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WO2002051865A3 - Proteinic antigens inducing antibodies neutralising hiv virus - Google Patents

Proteinic antigens inducing antibodies neutralising hiv virus Download PDF

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Publication number
WO2002051865A3
WO2002051865A3 PCT/FR2001/003957 FR0103957W WO02051865A3 WO 2002051865 A3 WO2002051865 A3 WO 2002051865A3 FR 0103957 W FR0103957 W FR 0103957W WO 02051865 A3 WO02051865 A3 WO 02051865A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv virus
inducing antibodies
proteinic
antigens inducing
antibodies neutralising
Prior art date
Application number
PCT/FR2001/003957
Other languages
French (fr)
Other versions
WO2002051865A2 (en
Inventor
Veronique Barban
Original Assignee
Aventis Pasteur
Veronique Barban
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0016986A external-priority patent/FR2818648B1/en
Application filed by Aventis Pasteur, Veronique Barban filed Critical Aventis Pasteur
Priority to AU2002219290A priority Critical patent/AU2002219290A1/en
Publication of WO2002051865A2 publication Critical patent/WO2002051865A2/en
Publication of WO2002051865A3 publication Critical patent/WO2002051865A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention concerns a proteinic antigen of formula P-E-S wherein: P represents a protein or a carrier peptide or a fragment derived therefrom; E represents a spacer arm of 2 to 25 amino acids, mainly consisting of glycine, proline or alanine; S represents a specific peptide sequence, said antigen being capable of inducing neutralising antibodies against HIV primary isolates and its use in an anti-HIV vaccine.
PCT/FR2001/003957 2000-12-22 2001-12-12 Proteinic antigens inducing antibodies neutralising hiv virus WO2002051865A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002219290A AU2002219290A1 (en) 2000-12-22 2001-12-12 Proteinic antigens inducing antibodies neutralising hiv virus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR00/16986 2000-12-22
FR0016986A FR2818648B1 (en) 2000-12-22 2000-12-22 PROTEIN ANTIGENS INDUCING HIV VIRUS NEUTRALIZING ANTIBODIES
US26481901P 2001-01-26 2001-01-26
US60/264,819 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002051865A2 WO2002051865A2 (en) 2002-07-04
WO2002051865A3 true WO2002051865A3 (en) 2002-09-12

Family

ID=26212802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/003957 WO2002051865A2 (en) 2000-12-22 2001-12-12 Proteinic antigens inducing antibodies neutralising hiv virus

Country Status (2)

Country Link
AU (1) AU2002219290A1 (en)
WO (1) WO2002051865A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964554B2 (en) * 2004-09-03 2011-06-21 Amateraspharma Inc. Polypeptide that binds anti-histone H1 antibody
US20180303740A1 (en) * 2015-10-26 2018-10-25 Basf Se Oral care products and methods comprising hlps
JP2018536644A (en) * 2015-10-26 2018-12-13 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ Oral care products and methods comprising hydroxyapatite binding protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035194A2 (en) * 1996-03-21 1997-09-25 President And Fellows Of Harvard College Enantiomeric screening process, and compositions therefor
WO1999066046A1 (en) * 1998-06-12 1999-12-23 Aventis Pasteur Hiv virus mimotopes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035194A2 (en) * 1996-03-21 1997-09-25 President And Fellows Of Harvard College Enantiomeric screening process, and compositions therefor
WO1999066046A1 (en) * 1998-06-12 1999-12-23 Aventis Pasteur Hiv virus mimotopes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FOMSGAARD A ET AL.: "Improved Humoral and Cellular Immune Responses Against the gp120 V3 Loop of HIV-1 Following Genetic Immunization with a Chimeric DNA Vaccine Encoding the V3 Inserted into the Hepatitis B Surface Antigen", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 47, 1998, pages 289 - 295, XP002181537 *

Also Published As

Publication number Publication date
WO2002051865A2 (en) 2002-07-04
AU2002219290A1 (en) 2002-07-08

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