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WO1997030158A3 - Recombinant protein containing a c-terminal fragment of plasmodium msp-1 - Google Patents

Recombinant protein containing a c-terminal fragment of plasmodium msp-1 Download PDF

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Publication number
WO1997030158A3
WO1997030158A3 PCT/FR1997/000290 FR9700290W WO9730158A3 WO 1997030158 A3 WO1997030158 A3 WO 1997030158A3 FR 9700290 W FR9700290 W FR 9700290W WO 9730158 A3 WO9730158 A3 WO 9730158A3
Authority
WO
WIPO (PCT)
Prior art keywords
terminal fragment
recombinant protein
protein containing
protein
plasmodium
Prior art date
Application number
PCT/FR1997/000290
Other languages
French (fr)
Other versions
WO1997030158A2 (en
WO1997030158A9 (en
Inventor
Shirley Longacre-Andre
Charles Roth
Faridabano Nato
John W Barnwell
Kamini Mendis
Original Assignee
Pasteur Institut
Univ New York
Longacre Andre Shirley
Charles Roth
Faridabano Nato
John W Barnwell
Kamini Mendis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT97905212T priority Critical patent/ATE456658T1/en
Priority to EP97905212A priority patent/EP0880588B1/en
Priority to DK97905212.3T priority patent/DK0880588T3/en
Priority to US09/125,031 priority patent/US6958235B1/en
Priority to KR1019980711023A priority patent/KR20000065266A/en
Priority to AU18841/97A priority patent/AU1884197A/en
Priority to JP09529057A priority patent/JP2000516083A/en
Priority to DE69739749T priority patent/DE69739749D1/en
Application filed by Pasteur Institut, Univ New York, Longacre Andre Shirley, Charles Roth, Faridabano Nato, John W Barnwell, Kamini Mendis filed Critical Pasteur Institut
Publication of WO1997030158A2 publication Critical patent/WO1997030158A2/en
Publication of WO1997030158A3 publication Critical patent/WO1997030158A3/en
Priority to US09/134,333 priority patent/US20020076403A1/en
Publication of WO1997030158A9 publication Critical patent/WO1997030158A9/en
Priority to US11/144,833 priority patent/US7696308B2/en
Priority to US11/476,865 priority patent/US20070036818A1/en
Priority to US11/622,845 priority patent/US8188213B2/en
Priority to US12/647,674 priority patent/US20100291133A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.
PCT/FR1997/000290 1996-02-14 1997-02-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1 WO1997030158A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE69739749T DE69739749D1 (en) 1996-02-14 1997-02-14 RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF MSP-1 FROM PLASMODIUM
EP97905212A EP0880588B1 (en) 1996-02-14 1997-02-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1
DK97905212.3T DK0880588T3 (en) 1996-02-14 1997-02-14 Recombinant protein containing a C-terminal fragment of MSP-1 from plasmodium
US09/125,031 US6958235B1 (en) 1996-02-14 1997-02-14 Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
KR1019980711023A KR20000065266A (en) 1996-02-14 1997-02-14 Recombinant Protein Containing C-terminal Fragment of Malaria Protozoal MSP-1
AU18841/97A AU1884197A (en) 1996-02-14 1997-02-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1
JP09529057A JP2000516083A (en) 1996-02-14 1997-02-14 Recombinant protein containing the C-terminal fragment of malaria parasite MSP-1
AT97905212T ATE456658T1 (en) 1996-02-14 1997-02-14 RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF MSP-1 FROM PLASMODIUM
US09/134,333 US20020076403A1 (en) 1996-02-14 1998-08-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1
US11/144,833 US7696308B2 (en) 1996-02-14 2005-06-06 Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1
US11/476,865 US20070036818A1 (en) 1996-02-14 2006-06-29 Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1
US11/622,845 US8188213B2 (en) 1996-02-14 2007-01-12 Purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI)
US12/647,674 US20100291133A1 (en) 1996-02-14 2009-12-28 Recombinant protein containing a c-terminal fragment of plasmodium msp-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9601822A FR2744724B1 (en) 1996-02-14 1996-02-14 RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PROTEIN MSP-1 OF A PLASMODIUM INFECTIOUS TO MAN FOR THE PRODUCTION OF ANTI-MALARIA VACCINES
FR96/01822 1996-02-14

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09125031 A-371-Of-International 1997-02-14
US09/134,333 Continuation-In-Part US20020076403A1 (en) 1996-02-14 1998-08-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1
US11/144,833 Continuation US7696308B2 (en) 1996-02-14 2005-06-06 Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1

Publications (3)

Publication Number Publication Date
WO1997030158A2 WO1997030158A2 (en) 1997-08-21
WO1997030158A3 true WO1997030158A3 (en) 1997-10-23
WO1997030158A9 WO1997030158A9 (en) 1999-06-24

Family

ID=9489188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1997/000290 WO1997030158A2 (en) 1996-02-14 1997-02-14 Recombinant protein containing a c-terminal fragment of plasmodium msp-1

Country Status (14)

Country Link
US (5) US6958235B1 (en)
EP (2) EP0880588B1 (en)
JP (1) JP2000516083A (en)
KR (1) KR20000065266A (en)
CN (2) CN101230104A (en)
AT (1) ATE456658T1 (en)
AU (1) AU1884197A (en)
CA (1) CA2241802A1 (en)
DE (1) DE69739749D1 (en)
DK (1) DK0880588T3 (en)
ES (1) ES2338832T3 (en)
FR (1) FR2744724B1 (en)
PT (1) PT880588E (en)
WO (1) WO1997030158A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1808443A1 (en) * 2006-01-13 2007-07-18 Institut Pasteur Purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI)
US8188213B2 (en) 1996-02-14 2012-05-29 Institut Pasteur Purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI)
FR2744724B1 (en) * 1996-02-14 2002-08-02 Pasteur Institut RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PROTEIN MSP-1 OF A PLASMODIUM INFECTIOUS TO MAN FOR THE PRODUCTION OF ANTI-MALARIA VACCINES
GB9616351D0 (en) * 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
KR20010031208A (en) 1997-10-20 2001-04-16 추후보정 NOVEL MODIFIED MSP-1 NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
BR0009823A (en) * 1999-04-20 2002-04-09 Medical Res Council Variant of the merozoite plasmodium (msp-1) surface protein and vaccine comprising the variant
AU1600401A (en) 1999-11-12 2001-06-06 Chinese University Of Hong Kong, The Malaria vaccine
US20030100106A1 (en) * 2000-02-08 2003-05-29 Chang Sandra P. Baculovirus produced Plasmodium falciparum vaccine
AR027370A1 (en) * 2000-02-17 2003-03-26 Lg Chemical Ltd IMMUNO TESTING AND REAGENT OF DIAGNOSIS FOR MALARIA, AND CORRESPONDING PREPARATION METHODS, EXPRESSION VECTORS AND TRANSFORMERS
KR100427513B1 (en) * 2000-02-17 2004-04-30 주식회사 엘지생명과학 IMMUNOASSAY, A DIAGNOSTIC REAGENT AND A DIAGNOSTIC METHOD FOR MALARIA BY DETECTION OF MALARIA-SPECIFIC IgM
KR100373918B1 (en) * 2000-02-17 2003-02-26 주식회사 엘지생명과학 Enzyme immuno assay for malaria and reagent used therefor
CN1176945C (en) * 2001-02-01 2004-11-24 中国人民解放军第二军医大学 Plasmodium fusion antigen and its preparation method and application
ES2346043T3 (en) 2002-04-05 2010-10-08 Institut Pasteur IDENTIFICATION OF THE RD1 AND RD5 REGIONS ASSOCIATED WITH THE VIRULENCE THAT ALLOWS THE DEVELOPMENT OF IMPROVED VACCINES OF M. BOVIS BCG AND M. MICROTI.
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use
DK1526178T3 (en) * 2003-10-24 2010-01-18 Pasteur Institut MSP-3-like gene family
EP1529536A1 (en) * 2003-11-05 2005-05-11 Institut Pasteur Immunogenic composition having improved immunostimulation capacity
WO2008059314A1 (en) * 2006-11-14 2008-05-22 Centro Internacional De Vacunas Malaria vaccine based on the 200l subunit of the plasmodium vivax msp1 protein
WO2010036293A1 (en) * 2008-09-24 2010-04-01 The Johns Hokins University Malaria vaccine
US8444996B2 (en) * 2008-10-01 2013-05-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia
CN101921337B (en) * 2010-07-21 2013-05-08 上海市疾病预防控制中心 Antibody against lactate dehydrogenase of plasmodium vivax, related preparation method, hybridoma cell strain and application
CN103965327B (en) * 2013-01-29 2016-08-10 苏州偲聚生物材料有限公司 Polypeptide, the detection device comprising this polypeptide and detection kit
WO2015055772A1 (en) 2013-10-16 2015-04-23 Shirley Longacre Combination of plasmodium merozoite surface proteins msp4 and 1 and uses thereof
WO2015056244A1 (en) * 2013-10-18 2015-04-23 Universidade Federal De Minas Gerais - Ufmg Kit and immunodiagnostic method for detecting anaemia caused by vivax malaria, synthetic peptides and uses
EP3559669A4 (en) * 2016-12-23 2020-11-18 The Walter and Eliza Hall Institute of Medical Research SYSTEM, PROCEDURE, DEVICE AND DIAGNOSTIC TEST FOR PLASMODIUM VIVAX
JP7134461B2 (en) * 2018-03-23 2022-09-12 国立大学法人金沢大学 Malaria therapeutic agent, malaria preventive agent and antimalarial natural immunostimulant
CN109825514A (en) * 2019-01-24 2019-05-31 华中农业大学 Babesia voles GPI10 gene and its encoded protein and application
CN111978413B (en) * 2020-08-21 2022-04-15 江南大学 An antibody that inhibits the growth of cynomolgus monkey Plasmodium in vitro

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0154454A1 (en) * 1984-02-22 1985-09-11 The Wellcome Foundation Limited Cloning of DNA for protozoal antigens
WO1993017107A1 (en) * 1992-02-22 1993-09-02 Medical Research Council Improvements in or relating to malaria vaccine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3280028D1 (en) * 1981-05-21 1989-12-28 Wellcome Found Protozoal antigen
US4937016A (en) * 1989-02-01 1990-06-26 Dai-Ichi Kogyo Seiyaku Co., Ltd. Copper conductor composition
FR2645877B1 (en) * 1989-04-12 1991-07-05 Pasteur Institut MOLECULES COMPRISING AT LEAST ONE PEPTIDE SEQUENCE CARRYING ONE, OR SEVERAL, CHARACTERISTIC EPITOPE OF A PROTEIN PRODUCED BY P. FALCIPARUM AT THE SPOROZOITE STAGE AND IN THE HEPATOCYTES
US5756101A (en) * 1991-07-01 1998-05-26 Pasteur Merieux Serums Et Vaccins Malaria recombinant poxvirus
EP0621337A1 (en) * 1993-01-25 1994-10-26 American Cyanamid Company Codon optimized DNA sequence for insect toxin AaIT
NZ308772A (en) * 1995-05-17 1999-04-29 Du Pont Recombinant baculovirus insecticides
FR2744724B1 (en) * 1996-02-14 2002-08-02 Pasteur Institut RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PROTEIN MSP-1 OF A PLASMODIUM INFECTIOUS TO MAN FOR THE PRODUCTION OF ANTI-MALARIA VACCINES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0154454A1 (en) * 1984-02-22 1985-09-11 The Wellcome Foundation Limited Cloning of DNA for protozoal antigens
WO1993017107A1 (en) * 1992-02-22 1993-09-02 Medical Research Council Improvements in or relating to malaria vaccine

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANGOV E ET AL: "CHARACTERIZATION OF A RECOMBINANT PLASMODIUM FALCIPARIUM MSP 1 C-TERMINAL FRAGMENT USING CONFORMATION-SPECIFIC MONOCLONAL ANTIBODIES", FASEB JOURNAL, vol. 10, no. 6, 2 June 1996 (1996-06-02), pages A1117, XP000604872 *
CHANG, S.P. ET AL.: "A carboxy-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth", JOURNAL OF IMMUNOLOGY, vol. 149, no. 2, 15 July 1992 (1992-07-15), BALTIMORE US, pages 548 - 555, XP000605417 *
CHAPPEL, J.A. & HOLDER, A.A.: "Monoclonal antibodies that inhibit Plasmodium falciparum invasion in vitro recognise the first growth factor-like domain of merozoite surface protein-1", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 60, no. 2, 1 January 1993 (1993-01-01), pages 303 - 310, XP000603763 *
LONGACRE, S. ET AL.: "Plasmodium vivax merozoite surface protein 1 C-terminal recombinant proteins in baculovirus", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 64, no. 2, 1 January 1994 (1994-01-01), pages 191 - 205, XP000603954 *
LONGACRE, S.: "The Plasmodium cynomolgi merozoite surface protein 1 C-terminal sequence and its homologies with other Plasmodium species", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 74, no. 1, 20 December 1995 (1995-12-20), pages 105 - 111, XP000603955 *

Also Published As

Publication number Publication date
PT880588E (en) 2010-03-22
EP0880588B1 (en) 2010-01-27
DE69739749D1 (en) 2010-03-18
CN1276975C (en) 2006-09-27
US6958235B1 (en) 2005-10-25
FR2744724A1 (en) 1997-08-14
WO1997030158A2 (en) 1997-08-21
AU1884197A (en) 1997-09-02
CN1222936A (en) 1999-07-14
DK0880588T3 (en) 2010-05-17
JP2000516083A (en) 2000-12-05
ATE456658T1 (en) 2010-02-15
WO1997030158A9 (en) 1999-06-24
CA2241802A1 (en) 1997-08-21
US20100291133A1 (en) 2010-11-18
CN101230104A (en) 2008-07-30
EP0880588A2 (en) 1998-12-02
ES2338832T3 (en) 2010-05-12
US20020076403A1 (en) 2002-06-20
KR20000065266A (en) 2000-11-06
US20060018932A1 (en) 2006-01-26
EP2194132A1 (en) 2010-06-09
US20070036818A1 (en) 2007-02-15
FR2744724B1 (en) 2002-08-02
US7696308B2 (en) 2010-04-13

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