WO1998002240B1 - Preservation by foam formation - Google Patents
Preservation by foam formationInfo
- Publication number
- WO1998002240B1 WO1998002240B1 PCT/US1997/012156 US9712156W WO9802240B1 WO 1998002240 B1 WO1998002240 B1 WO 1998002240B1 US 9712156 W US9712156 W US 9712156W WO 9802240 B1 WO9802240 B1 WO 9802240B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- foam
- dispersion
- solution
- temperature
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
A method of preserving sensitive biological dispersions, suspensions, emulsions and solutions by forming stable foams from fluid materials to be dehydrated, as an aid both to the drying of one or more biologically active substrates in the fluid and as an aid in preparing an easily divisible dried product suitable for further commercial use. The stable foams are formed by partially removing the water to form a viscous liquid and by further subjecting the reduced liquid to vacuum, to cause it to 'boil' during further drying at temperatures substantially lower than 100 degrees C. In other words, reduced pressure is applied to viscous solutions or suspensions of biologically active materials to cause the solutions or suspensions to foam during boiling, and during the foaming process further solvent removal causes the ultimate production of a stable open-cell or closed-cell foam.
Claims
1. A method of shelf preservation of biologically active materials by drying comprising the step of subjecting a solution, dispersion or suspension containing a biologically active agent to a vacuum corresponding to the remaining hydrostatic pressure lower than 24 Torr sufficient to cause said solution, dispersion or suspension to boil such that said boiled solution, dispersion or suspension is dried to yield a mechanically stable foam during boiling.
2. The method according to claim 1 wherein said hydrostatic pressure is between 0 and 7.6 Torr.
3. The method according to claim 1 wherein prior to the step of subjecting said solution, dispersion or suspension to a high vacuum said solution, dispersion or suspension is dehydrated or concentrated by evaporation from liquid state at a low vacuum corresponding to the remaining hydrostatic pressure higher than 7.6 Torr or by evaporation from partially frozen state or by concentration by reverse osmosis or other membrane technologies to reduce the time during which said high vacuum must be applied and to increase the viscosity of said solution, dispersion or suspension before boiling under high vacuum.
4. The method according to claim l wherein a secondary drying process is carried out by applying one of a vacuum or dry air to said stable foam at elevated temperature.
5. The method according to claim 4 wherein after the secondary drying procedure the foam is cooled to a temperature that is lower than the glass transition temperature of the dried foam.
6. The method according to claim 5 wherein a surfactant is added to said solution, dispersion or suspension prior to application of said high vacuum to enhance foam stability during secondary drying.
7. The method according to claim 6 wherein said solution, dispersion or suspension contains a protectant selected from the group consisting of a sugar, carbohydrate, polysaccharide, polymer, peptide, protein and i a mixture thereof, wherein said protectant enhances the ability of the biologically active material to withstand drying and storage.
8. The method according to claim 1 wherein said process further includes the step of rehydrating said stable foam by contacting said foam with a suitable solvent.
9. The method according to claim 8 wherein said rehydration is performed at a termperature higher than the temperature in which the foam was stored prior to rehydration.
10. The method according to claim 9 wherein the temperature in which the foam was stored prior to rehydration is at least as high as ambient temperature.
- 11 -
11. The method according to claim 8 wherein said rehydration is performed at a temperature the same or lower than the temperature in which the foam was stored prior to rehydration.
12. The method according to claim 8 wherein the temperature in which the foam was stored prior to rehydration is lower than or equal to ambient temperature.
13. The method according to claim 8 wherein said solvent is an aqueous solution including a cryoprotectant.
14. The method according to claim 7 wherein said sugar is sucrose.
- 12 -
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ333738A NZ333738A (en) | 1996-07-15 | 1997-07-14 | Shelf preservation of biological active material by forming a mechanically stable foam thereof |
| JP10506201A JP2000515856A (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
| DE0914202T DE914202T1 (en) | 1996-07-15 | 1997-07-14 | CONSERVATION THROUGH FOAM FORMING |
| EP97933415A EP0914202A4 (en) | 1996-07-15 | 1997-07-14 | PRESERVATION BY FORMATION OF FOAM |
| IL12797197A IL127971A (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
| AU36606/97A AU714328B2 (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
| EA199900268A EA001138B1 (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
| HU9903917A HUP9903917A3 (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
| BR9711808-7A BR9711808A (en) | 1996-07-15 | 1997-07-14 | Preservation through foaming. |
| NO990158A NO990158D0 (en) | 1996-07-15 | 1999-01-14 | Preservation by foaming |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2179696P | 1996-07-15 | 1996-07-15 | |
| US60/021,796 | 1996-07-15 | ||
| US08/785,473 US5766520A (en) | 1996-07-15 | 1997-01-17 | Preservation by foam formation |
| US08/785,473 | 1997-01-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998002240A1 WO1998002240A1 (en) | 1998-01-22 |
| WO1998002240B1 true WO1998002240B1 (en) | 1998-03-05 |
Family
ID=26695104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/012156 Ceased WO1998002240A1 (en) | 1996-07-15 | 1997-07-14 | Preservation by foam formation |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5766520A (en) |
| EP (1) | EP0914202A4 (en) |
| JP (1) | JP2000515856A (en) |
| KR (1) | KR100457748B1 (en) |
| CN (1) | CN1116104C (en) |
| AU (1) | AU714328B2 (en) |
| BR (1) | BR9711808A (en) |
| CA (1) | CA2260233A1 (en) |
| CZ (1) | CZ7999A3 (en) |
| DE (1) | DE914202T1 (en) |
| EA (1) | EA001138B1 (en) |
| HU (1) | HUP9903917A3 (en) |
| IL (1) | IL127971A (en) |
| NO (1) | NO990158D0 (en) |
| NZ (1) | NZ333738A (en) |
| PL (1) | PL331174A1 (en) |
| TR (1) | TR199900127T2 (en) |
| WO (1) | WO1998002240A1 (en) |
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-
1997
- 1997-01-17 US US08/785,473 patent/US5766520A/en not_active Expired - Fee Related
- 1997-07-14 EP EP97933415A patent/EP0914202A4/en not_active Withdrawn
- 1997-07-14 NZ NZ333738A patent/NZ333738A/en unknown
- 1997-07-14 JP JP10506201A patent/JP2000515856A/en not_active Ceased
- 1997-07-14 HU HU9903917A patent/HUP9903917A3/en not_active Application Discontinuation
- 1997-07-14 CA CA002260233A patent/CA2260233A1/en not_active Abandoned
- 1997-07-14 CN CN97196422A patent/CN1116104C/en not_active Expired - Fee Related
- 1997-07-14 TR TR1999/00127T patent/TR199900127T2/en unknown
- 1997-07-14 IL IL12797197A patent/IL127971A/en not_active IP Right Cessation
- 1997-07-14 KR KR10-1999-7000253A patent/KR100457748B1/en not_active Expired - Fee Related
- 1997-07-14 DE DE0914202T patent/DE914202T1/en active Pending
- 1997-07-14 EA EA199900268A patent/EA001138B1/en not_active IP Right Cessation
- 1997-07-14 CZ CZ9979A patent/CZ7999A3/en unknown
- 1997-07-14 BR BR9711808-7A patent/BR9711808A/en unknown
- 1997-07-14 WO PCT/US1997/012156 patent/WO1998002240A1/en not_active Ceased
- 1997-07-14 PL PL97331174A patent/PL331174A1/en unknown
- 1997-07-14 AU AU36606/97A patent/AU714328B2/en not_active Ceased
-
1999
- 1999-01-14 NO NO990158A patent/NO990158D0/en not_active Application Discontinuation
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