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WO2001087861A3 - Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators - Google Patents

Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators Download PDF

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Publication number
WO2001087861A3
WO2001087861A3 PCT/US2001/015377 US0115377W WO0187861A3 WO 2001087861 A3 WO2001087861 A3 WO 2001087861A3 US 0115377 W US0115377 W US 0115377W WO 0187861 A3 WO0187861 A3 WO 0187861A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzoxazinones
treatment
methods
activated receptor
peroxisome proliferator
Prior art date
Application number
PCT/US2001/015377
Other languages
French (fr)
Other versions
WO2001087861A2 (en
Inventor
Thomas P Burris
Keith T Demarest
Donald W Combs
Philip J Rybczynski
Ignatius J Turchi
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to EP01935404A priority Critical patent/EP1280783A2/en
Priority to AU2001261503A priority patent/AU2001261503A1/en
Publication of WO2001087861A2 publication Critical patent/WO2001087861A2/en
Publication of WO2001087861A3 publication Critical patent/WO2001087861A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma (PPARη) agonists or antagonists.
PCT/US2001/015377 2000-05-12 2001-05-11 Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators WO2001087861A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01935404A EP1280783A2 (en) 2000-05-12 2001-05-11 Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
AU2001261503A AU2001261503A1 (en) 2000-05-12 2001-05-11 Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20386100P 2000-05-12 2000-05-12
US60/203,861 2000-05-12
US85436801A 2001-05-11 2001-05-11
US09/854,368 2001-05-11

Publications (2)

Publication Number Publication Date
WO2001087861A2 WO2001087861A2 (en) 2001-11-22
WO2001087861A3 true WO2001087861A3 (en) 2002-03-28

Family

ID=26898968

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015377 WO2001087861A2 (en) 2000-05-12 2001-05-11 Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators

Country Status (3)

Country Link
EP (1) EP1280783A2 (en)
AU (1) AU2001261503A1 (en)
WO (1) WO2001087861A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
US7601841B2 (en) 2000-06-28 2009-10-13 Amgen Inc. Quinolinyl and benzothiazolyl modulators

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US6908908B2 (en) * 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019702A1 (en) * 1990-06-14 1991-12-26 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
WO1996004260A1 (en) * 1994-07-29 1996-02-15 Smithkline Beecham Plc Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes
WO1997017333A1 (en) * 1995-11-07 1997-05-15 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
WO1997028167A1 (en) * 1996-01-30 1997-08-07 Ortho Pharmaceutical Corporation 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
WO1999020614A1 (en) * 1998-05-27 1999-04-29 Dr. Reddy's Research Foundation Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019702A1 (en) * 1990-06-14 1991-12-26 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
WO1996004260A1 (en) * 1994-07-29 1996-02-15 Smithkline Beecham Plc Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes
WO1997017333A1 (en) * 1995-11-07 1997-05-15 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
WO1997028167A1 (en) * 1996-01-30 1997-08-07 Ortho Pharmaceutical Corporation 2-substituted amino and thio alkyl benzoxazine antimicrobial agents
WO1999020614A1 (en) * 1998-05-27 1999-04-29 Dr. Reddy's Research Foundation Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HILLIARD, JAMESE J. ET AL: "Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems", ANTIMICROB. AGENTS CHEMOTHER. (1999), 43(7), 1693-1699, XP002171516 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601841B2 (en) 2000-06-28 2009-10-13 Amgen Inc. Quinolinyl and benzothiazolyl modulators
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound

Also Published As

Publication number Publication date
AU2001261503A1 (en) 2001-11-26
EP1280783A2 (en) 2003-02-05
WO2001087861A2 (en) 2001-11-22

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