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WO2002060942A3 - Protein modification and maintenance molecules - Google Patents

Protein modification and maintenance molecules Download PDF

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Publication number
WO2002060942A3
WO2002060942A3 PCT/US2002/002813 US0202813W WO02060942A3 WO 2002060942 A3 WO2002060942 A3 WO 2002060942A3 US 0202813 W US0202813 W US 0202813W WO 02060942 A3 WO02060942 A3 WO 02060942A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein modification
pmmm
maintenance molecules
provides
molecules
Prior art date
Application number
PCT/US2002/002813
Other languages
French (fr)
Other versions
WO2002060942A2 (en
Inventor
Bridget A Warren
Cynthia D Honchell
Yan Lu
Narinder K Chawla
Original Assignee
Incyte Genomics Inc
Bridget A Warren
Cynthia D Honchell
Yan Lu
Narinder K Chawla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Bridget A Warren, Cynthia D Honchell, Yan Lu, Narinder K Chawla filed Critical Incyte Genomics Inc
Priority to CA002434953A priority Critical patent/CA2434953A1/en
Priority to EP02723076A priority patent/EP1356028A2/en
Priority to AU2002253883A priority patent/AU2002253883A1/en
Priority to JP2002561510A priority patent/JP2005503108A/en
Priority to US10/467,042 priority patent/US20040077048A1/en
Publication of WO2002060942A2 publication Critical patent/WO2002060942A2/en
Publication of WO2002060942A3 publication Critical patent/WO2002060942A3/en
Priority to US11/046,868 priority patent/US20050142600A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.
PCT/US2002/002813 2001-01-31 2002-01-30 Protein modification and maintenance molecules WO2002060942A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002434953A CA2434953A1 (en) 2001-01-31 2002-01-30 Protein modification and maintenance molecules
EP02723076A EP1356028A2 (en) 2001-01-31 2002-01-30 Protein modification and maintenance molecules
AU2002253883A AU2002253883A1 (en) 2001-01-31 2002-01-30 Protein modification and maintenance molecules
JP2002561510A JP2005503108A (en) 2001-01-31 2002-01-30 Protein modification and maintenance molecules
US10/467,042 US20040077048A1 (en) 2002-01-30 2002-01-30 Protein modification and maintenance molecules
US11/046,868 US20050142600A1 (en) 2001-01-31 2005-02-01 Protein modification and maintenance molecules

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US26570501P 2001-01-31 2001-01-31
US60/265,705 2001-01-31
US26676201P 2001-02-05 2001-02-05
US60/266,762 2001-02-05
US26958101P 2001-02-16 2001-02-16
US60/269,581 2001-02-16
US27119801P 2001-02-23 2001-02-23
US60/271,198 2001-02-23
US27281301P 2001-03-01 2001-03-01
US60/272,813 2001-03-01
US27558601P 2001-03-13 2001-03-13
US60/275,586 2001-03-13
US27850501P 2001-03-23 2001-03-23
US60/278,505 2001-03-23
US28053901P 2001-03-30 2001-03-30
US60/280,539 2001-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/046,868 Division US20050142600A1 (en) 2001-01-31 2005-02-01 Protein modification and maintenance molecules

Publications (2)

Publication Number Publication Date
WO2002060942A2 WO2002060942A2 (en) 2002-08-08
WO2002060942A3 true WO2002060942A3 (en) 2003-07-24

Family

ID=27575307

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002813 WO2002060942A2 (en) 2001-01-31 2002-01-30 Protein modification and maintenance molecules

Country Status (5)

Country Link
EP (1) EP1356028A2 (en)
JP (1) JP2005503108A (en)
AU (1) AU2002253883A1 (en)
CA (1) CA2434953A1 (en)
WO (1) WO2002060942A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20010121A1 (en) * 2000-02-18 2002-12-11 Hoffmann La Roche Novel Metalloproteases having Thrombospondin Domains and Nucleic Acid Compositions encoding the same
WO2002050277A2 (en) * 2000-12-21 2002-06-27 Curagen Corporation Protein and nucleic acids encoding same
AU2002304249A1 (en) 2001-06-11 2002-12-23 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same
AU2002319703A1 (en) 2001-07-27 2003-02-17 Wyeth Aggrecanase molecules
AU2003223124A1 (en) * 2002-04-26 2003-11-10 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
EP1673475B1 (en) * 2003-10-10 2010-04-28 Deutsches Krebsforschungszentrum Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt
EP1824996A2 (en) * 2004-11-19 2007-08-29 Oy Jurilab Ltd Method and kit for detecting a risk of essential arterial hypertension
HUE027179T2 (en) 2006-10-20 2016-10-28 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Rspondins as modulators of angiogenesis and vasculogenesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001098503A2 (en) * 2000-06-21 2001-12-27 Bayer Aktiengesellschaft Regulation of human eosinophil serine protease 1-like enzyme
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001098503A2 (en) * 2000-06-21 2001-12-27 Bayer Aktiengesellschaft Regulation of human eosinophil serine protease 1-like enzyme
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 September 1998 (1998-09-01), RICKE,D.O. ET AL.: "Homo sapiens chromosome 16, cosmid clone 407D8 (LANL), complete sequence", XP002225576, retrieved from EBI Database accession no. AC005570 *
DATABASE EMBL [online] 4 August 1998 (1998-08-04), RICKE D.O. ET AL.: "Homo sapiens chromosome 16, cosmid clone 352F10 (LANL), complete sequence.", XP002225575, retrieved from EBI Database accession no. AC005361 *
INOUE MASAHIRO ET AL: "Structural analysis of esp-1 gene (PRSS 21)", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 266, no. 2, 20 December 1999 (1999-12-20), pages 564 - 568, XP002208048, ISSN: 0006-291X *
RAWLINGS N D ET AL: "FAMILIES OF SERINE PEPTIDASES", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 244, 1994, pages 19 - 61, XP008008505, ISSN: 0076-6879 *

Also Published As

Publication number Publication date
AU2002253883A1 (en) 2002-08-12
JP2005503108A (en) 2005-02-03
CA2434953A1 (en) 2002-08-08
WO2002060942A2 (en) 2002-08-08
EP1356028A2 (en) 2003-10-29

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