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WO2000026185A3 - Solution d'omeprazole et methode d'utilisation associee - Google Patents

Solution d'omeprazole et methode d'utilisation associee Download PDF

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Publication number
WO2000026185A3
WO2000026185A3 PCT/US1999/025592 US9925592W WO0026185A3 WO 2000026185 A3 WO2000026185 A3 WO 2000026185A3 US 9925592 W US9925592 W US 9925592W WO 0026185 A3 WO0026185 A3 WO 0026185A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal
group
proton pump
pump inhibitor
bicarbonate salt
Prior art date
Application number
PCT/US1999/025592
Other languages
English (en)
Other versions
WO2000026185A9 (fr
WO2000026185A2 (fr
Inventor
Jeffrey O Phillips
Original Assignee
Univ Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri filed Critical Univ Missouri
Priority to AU19071/00A priority Critical patent/AU1907100A/en
Publication of WO2000026185A2 publication Critical patent/WO2000026185A2/fr
Publication of WO2000026185A3 publication Critical patent/WO2000026185A3/fr
Publication of WO2000026185A9 publication Critical patent/WO2000026185A9/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une méthode de traitement d'acidité gastrique par administration, à un patient, d'une composition pharmaceutique contenant un inhibiteur de pompe à proton dans un support acceptable sur le plan pharmaceutique, comprenant un sel bicarbonaté d'un métal du groupe IA, qui consiste à administrer une forme à dosage unique qui ne nécessite aucune administration ultérieure de sel bicarbonaté de métal du groupe IA. Une composition pharmaceutique comprend une formulation sèche d'inhibiteur de pompe à proton dans un support acceptable sur le plan pharmaceutique, comprenant un sel bicarbonaté d'un métal du groupe IA. L'invention concerne aussi une composition pharmaceutique destinée à fabriquer une formulation sèche d'un inhibiteur de proton qui comprend un inhibiteur de pompe à proton et un sel bicarbonaté d'un métal du groupe IA sous une forme adaptée au stockage, la formulation sèche de la composition convenant à l'administration par voie entérale.
PCT/US1999/025592 1998-10-30 1999-10-29 Solution d'omeprazole et methode d'utilisation associee WO2000026185A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19071/00A AU1907100A (en) 1998-10-30 1999-10-29 Omeprazole solution and method of using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18342298A 1998-10-30 1998-10-30
US09/183,422 1998-10-30

Publications (3)

Publication Number Publication Date
WO2000026185A2 WO2000026185A2 (fr) 2000-05-11
WO2000026185A3 true WO2000026185A3 (fr) 2000-08-10
WO2000026185A9 WO2000026185A9 (fr) 2000-09-21

Family

ID=22672726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025592 WO2000026185A2 (fr) 1998-10-30 1999-10-29 Solution d'omeprazole et methode d'utilisation associee

Country Status (2)

Country Link
AU (1) AU1907100A (fr)
WO (1) WO2000026185A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780882B2 (en) 1996-01-04 2004-08-24 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
USRE45198E1 (en) 1996-01-04 2014-10-14 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
MY137726A (en) 2000-11-22 2009-03-31 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
US8697094B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations
US20050031700A1 (en) * 2003-07-18 2005-02-10 Sanatarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853230A (en) * 1986-04-30 1989-08-01 Aktiebolaget Hassle Pharmaceutical formulations of acid labile substances for oral use
US5753265A (en) * 1994-07-08 1998-05-19 Astra Aktiebolag Multiple unit pharmaceutical preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853230A (en) * 1986-04-30 1989-08-01 Aktiebolaget Hassle Pharmaceutical formulations of acid labile substances for oral use
US5753265A (en) * 1994-07-08 1998-05-19 Astra Aktiebolag Multiple unit pharmaceutical preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAKAGAWA ET AL.: "Phase I study of Lansoprazole (AG-1749), anticulcer agent", JOURNAL OF CLINICAL THERAPEUTICS & MEDICINES,, vol. 7, no. 1, January 1991 (1991-01-01), pages 33 - 50, XP002928123 *
PILBRANT ET AL.: "Development of an oral formulation of omeprazole", SCAND J. GASTROENTEROL.,, vol. 20, (SUPPL. 108), 1985, pages 113 - 120, XP002928124 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780882B2 (en) 1996-01-04 2004-08-24 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
USRE45198E1 (en) 1996-01-04 2014-10-14 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them

Also Published As

Publication number Publication date
WO2000026185A9 (fr) 2000-09-21
AU1907100A (en) 2000-05-22
WO2000026185A2 (fr) 2000-05-11

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