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WO2000010007A3 - Dispositifs et procedes d'analyse de solutes non ioniques - Google Patents

Dispositifs et procedes d'analyse de solutes non ioniques Download PDF

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Publication number
WO2000010007A3
WO2000010007A3 PCT/US1999/018615 US9918615W WO0010007A3 WO 2000010007 A3 WO2000010007 A3 WO 2000010007A3 US 9918615 W US9918615 W US 9918615W WO 0010007 A3 WO0010007 A3 WO 0010007A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor composition
target molecule
sensor
electrode
concentration
Prior art date
Application number
PCT/US1999/018615
Other languages
English (en)
Other versions
WO2000010007A2 (fr
WO2000010007A9 (fr
Inventor
Frances H Arnold
Alan S Michaels
Weigong Zheng
Original Assignee
California Inst Of Techn
Frances H Arnold
Alan S Michaels
Weigong Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Frances H Arnold, Alan S Michaels, Weigong Zheng filed Critical California Inst Of Techn
Priority to AU55652/99A priority Critical patent/AU5565299A/en
Publication of WO2000010007A2 publication Critical patent/WO2000010007A2/fr
Publication of WO2000010007A9 publication Critical patent/WO2000010007A9/fr
Publication of WO2000010007A3 publication Critical patent/WO2000010007A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des dispositifs et procédés de détection et de contrôle de la concentration, du niveau ou de la quantité d'une molécule cible dans une solution. Plus particulièrement, l'invention concerne des détecteurs évaluant des changements de conductivité produits par la réaction d'une molécule cible avec une composition de détection. L'invention est particulièrement appropriée pour déterminer la concentration de composés d'hydrates de carbone dans une solution, tels que des composés diols, de préférence des diols cis biologiquement importants tels que différents sucres, y compris le glucose. L'invention concerne également des détecteurs permettant de déterminer la quantité totale ou relative d'une molécule cible dans un échantillon, en particulier un échantillon biologique tel que le sang, l'urine ou d'autres liquides organiques. Un détecteur stratifié selon l'invention comprend une composition de détection appliquée sur une électrode métallique telle qu'une électrode en or interdigitée ou un support non conducteur. La composition de détection et l'électrode sont de préférence entourées d'une membrane bipolaire. Dans un mode de réalisation préférée, la composition de détection est formée d'un mélange de polymère d'acide borique et d'une matrice d'hydrogel non ionogène.
PCT/US1999/018615 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques WO2000010007A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55652/99A AU5565299A (en) 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9673998P 1998-08-17 1998-08-17
US60/096,739 1998-08-17
US30125299A 1999-04-28 1999-04-28
US09/301,252 1999-04-28

Publications (3)

Publication Number Publication Date
WO2000010007A2 WO2000010007A2 (fr) 2000-02-24
WO2000010007A9 WO2000010007A9 (fr) 2000-07-06
WO2000010007A3 true WO2000010007A3 (fr) 2000-08-17

Family

ID=26792028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018615 WO2000010007A2 (fr) 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques

Country Status (2)

Country Link
AU (1) AU5565299A (fr)
WO (1) WO2000010007A2 (fr)

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US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US20020142306A1 (en) * 2001-03-28 2002-10-03 3M Innovative Properties Company Method of transferring molecules to a film laminate
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
IL164685A0 (en) 2002-04-22 2005-12-18 Marcio Marc Aurelio Martins Ab Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US9296820B2 (en) 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
CA2627278A1 (fr) 2005-10-24 2007-05-03 Marcio Marc Abreu Appareil et procede de mesure de parametres biologiques
DE102006026668B4 (de) 2006-06-08 2008-07-10 Technische Universität Dresden Sensor und Verfahren zur Messung der Konzentration von Komponenten in einer Flüssigkeit
EP2073698B1 (fr) 2006-09-29 2015-09-09 Medimetrics Personalized Drug Delivery B.V. Capteur de seuil miniaturisé
EP2118177A1 (fr) 2007-03-05 2009-11-18 MIP Technologies AB Polymères à empreintes moléculaires
US20090014340A1 (en) * 2007-06-15 2009-01-15 Williams John R Devices, systems, and methods for measuring glucose
US8181531B2 (en) 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
JP5848127B2 (ja) 2008-08-13 2016-01-27 カリフォルニア インスティテュート オブ テクノロジー 担体ナノ粒子ならびに関連する組成物、方法およびシステム
US9011670B2 (en) 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
WO2010077709A2 (fr) * 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Dispositifs biomédicaux
US8706425B2 (en) 2011-07-20 2014-04-22 Veolia Water Solutions & Technologies Support Method for validation of polymer aqueous solutions concentration and activation in water treatment applications and polymer make-up unit therefor
EP3513812B1 (fr) * 2013-03-01 2020-07-15 California Institute of Technology Nanoparticules stabilisées avec des compositions d'acide nitrophénylboronique
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
WO2015054679A1 (fr) 2013-10-11 2015-04-16 Marcio Marc Abreu Procédé et appareil pour évaluation biologique
CA2936229A1 (fr) 2014-01-10 2015-07-16 Marcio Marc Abreu Dispositif de mesure de sortie infrarouge du tunnel thermique du cerveau abreu
US10251776B2 (en) 2014-01-10 2019-04-09 Geelux Holding, Ltd. Devices configured to monitor biological parameters, and to provide treatment, at an Abreu brain thermal tunnel
CA2936247A1 (fr) 2014-01-22 2015-07-30 Marcio Marc Abreu Dispositifs concus pour effectuer un traitement au niveau d'un tunnel de temperature cerebrale d'abreu
JP5599012B1 (ja) * 2014-06-23 2014-10-01 国立大学法人 東京大学 採取部及びバイオセンサ
KR102255158B1 (ko) * 2014-10-21 2021-05-27 엘지전자 주식회사 당 검출용 센서와 이의 제조방법 및 이를 이용한 당화 혈색소 검출 방법
AU2016228998A1 (en) 2015-03-10 2017-09-28 Marcio Marc Abreu Devices, apparatuses, systems, and methods for measuring temperature of an ABTT terminus
JP2016217929A (ja) * 2015-05-22 2016-12-22 セイコーエプソン株式会社 センサー用ゲルおよびセンサー
CN111643479B (zh) 2015-07-01 2023-10-27 加州理工学院 基于阳离子粘酸聚合物的递送系统
WO2017030930A1 (fr) * 2015-08-14 2017-02-23 Razzberry Inc. Électrodes et procédé d'utilisation destiné à être utilisé dans la détection d'explosifs et d'autres matières volatiles
JP7483193B2 (ja) 2018-06-13 2024-05-15 カリフォルニア・インスティテュート・オブ・テクノロジー 血脳バリアを越えるためのナノ粒子とそれを用いた治療法
AU2019336336B2 (en) * 2018-09-06 2025-05-01 AusMed Global Limited Systems, sensors and methods for determining a concentration of an analyte
CN112782251B (zh) * 2021-01-07 2022-03-25 安徽大学 一种定量检测重铬酸钾的方法
AU2022311813A1 (en) * 2021-07-16 2024-02-29 Victor Javier Cadarso Busto Sensor having contoured membrane

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
EP0539625A1 (fr) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Capteur électrochimique pour mesurer la teneur en glucose des fluides
JPH05262779A (ja) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd ボロン酸基含有モノマーおよびそのポリマー
EP0596700A1 (fr) * 1992-11-03 1994-05-11 Hewlett-Packard Company Méthode de détection de cis-diol et supports solides
DE4437274A1 (de) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analytselektiver Sensor
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
WO1997033177A1 (fr) * 1996-03-04 1997-09-12 California Institute Of Technology Detecteurs de sucres et d'autres analytes se liant a des metaux

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650547A (en) * 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
EP0539625A1 (fr) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Capteur électrochimique pour mesurer la teneur en glucose des fluides
JPH05262779A (ja) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd ボロン酸基含有モノマーおよびそのポリマー
EP0596700A1 (fr) * 1992-11-03 1994-05-11 Hewlett-Packard Company Méthode de détection de cis-diol et supports solides
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
DE4437274A1 (de) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analytselektiver Sensor
WO1997033177A1 (fr) * 1996-03-04 1997-09-12 California Institute Of Technology Detecteurs de sucres et d'autres analytes se liant a des metaux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 016, no. 383 (C - 0974) 17 August 1992 (1992-08-17) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 032 (C - 1154) 18 January 1994 (1994-01-18) *

Also Published As

Publication number Publication date
AU5565299A (en) 2000-03-06
WO2000010007A2 (fr) 2000-02-24
WO2000010007A9 (fr) 2000-07-06

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