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WO2001074240A3 - Method and apparatus for objectively measuring pain, pain treatment and other related techniques - Google Patents

Method and apparatus for objectively measuring pain, pain treatment and other related techniques Download PDF

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Publication number
WO2001074240A3
WO2001074240A3 PCT/US2001/010377 US0110377W WO0174240A3 WO 2001074240 A3 WO2001074240 A3 WO 2001074240A3 US 0110377 W US0110377 W US 0110377W WO 0174240 A3 WO0174240 A3 WO 0174240A3
Authority
WO
WIPO (PCT)
Prior art keywords
pain
regions
measuring
signals
conscious
Prior art date
Application number
PCT/US2001/010377
Other languages
French (fr)
Other versions
WO2001074240A2 (en
Inventor
Lino R Becerra
Hans C Breiter
David Borsook
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Priority to AU2001253040A priority Critical patent/AU2001253040A1/en
Priority to JP2001571988A priority patent/JP2003528679A/en
Priority to EP01926507A priority patent/EP1272105A2/en
Priority to CA002403974A priority patent/CA2403974A1/en
Publication of WO2001074240A2 publication Critical patent/WO2001074240A2/en
Publication of WO2001074240A3 publication Critical patent/WO2001074240A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Radiology & Medical Imaging (AREA)
  • Psychiatry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Social Psychology (AREA)
  • Educational Technology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A method and apparatus for measuring indices of brain activity includes non-invasively obtaining signals of central nervous system (CNS) activity, localizing signals to specific anatomical and functional CNS regions, correlating the signals from pain and reward brain regions, and interpreting the correlation results. The results of interpreting the correlation results can be used for objectively measuring, in individual humans or animals, their responses to motivationally salient stimuli including but not limited to stimuli which are internal or external, conscious or non-conscious, pharmacological or non-pharmacological therapies, and diseased based processes. This method for measuring brain activity in reward/aversive central nervous system regions, can further be used to determine the efficacy of compounds.
PCT/US2001/010377 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain, pain treatment and other related techniques WO2001074240A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001253040A AU2001253040A1 (en) 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain, pain treatment and other related techniques
JP2001571988A JP2003528679A (en) 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain
EP01926507A EP1272105A2 (en) 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain, pain treatment and other related techniques
CA002403974A CA2403974A1 (en) 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain, pain treatment and other related techniques

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19330000P 2000-03-30 2000-03-30
US60/193,300 2000-03-30
US22895000P 2000-08-28 2000-08-28
US60/228,950 2000-08-28
US72966500A 2000-12-04 2000-12-04
US09/729,665 2000-12-04

Publications (2)

Publication Number Publication Date
WO2001074240A2 WO2001074240A2 (en) 2001-10-11
WO2001074240A3 true WO2001074240A3 (en) 2002-05-23

Family

ID=27393183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010377 WO2001074240A2 (en) 2000-03-30 2001-03-30 Method and apparatus for objectively measuring pain, pain treatment and other related techniques

Country Status (5)

Country Link
EP (1) EP1272105A2 (en)
JP (1) JP2003528679A (en)
AU (1) AU2001253040A1 (en)
CA (1) CA2403974A1 (en)
WO (1) WO2001074240A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10006978B2 (en) 2014-05-30 2018-06-26 Leidos Innovations Technology, Inc. Method and system for signal processing

Families Citing this family (21)

* Cited by examiner, † Cited by third party
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FR2838040B1 (en) * 2002-04-03 2004-07-02 Oreal PROCESS FOR VERIFYING THE EFFECTIVENESS OF A PRODUCT FOR ACTING ON SKIN SENSITIVITY
AU2003221553A1 (en) * 2002-04-05 2003-10-20 Oliver Holzner Method and device for the electromagnetic modification of cerebral activity
WO2004016167A1 (en) * 2002-08-16 2004-02-26 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US7447541B2 (en) 2004-06-30 2008-11-04 Instrumentarium Corporation Monitoring subcortical responsiveness of a patient
EP1637075A1 (en) * 2004-09-20 2006-03-22 Centre Hospitalier Regional Universitaire de Lille Method and device for evaluating pain in a living being
JP4728886B2 (en) * 2006-06-20 2011-07-20 日本電信電話株式会社 Perceptual information presentation device
US9402558B2 (en) * 2007-04-05 2016-08-02 New York University System and method for pain detection and computation of a pain quantification index
CN101896942B (en) * 2007-12-14 2014-09-10 皇家飞利浦电子股份有限公司 Image analysis of brain image data
EP2301431A4 (en) * 2008-06-24 2015-12-23 Nihon Kohden Corp DEVICE FOR JUDGING PAIN
EP2284576B1 (en) 2009-07-31 2013-07-10 Deutsche Telekom AG Method and system for predicting events
ES2821490T3 (en) * 2010-03-30 2021-04-26 The Childrens Res Institute Human algometry apparatus and method
JP6011636B2 (en) * 2012-11-15 2016-10-19 株式会社島津製作所 Optical biological measurement device
JP6583719B2 (en) * 2015-07-24 2019-10-02 国立研究開発法人情報通信研究機構 Information processing apparatus operating method and estimation system
KR102081839B1 (en) * 2017-12-14 2020-02-27 김효준 Pain-sensitivity analyzer and method thereof
KR102027368B1 (en) * 2018-05-29 2019-10-01 서울대학교산학협력단 Method for assessment of pain intensity
CN110090017B (en) * 2019-03-11 2021-09-14 北京工业大学 Electroencephalogram signal source positioning method based on LSTM
SG10201907343SA (en) * 2019-08-08 2021-03-30 Symrise Ag Prediction of the long-term hedonic response to a sensory stimulus
CN110742604B (en) * 2019-09-20 2022-04-01 复旦大学附属华山医院 Cortical electroencephalogram-based brain function positioning method under electrical stimulation of median nerve
JP6841982B1 (en) * 2019-10-31 2021-03-10 楽天株式会社 Core rate generator, core rate generator and program
WO2021132813A1 (en) * 2019-12-23 2021-07-01 경희대학교 산학협력단 Pain evaluation method and analysis device using deep learning model
JP7193563B2 (en) * 2021-02-18 2022-12-20 楽天グループ株式会社 Core rate generation device, core rate generation method and program

Citations (2)

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US5662112A (en) * 1995-08-11 1997-09-02 Siemens Aktiengesellschaft Method for time- and location-resolved display of functional brain activities of a patient
WO1997033515A1 (en) * 1996-03-15 1997-09-18 Kenneth Michael Zawilinski Emotional response analyzer system with multimedia display

Patent Citations (2)

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US5662112A (en) * 1995-08-11 1997-09-02 Siemens Aktiengesellschaft Method for time- and location-resolved display of functional brain activities of a patient
WO1997033515A1 (en) * 1996-03-15 1997-09-18 Kenneth Michael Zawilinski Emotional response analyzer system with multimedia display

Non-Patent Citations (6)

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Title
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BREITER HANS C ET AL.: "Response and habituation of the human amydala during visual processing of facial expression", NEURON, vol. 17, November 1996 (1996-11-01), pages 875 - 887, XP002178823 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10006978B2 (en) 2014-05-30 2018-06-26 Leidos Innovations Technology, Inc. Method and system for signal processing

Also Published As

Publication number Publication date
AU2001253040A1 (en) 2001-10-15
EP1272105A2 (en) 2003-01-08
JP2003528679A (en) 2003-09-30
WO2001074240A2 (en) 2001-10-11
CA2403974A1 (en) 2001-10-11

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