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WO2000042045A3 - Functionalized heterocycles as chemokine receptor modulators - Google Patents

Functionalized heterocycles as chemokine receptor modulators Download PDF

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Publication number
WO2000042045A3
WO2000042045A3 PCT/US1999/030434 US9930434W WO0042045A3 WO 2000042045 A3 WO2000042045 A3 WO 2000042045A3 US 9930434 W US9930434 W US 9930434W WO 0042045 A3 WO0042045 A3 WO 0042045A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemokine receptor
receptor modulators
useful
functionalized heterocycles
modulators
Prior art date
Application number
PCT/US1999/030434
Other languages
French (fr)
Other versions
WO2000042045A2 (en
Inventor
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR9916905-3A priority Critical patent/BR9916905A/en
Priority to EP99963110A priority patent/EP1144415A2/en
Priority to IL14428999A priority patent/IL144289A0/en
Priority to HU0202932A priority patent/HUP0202932A3/en
Priority to SK997-2001A priority patent/SK9972001A3/en
Priority to AU19409/00A priority patent/AU1940900A/en
Priority to CA002372197A priority patent/CA2372197A1/en
Priority to MXPA01007033A priority patent/MXPA01007033A/en
Priority to PL99349348A priority patent/PL349348A1/en
Application filed by Warner Lambert Co, Geraldine C Harriman, Christine Nylund Kolz, Jay R Luly, Bruce David Roth, Yuntao Song, Bharat Kalidas Trivedi filed Critical Warner Lambert Co
Priority to JP2000593612A priority patent/JP2002534526A/en
Priority to APAP/P/2001/002228A priority patent/AP2001002228A0/en
Priority to KR1020017008905A priority patent/KR20010086166A/en
Priority to EA200100774A priority patent/EA200100774A1/en
Publication of WO2000042045A2 publication Critical patent/WO2000042045A2/en
Publication of WO2000042045A3 publication Critical patent/WO2000042045A3/en
Priority to NO20013456A priority patent/NO20013456L/en
Priority to HK02106357.2A priority patent/HK1044539A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is a novel series of functionalized heterocycles as chemokine receptor modulators of Formula (I) useful as modulators of chemokine receptor activity. The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the prepartion of the final products, pharmaceutical compositions containing the final products are also taught.
PCT/US1999/030434 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators WO2000042045A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
PL99349348A PL349348A1 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
IL14428999A IL144289A0 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
HU0202932A HUP0202932A3 (en) 1999-01-13 1999-12-20 Heterocyclic compounds and pharmaceutical compositions can be used as chemokine receptor modulators
SK997-2001A SK9972001A3 (en) 1999-01-13 1999-12-20 Quinolizine derivative, pharmaceutical composition containing same and use thereof
AU19409/00A AU1940900A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
CA002372197A CA2372197A1 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
MXPA01007033A MXPA01007033A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators.
BR9916905-3A BR9916905A (en) 1999-01-13 1999-12-20 Compound, pharmaceutical composition, methods to modulate the activity of a chemokine receptor, to prevent HIV infection, to treat HIV infection, to delay the onset of AIDS, or to treat AIDS and to treat an inflammatory disease, and, combination
JP2000593612A JP2002534526A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as modulators of chemokine receptors
EP99963110A EP1144415A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
APAP/P/2001/002228A AP2001002228A0 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators.
KR1020017008905A KR20010086166A (en) 1999-01-13 1999-12-20 Functionalized Heterocycles as Chemokine Receptor Modulators
EA200100774A EA200100774A1 (en) 1999-01-13 1999-12-20 HYDRONIC
NO20013456A NO20013456L (en) 1999-01-13 2001-07-12 Functionalized heterocycles as chemokine receptor modulators
HK02106357.2A HK1044539A1 (en) 1999-01-13 2002-08-28 Functionalized heterocycles as chemokine receptor modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11565499P 1999-01-13 1999-01-13
US60/115,654 1999-01-13

Publications (2)

Publication Number Publication Date
WO2000042045A2 WO2000042045A2 (en) 2000-07-20
WO2000042045A3 true WO2000042045A3 (en) 2000-11-09

Family

ID=22362668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030434 WO2000042045A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Country Status (20)

Country Link
EP (1) EP1144415A2 (en)
JP (1) JP2002534526A (en)
KR (1) KR20010086166A (en)
CN (1) CN1344270A (en)
AP (1) AP2001002228A0 (en)
AU (1) AU1940900A (en)
BR (1) BR9916905A (en)
CA (1) CA2372197A1 (en)
CZ (1) CZ20012502A3 (en)
EA (1) EA200100774A1 (en)
HK (1) HK1044539A1 (en)
HU (1) HUP0202932A3 (en)
IL (1) IL144289A0 (en)
MX (1) MXPA01007033A (en)
NO (1) NO20013456L (en)
OA (1) OA11820A (en)
PL (1) PL349348A1 (en)
SK (1) SK9972001A3 (en)
WO (1) WO2000042045A2 (en)
ZA (1) ZA200106592B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072549A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
NZ527815A (en) * 2001-03-29 2005-05-27 Lilly Co Eli N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor
WO2003035650A1 (en) * 2001-09-25 2003-05-01 Takeda Chemical Industries, Ltd. Entry inhibitor
MXPA05009771A (en) 2003-03-14 2005-10-26 Ono Pharmaceutical Co Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient.
EP2364982A1 (en) 2003-04-18 2011-09-14 ONO Pharmaceutical Co., Ltd. Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof
SG146673A1 (en) 2004-09-13 2008-10-30 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
JP5251127B2 (en) 2005-10-28 2013-07-31 小野薬品工業株式会社 COMPOUND CONTAINING BASIC GROUP AND USE THEREOF
US8168783B2 (en) 2005-11-18 2012-05-01 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonists and use thereof
CN101460458A (en) 2006-02-15 2009-06-17 阿勒根公司 Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
KR20080102181A (en) * 2006-02-15 2008-11-24 알러간, 인코포레이티드 Sphingosine-1-phosphate (Spi) Receptor Antagonist Indole-3-carbosylic acid amides, esters, thioamides and thiol ester compounds comprising aryl or heteroaryl groups having biological activity
MX2008011414A (en) 2006-03-10 2008-09-22 Ono Pharmaceutical Co Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient.
US8618122B2 (en) 2006-05-16 2013-12-31 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
EP2036889A4 (en) * 2006-05-23 2009-11-04 Alla Chem Llc Substituted indoles and a method for the production and use thereof
JP5245827B2 (en) 2006-07-31 2013-07-24 小野薬品工業株式会社 Compound containing spiro-bonded cyclic group and use thereof
JP2010515750A (en) * 2007-01-11 2010-05-13 アラーガン インコーポレイテッド 6-Substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
US8524917B2 (en) 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
WO2011143430A1 (en) 2010-05-12 2011-11-17 Abbott Laboratories Indazole inhibitors of kinase
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JO3459B1 (en) 2012-09-09 2020-07-05 H Lundbeck As Pharmaceutical formulations for the treatment of Alzheimer's disease
CN104193669B (en) * 2014-08-01 2016-12-07 大连理工大学 A kind of Arbidol analog or its salt, its preparation method and application
WO2016112088A1 (en) * 2015-01-06 2016-07-14 Spero Therapeutics, Inc. Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors
CN110256324A (en) * 2019-06-13 2019-09-20 苏州莱安医药化学技术有限公司 A kind of preparation method of 2- methyl -5-OHi
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
EP0820998A2 (en) * 1996-07-26 1998-01-28 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Novel coumarin quinolone carboxylic acids and processes for the preparation thereof
WO1998038167A1 (en) * 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
EP0820998A2 (en) * 1996-07-26 1998-01-28 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Novel coumarin quinolone carboxylic acids and processes for the preparation thereof
WO1998038167A1 (en) * 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. VON STRANDTMANN ET AL.: "Reaction of Phenolic Mannich Bases with Enamines. General Synthesis of Pyran-Containing Fused Ring Systems.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 7, 1970, HETEROCORPORATION. PROVO., US, pages 1311 - 1319, XP002143638, ISSN: 0022-152X *

Also Published As

Publication number Publication date
JP2002534526A (en) 2002-10-15
HUP0202932A3 (en) 2003-07-28
BR9916905A (en) 2002-01-29
IL144289A0 (en) 2002-05-23
HUP0202932A2 (en) 2002-12-28
NO20013456L (en) 2001-09-12
PL349348A1 (en) 2002-07-15
CN1344270A (en) 2002-04-10
AP2001002228A0 (en) 2001-09-30
KR20010086166A (en) 2001-09-08
HK1044539A1 (en) 2002-10-25
AU1940900A (en) 2000-08-01
WO2000042045A2 (en) 2000-07-20
NO20013456D0 (en) 2001-07-12
OA11820A (en) 2005-08-17
CZ20012502A3 (en) 2002-03-13
SK9972001A3 (en) 2002-03-05
MXPA01007033A (en) 2003-07-21
CA2372197A1 (en) 2000-07-20
ZA200106592B (en) 2002-08-12
EP1144415A2 (en) 2001-10-17
EA200100774A1 (en) 2002-02-28

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