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WO2002034913A3 - Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof - Google Patents

Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof Download PDF

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Publication number
WO2002034913A3
WO2002034913A3 PCT/US2001/031454 US0131454W WO0234913A3 WO 2002034913 A3 WO2002034913 A3 WO 2002034913A3 US 0131454 W US0131454 W US 0131454W WO 0234913 A3 WO0234913 A3 WO 0234913A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
molecules encoding
protein coupled
coupled receptors
Prior art date
Application number
PCT/US2001/031454
Other languages
French (fr)
Other versions
WO2002034913A2 (en
Inventor
Ming-Hui Wei
Chunhua Yan
Karen A Ketchum
Anibal Cravchik
Francesco Valentina Di
Ellen M Beasley
Original Assignee
Pe Corp Ny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corp Ny filed Critical Pe Corp Ny
Priority to AU2002213061A priority Critical patent/AU2002213061A1/en
Priority to JP2002537883A priority patent/JP2004535756A/en
Priority to CA002425897A priority patent/CA2425897A1/en
Priority to EP01981419A priority patent/EP1330521A2/en
Publication of WO2002034913A2 publication Critical patent/WO2002034913A2/en
Publication of WO2002034913A3 publication Critical patent/WO2002034913A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.
PCT/US2001/031454 2000-10-24 2001-10-09 Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof WO2002034913A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002213061A AU2002213061A1 (en) 2000-10-24 2001-10-09 Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
JP2002537883A JP2004535756A (en) 2000-10-24 2001-10-09 Isolated human G-protein coupled receptor, nucleic acid molecule encoding human GPCR protein, and uses thereof
CA002425897A CA2425897A1 (en) 2000-10-24 2001-10-09 Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
EP01981419A EP1330521A2 (en) 2000-10-24 2001-10-09 Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69482100A 2000-10-24 2000-10-24
US09/694,821 2000-10-24
US78155901A 2001-02-13 2001-02-13
US09/781,559 2001-02-13

Publications (2)

Publication Number Publication Date
WO2002034913A2 WO2002034913A2 (en) 2002-05-02
WO2002034913A3 true WO2002034913A3 (en) 2002-10-31

Family

ID=27105446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031454 WO2002034913A2 (en) 2000-10-24 2001-10-09 Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof

Country Status (5)

Country Link
EP (1) EP1330521A2 (en)
JP (1) JP2004535756A (en)
AU (1) AU2002213061A1 (en)
CA (1) CA2425897A1 (en)
WO (1) WO2002034913A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002101043A2 (en) * 2001-06-08 2002-12-19 Bayer Aktiengesellschaft Regulation of human ta4 receptor
WO2003020980A2 (en) * 2001-08-28 2003-03-13 Pharmacia & Upjohn Company Single nucleotide polymorphisms diagnostic for schizophrenia
WO2004008153A2 (en) * 2002-07-16 2004-01-22 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with homo sapiens putative neurotransmitter receptor (pnr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060081A1 (en) * 1999-04-06 2000-10-12 Synaptic Pharmaceutical Corporation Dna encoding orphan receptors
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060081A1 (en) * 1999-04-06 2000-10-12 Synaptic Pharmaceutical Corporation Dna encoding orphan receptors
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOROWSKY B. ET AL.: "Trace amines: Identification of a family of mammalian G protein-coupled receptors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 98, no. 16, 31 July 2001 (2001-07-31), pages 8966 - 8971, XP002185201, ISSN: 0027-8424 *
DATABASE EMBL [online] 2 August 2001 (2001-08-02), "Homo sapiens trace amine receptor 4 (TA4) gene, complete cds.", XP002205531, Database accession no. AF380192 *

Also Published As

Publication number Publication date
WO2002034913A2 (en) 2002-05-02
JP2004535756A (en) 2004-12-02
AU2002213061A1 (en) 2002-05-06
EP1330521A2 (en) 2003-07-30
CA2425897A1 (en) 2002-05-02

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