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WO2001029231A3 - Genetic switch - Google Patents

Genetic switch Download PDF

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Publication number
WO2001029231A3
WO2001029231A3 PCT/IB2000/001624 IB0001624W WO0129231A3 WO 2001029231 A3 WO2001029231 A3 WO 2001029231A3 IB 0001624 W IB0001624 W IB 0001624W WO 0129231 A3 WO0129231 A3 WO 0129231A3
Authority
WO
WIPO (PCT)
Prior art keywords
genetic switch
systems
living
molecules
encode
Prior art date
Application number
PCT/IB2000/001624
Other languages
French (fr)
Other versions
WO2001029231A2 (en
Inventor
Adrian Francis Stewart
Original Assignee
European Molecular Biology Lab Embl
Adrian Francis Stewart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by European Molecular Biology Lab Embl, Adrian Francis Stewart filed Critical European Molecular Biology Lab Embl
Priority to AU10473/01A priority Critical patent/AU1047301A/en
Publication of WO2001029231A2 publication Critical patent/WO2001029231A2/en
Publication of WO2001029231A3 publication Critical patent/WO2001029231A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides nucleic acid molecules that are useful in genetic manipulations of living systems. These molecules may be used to create transgenic animal systems that facilitate the study of the physiological role played in a living system by genes and the proteins that they encode.
PCT/IB2000/001624 1999-10-18 2000-10-18 Genetic switch WO2001029231A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10473/01A AU1047301A (en) 1999-10-18 2000-10-18 Genetic switch

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9924604.3 1999-10-18
GBGB9924604.3A GB9924604D0 (en) 1999-10-18 1999-10-18 Genetic switch

Publications (2)

Publication Number Publication Date
WO2001029231A2 WO2001029231A2 (en) 2001-04-26
WO2001029231A3 true WO2001029231A3 (en) 2001-11-01

Family

ID=10862918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001624 WO2001029231A2 (en) 1999-10-18 2000-10-18 Genetic switch

Country Status (3)

Country Link
AU (1) AU1047301A (en)
GB (1) GB9924604D0 (en)
WO (1) WO2001029231A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2160534B1 (en) * 1999-12-30 2002-04-16 Vita Invest Sa NEW ESTERS DERIVED FROM (RR, SS) -2-HYDROXIBENZOATE 3- (2-DIMETHYLMINOME-1-HYDROXICICLOHEXIL) PHENYL.
EP1264891A1 (en) * 2001-05-31 2002-12-11 Plant Research International B.V. Modification of plant genomes by inducible site-specific recombination of transgenes
CA3000395A1 (en) * 2015-10-01 2017-04-06 Massachusetts Institute Of Technology Biological state machines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000555A1 (en) * 1993-06-28 1995-01-05 European Molecular Biology Laboratory (Embl) Regulation of site-specific recombination by site-specific recombinase/nuclear receptor fusion proteins
WO1999011807A1 (en) * 1997-09-05 1999-03-11 Purdue Research Foundation Selective expression of genes in plants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000555A1 (en) * 1993-06-28 1995-01-05 European Molecular Biology Laboratory (Embl) Regulation of site-specific recombination by site-specific recombinase/nuclear receptor fusion proteins
WO1999011807A1 (en) * 1997-09-05 1999-03-11 Purdue Research Foundation Selective expression of genes in plants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MEYERS, E.N. ET AL.: "An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination", NATURE GENETICS, vol. 18, 18 February 1998 (1998-02-18), XP002919952 *
ROSSANT, J. & MCMAHON, A.: ""Cre"-ating mouse mutants -a meeting review on conditional mouse genetics", GENES & DEVELOPMENT, vol. 13, 15 January 1999 (1999-01-15), pages 142 - 145, XP001004604 *
ROSSI F ET AL: "EXCISION OF ETS BY AN INDUCIBLE SITE-SPECIFIC RECOMBINASE CAUSES DIFFERENTIATION OF MYB-ETS-TRANSFORMED HEMATOPOIETIC PROGENITORS", CURRENT BIOLOGY,GB,CURRENT SCIENCE,, vol. 6, no. 7, 1 July 1996 (1996-07-01), pages 866 - 872, XP000617923, ISSN: 0960-9822 *
SCHWENK FRIEDER ET AL: "Temporally and spatially regulated somatic mutagenesis in mice", NUCLEIC ACIDS RESEARCH,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 26, no. 6, 15 March 1998 (1998-03-15), pages 1427 - 1432, XP002154789, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2001029231A2 (en) 2001-04-26
AU1047301A (en) 2001-04-30
GB9924604D0 (en) 1999-12-22

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