfur-containing bicyclic compound
CN105636965B (zh) * 2013-10-17 2017-11-24 安斯泰来制药株式会社 含硫二环式化合物
EA029075B1 (ru) * 2013-10-17 2018-02-28 Астеллас Фарма Инк. Серосодержащее бициклическое соединение

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