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WO2002039992A3 - Adducts of quinolonic agents with natural polysaccharide polymers - Google Patents

Adducts of quinolonic agents with natural polysaccharide polymers Download PDF

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Publication number
WO2002039992A3
WO2002039992A3 PCT/IB2001/002171 IB0102171W WO0239992A3 WO 2002039992 A3 WO2002039992 A3 WO 2002039992A3 IB 0102171 W IB0102171 W IB 0102171W WO 0239992 A3 WO0239992 A3 WO 0239992A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinolonic
adducts
agents
natural polysaccharide
polysaccharide polymers
Prior art date
Application number
PCT/IB2001/002171
Other languages
French (fr)
Other versions
WO2002039992A2 (en
Inventor
Piergiorgio Anzaghi
Rosanna Stefli
Original Assignee
Pharma Biotech Ltd
Piergiorgio Anzaghi
Rosanna Stefli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Biotech Ltd, Piergiorgio Anzaghi, Rosanna Stefli filed Critical Pharma Biotech Ltd
Priority to AU2002212631A priority Critical patent/AU2002212631A1/en
Publication of WO2002039992A2 publication Critical patent/WO2002039992A2/en
Publication of WO2002039992A3 publication Critical patent/WO2002039992A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Adducts of natural polyssacharide polymers with quinolonic antibacterial agents, in the form of aqueous solutions or solid powder form, possess an identical therapeutic efficacy if compared with the corresponding active ingredient alone, used at the same doses. Therefore they show lower toxicity with equal antimicrobial activity.
PCT/IB2001/002171 2000-11-17 2001-11-16 Adducts of quinolonic agents with natural polysaccharide polymers WO2002039992A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212631A AU2002212631A1 (en) 2000-11-17 2001-11-16 Adducts of quinolonic agents with natural polysaccharide polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2000A002476 2000-11-17
IT2000MI002476A IT1319664B1 (en) 2000-11-17 2000-11-17 ADDINTS OF QUINOLONIC ANTIBACTERIALS WITH POLYSACCHARIDICINATURAL POLYMERS.

Publications (2)

Publication Number Publication Date
WO2002039992A2 WO2002039992A2 (en) 2002-05-23
WO2002039992A3 true WO2002039992A3 (en) 2002-08-01

Family

ID=11446117

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002171 WO2002039992A2 (en) 2000-11-17 2001-11-16 Adducts of quinolonic agents with natural polysaccharide polymers

Country Status (3)

Country Link
AU (1) AU2002212631A1 (en)
IT (1) IT1319664B1 (en)
WO (1) WO2002039992A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE382338T1 (en) * 2003-03-19 2008-01-15 Jordanian Pharmaceutical Mfg NON-HYGROSCOPIC PHARMACEUTICAL COMPOSITIONS CONTAINING NON-HYDRATED QUINOLONE CARBONIC ACID
EP1930006A4 (en) * 2005-09-28 2010-10-13 Daiichi Sankyo Co Ltd PROCESS FOR PRODUCING LYOPHILIZED PREPARATION CONTAINING QUINOLONE
JO3112B1 (en) * 2010-03-29 2017-09-20 Ferring Bv A fast dissolving pharmaceutical composition
BR112014005134A2 (en) * 2011-09-16 2017-04-18 Ferring Bv fast dissolving pharmaceutical composition
CN102824319B (en) * 2012-09-27 2013-11-20 西南大学 Synergistic ofloxacin freeze-dried powder injection and preparing method thereof
CN110755374A (en) * 2019-11-22 2020-02-07 南京知和医药科技有限公司 Levofloxacin injection and preparation process thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792552A (en) * 1986-10-30 1988-12-20 Abic Ltd. Water-soluble adduct of norfloxacin
WO2000078287A1 (en) * 1999-05-18 2000-12-28 Istituto Biochimico Pavese Pharma S.P.A. Antibiotic-natural polysaccharide polymer adducts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792552A (en) * 1986-10-30 1988-12-20 Abic Ltd. Water-soluble adduct of norfloxacin
WO2000078287A1 (en) * 1999-05-18 2000-12-28 Istituto Biochimico Pavese Pharma S.P.A. Antibiotic-natural polysaccharide polymer adducts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIHAI D, MOCANU G: "Macromolecular-drug conjugates, Nalidixic acid and oxacillin dextran", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 15, no. 3, 2000, pages 245 - 256, XP001064795 *

Also Published As

Publication number Publication date
ITMI20002476A1 (en) 2002-05-17
AU2002212631A1 (en) 2002-05-27
WO2002039992A2 (en) 2002-05-23
IT1319664B1 (en) 2003-10-23

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