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WO1999045011A8 - Glycine transport inhibitors - Google Patents

Glycine transport inhibitors

Info

Publication number
WO1999045011A8
WO1999045011A8 PCT/EP1999/001308 EP9901308W WO9945011A8 WO 1999045011 A8 WO1999045011 A8 WO 1999045011A8 EP 9901308 W EP9901308 W EP 9901308W WO 9945011 A8 WO9945011 A8 WO 9945011A8
Authority
WO
WIPO (PCT)
Prior art keywords
glycine transport
transport inhibitors
preparation
piperidinebutanamides
epilepsy
Prior art date
Application number
PCT/EP1999/001308
Other languages
French (fr)
Other versions
WO1999045011A1 (en
Inventor
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002322136A priority Critical patent/CA2322136A1/en
Priority to EP99937930A priority patent/EP1058684A1/en
Priority to KR1020007006314A priority patent/KR20010032967A/en
Priority to HU0101281A priority patent/HUP0101281A3/en
Priority to BR9907953-4A priority patent/BR9907953A/en
Priority to JP2000534553A priority patent/JP2002505332A/en
Priority to AU32544/99A priority patent/AU3254499A/en
Priority to PL99342818A priority patent/PL342818A1/en
Priority to IL138227??A priority patent/IL138227A0/en
Priority to EEP200000483A priority patent/EE200000483A/en
Application filed by Janssen Pharmaceutica Nv, Walter Herman Maria Lou Luyten, Frans Eduard Janssens, Ludo Edmond Josephine Kennis filed Critical Janssen Pharmaceutica Nv
Priority to SK1309-2000A priority patent/SK13092000A3/en
Publication of WO1999045011A1 publication Critical patent/WO1999045011A1/en
Publication of WO1999045011A8 publication Critical patent/WO1999045011A8/en
Priority to HR20000524A priority patent/HRP20000524A2/en
Priority to BG104686A priority patent/BG104686A/en
Priority to NO20004432A priority patent/NO20004432L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

The present invention is concerned with the use of glycine transport inhibiting α,α-diphenyl-1-piperidinebutanamides for the preparation of medicaments for treating disorders of the central and peripheral nervous system, in particular psychoses, pain, epilepsy, neurodegenerative diseases (Alzheimer's disease), stroke, head trauma, multiple sclerosis and the like. The invention further comprises novel compounds, their preparation and their pharmaceutical forms.
PCT/EP1999/001308 1998-03-06 1999-02-26 Glycine transport inhibitors WO1999045011A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IL138227??A IL138227A0 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
KR1020007006314A KR20010032967A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
HU0101281A HUP0101281A3 (en) 1998-03-06 1999-02-26 Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing them
BR9907953-4A BR9907953A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
JP2000534553A JP2002505332A (en) 1998-03-06 1999-02-26 Glycine transport inhibitor
AU32544/99A AU3254499A (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
PL99342818A PL342818A1 (en) 1998-03-06 1999-02-26 Glycin transport inhibitors
CA002322136A CA2322136A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
EP99937930A EP1058684A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
EEP200000483A EE200000483A (en) 1998-03-06 1999-02-26 Use of a Glycine Transfer Inhibitory Compound in the manufacture of a medicament, a compound, a composition comprising it, and a process for the preparation of the compound and
SK1309-2000A SK13092000A3 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors
HR20000524A HRP20000524A2 (en) 1998-03-06 2000-08-02 Gylcine transport inhibitors
BG104686A BG104686A (en) 1998-03-06 2000-08-11 Glycine transport inhibitors
NO20004432A NO20004432L (en) 1998-03-06 2000-09-05 Glysintransportinhibitorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200700.7 1998-03-06
EP98200700 1998-03-06

Publications (2)

Publication Number Publication Date
WO1999045011A1 WO1999045011A1 (en) 1999-09-10
WO1999045011A8 true WO1999045011A8 (en) 1999-10-14

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PCT/EP1999/001308 WO1999045011A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

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KR (1) KR20010032967A (en)
CN (1) CN1291984A (en)
AU (1) AU3254499A (en)
BG (1) BG104686A (en)
BR (1) BR9907953A (en)
CA (1) CA2322136A1 (en)
EE (1) EE200000483A (en)
HR (1) HRP20000524A2 (en)
HU (1) HUP0101281A3 (en)
IL (1) IL138227A0 (en)
NO (1) NO20004432L (en)
PL (1) PL342818A1 (en)
SK (1) SK13092000A3 (en)
TR (1) TR200002570T2 (en)
WO (1) WO1999045011A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
EP1318802A2 (en) 2000-09-08 2003-06-18 Gliatech, Inc. Substituted hydrazine derivatives
EP1324986A1 (en) * 2000-09-14 2003-07-09 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AU2001294240A1 (en) * 2000-10-12 2002-04-22 Ssp Co., Ltd. 2,2-diphenylbutanamide derivatives and medicines containing the same
AR032653A1 (en) 2001-02-09 2003-11-19 Telik Inc HYPERCYCLIC INHIBITORS OF THE GLICINE TRANSPORTER 2 PHARMACEUTICAL COMPOSITIONS, USE AND METHODS.
JPWO2003082819A1 (en) * 2002-04-01 2005-08-04 日本ケミファ株式会社 N-phenyl-N- (4-piperidinyl) amide derivatives
FR2838739B1 (en) * 2002-04-19 2004-05-28 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL) BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
FR2842804B1 (en) 2002-07-29 2004-09-03 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2842805A1 (en) * 2002-07-29 2004-01-30 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND APPLICATION THERAPEUTICS
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
KR100729878B1 (en) * 2003-02-17 2007-06-18 에프. 호프만-라 로슈 아게 Piperidine-benzenesulfonamide derivatives
BRPI0413497B8 (en) 2003-08-11 2021-05-25 Hoffmann La Roche piperazine with or substituting phenyl group, and its use and preparation process, as well as medicine
FR2861070B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo DERIVATIVES OF N- [PHENYL (PYRROLIDIN-2-YL) METHYL] BENZAMIDE AND N - [(AZEPAN-2-YL) PHENYLMETHYL] BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861071B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo N- [PHENYL (ALKYLPIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2861076B1 (en) 2003-10-17 2006-01-06 Sanofi Synthelabo N-HETEROCYCLYMETHYLBENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
WO2005058317A1 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Glycine transporter-1 inhibirors
BRPI0506548A (en) * 2004-01-30 2007-05-02 Euro Celtique Sa Methods for Making 4-Tetrazolyl-4-Phenylpiperidine Compounds
GB0408774D0 (en) * 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
NZ555290A (en) 2004-12-09 2009-09-25 Hoffmann La Roche Phenyl-piperazin methanone derivatives
RU2007121768A (en) 2004-12-15 2009-01-27 Ф. Хоффманн-Ля Рош Аг (Ch) BI- AND TRICYCLIC SUBSTITUTED PHENYLMETHANONES AS Glycine 1 (GLYT-1) CARRIER INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
JP5006799B2 (en) 2005-01-07 2012-08-22 エフ．ホフマン−ラ ロシュ アーゲー [4- (Heteroaryl) piperazin-1-yl]-(2,5-substituted phenyl) -methanone derivatives as glycine transporter 1 (GLYT-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
DE602006007682D1 (en) 2005-01-18 2009-08-20 Hoffmann La Roche 2.5-DISUBSTITUTED PHENYLMETHANONE DERIVATIVES AS GLYCINTRANSPORTER-1 INHIBITORS (GLYT-1) FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDER
DE602006010175D1 (en) 2005-01-26 2009-12-17 Hoffmann La Roche PHENYLMETHANONE DERIVATIVES AND THEIR USE AS GLYCIN TRANSPORTER 1 HEMMER
DK1848694T3 (en) 2005-02-07 2010-01-25 Hoffmann La Roche Heterocyclic substituted phenylmethanones as inhibitors of glycine transport
AU2006231917B2 (en) 2005-04-08 2011-07-28 Pfizer Products Inc. Bicyclic [3.1.0] heteroaryl amides as type I glycine transport inhibitors
WO2009010479A2 (en) * 2007-07-13 2009-01-22 Euroscreen S.A. Heterocyclic methylene piperidine derivatives and their use
WO2010065701A1 (en) * 2008-12-04 2010-06-10 Sanofi-Aventis Novel polymorphic forms of an azabicyclo-trifluoromethyl benzamide derivative
CN102766080B (en) * 2011-05-06 2015-09-23 上海医药工业研究院 One class pyrrolidin derivatives, its preparation method and application
JP5893135B2 (en) * 2011-06-28 2016-03-23 ビボゾーン インコーポレイテッド Combinations of active substances that induce the synergistic effect of multiple targeting and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714159A (en) * 1971-03-30 1973-01-30 Janssen Pharmaceutica Nv 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
CA1332236C (en) * 1985-10-11 1994-10-04 Lourens Wals –,-–-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, n-oxides
JP4403212B2 (en) * 1996-05-31 2010-01-27 エヌピーエス ファーマシューティカルズ インコーポレイテッド Pharmaceutical agents for the treatment of neurological and neuropsychological disorders

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PL342818A1 (en) 2001-07-02
AU3254499A (en) 1999-09-20
BG104686A (en) 2001-04-30
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IL138227A0 (en) 2001-10-31
EP1058684A1 (en) 2000-12-13
HUP0101281A3 (en) 2001-11-28
HUP0101281A2 (en) 2001-09-28
EE200000483A (en) 2002-02-15
JP2002505332A (en) 2002-02-19
NO20004432D0 (en) 2000-09-05
NO20004432L (en) 2000-11-02
CN1291984A (en) 2001-04-18
CA2322136A1 (en) 1999-09-10
HRP20000524A2 (en) 2001-02-28
BR9907953A (en) 2000-10-24
WO1999045011A1 (en) 1999-09-10
SK13092000A3 (en) 2001-03-12

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