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WO1999045886A3 - New contraceptive kit for monotherapy - Google Patents

New contraceptive kit for monotherapy Download PDF

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Publication number
WO1999045886A3
WO1999045886A3 PCT/EP1999/001404 EP9901404W WO9945886A3 WO 1999045886 A3 WO1999045886 A3 WO 1999045886A3 EP 9901404 W EP9901404 W EP 9901404W WO 9945886 A3 WO9945886 A3 WO 9945886A3
Authority
WO
WIPO (PCT)
Prior art keywords
steroids
monotherapy
contraceptive
contraceptive kit
contraceptive agent
Prior art date
Application number
PCT/EP1999/001404
Other languages
French (fr)
Other versions
WO1999045886A2 (en
Inventor
Helenius Jan Kloosterboer
Godefridus Hermanus Jo Deckers
Johannes Antonius Mar Hamersma
Pieter Michiel Verbost
Bennink Herman Jan Ti Coelingh
Original Assignee
Akzo Nobel Nv
Helenius Jan Kloosterboer
Godefridus Hermanus Jo Deckers
Johannes Antonius Mar Hamersma
Pieter Michiel Verbost
Bennink Herman Jan Ti Coelingh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ506115A priority Critical patent/NZ506115A/en
Priority to CA002319765A priority patent/CA2319765A1/en
Priority to AU31437/99A priority patent/AU756882B2/en
Priority to BR9908605-0A priority patent/BR9908605A/en
Priority to JP2000535302A priority patent/JP2002506014A/en
Priority to IL13754199A priority patent/IL137541A0/en
Priority to EP99939157A priority patent/EP1061928A2/en
Priority to KR1020007009917A priority patent/KR20010041698A/en
Priority to PL99343428A priority patent/PL343428A1/en
Priority to HU0101007A priority patent/HUP0101007A3/en
Application filed by Akzo Nobel Nv, Helenius Jan Kloosterboer, Godefridus Hermanus Jo Deckers, Johannes Antonius Mar Hamersma, Pieter Michiel Verbost, Bennink Herman Jan Ti Coelingh filed Critical Akzo Nobel Nv
Publication of WO1999045886A2 publication Critical patent/WO1999045886A2/en
Publication of WO1999045886A3 publication Critical patent/WO1999045886A3/en
Priority to NO20004492A priority patent/NO20004492D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention pertains to a contraceptive kit comprising means for the daily administration of a contraceptive agent, characterised in that the single contraceptive agent is a steroid compound having an activity profile inherently combining progestagenic and estrogenic activity. Within a general class of known steroidal compounds, steroids have been found which possess an outstanding combined profile of biological properties for use in contraception, especially via monotherapy. These steroids are selected from the group consisting of steroids satisfying structural formula (I) and prodrugs thereof, wherein the dotted lines each independently indicate an optional bond.
PCT/EP1999/001404 1998-03-09 1999-03-03 New contraceptive kit for monotherapy WO1999045886A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PL99343428A PL343428A1 (en) 1998-03-09 1999-03-03 New contraceptive kit
AU31437/99A AU756882B2 (en) 1998-03-09 1999-03-03 New contraceptive kit
BR9908605-0A BR9908605A (en) 1998-03-09 1999-03-03 Contraceptive kit, use of a steroid compound, and contraception process
JP2000535302A JP2002506014A (en) 1998-03-09 1999-03-03 New contraceptive kit
IL13754199A IL137541A0 (en) 1998-03-09 1999-03-03 New contraceptive kit
NZ506115A NZ506115A (en) 1998-03-09 1999-03-03 Contraceptive kit containing a compound with both estrogenic and progestagenic activity
KR1020007009917A KR20010041698A (en) 1998-03-09 1999-03-03 New contraceptive kit
EP99939157A EP1061928A2 (en) 1998-03-09 1999-03-03 New contraceptive kit
HU0101007A HUP0101007A3 (en) 1998-03-09 1999-03-03 Contraceptive kit for monotherapy
CA002319765A CA2319765A1 (en) 1998-03-09 1999-03-03 New contraceptive kit
NO20004492A NO20004492D0 (en) 1998-03-09 2000-09-08 New contraceptive set for monotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200744 1998-03-09
EP98200744.5 1998-03-09

Publications (2)

Publication Number Publication Date
WO1999045886A2 WO1999045886A2 (en) 1999-09-16
WO1999045886A3 true WO1999045886A3 (en) 1999-12-02

Family

ID=8233452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/001404 WO1999045886A2 (en) 1998-03-09 1999-03-03 New contraceptive kit for monotherapy

Country Status (20)

Country Link
EP (1) EP1061928A2 (en)
JP (1) JP2002506014A (en)
KR (1) KR20010041698A (en)
CN (1) CN1292702A (en)
AR (1) AR018313A1 (en)
AU (1) AU756882B2 (en)
BR (1) BR9908605A (en)
CA (1) CA2319765A1 (en)
CO (1) CO5070598A1 (en)
HU (1) HUP0101007A3 (en)
ID (1) ID25621A (en)
IL (1) IL137541A0 (en)
NO (1) NO20004492D0 (en)
NZ (1) NZ506115A (en)
PE (1) PE20000330A1 (en)
PL (1) PL343428A1 (en)
RU (1) RU2225714C2 (en)
TR (1) TR200002593T2 (en)
WO (1) WO1999045886A2 (en)
ZA (1) ZA991851B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051214A2 (en) * 1998-04-07 1999-10-14 Akzo Nobel N.V. Progestogen-only contraceptive kit
AU770331B2 (en) 1999-09-06 2004-02-19 N.V. Organon Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
JP2004505093A (en) 2000-07-28 2004-02-19 アクゾ・ノベル・エヌ・ベー 16α-methyl or ethyl substituted estrogens
AU2003213842A1 (en) * 2002-03-11 2003-09-29 Janssen Pharmaceutica N.V. Sulfatase inhibiting continuous progestogen contraceptive regimens
WO2003077927A1 (en) * 2002-03-11 2003-09-25 Janssen Pharmaceutica N.V. Sulfatase inhibiting progestogen-only contraceptive regimens
UA89964C2 (en) 2004-09-08 2010-03-25 Н.В. Органон 15beta-substituted steroids having selective estrogenic activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292251A (en) * 1977-02-10 1981-09-29 Akzona Incorporated 11β-Substituted steroids
WO1994004157A1 (en) * 1992-08-21 1994-03-03 Schering Aktiengesellschaft Transdermal application agent containing 3-keto-desogestrel
WO1994018224A1 (en) * 1993-02-08 1994-08-18 Akzo Nobel N.V. Steroids for treating menopausal complaints

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292251A (en) * 1977-02-10 1981-09-29 Akzona Incorporated 11β-Substituted steroids
WO1994004157A1 (en) * 1992-08-21 1994-03-03 Schering Aktiengesellschaft Transdermal application agent containing 3-keto-desogestrel
WO1994018224A1 (en) * 1993-02-08 1994-08-18 Akzo Nobel N.V. Steroids for treating menopausal complaints

Also Published As

Publication number Publication date
PL343428A1 (en) 2001-08-13
RU2225714C2 (en) 2004-03-20
KR20010041698A (en) 2001-05-25
CA2319765A1 (en) 1999-09-16
CO5070598A1 (en) 2001-08-28
AR018313A1 (en) 2001-11-14
JP2002506014A (en) 2002-02-26
WO1999045886A2 (en) 1999-09-16
IL137541A0 (en) 2001-07-24
BR9908605A (en) 2001-04-24
ID25621A (en) 2000-10-19
AU756882B2 (en) 2003-01-23
EP1061928A2 (en) 2000-12-27
NO20004492L (en) 2000-09-08
CN1292702A (en) 2001-04-25
AU3143799A (en) 1999-09-27
NO20004492D0 (en) 2000-09-08
NZ506115A (en) 2003-07-25
TR200002593T2 (en) 2000-12-21
PE20000330A1 (en) 2000-05-16
ZA991851B (en) 1999-09-22
HUP0101007A3 (en) 2002-02-28
HUP0101007A2 (en) 2001-12-28

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