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WO2001035979A3 - Combined pde3 and pde4 inhibitor therapy for the treatment of obesity - Google Patents

Combined pde3 and pde4 inhibitor therapy for the treatment of obesity Download PDF

Info

Publication number
WO2001035979A3
WO2001035979A3 PCT/US2000/042137 US0042137W WO0135979A3 WO 2001035979 A3 WO2001035979 A3 WO 2001035979A3 US 0042137 W US0042137 W US 0042137W WO 0135979 A3 WO0135979 A3 WO 0135979A3
Authority
WO
WIPO (PCT)
Prior art keywords
obesity
treatment
pde4 inhibitor
inhibitor therapy
pde3
Prior art date
Application number
PCT/US2000/042137
Other languages
French (fr)
Other versions
WO2001035979A2 (en
Inventor
Peter Snyder
Original Assignee
Icos Corp
Peter Snyder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp, Peter Snyder filed Critical Icos Corp
Priority to AU32703/01A priority Critical patent/AU3270301A/en
Publication of WO2001035979A2 publication Critical patent/WO2001035979A2/en
Publication of WO2001035979A3 publication Critical patent/WO2001035979A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides materials and methods for the treatment of obesity that involve a combination of a PDE3 and PDE4 inhibitor in synergistically effective amounts.
PCT/US2000/042137 1999-11-13 2000-11-13 Combined pde3 and pde4 inhibitor therapy for the treatment of obesity WO2001035979A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32703/01A AU3270301A (en) 1999-11-13 2000-11-13 Combined pde3 and pde4 inhibitor therapy for the treatment of obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16541899P 1999-11-13 1999-11-13
US60/165,418 1999-11-13

Publications (2)

Publication Number Publication Date
WO2001035979A2 WO2001035979A2 (en) 2001-05-25
WO2001035979A3 true WO2001035979A3 (en) 2002-01-03

Family

ID=22598815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042137 WO2001035979A2 (en) 1999-11-13 2000-11-13 Combined pde3 and pde4 inhibitor therapy for the treatment of obesity

Country Status (2)

Country Link
AU (1) AU3270301A (en)
WO (1) WO2001035979A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051502A1 (en) * 2000-12-22 2002-07-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combined inhibition of phosphodiesterase-4 (pde-4) and phosphodiesterase-3 (pde-3) as a therapy for th1-mediated autoimmune diseases
US20030158133A1 (en) 2001-08-01 2003-08-21 Movsesian Matthew A. Isoform-selective inhibitors and activators of PDE3 cyclic nucleotide phosphodiesterases
FR2849594B1 (en) * 2003-01-03 2006-10-27 Oreal USE OF ZARDAVERINE AS SLIMMING
US7776893B2 (en) 2003-09-05 2010-08-17 Nycomed Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
EP1824463A1 (en) * 2004-12-14 2007-08-29 Menarini Ricerche S.p.A. Pharmaceutical compositions for the treatment of cellulite
NZ560269A (en) 2005-03-08 2010-12-24 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
EP2213289A1 (en) 2006-09-07 2010-08-04 Nycomed GmbH Combination treatment for diabetes mellitus
US20110105510A1 (en) * 2008-06-17 2011-05-05 Hiroshi Ishikawa Prophylactic/ameliorating or therapeutic agent for non-alcoholic steatohepatitis
US20130172356A1 (en) * 2010-06-23 2013-07-04 Kyushu University, National University Corporation Combination of egcg or methylated egcg and a pde inhibitor
US20150359798A1 (en) * 2011-09-06 2015-12-17 Jansfat Biotechnology Co., Ltd. Piperazinyl derivative reduces high-fat diet-induced accumulation of fat in the livers, therapeutically
IL294407B2 (en) * 2016-06-03 2025-01-01 Univ Columbia Posohodiesterase 4 inhibitor for use in a method of terating diseases associated with reduced pc1 levels and/or activity
WO2020076752A1 (en) * 2018-10-08 2020-04-16 The Johns Hopkins University Use of pde9 inhibitors for treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014239A1 (en) * 1997-09-12 1999-03-25 Wolf Georg Forssmann Composition for treating diabetes mellitus and obesity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014239A1 (en) * 1997-09-12 1999-03-25 Wolf Georg Forssmann Composition for treating diabetes mellitus and obesity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOUSA M K ET AL: "Antagonists of cyclic nucleotide phosphodiesterase (PDE) isozymes PDE 3 and PDE 4 suppress lymphoblastic response to HLA class II alloantigens: a potential novel approach to preventing allograft rejection?.", CLINICAL NEPHROLOGY, (1997 MAR) 47 (3) 187-9., XP002168562 *
PAN X ET AL: "Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isozyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells.", BIOCHEMICAL PHARMACOLOGY, (1994 AUG 17) 48 (4) 827-35., XP002168561 *
SCHMITZ-PEIFFER C ET AL: "Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells.", CELLULAR SIGNALLING, (1992 JAN) 4 (1) 37-49., XP002168563 *

Also Published As

Publication number Publication date
AU3270301A (en) 2001-05-30
WO2001035979A2 (en) 2001-05-25

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