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WO1999049876A3 - Bacterial or yeast extracts which stimulate the production of defensins and methods of use thereof - Google Patents

Bacterial or yeast extracts which stimulate the production of defensins and methods of use thereof

Info

Publication number
WO1999049876A3
WO1999049876A3 PCT/US1999/007071 US9907071W WO9949876A3 WO 1999049876 A3 WO1999049876 A3 WO 1999049876A3 US 9907071 W US9907071 W US 9907071W WO 9949876 A3 WO9949876 A3 WO 9949876A3
Authority
WO
WIPO (PCT)
Prior art keywords
defensins
stimulate
production
methods
bacterial
Prior art date
Application number
PCT/US1999/007071
Other languages
French (fr)
Other versions
WO1999049876A2 (en
Inventor
Pradip Mukerji
Glen M Anderson
Terry A Kroening
Stephen J Kirchner
Michael A Zasloff
Pascale Fehlbaum
Original Assignee
Abbott Lab
Magainin Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Magainin Pharma filed Critical Abbott Lab
Priority to AU35474/99A priority Critical patent/AU3547499A/en
Publication of WO1999049876A2 publication Critical patent/WO1999049876A2/en
Publication of WO1999049876A3 publication Critical patent/WO1999049876A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The subject invention relates to extracts derived from, for example, a spent medium, a portion of a bacterial cell, a lysed yeast cell, or a portion of a lysed yeast cell which may be used to stimulate the production of defensins in eukaryotic cells such as, for example, mammalian cells. Furthermore, the present invention includes compositions containing these extracts as well as methods of using these extracts, for example, in the prevention and treatment of various disease states, in rehydration, and in the stimulation of the immune system.
PCT/US1999/007071 1998-03-31 1999-03-31 Bacterial or yeast extracts which stimulate the production of defensins and methods of use thereof WO1999049876A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35474/99A AU3547499A (en) 1998-03-31 1999-03-31 Bacterial or yeast extracts which stimulate the production of defensins and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5247198A 1998-03-31 1998-03-31
US09/052,471 1998-03-31

Publications (2)

Publication Number Publication Date
WO1999049876A2 WO1999049876A2 (en) 1999-10-07
WO1999049876A3 true WO1999049876A3 (en) 1999-12-23

Family

ID=21977814

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007071 WO1999049876A2 (en) 1998-03-31 1999-03-31 Bacterial or yeast extracts which stimulate the production of defensins and methods of use thereof

Country Status (2)

Country Link
AU (1) AU3547499A (en)
WO (1) WO1999049876A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001245726A1 (en) * 2000-03-15 2001-09-24 Genaera Corporation A method for stimulation of defensin production
FR2843125B1 (en) * 2002-08-02 2012-11-16 Coletica ACTIVE PRINCIPLES STIMULATING HUMAN BETA-DEFENSIVE TYPE 2 AND / OR TYPE 3, AND COSMETIC OR PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS
FR2887772B1 (en) * 2005-07-01 2010-08-13 Soc Extraction Principes Actif USE OF YEAST EXTRACT AS AN ACTIVE AGENT INDUCING THE SYNTHESIS OF SIRT PROTEINS IN SKIN CELLS.
FR2887775B1 (en) * 2005-07-01 2010-08-13 Soc Extraction Principes Actif USE OF YEAST EXTRACT AS AN ACTIVE AGENT INDUCING THE SYNTHESIS OF SIRT PROTEINS IN SKIN CELLS.
EP2108706A1 (en) * 2008-04-10 2009-10-14 Institut Pasteur New method for selecting compounds useful for treating and/or preventing microbial Shigella infection
KR20190086482A (en) * 2010-11-12 2019-07-22 알러간, 인코포레이티드 Metabolized conditioned growth medium and methods of use
CN111148511A (en) 2017-07-27 2020-05-12 轨迹Ip有限责任公司 Compositions for increasing the bioavailability of drugs, supplements and ingested substances
CN108103004A (en) * 2017-12-20 2018-06-01 中国农业科学院特产研究所 A kind of method of sika deer cud epithelial cell culture
CN109097320A (en) * 2018-07-23 2018-12-28 南京农业大学 A kind of sheep lamb cud epithelial cell cultural method
CA3127667A1 (en) * 2019-01-28 2020-08-06 Locus Ip Company, Llc Production and use of yeast extract as a medical adjuvant

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035937A1 (en) * 1980-03-10 1981-09-16 Univablot Use of Hansenula or extracts from Hansenula as medicament
EP0202019A2 (en) * 1985-04-12 1986-11-20 Kabushiki Kaisya Advance Anticariogenic or antiperiodontitic agent
EP0406087A2 (en) * 1989-06-26 1991-01-02 Kabushiki Kaisha Yakult Honsha Antihypertensives and food and drinks containing such antihypertensives
EP0577903A1 (en) * 1992-07-06 1994-01-12 Societe Des Produits Nestle S.A. Agent antigastrite contenant lactobacillus acidophilus
EP0599479A2 (en) * 1992-11-24 1994-06-01 Institut Pasteur De Kyoto Lactobacillus used to enhance immunological functions
EP0650731A1 (en) * 1993-10-28 1995-05-03 Thiemann Arzneimittel GmbH Product obtained from yeast cells of saccharomyces boulardii and its utilisation
WO1997007232A1 (en) * 1995-08-11 1997-02-27 Boehringer Ingelheim Vetmedica Gmbh Antigenic preparations

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035937A1 (en) * 1980-03-10 1981-09-16 Univablot Use of Hansenula or extracts from Hansenula as medicament
EP0202019A2 (en) * 1985-04-12 1986-11-20 Kabushiki Kaisya Advance Anticariogenic or antiperiodontitic agent
EP0406087A2 (en) * 1989-06-26 1991-01-02 Kabushiki Kaisha Yakult Honsha Antihypertensives and food and drinks containing such antihypertensives
EP0577903A1 (en) * 1992-07-06 1994-01-12 Societe Des Produits Nestle S.A. Agent antigastrite contenant lactobacillus acidophilus
EP0599479A2 (en) * 1992-11-24 1994-06-01 Institut Pasteur De Kyoto Lactobacillus used to enhance immunological functions
EP0650731A1 (en) * 1993-10-28 1995-05-03 Thiemann Arzneimittel GmbH Product obtained from yeast cells of saccharomyces boulardii and its utilisation
WO1997007232A1 (en) * 1995-08-11 1997-02-27 Boehringer Ingelheim Vetmedica Gmbh Antigenic preparations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B. SCHONWETTER ET AL.: "Epithelial antibiotics induced at sites of inflammation.", SCIENCE, vol. 267, no. 5204, 17 March 1995 (1995-03-17), Washington, DC, USA, pages 1645 - 1648, XP002120032 *
E. STOLZENBERG ET AL.: "Epithelial antibiotic induced in states of disease.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., vol. 94, no. 16, 5 August 1997 (1997-08-05), Washington, DC, USA, pages 8686 - 8690, XP002120031 *

Also Published As

Publication number Publication date
AU3547499A (en) 1999-10-18
WO1999049876A2 (en) 1999-10-07

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