WO1998057149B1 - A method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment - Google Patents
A method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodimentInfo
- Publication number
- WO1998057149B1 WO1998057149B1 PCT/RU1998/000128 RU9800128W WO9857149B1 WO 1998057149 B1 WO1998057149 B1 WO 1998057149B1 RU 9800128 W RU9800128 W RU 9800128W WO 9857149 B1 WO9857149 B1 WO 9857149B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radiation
- metal layer
- plasmon resonance
- surface plasmon
- interference
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 13
- 239000000126 substance Substances 0.000 title claims abstract 8
- 230000005855 radiation Effects 0.000 claims abstract 47
- 239000002184 metal Substances 0.000 claims abstract 35
- 239000000463 material Substances 0.000 claims abstract 24
- 230000035945 sensitivity Effects 0.000 claims abstract 3
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 34
- 230000015572 biosynthetic process Effects 0.000 claims 11
- 230000003993 interaction Effects 0.000 claims 9
- 239000000470 constituent Substances 0.000 claims 6
- 230000005672 electromagnetic field Effects 0.000 claims 6
- 230000005670 electromagnetic radiation Effects 0.000 claims 6
- 230000007704 transition Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract 1
Abstract
Technical field: examinations of biological, biochemical, and chemical characteristics of media, mainly of biologic origin, or media that are in contact with biological objects whose living is influenced by the media characteristics. Principle: one excites surface plasmon polaritons on a metal layer covered with a material sensitive to the examined characteristics of a medium, produces an interference with a beam of radiation reflected under these conditions and a reference beam, records parameters of a spatial intensity distribution in the resulting interference pattern, and judges the examined characteristics on the basis of the recorded parameters. The proposed method and apparatus ensure the technical result that consists in upgrading of sensitivity and resolution of measurements, at least, by two orders.
Claims
1. A method of examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
- introducing a volume or a constituent of a medium under test into contact with a sensitive material;
- acting by electromagnetic radiation through a transparent body on a metal layer located on a boundary surface of the body, said sensitive material being placed on said boundary surface above the metal layer directly or through an intermediate material;
- providing a surface plasmon resonance by means of said acting;
- reflecting partially said radiation under said surface plasmon resonance from said metal layer, with formation of a reflected beam;
- using said reflected beam for producing a spatial distribution of electromagnetic field intensity, which is determined by said surface plasmon resonance;
- recording parameters of said distribution, from which the examined characteristics are judged; wherein said distribution is produced using interference of said reflected beam and, at least, one more radiation beam, which differs from said reflected beam in position and/or direction in space anywhere over its propagation path preceding to the interference, at a number or within a band of frequencies chosen among the frequencies inherent in said radiation.
2. A method according to claim 1, wherein one controls sensitivity of parameters of said distribution to the interaction of the medium under test with said sensitive material by choosing a frequency (frequencies) within said number or band, at which parameters of said distribution are recorded.
3. A method according to claim 1 or 2, wherein said interference occurs at a plane where the phase difference between two beams participating in said interference and their frequency undergo the most rapid changes along different directions which are orthogonal or tilted to each other.
4. A method of examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
- introducing a volume or a constituent of a medium under test into contact with a sensitive material;
- acting by electromagnetic radiation through a transparent body on a metal layer located on a boundary surface of the body, said sensitive material being placed on said boundary surface above the metal layer directly or through an intermediate material;
- providing a surface plasmon resonance by means of said acting;
- reflecting partially said radiation under said surface plasmon resonance from said metal layer, with formation of a reflected beam;
- using said reflected beam for producing a spatial distribution of electromagnetic field intensity, which is determined by said surface plasmon resonance;
- recording parameters of said distribution, from which the examined characteristics are judged; wherein said distribution is produced using interference of, at least, two beams, said reflected beam and a second radiation beam reflected from said metal layer, said second beam differing from the former beam in position and/or direction in space anywhere over its propagation path preceding to the interference.
5. A method according to claim 4, wherein said radiation includes two components with mutually orthogonal polarisation directions, and said distribution is produced using interference of said two beams, each one comprising one of said components.
6. A method according to any one of claims 1, 2, 4, 5, wherein said interference occurs at a plane where the angle of incidence of said radiation on said metal layer and the phase difference between two beams participating in said interference undergo the most rapid changes along different directions which are orthogonal or tilted to each other.
7. A method of examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
21
- introducing a volume or a constituent of a medium under test into contact with a sensitive material;
- acting by electromagnetic radiation through a transparent body on a metal layer located on a boundary surface of the body, said sensitive material being placed on said boundary surface above the metal layer directly or through an intermediate material;
- providing a surface plasmon resonance by means of said acting;
- reflecting partially said radiation under said surface plasmon resonance from said metal layer, with formation of a reflected beam;
- using said reflected beam for producing a spatial distribution of electromagnetic field intensity, which is determined by said surface plasmon resonance;
- recording parameters of said distribution, from which the examined characteristics are judged; wherein said distribution is produced using interference of said reflected beam and, at least, one more radiation beam, which differs from said reflected beam in position and/or direction in space anywhere over its propagation path preceding to the interference, and on said boundary surface there is a layer that influences said surface plasmon resonance and has a pre-assigned variation in its thickness over said boundary surface, and one controls sensitivity of parameters of said distribution to the interaction of the medium under test with said sensitive material by choosing on said boundary surface an area, which accounts for said distribution through partial reflection of said radiation from this area under said surface plasmon resonance with the formation of said reflected beam.
8. A method according to claim 7, wherein said layer that influences said surface plasmon resonance and has a pre-assigned variation in its thickness over said boundary surface is said metal layer.
9. A method according to claim 7, wherein said layer that influences said surface plasmon resonance and has a pre-assigned variation in its thickness over said boundary surface is the layer of said sensitive material.
10. A method according to any one of claims 1-9, or their combination, wherein in said distribution there are provided two different directions which can serve as co-ordinate axes, orthogonal or tilted to each other, such that the phase difference between two beams
22 participating in said interference undergoes the most rapid change along one direction and along the other direction there occurs the most rapid change of a first parameter relevant to said surface plasmon resonance, such as frequency of said radiation, or angle of incidence of said radiation on said metal layer, or thickness of a layer on said boundary surface, and the interaction of the medium under test with said sensitive material is monitored by a change of the slope, or the sign of the slope, of interference fringes within said distribution near the value of said first parameter that corresponds to said surface plasmon resonance, with respect to said co-ordinate axes.
11. A method according to any one of claims 1-9, or their combination, wherein said distribution comprises two directions which can serve as co-ordinate axes, orthogonal or tilted to each other, such that the phase difference between two beams participating in said interference undergoes the most rapid change along one direction and along the other direction there occurs the most rapid change of a first parameter relevant to said surface plasmon resonance, such as frequency of said radiation, or angle of incidence of said radiation on said metal layer, or thickness of a layer on said boundary surface, and one uses a variation in a second parameter, different from said first parameter and relevant to said surface plasmon resonance, such as frequency of said radiation, or angle of incidence of said radiation on said metal layer, or thickness of a layer on said boundary surface, to approach that value of said second parameter, at which interference fringes within said distribution change the sign of their slope near the value of said first parameter that corresponds to said surface plasmon resonance or have no distinct sign under transition from one sign of the slope to the other, with respect to said co-ordinate axes.
12. An apparatus for examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
- a source of electromagnetic radiation,
- a transparent body,
- a metal layer located on a boundary surface of the transparent body,
- a sensitive material placed on said boundary surface above said metal layer directly or through an intermediate material,
23
- a unit for introducing a volume or a constituent of a medium under test into contact with said sensitive material, all being positioned so that radiation from said source is directed on said metal layer through said transparent body, thereby providing a surface plasmon resonance and partial reflection of said radiation under said surface plasmon resonance from said metal layer with formation of a reflected beam, and
- a means for producing, with the use of said reflected beam, a spatial electromagnetic field intensity distribution, which is determined by said surface plasmon resonance,
- a block for recording parameters of said distribution to obtain an output information signal, wherein said means comprises facilities (facility) for separating radiation, which comes from said source, into, at least, two beams that differ from each other in position and/or direction in space, one of the beams comprising radiation that participates in formation of said reflected beam, and bringing radiation from said two beams to an area where interference of radiation from these beams occurs, the position of said block being appropriate to the position of said area of interference, and, besides, said source allows one to specify a discrete or continuous set of frequencies of the outgoing radiation, and said block allows said recording at a number, or within a band, of frequencies that belong to said set.
13. An apparatus for examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
- a source of electromagnetic radiation,
- a transparent body,
- a metal layer located on a boundary surface of the transparent body,
- a sensitive material placed on said boundary surface above said metal layer directly or through an intermediate material,
- a unit for introducing a volume or a constituent of a medium under test into contact with said sensitive material, all being positioned so that radiation from said source is directed on said metal layer through said transparent body, thereby providing a surface plasmon resonance and partial
24 reflection of said radiation under said surface plasmon resonance from said metal layer with formation of a reflected beam, and
- a means for producing, with the use of said reflected beam, a spatial electromagnetic field intensity distribution, which is determined by said surface plasmon resonance,
- a block for recording parameters of said distribution to obtain an output information signal, wherein said means comprises facilities (facility) for separating radiation, which comes from said source, into, at least, two beams that both comprise radiation incident on, or reflected from, said metal layer and differ from each other in position and/or direction in space, one of the beams comprising radiation that participates in formation of said reflected beam, and bringing radiation from said two beams to an area where interference of radiation from these beams occurs, the position of said block being appropriate to the position of said area of interference.
14. An apparatus according to claim 13, wherein said facility for separating radiation is designed so as to yield said two beams with polarisation directions orthogonal to each other.
15. An apparatus for examining biological, biochemical, chemical characteristics of media, including characteristics of media interactions with surfaces and superficial layers, which comprises:
- a source of electromagnetic radiation,
- a transparent body,
- a metal layer located on a boundary surface of the transparent body,
- a sensitive material placed on said boundary surface above said metal layer directly or through an intermediate material,
- a unit for introducing a volume or a constituent of a medium under test into contact with said sensitive material, all being positioned so that radiation from said source is directed on said metal layer through said transparent body, thereby providing a surface plasmon resonance and partial reflection of said radiation under said surface plasmon resonance from said metal layer with formation of a reflected beam, and
- a means for producing, with the use of said reflected beam, a spatial electromagnetic field intensity distribution, which is determined by said surface plasmon resonance,
- a block for recording parameters of said distribution to obtain an output information signal, wherein said means comprises facilities (facility) for separating radiation, which comes from said source, into, at least, two beams that differ from each other in position and/or direction in space, one of the beams comprising radiation that participates in formation of said reflected beam, and bringing radiation from said two beams to an area where interference of radiation from these beams occurs, the position of said block being appropriate to the position of said area of interference, and, besides, on said boundary surface there is a layer that has a pre-assigned variation in its thickness over said boundary surface and influences said surface plasmon resonance, and there is provided a means for choosing on said boundary surface an area, which accounts for said distribution through partial reflection of said radiation from this area under said surface plasmon resonance with the formation of said reflected beam.
16. An apparatus according to claim 15, wherein said layer that has a pre-assigned variation in its thickness over said boundary surface and influences said surface plasmon resonance is said metal layer.
17. An apparatus according to claim 15, wherein said layer that has a pre-assigned variation in its thickness over said boundary surface and influences said surface plasmon resonance is the layer of said sensitive material.
18. An apparatus according to claim 15, wherein said means for choosing on said boundary surface an area is a means scanning the irradiated spot over said boundary surface.
19. An apparatus according to any one of claims 12-18, or their combination, wherein there is provided a number or a range of values of a first parameter relevant to said surface plasmon resonance, such as frequency of said radiation, or angle of incidence of said radiation on said metal layer, or thickness of a layer on said boundary surface, and
26 said facilities (facility) for separating radiation and bringing radiation are (is) designed so that in said area of interference there are two different directions, orthogonal or tilted to each other, one being the direction of the most rapid change in the phase difference between two beams participating in said interference, and the other being the direction of the most rapid change of said first parameter.
20. An apparatus according to claim 19, wherein said first parameter is the angle of incidence of said radiation on said metal layer, and there is provided a means to form a beam incident on or reflected from said metal layer, which is divergent or convergent in the plane of incidence of the axial ray of that beam on said metal layer, and said facility for separating and bringing radiation is designed so as to split said divergent or convergent beam into two beams that have mutually orthogonal polarisation directions and overlap within said area of interference, the direction of said split lying out of said plane of incidence.
21. An apparatus according to claim 19 or 20, wherein there is provided a variation in a second parameter, different from said first parameter and relevant to said surface plasmon resonance, such as frequency of said radiation, or angle of incidence of said radiation on said metal layer, or thickness of a layer on said boundary surface, said variation affecting the slope of interference fringes within said area of interference near the value of said first parameter that corresponds to said surface plasmon resonance, with respect to co-ordinate axes coincident with said two directions.
27
STATEMENT UNDER ARTICLE 19
Claims 1-14 as filed were replaced by amended claims 1-14 and new claims 15-21 were added which used claims as filed and the description of the International application
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU75576/98A AU7557698A (en) | 1997-06-11 | 1998-05-07 | A method of examining biological, biochemical, and chemical characteristics of amedium and apparatus for its embodiment |
| EP98923239A EP0988522A1 (en) | 1997-06-11 | 1998-05-07 | A method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment |
| US09/445,686 US6628376B1 (en) | 1997-06-11 | 1998-05-07 | Method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU97109315 | 1997-06-11 | ||
| RU97109315A RU2141645C1 (en) | 1997-06-11 | 1997-06-11 | Method and device for examination of biological, biochemical and chemical characteristics of media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998057149A1 WO1998057149A1 (en) | 1998-12-17 |
| WO1998057149B1 true WO1998057149B1 (en) | 1999-02-04 |
Family
ID=20193769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU1998/000128 WO1998057149A1 (en) | 1997-06-11 | 1998-05-07 | A method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6628376B1 (en) |
| EP (1) | EP0988522A1 (en) |
| AU (1) | AU7557698A (en) |
| RU (1) | RU2141645C1 (en) |
| WO (1) | WO1998057149A1 (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL146207A (en) * | 1999-05-17 | 2005-05-17 | Florida Internat University | Surface plasmon resonance detection with high angular resolution and fast response time |
| IL131903A0 (en) * | 1999-09-15 | 2001-03-19 | Technion Res & Dev Foundation | Plasmon resonance phase imaging |
| DE10006083B4 (en) | 2000-02-11 | 2004-01-22 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Method for the quantitative and / or qualitative determination of layer thicknesses as well as a microreaction vessel and a titer plate |
| DE10020313C1 (en) * | 2000-04-20 | 2001-07-05 | Cybio Systems Gmbh | Arrangement for electrochemical analysis in biochemical processes, comprises a light bundle which leaves the acoustically adjustable filter and is simultaneously directed onto the receiving surfaces of several waveguides |
| RU2181487C2 (en) * | 2000-05-11 | 2002-04-20 | Никитин Петр Иванович | Process of optical detection of attachment of real component to sensor material based on biological, chemical or physical coupling and device for its implementation ( variants ) |
| DE60213056T2 (en) * | 2001-12-25 | 2007-01-04 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Sensor system with evanescent waves |
| EP1411383A1 (en) * | 2002-10-14 | 2004-04-21 | Agilent Technologies, Inc. - a Delaware corporation - | Surface plasmon resonance optical notch filter apparatus and method therefor |
| WO2004059301A1 (en) | 2002-12-25 | 2004-07-15 | Proteoptics Ltd. | Surface plasmon resonance sensor |
| RU2257577C2 (en) * | 2003-09-23 | 2005-07-27 | Курский государственный университет | Lipid structure-phase conversions in aqueous solutions |
| US7420682B2 (en) * | 2003-09-30 | 2008-09-02 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Sensor device for interference and plasmon-waveguide/interference spectroscopy |
| US20050070027A1 (en) | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
| EP1668334A1 (en) * | 2003-09-30 | 2006-06-14 | The Arizona Board of Regents on Behalf of the University of Arizona | Sensor device for interference and plasmon-waveguide/interference spectroscopy |
| RU2356033C2 (en) * | 2003-10-16 | 2009-05-20 | НАРД Инститьют, Лтд. | Method of measuring surface plasmon resonance (versions) noble metal compound used for this method |
| US7804592B2 (en) | 2003-10-16 | 2010-09-28 | Nard Institute, Ltd. | Method for measuring a surface plasmon resonance and noble metal compound used for the same |
| RU2251681C1 (en) * | 2003-10-23 | 2005-05-10 | Алиева Елена Владимировна | Method and device for registering biological, chemical and biochemical processes at liquid-solid body boundary |
| CN1894576B (en) * | 2003-11-19 | 2010-04-28 | 比恩诺尔股份公司 | Method and apparatus for actuating surface plasma resonance measuring |
| US7365855B2 (en) * | 2005-07-08 | 2008-04-29 | The Chinese University Of Hong Kong | Optical sensing devices with SPR sensors based on differential phase interrogation and measuring method using the same |
| US7532330B2 (en) * | 2005-08-16 | 2009-05-12 | Zygo Corporation | Angle interferometers |
| US7879619B2 (en) * | 2005-10-07 | 2011-02-01 | Tianwei Jing | Apparatus for detecting one or more substances and method of detecting a substance |
| US7233396B1 (en) * | 2006-04-17 | 2007-06-19 | Alphasniffer Llc | Polarization based interferometric detector |
| US7375808B2 (en) * | 2006-09-28 | 2008-05-20 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method and system for sensing and identifying foreign particles in a gaseous environment |
| US20090213383A1 (en) * | 2006-10-06 | 2009-08-27 | Nguyen Ly | Apparatus and method for detecting one or more substances |
| EP2221603A1 (en) * | 2009-02-18 | 2010-08-25 | Koninklijke Philips Electronics N.V. | Sensing device for detecting a target substance |
| TWI426260B (en) * | 2010-05-04 | 2014-02-11 | Univ Nat Central | Surface plasmon resonance measurement device |
| US8542353B2 (en) * | 2010-09-30 | 2013-09-24 | Precision Energy Services, Inc. | Refractive index sensor for fluid analysis |
| US8953168B2 (en) * | 2012-06-08 | 2015-02-10 | City University Of Hong Kong | Optical sensing devices and methods for detecting samples using the same |
| EP2741074A1 (en) * | 2012-12-04 | 2014-06-11 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
| RU2551372C1 (en) * | 2014-01-10 | 2015-05-20 | Федеральное государственное бюджетное учреждение науки Институт проблем управления им. В.А. Трапезникова Российской академии наук | Device for measurement of physical parameters of dielectric sheet material |
| RU169687U1 (en) * | 2016-08-17 | 2017-03-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" | Plasmon-polariton two-resonance sensor |
| WO2019176157A1 (en) * | 2018-03-15 | 2019-09-19 | 三菱電機株式会社 | Biological material measurement device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2197068B (en) * | 1986-11-03 | 1990-08-08 | Stc Plc | Optical sensor device |
| NL8700851A (en) * | 1987-04-10 | 1988-11-01 | Tno | METHOD AND APPARATUS FOR DETECTING VERY LOW CONCENTRATIONS OF A MEASURING MEDIA CHEMICAL COMPONENT USING SURFACE-PLASMON RESONANCE AND ELECTROCHEMICALLY STIMULATED ADSORPTION |
| CA1321488C (en) * | 1987-08-22 | 1993-08-24 | Martin Francis Finlan | Biological sensors |
| WO1989006354A1 (en) * | 1988-01-11 | 1989-07-13 | The Commonwealth Of Australia | Differential ellipsometer |
| GB8801807D0 (en) | 1988-01-27 | 1988-02-24 | Amersham Int Plc | Biological sensors |
| GB2248497B (en) * | 1990-09-26 | 1994-05-25 | Marconi Gec Ltd | An optical sensor |
| EP0517930B1 (en) * | 1991-06-08 | 1995-05-24 | Hewlett-Packard GmbH | Method and apparatus for detecting the presence and/or concentration of biomolecules |
| RU2022247C1 (en) * | 1991-10-18 | 1994-10-30 | Всеволод Петрович Редько | Method and device for measuring parameters of modes of planar optical waveguides |
| GB2268800A (en) | 1992-07-10 | 1994-01-19 | Marconi Gec Ltd | Optical sensor |
| DE69321191T2 (en) * | 1992-11-17 | 1999-04-29 | Hoechst Ag, 65929 Frankfurt | Optical sensor for the detection of chemical species |
| DE4439900A1 (en) * | 1994-11-08 | 1996-05-09 | Boehringer Mannheim Gmbh | Measurement of glucose concn. in a biological sample |
-
1997
- 1997-06-11 RU RU97109315A patent/RU2141645C1/en not_active IP Right Cessation
-
1998
- 1998-05-07 WO PCT/RU1998/000128 patent/WO1998057149A1/en not_active Application Discontinuation
- 1998-05-07 US US09/445,686 patent/US6628376B1/en not_active Expired - Fee Related
- 1998-05-07 EP EP98923239A patent/EP0988522A1/en not_active Withdrawn
- 1998-05-07 AU AU75576/98A patent/AU7557698A/en not_active Abandoned
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