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WO2000023059A3 - Use of anticonvulsant derivatives for treating alcohol dependency - Google Patents

Use of anticonvulsant derivatives for treating alcohol dependency Download PDF

Info

Publication number
WO2000023059A3
WO2000023059A3 PCT/US1999/023769 US9923769W WO0023059A3 WO 2000023059 A3 WO2000023059 A3 WO 2000023059A3 US 9923769 W US9923769 W US 9923769W WO 0023059 A3 WO0023059 A3 WO 0023059A3
Authority
WO
WIPO (PCT)
Prior art keywords
alcohol dependency
treating alcohol
alkyl
hydrogen
treating
Prior art date
Application number
PCT/US1999/023769
Other languages
French (fr)
Other versions
WO2000023059A2 (en
Inventor
Marina Gordey
Richard Olsen
Richard Shank
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to BR9914722-0A priority Critical patent/BR9914722A/en
Priority to MXPA01004015A priority patent/MXPA01004015A/en
Priority to NZ511173A priority patent/NZ511173A/en
Priority to CA002348017A priority patent/CA2348017C/en
Priority to AU13131/00A priority patent/AU759756B2/en
Priority to JP2000576834A priority patent/JP2002527470A/en
Publication of WO2000023059A2 publication Critical patent/WO2000023059A2/en
Publication of WO2000023059A3 publication Critical patent/WO2000023059A3/en
Priority to NO20011901A priority patent/NO20011901L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A method for treating alcohol dependency, addition and abuse comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of formula (I): wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and, when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II): wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
PCT/US1999/023769 1998-10-20 1999-10-18 Use of anticonvulsant derivatives for treating alcohol dependency WO2000023059A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR9914722-0A BR9914722A (en) 1998-10-20 1999-10-18 Anticonvulsant derivatives useful in the treatment of alcohol dependence, addiction and abuse
MXPA01004015A MXPA01004015A (en) 1998-10-20 1999-10-18 Anticonvulsant derivatives useful in treating alcohol dependency, addiction and abuse.
NZ511173A NZ511173A (en) 1998-10-20 1999-10-18 Method for treating alcohol dependency, addiction and abuse using anticonvulsant derivatives (such as 2,3:4,5-bis- O-(1-methylethylidene)-beta-D-fructopyranose sulfamate (topiramate))
CA002348017A CA2348017C (en) 1998-10-20 1999-10-18 Anticonvulsant derivatives useful in treating alcohol dependency, addiction and abuse
AU13131/00A AU759756B2 (en) 1998-10-20 1999-10-18 Anticonvulsant derivatives useful in treating alcohol dependency, addiction and abuse
JP2000576834A JP2002527470A (en) 1998-10-20 1999-10-18 Anticonvulsant derivatives useful in the treatment of alcoholism, addiction and abuse
NO20011901A NO20011901L (en) 1998-10-20 2001-04-18 Anti-convulsive derivatives useful in the treatment of alcohol dependence and abuse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10488798P 1998-10-20 1998-10-20
US60/104,887 1998-10-20

Publications (2)

Publication Number Publication Date
WO2000023059A2 WO2000023059A2 (en) 2000-04-27
WO2000023059A3 true WO2000023059A3 (en) 2000-11-23

Family

ID=22302937

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/023769 WO2000023059A2 (en) 1998-10-20 1999-10-18 Use of anticonvulsant derivatives for treating alcohol dependency

Country Status (9)

Country Link
JP (1) JP2002527470A (en)
AU (1) AU759756B2 (en)
BR (1) BR9914722A (en)
CA (1) CA2348017C (en)
MX (1) MXPA01004015A (en)
NO (1) NO20011901L (en)
NZ (1) NZ511173A (en)
WO (1) WO2000023059A2 (en)
ZA (1) ZA200104037B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541520B1 (en) 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
US6890951B2 (en) 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
PT1158973E (en) 1999-02-24 2005-07-29 Univ Cincinnati USE OF SULFAMATE DERIVATIVES FOR THE TREATMENT OF DRIVE CONTROL DISTURBLES
WO2002043731A2 (en) * 2000-11-30 2002-06-06 University Of Florida Treatments for neurogenetic disorders, impulse control disorders, and wound healing
US6462084B1 (en) * 2001-05-14 2002-10-08 Brookhaven Science Associates, Llc Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007583A2 (en) * 1998-08-05 2000-02-17 Brookhaven Science Associates Treatment of addiction and addiction-related behavior

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007583A2 (en) * 1998-08-05 2000-02-17 Brookhaven Science Associates Treatment of addiction and addiction-related behavior

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D.A. GORELICK: "Pharmacological treatment", RECENT DEVELOPMENTS IN ALCOHOLISM, vol. 11, 1993, pages 413 - 427, XP000913482 *
KYOWA HAKKO: "TOPIRAMATE", DRUGS OF THE FUTURE,ES,BARCELONA, vol. 21, no. 4, 1 January 1996 (1996-01-01), pages 463 - 465, XP002043895, ISSN: 0377-8282 *
T.I. MIELLER: "A double-blind, placebo-controlled pilot study of carbamazepine for the treatment of alcohol dependence", ALCOHOLISM. CLIN. EXP. RES., vol. 21, no. 1, 1997, pages 86 - 92, XP000913485 *
WAUQUIER A ET AL: "TOPIRAMATE: A POTENT ANTICONVULSANT IN THE AMYGDALA-KINDLED RAT", EPILEPSY RESEARCH,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 24, no. 2, 1 June 1996 (1996-06-01), pages 73 - 77, XP002042953, ISSN: 0920-1211 *

Also Published As

Publication number Publication date
AU759756B2 (en) 2003-05-01
CA2348017C (en) 2005-07-19
JP2002527470A (en) 2002-08-27
WO2000023059A2 (en) 2000-04-27
NO20011901D0 (en) 2001-04-18
ZA200104037B (en) 2002-06-28
BR9914722A (en) 2001-07-10
NZ511173A (en) 2003-09-26
AU1313100A (en) 2000-05-08
MXPA01004015A (en) 2003-03-10
NO20011901L (en) 2001-04-18
CA2348017A1 (en) 2000-04-27

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