[go: up one dir, main page]

WO2001046412A3 - Interaktionsprotein für stat transkriptionsfaktor - Google Patents

Interaktionsprotein für stat transkriptionsfaktor Download PDF

Info

Publication number
WO2001046412A3
WO2001046412A3 PCT/DE2000/004557 DE0004557W WO0146412A3 WO 2001046412 A3 WO2001046412 A3 WO 2001046412A3 DE 0004557 W DE0004557 W DE 0004557W WO 0146412 A3 WO0146412 A3 WO 0146412A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
transcription factor
relates
stat transcription
interaction
Prior art date
Application number
PCT/DE2000/004557
Other languages
English (en)
French (fr)
Other versions
WO2001046412A2 (de
Inventor
Renate Weber-Nordt
Angelika Gabler
Original Assignee
Univ Ruprecht Karls Heidelberg
Weber Nordt Renate
Angelika Gabler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ruprecht Karls Heidelberg, Weber Nordt Renate, Angelika Gabler filed Critical Univ Ruprecht Karls Heidelberg
Priority to AU33593/01A priority Critical patent/AU3359301A/en
Publication of WO2001046412A2 publication Critical patent/WO2001046412A2/de
Publication of WO2001046412A3 publication Critical patent/WO2001046412A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft isolierte Polypeptide, die als Interaktionsprotein des STAT Transkriptionsfaktors STAT3 fungieren und die entweder die im Sequenzprotokoll SEQ ID NO: 2 dargestellte oder eine durch Aminosäuresubstitution, -deletion, -insertion, oder -inversion als Allel oder Derivat daraus entstandene Aminosaüresequenz aufweisen. Sie betrifft ferner isolierte Nukleinsäuren, die solche Interaktionsproteine oder zumindest Teile davon kodieren, die Verwendung solcher Polypeptide und Nukleinsäuren für nachweisende, insbesondere diagnostische, therapeutische und Forschungszwecke und sie betrifft Reagenzien, die unter Verwendung wenigstens eines dieser Moleküle hergestellt sind, insbesondere rekombinante Vektormoleküle und Antikörper.
PCT/DE2000/004557 1999-12-21 2000-12-19 Interaktionsprotein für stat transkriptionsfaktor WO2001046412A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33593/01A AU3359301A (en) 1999-12-21 2000-12-19 Interaction proteins for the stat transcription factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19961899.2 1999-12-21
DE1999161899 DE19961899A1 (de) 1999-12-21 1999-12-21 Interaktikonsproteine für STAT Transkriptionsfaktor

Publications (2)

Publication Number Publication Date
WO2001046412A2 WO2001046412A2 (de) 2001-06-28
WO2001046412A3 true WO2001046412A3 (de) 2002-03-14

Family

ID=7933731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/004557 WO2001046412A2 (de) 1999-12-21 2000-12-19 Interaktionsprotein für stat transkriptionsfaktor

Country Status (3)

Country Link
AU (1) AU3359301A (de)
DE (1) DE19961899A1 (de)
WO (1) WO2001046412A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1066411A4 (de) * 1998-03-27 2004-09-22 Univ Temple Verfahren zur krebsprognose und zum screening antiproliferierender wirkstoffe

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat
EP0989186A1 (de) * 1997-01-10 2000-03-29 Kishimoto, Tadami Neues protein, welches die funktion von stat reguliert

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHIEN C-T ET AL: "THE TWO-HYBRID SYSTEM: A METHOD TO IDENTIFY AND CLONE GENES FOR PROTEINS THAT INTERACT WITH A PROTEIN OF INTEREST", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, 1 November 1991 (1991-11-01), pages 9578 - 9582, XP000647704, ISSN: 0027-8424 *
FRANK DAVID A: "STAT signaling in the pathogenesis and treatment of cancer.", MOLECULAR MEDICINE (NEW YORK), vol. 5, no. 7, July 1999 (1999-07-01), pages 432 - 456, XP001021603, ISSN: 1076-1551 *
GABLER ANGELIKA ET AL: "C102: A novel STAT3 interacting protein.", BLOOD, vol. 96, no. 11 Part 1, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 94a, XP001025916, ISSN: 0006-4971 *
NAKA T ET AL: "NEGATIVE REGULATION OF CYTOKINE SIGNALING: STAT-INDUCED STAT INHIBITOR", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 24, no. 10, October 1999 (1999-10-01), pages 394 - 398, XP001019044, ISSN: 0968-0004 *
NAKA T ET AL: "Structure and function of a new STAT-induced STAT inhibitor", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, no. 6636, 26 June 1997 (1997-06-26), pages 924 - 929, XP002088455, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
DE19961899A1 (de) 2001-07-12
AU3359301A (en) 2001-07-03
WO2001046412A2 (de) 2001-06-28

Similar Documents

Publication Publication Date Title
WO1999066025A3 (en) Mtbx protein and nucleic acid molecules and uses therefor
BR0015137A (pt) Peptìdeos antigênicos de neisseria
WO1999055868A3 (en) Fizz proteins
EA199800046A1 (ru) Полипептид, последовательность днк, вакцинная композиция (варианты), антитело или его фрагмент, вакцина, применения указанных полипептида, последовательности днк и антитела или его фрагмента
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
EP1009752A4 (de) Neue moleküle aus der familieder tango-77-ähnlichen proteine und ihre verewendungen.
AU3217100A (en) Methods of use of a novel lysyl oxidase-related protein
WO2000052047A3 (en) Human dickkopf-related protein and nucleic acid molecules and uses therefor
WO2000019988A8 (en) NOVEL Th2-SPECIFIC MOLECULES AND USES THEREOF
AU6517400A (en) 15571, a novel gpcr-like molecule of the secretin-like family and uses thereof
WO2001061005A3 (en) Molecules of the pyrin domain protein family and uses thereof
WO2000012544A3 (en) Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
WO1995008628A3 (en) Nucleic acids encoding merosin, merosin fragments and uses thereof
WO2002061049A3 (en) Novel molecules of the pyrin/nbs/lrr protein family and uses thereof
WO1999054437A3 (en) Novel molecules of the t125-related protein family and uses thereof
WO2000008045A3 (en) Novel molecules of the tango-93-related protein family and uses thereof
WO2001046412A3 (de) Interaktionsprotein für stat transkriptionsfaktor
WO2003029434A3 (en) Novel molecules of the hkid-1-related protein family and uses thereof
WO2001049714A3 (en) Nope polypeptides, encoding nucleic acids and methods of use
WO2000018890A3 (en) Protein phosphatase molecules and uses therefor
WO2003020912A3 (en) Novel clark protein and nucleic acid molecules and uses therefor
WO1999062943A3 (en) Novel molecules of the aip-related protein family and uses thereof
WO2000018923A3 (en) Slgp protein and nucleic acid molecule and uses therefor
WO2000055192A3 (de) Hämocyanin und dafür kodierende nukleinsäuresequenz
WO2001083753A3 (en) Molecules of the nbs/lrr protein family and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN IL JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA CN IL JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP