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WO2000034295A3 - Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation - Google Patents

Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation Download PDF

Info

Publication number
WO2000034295A3
WO2000034295A3 PCT/US1999/027777 US9927777W WO0034295A3 WO 2000034295 A3 WO2000034295 A3 WO 2000034295A3 US 9927777 W US9927777 W US 9927777W WO 0034295 A3 WO0034295 A3 WO 0034295A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
smooth muscle
inhibitors
muscle cell
benzylmaltosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/027777
Other languages
French (fr)
Other versions
WO2000034295A2 (en
Inventor
Scott Christian Mayer
Robert Emmett Mcdevitt
Paul Jeffrey Dollings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to AU37912/00A priority Critical patent/AU3791200A/en
Priority to JP2000586738A priority patent/JP2003521460A/en
Priority to EP99973295A priority patent/EP1133510A2/en
Priority to BR9915632-6A priority patent/BR9915632A/en
Priority to CA002351059A priority patent/CA2351059A1/en
Publication of WO2000034295A2 publication Critical patent/WO2000034295A2/en
Publication of WO2000034295A3 publication Critical patent/WO2000034295A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

This invention provides smooth muscle cell proliferation inhibitors of formula (I) having the structure or pharmaceutically acceptable salts thereof.
PCT/US1999/027777 1998-11-24 1999-11-23 Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation Ceased WO2000034295A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU37912/00A AU3791200A (en) 1998-11-24 1999-11-23 Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
JP2000586738A JP2003521460A (en) 1998-11-24 1999-11-23 Acetylated benzylmaltoside as an inhibitor of smooth muscle cell proliferation
EP99973295A EP1133510A2 (en) 1998-11-24 1999-11-23 Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
BR9915632-6A BR9915632A (en) 1998-11-24 1999-11-23 Acylated benzylmaltides as inhibitors of smooth muscle cell proliferation
CA002351059A CA2351059A1 (en) 1998-11-24 1999-11-23 Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19880498A 1998-11-24 1998-11-24
US09/198,804 1998-11-24

Publications (2)

Publication Number Publication Date
WO2000034295A2 WO2000034295A2 (en) 2000-06-15
WO2000034295A3 true WO2000034295A3 (en) 2000-11-23

Family

ID=22734932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027777 Ceased WO2000034295A2 (en) 1998-11-24 1999-11-23 Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation

Country Status (7)

Country Link
EP (1) EP1133510A2 (en)
JP (1) JP2003521460A (en)
CN (1) CN1329616A (en)
AU (1) AU3791200A (en)
BR (1) BR9915632A (en)
CA (1) CA2351059A1 (en)
WO (1) WO2000034295A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101952300B (en) * 2007-07-19 2014-08-06 综合植物遗传股份有限公司 Application of a bacteriophage outer membrane-disrupting protein expressed in plants for the control of Gram-negative bacteria
CN118406096B (en) * 2024-06-28 2024-08-23 成都施贝康生物医药科技有限公司 Maltose fatty acid ester compound and preparation method and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
WO1996014325A1 (en) * 1994-11-07 1996-05-17 American Home Products Corporation Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
US5565432A (en) * 1994-11-07 1996-10-15 American Home Products Corporation Smooth muscle cell proliferation inhibitors
WO2000031096A1 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
WO2000031100A2 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
WO2000034338A2 (en) * 1998-11-24 2000-06-15 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
WO1996014325A1 (en) * 1994-11-07 1996-05-17 American Home Products Corporation Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
US5565432A (en) * 1994-11-07 1996-10-15 American Home Products Corporation Smooth muscle cell proliferation inhibitors
WO2000031096A1 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
WO2000031100A2 (en) * 1998-11-24 2000-06-02 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
WO2000034338A2 (en) * 1998-11-24 2000-06-15 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
EP1133510A2 (en) 2001-09-19
CN1329616A (en) 2002-01-02
AU3791200A (en) 2000-06-26
WO2000034295A2 (en) 2000-06-15
BR9915632A (en) 2001-08-07
CA2351059A1 (en) 2000-06-15
JP2003521460A (en) 2003-07-15

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