WO2001068699A3 - Regulation of human neuropeptide y-like g protein-coupled receptor - Google Patents
Regulation of human neuropeptide y-like g protein-coupled receptor Download PDFInfo
- Publication number
- WO2001068699A3 WO2001068699A3 PCT/EP2001/002846 EP0102846W WO0168699A3 WO 2001068699 A3 WO2001068699 A3 WO 2001068699A3 EP 0102846 W EP0102846 W EP 0102846W WO 0168699 A3 WO0168699 A3 WO 0168699A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- disease
- coupled receptor
- regulation
- human neuropeptide
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 3
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 3
- 102000003797 Neuropeptides Human genes 0.000 title 1
- 108090000189 Neuropeptides Proteins 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010017708 Ganglioneuroblastoma Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 101500025005 Homo sapiens Neuropeptide Y Proteins 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- XKWCTHKJQNUFOQ-HRPSIEBRSA-N gtpl1504 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 XKWCTHKJQNUFOQ-HRPSIEBRSA-N 0.000 abstract 1
- 208000001286 intracranial vasospasm Diseases 0.000 abstract 1
- 230000006993 memory improvement Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000028591 pheochromocytoma Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reagents which regulate human neuropeptide Y G protein-coupled receptor (NPY- GPCR) protein and reagents which bind to human NPY-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma, ganglioneuroblastoma, Huntington's disease, Alzheimer' disease, and Parkinson's disease.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001254686A AU2001254686A1 (en) | 2000-03-16 | 2001-03-14 | Regulation of human neuropeptide y-like g protein-coupled receptor |
| EP01927726A EP1272519A2 (en) | 2000-03-16 | 2001-03-14 | Regulation of human neuropeptide y-like g protein-coupled receptor |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18987700P | 2000-03-16 | 2000-03-16 | |
| US60/189,877 | 2000-03-16 | ||
| US21074300P | 2000-06-12 | 2000-06-12 | |
| US60/210,743 | 2000-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001068699A2 WO2001068699A2 (en) | 2001-09-20 |
| WO2001068699A3 true WO2001068699A3 (en) | 2002-05-16 |
Family
ID=26885571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2001/002846 WO2001068699A2 (en) | 2000-03-16 | 2001-03-14 | Regulation of human neuropeptide y-like g protein-coupled receptor |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1272519A2 (en) |
| AU (1) | AU2001254686A1 (en) |
| WO (1) | WO2001068699A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004532609A (en) | 2000-11-03 | 2004-10-28 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | Prokineticin polypeptides, related compositions and methods |
| US20040241757A1 (en) * | 2001-09-20 | 2004-12-02 | Shunichiro Matsumoto | Novel screening method using prokineticin receptor |
| US20050015820A1 (en) | 2001-09-24 | 2005-01-20 | Michael Cowley | Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior |
| EP2050460A1 (en) | 2001-09-24 | 2009-04-22 | Imperial Innovations Limited | PYY and agonists thereof for modification of feeding behaviour |
| WO2005042717A2 (en) * | 2003-10-31 | 2005-05-12 | The Regents Of The University Of California | Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods |
| TWI428346B (en) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014331A1 (en) * | 1994-11-07 | 1996-05-17 | Merck & Co., Inc. | Modified neuropeptide y receptors |
| WO1998046620A1 (en) * | 1997-04-17 | 1998-10-22 | Millennium Pharmaceuticals, Inc. | A novel human g-protein coupled receptor |
| WO2001053308A1 (en) * | 2000-01-19 | 2001-07-26 | Smithkline Beecham Corporation | Cloning of a monkey 7tm receptor (axor8) |
-
2001
- 2001-03-14 WO PCT/EP2001/002846 patent/WO2001068699A2/en not_active Application Discontinuation
- 2001-03-14 EP EP01927726A patent/EP1272519A2/en not_active Withdrawn
- 2001-03-14 AU AU2001254686A patent/AU2001254686A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014331A1 (en) * | 1994-11-07 | 1996-05-17 | Merck & Co., Inc. | Modified neuropeptide y receptors |
| WO1998046620A1 (en) * | 1997-04-17 | 1998-10-22 | Millennium Pharmaceuticals, Inc. | A novel human g-protein coupled receptor |
| WO2001053308A1 (en) * | 2000-01-19 | 2001-07-26 | Smithkline Beecham Corporation | Cloning of a monkey 7tm receptor (axor8) |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001254686A1 (en) | 2001-09-24 |
| WO2001068699A2 (en) | 2001-09-20 |
| EP1272519A2 (en) | 2003-01-08 |
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