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WO2002030958A3 - Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen - Google Patents

Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen Download PDF

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Publication number
WO2002030958A3
WO2002030958A3 PCT/DE2001/003849 DE0103849W WO0230958A3 WO 2002030958 A3 WO2002030958 A3 WO 2002030958A3 DE 0103849 W DE0103849 W DE 0103849W WO 0230958 A3 WO0230958 A3 WO 0230958A3
Authority
WO
WIPO (PCT)
Prior art keywords
decapeptide
growth
casein
cell cultures
peptide fragments
Prior art date
Application number
PCT/DE2001/003849
Other languages
English (en)
French (fr)
Other versions
WO2002030958A2 (de
Inventor
Juan Claus
Marcelo Comini
Georgina Tonarelli
Juan Carlos Perin
Jorge Luis Salvetti
Ronald Frank
Original Assignee
Biotechnolog Forschung Gmbh
Univ Nac Del Litoral
Juan Claus
Marcelo Comini
Georgina Tonarelli
Juan Carlos Perin
Jorge Luis Salvetti
Ronald Frank
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh, Univ Nac Del Litoral, Juan Claus, Marcelo Comini, Georgina Tonarelli, Juan Carlos Perin, Jorge Luis Salvetti, Ronald Frank filed Critical Biotechnolog Forschung Gmbh
Priority to JP2002534343A priority Critical patent/JP2004535152A/ja
Priority to US10/380,371 priority patent/US20040086965A1/en
Priority to EP01986693A priority patent/EP1325027A2/de
Publication of WO2002030958A2 publication Critical patent/WO2002030958A2/de
Publication of WO2002030958A3 publication Critical patent/WO2002030958A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732—Casein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Aus einem enzymatischen Hydrolysat von bovinem Casein wurde ein Dekapeptid isoliert, dessen Sequenz eindeutig in der Primärsequenz des Caseins identifiziert werden konnte. Dieses Dekapeptid, das auch chemisch-synthetisch hergestellt wurde, beeinflusst das Wachstum der Insektenzellinie IPLB-Sf-21 in konzentrationsabhängiger Weise. Das Tripeptid, his-gln-pro das zweimal in der Sequenz des Dekapeptids bzw. des Caseins enthalten ist, hat eine noch stärkere Wirkung als das Dekapeptid, welche ebenfalls konzentrationsabhängig ist. Diese Peptide können daher vorteilhaft als Zusätze für serumfreie, chemisch definierte Zellkulturmedien eingesetzt werden.
PCT/DE2001/003849 2000-10-09 2001-10-09 Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen WO2002030958A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002534343A JP2004535152A (ja) 2000-10-09 2001-10-09 細胞培養物に対する成長影響活性を有するカゼインペプチドフラグメント
US10/380,371 US20040086965A1 (en) 2000-10-09 2001-10-09 Casein peptide fragments with growth-influencing activity on cell cultures
EP01986693A EP1325027A2 (de) 2000-10-09 2001-10-09 Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050091.9 2000-10-09
DE10050091A DE10050091A1 (de) 2000-10-09 2000-10-09 Casein-Peptidfragmente mit wachstumsbeeinflußender Aktivität auf Zellkulturen

Publications (2)

Publication Number Publication Date
WO2002030958A2 WO2002030958A2 (de) 2002-04-18
WO2002030958A3 true WO2002030958A3 (de) 2002-12-12

Family

ID=7659237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/003849 WO2002030958A2 (de) 2000-10-09 2001-10-09 Casein-peptidfragmente mit wachstumsbeeinflussender aktivität auf zellkulturen

Country Status (5)

Country Link
US (1) US20040086965A1 (de)
EP (1) EP1325027A2 (de)
JP (1) JP2004535152A (de)
DE (1) DE10050091A1 (de)
WO (1) WO2002030958A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009000899A1 (en) 2007-06-27 2008-12-31 Laboratorios Ordesa, S.L. A novel strain of bifidobacterium and active peptides against rotavirus infections
CN107141346B (zh) * 2017-06-22 2020-04-14 浙江辉肽生命健康科技有限公司 一种生物活性多肽atledspevi及其制备方法和应用
CN107759682B (zh) * 2017-12-07 2021-03-02 浙江辉肽生命健康科技有限公司 一种生物活性多肽pigsensgkttmpl及其制备方法和应用
CN107880103B (zh) * 2017-12-07 2020-05-12 浙江辉肽生命健康科技有限公司 生物活性多肽qpevmgvskvkeamapkqkempfpky及其制备和应用
CN107814837B (zh) * 2017-12-07 2020-04-14 浙江辉肽生命健康科技有限公司 一种生物活性多肽qqqtedelqdkihpf及其制备方法和应用
CN107880102A (zh) * 2017-12-07 2018-04-06 浙江辉肽生命健康科技有限公司 一种生物活性多肽peviesppein及其制备方法和应用
CN107880104A (zh) * 2017-12-11 2018-04-06 浙江辉肽生命健康科技有限公司 一种生物活性多肽sppeintvqvt及其制备方法和应用
CN107973847B (zh) * 2017-12-11 2020-05-12 浙江辉肽生命健康科技有限公司 一种生物活性多肽vateevkitvd及其制备方法和应用
CN107880107B (zh) * 2017-12-11 2020-05-12 浙江辉肽生命健康科技有限公司 一种生物活性多肽qvlsntvpa及其制备方法和应用
CN107814842B (zh) * 2017-12-12 2020-04-14 浙江辉肽生命健康科技有限公司 一种生物活性多肽sqskvlpvpe及其制备方法和应用
CN107903316B (zh) * 2017-12-12 2020-05-12 浙江辉肽生命健康科技有限公司 一种生物活性多肽lpypyya及其制备方法和应用
CN108017705A (zh) * 2017-12-12 2018-05-11 浙江辉肽生命健康科技有限公司 一种生物活性多肽tvmfppq及其制备方法和应用
CN107814841B (zh) * 2017-12-12 2020-04-14 浙江辉肽生命健康科技有限公司 一种生物活性多肽qqpvlgpvrgp及其制备方法和应用
CN107892716A (zh) * 2017-12-12 2018-04-10 浙江辉肽生命健康科技有限公司 一种生物活性多肽lppll及其制备方法和应用
CN108017704B (zh) * 2017-12-12 2020-05-12 浙江辉肽生命健康科技有限公司 一种生物活性多肽terqsltltdve及其制备方法和应用
CN112041450A (zh) * 2018-04-12 2020-12-04 生命技术公司 化学限定的杆状病毒表达系统和细胞培养基
JPWO2021059755A1 (de) * 2019-09-26 2021-04-01

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1130027A1 (de) * 2000-02-29 2001-09-05 Aventis Pharma Deutschland GmbH Memno-Peptide, Verfahren zu ihrer Herstellung und Verwendung derselben

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KONOVALOVA E YU ET AL.: "[Development of serum-free culture media for cultivation of mammalian cells. III. Investigation of the peptide spectrum of casein pancreatic hydrolysate and its ultrafiltered fractions with growth stimulating activity]", BIOTEKHNOLOGIYA, no. 5, 1991, pages 72 - 76, XP008004189 *

Also Published As

Publication number Publication date
EP1325027A2 (de) 2003-07-09
WO2002030958A2 (de) 2002-04-18
DE10050091A1 (de) 2002-04-25
US20040086965A1 (en) 2004-05-06
JP2004535152A (ja) 2004-11-25

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