[go: up one dir, main page]

WO1998049317A3 - Diagnosis and treatment of phosphatase- 0r kinase-related disorders - Google Patents

Diagnosis and treatment of phosphatase- 0r kinase-related disorders Download PDF

Info

Publication number
WO1998049317A3
WO1998049317A3 PCT/US1998/008439 US9808439W WO9849317A3 WO 1998049317 A3 WO1998049317 A3 WO 1998049317A3 US 9808439 W US9808439 W US 9808439W WO 9849317 A3 WO9849317 A3 WO 9849317A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphatase
kinase
diagnosis
treatment
polypeptides
Prior art date
Application number
PCT/US1998/008439
Other languages
French (fr)
Other versions
WO1998049317A2 (en
Inventor
Greg D Plowman
Douglas Clary
Bahija Jallal
Elior Peles
Susan Onrust
Dave Markby
Sara A Courtneidge
Harald App
Terance H Hui
Original Assignee
Sugen Inc
Greg D Plowman
Douglas Clary
Bahija Jallal
Elior Peles
Susan Onrust
Dave Markby
Sara A Courtneidge
Harald App
Terance H Hui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Greg D Plowman, Douglas Clary, Bahija Jallal, Elior Peles, Susan Onrust, Dave Markby, Sara A Courtneidge, Harald App, Terance H Hui filed Critical Sugen Inc
Priority to JP54724498A priority Critical patent/JP2002513289A/en
Priority to AU72600/98A priority patent/AU7260098A/en
Priority to CA002288221A priority patent/CA2288221A1/en
Priority to EP98919919A priority patent/EP0979288A2/en
Publication of WO1998049317A2 publication Critical patent/WO1998049317A2/en
Publication of WO1998049317A3 publication Critical patent/WO1998049317A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to phosphatases and kinases, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for phosphatase- or kinase-related diseases or conditions characterized by an abnormal interaction between a phosphatase or a kinase and its binding partner.
PCT/US1998/008439 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase- 0r kinase-related disorders WO1998049317A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP54724498A JP2002513289A (en) 1997-04-28 1998-04-27 Diagnosis and treatment of tyrosine phosphatase-related diseases and related methods
AU72600/98A AU7260098A (en) 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase 0r kinase-related disorders
CA002288221A CA2288221A1 (en) 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase 0r kinase-related disorders
EP98919919A EP0979288A2 (en) 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase- or kinase-related disorders

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US4442897P 1997-04-28 1997-04-28
US60/044,428 1997-04-28
US4722297P 1997-05-20 1997-05-20
US60/047,222 1997-05-20
US4975697P 1997-06-11 1997-06-11
US4947797P 1997-06-11 1997-06-11
US60/049,477 1997-06-11
US60/049,756 1997-06-11
US4991497P 1997-06-18 1997-06-18
US60/049,914 1997-06-18
US6359597P 1997-10-23 1997-10-23
US60/063,595 1997-10-23

Publications (2)

Publication Number Publication Date
WO1998049317A2 WO1998049317A2 (en) 1998-11-05
WO1998049317A3 true WO1998049317A3 (en) 1999-02-25

Family

ID=27556472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/008439 WO1998049317A2 (en) 1997-04-28 1998-04-27 Diagnosis and treatment of phosphatase- 0r kinase-related disorders

Country Status (5)

Country Link
EP (1) EP0979288A2 (en)
JP (1) JP2002513289A (en)
AU (1) AU7260098A (en)
CA (1) CA2288221A1 (en)
WO (1) WO1998049317A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2220853A1 (en) * 1998-01-16 1999-07-16 Hsc Research And Development Limited Partnership Human lymphoid protein tyrosine phosphatases
WO2000063392A1 (en) * 1999-04-16 2000-10-26 Kyowa Hakko Kogyo Co., Ltd. Novel tyrosine phosphatase
EP1046715A1 (en) * 1999-04-23 2000-10-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
CA2394753A1 (en) * 2000-01-18 2001-07-26 Human Genome Sciences, Inc. Human protein tyrosine phosphatase polynucleotides, polypeptides, and antibodies
AU2002233201A1 (en) * 2000-11-27 2002-06-03 Bayer Aktiengesellschaft Regulation of human tyrosine phosphatase
ATE328112T1 (en) * 2003-03-07 2006-06-15 Ist Naz Stud Cura Dei Tumori ANAPLASTIC LYMPHOMA KINASE TESTING METHODS, REAGENTS AND COMPOSITIONS THEREOF
JP2007526337A (en) 2004-03-02 2007-09-13 アクセルロン ファーマ インコーポレーテッド ALK7 and myostatin inhibitors and uses thereof
JPWO2007037532A1 (en) * 2005-09-30 2009-04-16 リンク・ジェノミクス株式会社 Therapeutic or diagnostic use of SRMS gene
US20230374591A1 (en) * 2020-10-08 2023-11-23 The Trustees Of Dartmouth College Methods and agents for treating, preventing, diagnosing, and evaluating therapy for fibrotic, autoimmune, and inflammatory conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (en) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOVEL HUMAN cdc25 GENES, ENCODED PRODUCTS AND USES THEREFOR
WO1995006735A2 (en) * 1993-09-01 1995-03-09 The Ludwig Institute For Cancer Research Nucleotide sequences for novel protein tyrosine phosphatases
WO1996034985A1 (en) * 1995-05-05 1996-11-07 Sugen, Inc. Assay and method for transcript imaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (en) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOVEL HUMAN cdc25 GENES, ENCODED PRODUCTS AND USES THEREFOR
WO1995006735A2 (en) * 1993-09-01 1995-03-09 The Ludwig Institute For Cancer Research Nucleotide sequences for novel protein tyrosine phosphatases
WO1996034985A1 (en) * 1995-05-05 1996-11-07 Sugen, Inc. Assay and method for transcript imaging

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AOKI N. ET AL.: "THE NOVEL PROTEIN-TYROSINE PHOSPHATASE PTP20 IS A POSITIVE REGULATOR OF PC12 CELL NEURONAL DIFFERENTIATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 46, 15 November 1996 (1996-11-15), pages 29422 - 29426, XP002053901 *
EMBL database entry HS1185621; accessionnumber AA281242; 4. April 1997; Robert Strausberg: 'National Cancer Institute, Cancer Genome Anatomy Project.' *
MAEKAWA K. ET AL.: "MOLECULAR CLONING OF A NOVEL PROTEIN-TYROSINE PHOSPHATASE CONTAINING A MEMBRANE-BINDING DOMAIN AND glgf REPEATS.", FEBS LETTERS, vol. 337, 1994, pages 200 - 206, XP002076842 *
MATTHEWS R. J. ET AL.: "Characterization of hematopoietic intracellular protein tyrosine phosphatases: Description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.", MOLECULAR AND CELLULAR BIOLOGY, vol. 12, no. 5, 1992, pages 2396 - 2405, XP002076841 *
SARAS J. ET AL.: "CLONING AND CHARACTERIZATION OF PTPL1, A PROTEIN TYROSINE PHOSPHATASE WITH SIMILARITIES TO CYTOSKELETAL-ASSOCIATED PROTEINS.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 39, 1994, pages 24082 - 24089, XP002076840 *

Also Published As

Publication number Publication date
JP2002513289A (en) 2002-05-08
WO1998049317A2 (en) 1998-11-05
AU7260098A (en) 1998-11-24
EP0979288A2 (en) 2000-02-16
CA2288221A1 (en) 1998-11-05

Similar Documents

Publication Publication Date Title
WO1999037788A3 (en) Diagnosis and treatment of aur1 and/or aur2 related disorders
CA2239692A1 (en) Diagnosis and treatment of aur-1 and/or aur-2 related disorders
WO1999024463A3 (en) Signal peptide-containing proteins
WO2001055310A3 (en) Nucleic acids, proteins, and antibodies
CA2294516A1 (en) Ikk-.beta. proteins, nucleic acids and methods
WO1998058052A3 (en) Disease associated protein kinases
WO2001054472A8 (en) Nucleic acids, proteins, and antibodies
WO2005007090A3 (en) Inhibitors of the map kinase pathway
WO2000018922A3 (en) Human carbohydrate-associated proteins
WO1998049317A3 (en) Diagnosis and treatment of phosphatase- 0r kinase-related disorders
WO1999058692A3 (en) Human apoptosis associated proteins
WO2002057460A3 (en) Polynucleotides encoding human phosphatases
WO2000044900A3 (en) Nucleic-acid binding proteins
WO1999061614A3 (en) Human socs proteins
WO2001055168A8 (en) Nucleic acids, proteins and antibodies
WO2003014142A3 (en) Phosphorylated histone h2b as an apoptosis marker
WO2000028045A3 (en) Human hydrolase proteins
WO1999031225A3 (en) Human phosphatases
WO1998059041A3 (en) Disease related nucleotide kinases
WO1996037610A3 (en) Cck-4, a receptor tyrosine kinase, and methods for diagnosis and treatment of cck-4 signal transduction disorders
WO1999049037A3 (en) Protein phosphatase-related molecules
WO2000001821A3 (en) Neurotransmission associated proteins
WO1998051782A3 (en) Human 3-hydroxyisobutyryl-coenzyme a hydrolase
WO2000012754A8 (en) Method for identifying substances for the treatment of c-jun-mediated disorders
WO2001046227A3 (en) 'dispatched' polypeptides

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2288221

Country of ref document: CA

Ref country code: CA

Ref document number: 2288221

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1998919919

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998919919

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1998919919

Country of ref document: EP