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WO1997028835A1 - Dispositif d'application de medicaments pour pompes de seringue - Google Patents

Dispositif d'application de medicaments pour pompes de seringue Download PDF

Info

Publication number
WO1997028835A1
WO1997028835A1 PCT/EP1997/000512 EP9700512W WO9728835A1 WO 1997028835 A1 WO1997028835 A1 WO 1997028835A1 EP 9700512 W EP9700512 W EP 9700512W WO 9728835 A1 WO9728835 A1 WO 9728835A1
Authority
WO
WIPO (PCT)
Prior art keywords
application device
pressure
piston
cylinder
syringe
Prior art date
Application number
PCT/EP1997/000512
Other languages
German (de)
English (en)
Inventor
Volker Lang
Original Assignee
Volker Lang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19614337A external-priority patent/DE19614337A1/de
Priority claimed from DE19623779A external-priority patent/DE19623779A1/de
Application filed by Volker Lang filed Critical Volker Lang
Publication of WO1997028835A1 publication Critical patent/WO1997028835A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Definitions

  • the invention relates to a hydraulic medication application infusion device according to the preamble of patent claim 1.
  • microlumen tubes or drawn glass microcapillaries used as flow restrictors are difficult to manufacture exactly in series with the required small tolerances and can therefore only be offered at a very high price
  • the object of the invention is to develop a generic medication application infusion device so that it enables a technically simple, exact medication application infusion at low cost.
  • FIG. 4 shows a perspective view of the hydraulic medication application infusion device with a single-use injection infusion syringe inserted
  • Fig. 5 a schematic representation of the function of the
  • Fig. 6 a schematic representation of the function of the
  • Fig. 12 schematically in section, a spring-driven
  • Hydraulic device which uses bags filled with hydraulic fluid in connection with a downstream capillary metering device as a hydraulic pump
  • Fig. 14 the hydraulic cassette in the view as in
  • Part A consists of a 10-60 ml Disposable syringe for syringe pumps. This is inserted with its syringe cylinder 1 provided with a Luer lock connection 2, which also carries the two tabs 3, into the fixed holder of the syringe pump 4, which is shown schematically in broken lines.
  • the syringe plunger 5, on which the compression spring 6 acts, is connected to the syringe plunger 7 with the pressure plate 8. This pressure plate 8 is inserted into the holding device of the syringe pump feed 9, shown schematically in dashed lines.
  • Part B the pressure-resistant infusion line 10 via its connectors 11, 12 are not detachably connected to the Luer lock connection 13 of the syringe barrel 14 of part C via the Luer lock connection 2.
  • a tightly closing piston 15 with a pressure transmission disc 16 is fitted. This transfers the pressure to the pressure plate 17, the stamp 18 and the piston 19 connected to it.
  • Part D with cylinder 20, Luer lock connection 21 and the two tabs 23 is a sterile disposable syringe which is filled with medication. This syringe is locked with its tabs 23 in the locking element formed by the base plate 24 and cover plate 25.
  • part D can be detachably connected and locked to a line leading to the patient P and provided with a female Luer lock connector.
  • Fig. 2 shows the in an exploded perspective view hydraulic feed device with syringe locking element.
  • the feed device consists of the syringe cylinder 14 with the two tabs 22 and the piston 15 with pressure transmission disk 16.
  • the syringe locking element 23 consists of the base plate 24, provided with the round cutout 27 and the two connecting holes 28 ⁇ the spacer rollers 29 and the two rivets 30, the thin, resilient cover plate 25 with its oval cutout 31 via the two connecting holes 32 with the rigid base plate 24 and the two tabs 22 of the syringe barrel is firmly connected to form a unit.
  • FIG. 3 shows a perspective view of the hydraulic feed unit with syringe locking element, completely assembled with an inserted and locked disposable medication syringe D.
  • the syringe cylinder 20 with its two tabs 23 was first inserted into the oval-horizontal opening 31 and subsequently locked by a rotation of 90 degrees around its longitudinal axis, and is now held between the rigid base plate 24 and the resilient cover plate 25. If the medication filling of the syringe cylinder 20 is stronger than that shown, the piston 19 with the stamp 18 and Pressure plate 17, mechanically protected in the cylinder 14, push the pressure plate 16 and the piston 15 in the direction of the Luer lock connection 13.
  • the medicament application device consists of the three parts A, B and C, which are preferably delivered completely assembled, not separable, filled with liquid approximately half free of air bubbles.
  • Part A the 10-60 ml infusion syringe with compression spring 6 acting on the plunger 5 is now placed in the holder of the syringe pump 4 (dashed line) for the tabs 3 of the cylinder 1 inserted.
  • the small medication syringe D is filled with the desired amount of medication solution without air bubbles and subsequently its outlet connector 21, which is provided with a Luer lock connector, is closed with a closure cap.
  • the desired infusion quantity per unit of time can now be set on the infusion pump, for example after multiplication by a factor specified on the medication application device, and the pump can be started.
  • the patient is still connected via the connecting section 26.
  • the infusion syringe pump now pushes the piston 5 against the defined resistance of the compression spring 6 in the direction of the Luer lock connection 2.
  • the liquid that is displaced thereby passes through the pressure hose 10 into the cylinder 14, pushes the piston there 15 with pressure plate 16 and pressure plate 17 with plunger 18 and piston 19 in the direction of the arrow towards the syringe outlet connector 21.
  • the medication syringe D is now slowly emptied into the connected patient.
  • Colored or uncolored water, oil, aqueous glycerin solution or glycerin can preferably be used as the hydraulic fluid.
  • alarm pressure settings on the syringe pumps for example to values of 1.2 to 0.5 bar.
  • the hydraulic elements (1, 14) are not designed as hydraulic cylinders with a tightly fitted piston, but occur here instead of the piston, a tightly fitted roller membrane.
  • the piston of the hydraulic element is produced by a bellows not fitted in the hydraulic cylinder, preferably made of plastic or an elastomer. tigt, replaced.
  • FIG. 4 shows in perspective an embodiment of the medication application infusion device. It consists of two infusion syringe cylinders 35, 45 with tightly fitted pistons 37, 42.
  • the cylinders 33, 34 are fixed at a certain distance from one another by holding devices 33, 34.
  • the cylinder 35 contains a spiral compression spring 36 which loads the tightly fitted piston 37 in the direction of arrow 38 and thus moves the adjacent syringe plunger 39 with piston 40 in the syringe cylinder 41 in the direction of its outlet cone 44.
  • the syringe cylinder 41 is part of the disposable syringe 43 flanged over a locking device 42.
  • the second cylinder 45 is closed with an air-permeable cover 46 and contains the tightly fitted piston 47.
  • a round piston rod 48 which ends in a handle 51 and has on its outer half a thread 49 on which a stop nut 50 is adjustably arranged.
  • a metering module 52 is locked with the luer connectors 53, 54 of the syringe cylinders 35, 45.
  • FIGS. 5 and 6 serve to provide a descriptive description of the function.
  • 5 shows schematically and in section the medicament application device, ready for use with the patient.
  • the disposable syringe 43 which is filled with medication solution without air bubbles, is connected with its outlet cone 44 to a connecting line (not shown) to the patient.
  • the compressed spiral compression spring 55 expands in the direction of arrow 56 and thus displaces piston 37 and the adjoining one Syringe plunger 39 with piston 40 in the syringe cylinder 41. Since this cylinder 41 is firmly connected to the locking device 42, medication solution is dispensed to the patient.
  • the movement of the compression spring 55 which is striving for expansion, is hydraulically controlled in a controlled manner by drawing in liquid from the syringe cylinder 45 serving as liquid reservoir 57 with piston 47 via the metering module 52 becomes.
  • This module contains a particle filter 59 upstream of the metering nozzle 58 (metering tube, hose) (to keep away any abrasion dirt particles that may occur) and the bypass a one-way valve 60 with low flow resistance and the lowest backflow, which is closed.
  • FIG. 6 shows the state after the drug infusion has ended and the syringe 43 has been removed, as well as the measures required for the device to be used again for the drug application.
  • the spring 61 which has been largely relaxed in the cylinder 35, can now either by manually exerting pressure in the direction of arrow 62 with the aid of the plunger 39, a new injection syringe filled with medication solution, firmly closed on the outlet cone, on the piston 37 or by manually withdrawing the piston 47 the piston rod 48 and the handle 51 be compressed again.
  • the liquid can flow back into the liquid reservoir 57 quickly and with little resistance via the open one-way valve 63 (even in a very small amount via the nozzle 58).
  • the state as shown in Fig. 1, is restored.
  • FIGS. 7 to 11 show schematically in section further exemplary embodiments.
  • FIG. 7 shows schematically in section a pneumatic-hydraulic feed unit after restoration of the operating state with an inserted medication-filled syringe, now ready for use again.
  • compressed air flows through the inlet connection 74, for example from a hand blower with a manometer and inflatable cuff, as used for blood pressure measurement, into the feed cylinder 73 with piston 75, piston rod 72 and return spring 76.
  • the piston compresses in the process 75, as shown in FIG. 8, the return spring 76 and displaces the liquid present in the cylinder 73.
  • the holding device 71 is pulled out / back to the stop, for example manually, with the piston rod 72 and the connected piston 75. Liquid thus flows quickly from the reservoir cylinder 57 through the now open one-way valve 64 and in small quantities also through the particle filter 59 and metering nozzle 58 of the metering module 52 into the cylinder 73 while simultaneously relieving the return spring 76.
  • the new drug-filled disposable spring can thus be used syringe and start the infusion again.
  • FIGS. 9 and 10 show a pneumatic syringe feed unit with an integrated oil-hydraulic braking device with a closed oil circuit as a further exemplary embodiment.
  • the disposable syringe filled with medication and its holders are omitted, since they largely correspond to those of FIGS. 7 and 8.
  • 9 shows the pneumatic syringe feed unit, prepared for the insertion of the drug-filled disposable syringe.
  • a non-rotatable piston rod 77 which carries the holding device 71 for the syringe plunger 39 (only this part of the disposable syringe is shown), is retracted to the maximum.
  • a cylinder inlet connection 87 is connected to a compressed air source (not shown). Compressed air now flows into the right cylinder chamber 85 and pushes the working piston 78 seated on the piston rod 77 and the brake piston 79 to the left in the drawing. This process is shown in FIG. 10. In this case, 78 is released from the working piston left cylinder chamber 87, which is separated from the oil-filled brake cylinder by the partition 85, is expelled through the vent opening 89.
  • the oil in the brake cylinder can flow quickly and without resistance from the right chamber 90 through the now wide open one-way valve 81 in the piston 79 into the left half of the chamber 91. This makes it possible to quickly reinsert a new drug-filled syringe.
  • This integration of the pneumatic cylinder and metering module, implemented as an oil brake cylinder in a cylinder tube 86 with a partition 85, enables a very compact, flow-prone, precise, easy-to-use, inexpensive medication application device to be implemented.
  • FIG. 11 shows a further embodiment schematically.
  • a tension spring 93 under tension which is arranged in a cylinder 92 with a piston 94 and holding device 97 for a syringe, serves as the drive element.
  • FIGS. 12 to 14 show a hydraulic medication application infusion device for multiple use, in which only the medication apoplication infusion bags with filler neck and discharge tube that are in direct connection with the patient are sterile disposable articles. It consists of the spring-driven hydraulic device shown in FIG. 12 with a downstream metering device, as Hydraulic pump and the in Fig. 13 and fig. 14 shown hydraulic cassettes, in which the medication application infusion bags are inserted as sterile disposable items.
  • the hydraulic device 112 consists of two cylindrical, can-shaped parts, a base part 114 and a cover part 115, which are detachably screwed together by means of an applied threaded piece 113.
  • the bag 116 inserted in the lid part 115 and filled with hydraulic fluid is compressed by the spiral pressure fields 117 in the bottom part 114 via the pressure plate 118.
  • Hydraulic fluid is delivered to the metering device 120 via the bag outflow nozzle and the connected pressure line 119. From here it passes through the particle filter 122 to the precision metering capillary 123 and from there via the pressure hose 124 and 136 to the inlet port 125 of the hydraulic cassette.
  • FIG. 13 shows the hydraulic cassette with the medication application infusion bag 133 inserted at the end of the filling process. It consists of two cylindrical, nozzle-shaped parts, a base part 126 with inlet connection piece 125 and a cover part 127, which are screwed to one another in a readily detachable manner by means of an applied threaded piece 128.
  • cover part 127 there is the medication application filled with medication infusion solution via the large syringe 129, the connection piece 130, the Y-piece 131 (one leg of which is closed), the bag connection hose and connection piece 132 Infusion bag 133 (dashed lines), inserted.
  • the pressurized hydraulic fluid which has flowed in via the connecting hose 124 and 136 as well as the connector 125 has greatly expanded the space 137 delimited by the rolling membrane 134 with compression and emptying of the medication application infusion bag 140 via the outlet connector and hose 138, the Y-piece 131 and the connecting hose to the patient 139.
  • the second leg of the Y-piece with the connector 130 is securely closed by the closure piece 141.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'application de médicaments pour pompes de seringue qui comprend au moins deux éléments hydrauliques interconnectés par une conduite résistant à la pression, remplie de liquide. Un de ces éléments hydrauliques, disposé à distance du patient à traiter, fait office de pompe, alors que l'autre élément, disposé à proximité du patient, sert de dispositif de poussée pour seringue d'injection de médicaments.
PCT/EP1997/000512 1996-02-05 1997-02-05 Dispositif d'application de medicaments pour pompes de seringue WO1997028835A1 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
DE19604062 1996-02-05
DE19604062.0 1996-02-05
DE19605929 1996-02-17
DE19605929.1 1996-02-17
DE19606677 1996-02-22
DE19606677.8 1996-02-22
DE19614337A DE19614337A1 (de) 1996-02-05 1996-04-11 Medikamenten-Applikationsvorrichtung
DE19614337.3 1996-04-11
DE19614351 1996-04-11
DE19614351.9 1996-04-11
DE19623779A DE19623779A1 (de) 1996-02-17 1996-06-16 Medikamenten-Applikationsvorrichtung für Spritzenpumpen
DE19623779.3 1996-06-16

Publications (1)

Publication Number Publication Date
WO1997028835A1 true WO1997028835A1 (fr) 1997-08-14

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ID=27545040

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000512 WO1997028835A1 (fr) 1996-02-05 1997-02-05 Dispositif d'application de medicaments pour pompes de seringue

Country Status (1)

Country Link
WO (1) WO1997028835A1 (fr)

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2839454A1 (fr) * 2002-05-07 2003-11-14 Primebiotech Dispositif pour la micro-injection de liquide en milieu confine
JP2004524115A (ja) * 2001-03-27 2004-08-12 ディーシーエー デザイン インターナショナル リミテッド 注入装置の改良および注入装置に関連する改良
WO2004080357A1 (fr) * 2003-03-14 2004-09-23 Ferreyro Irigoyen Roque Humber Dispositif hydraulique d'injecton de ciment osseux utilise dans le domaine de la vertebroplastie percutanee
WO2004094823A3 (fr) * 2003-04-23 2005-02-03 Biovalve Technologies Inc Pompe hydraulique d'administration de medicaments sur de longues durees
JP2006514850A (ja) * 2002-12-23 2006-05-18 カゼムザデー、ファラッド 投薬装置
JP2006223570A (ja) * 2005-02-17 2006-08-31 Jms Co Ltd 医療用容器
WO2007131367A1 (fr) * 2006-05-15 2007-11-22 Tecpharma Licensing Ag Dispositif destiné à l'administration d'un produit fluide
WO2008106810A1 (fr) * 2007-03-02 2008-09-12 Tecpharma Licensing Ag Détection hydraulique d'une occlusion dans un appareil médical d'administration
US7621950B1 (en) 1999-01-27 2009-11-24 Kyphon Sarl Expandable intervertebral spacer
WO2010006436A1 (fr) * 2008-07-15 2010-01-21 Altavance Ltd. Dispositif d'injection de ciment osseux
EP2228085A1 (fr) * 2007-08-20 2010-09-15 Mallinckrodt Inc. Injecteur médical actionné par des fluides
ITVR20090134A1 (it) * 2009-09-08 2011-03-09 Al Chi Mi A S R L "dispositivo per l iniezione in un bulbo oculare di un liquido sterile scelto tra i perfluorocarburi o perfluorocarboni"
US8038682B2 (en) 2004-08-17 2011-10-18 Boston Scientific Scimed, Inc. Apparatus and methods for delivering compounds into vertebrae for vertebroplasty
US8333773B2 (en) * 2003-03-31 2012-12-18 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8809418B2 (en) 2004-03-21 2014-08-19 DePuy Synthes Products, LLC Methods, materials and apparatus for treating bone and other tissue
US8950929B2 (en) 2006-10-19 2015-02-10 DePuy Synthes Products, LLC Fluid delivery system
US8956368B2 (en) 2003-06-17 2015-02-17 DePuy Synthes Products, LLC Methods, materials and apparatus for treating bone and other tissue
AU2012201924B2 (en) * 2003-04-23 2015-06-18 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US9259696B2 (en) 2005-11-22 2016-02-16 DePuy Synthes Products, Inc. Mixing apparatus having central and planetary mixing elements
CN105343958A (zh) * 2015-10-23 2016-02-24 刘齐山 输血装置
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
CN106109050A (zh) * 2016-08-03 2016-11-16 河北霞辉节能科技有限公司 一种兽用液压远距离防疫注射的装置
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
US9687599B2 (en) 2006-03-30 2017-06-27 Valeritas, Inc. Multi-cartridge fluid delivery device
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US10111697B2 (en) 2003-09-26 2018-10-30 DePuy Synthes Products, Inc. Device for delivering viscous material
AU2017202411B2 (en) * 2003-04-23 2019-01-31 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
CN112274725A (zh) * 2020-12-24 2021-01-29 时新(上海)产品设计有限公司 介质输注结构、介质输注方法、微剂量分泌泵、胰岛素泵
US10933188B2 (en) 2009-10-13 2021-03-02 Zealand Pharma A/S Fluid delivery device
WO2022122099A1 (fr) * 2020-12-09 2022-06-16 Andersen Mikkel Styrbjoern Hartvig Distribution de pression de fluide pour dosage et décharge de fluides
EP3182915B1 (fr) * 2014-08-22 2023-10-25 Dfine, Inc. Systèmes de traitement de l'os

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FR2505190A1 (fr) * 1981-05-06 1982-11-12 Wonder Appareil de perfusion
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EP0235905A1 (fr) * 1986-01-23 1987-09-09 Omar Mahmood Atia Al-Rawi Adaptateur pour une seringue à injection
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GB2042091A (en) * 1978-11-30 1980-09-17 Godrich J Drip feed arrangements
FR2446114A1 (fr) * 1979-01-15 1980-08-08 Hyco Et Aulas Procede d'injection par seringue en quantite et debit precis d'un produit et pousse-seringue pour sa mise en oeuvre
FR2505190A1 (fr) * 1981-05-06 1982-11-12 Wonder Appareil de perfusion
US4437859A (en) * 1981-08-03 1984-03-20 Drs Infusion Systems, Inc. Hydraulic syringe drive
EP0235905A1 (fr) * 1986-01-23 1987-09-09 Omar Mahmood Atia Al-Rawi Adaptateur pour une seringue à injection
GB2197691A (en) * 1986-11-23 1988-05-25 Dan Bron Hydraulic pump

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7621950B1 (en) 1999-01-27 2009-11-24 Kyphon Sarl Expandable intervertebral spacer
USRE47427E1 (en) 1999-01-27 2019-06-11 Medtronic Holding Company Sárl Expandable intervertebral spacer
JP2004524115A (ja) * 2001-03-27 2004-08-12 ディーシーエー デザイン インターナショナル リミテッド 注入装置の改良および注入装置に関連する改良
WO2003094992A3 (fr) * 2002-05-07 2004-04-01 Primebiotech Dispositif pour la micro-injection de liquide en milieu confine
FR2839454A1 (fr) * 2002-05-07 2003-11-14 Primebiotech Dispositif pour la micro-injection de liquide en milieu confine
US7270648B2 (en) 2002-12-23 2007-09-18 Farhad Kazemzadeh Drug delivery apparatus
US8394061B2 (en) 2002-12-23 2013-03-12 Farhad Kazemzadeh Drug delivery apparatus
JP2006514850A (ja) * 2002-12-23 2006-05-18 カゼムザデー、ファラッド 投薬装置
EP1596896A4 (fr) * 2002-12-23 2006-09-20 Farhad Kazemzadeh Appareil d'administration de medicaments
US8992541B2 (en) 2003-03-14 2015-03-31 DePuy Synthes Products, LLC Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US9186194B2 (en) 2003-03-14 2015-11-17 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
EP2314259B1 (fr) 2003-03-14 2015-07-29 Depuy Spine, Inc. Dispositif hydraulique d'injecton de ciment osseux utilisé dans le domaine de la vertebroplastie percutanée
US10799278B2 (en) 2003-03-14 2020-10-13 DePuy Synthes Products, Inc. Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
EP1614403B2 (fr) † 2003-03-14 2014-06-18 Depuy Spine, Inc. Dispositif hydraulique d'injecton de ciment osseux utilise dans le domaine de la vertebroplastie percutanee
WO2004080357A1 (fr) * 2003-03-14 2004-09-23 Ferreyro Irigoyen Roque Humber Dispositif hydraulique d'injecton de ciment osseux utilise dans le domaine de la vertebroplastie percutanee
EP2311408A1 (fr) * 2003-03-14 2011-04-20 DePuy Spine, Inc. Dispositif hydraulique d'injecton de ciment osseux utilisé dans le domaine de la vertebroplastie percutanée
EP2314259A1 (fr) * 2003-03-14 2011-04-27 Depuy Spine, Inc. Dispositif hydraulique d'injecton de ciment osseux utilisé dans le domaine de la vertebroplastie percutanée
US9839460B2 (en) 2003-03-31 2017-12-12 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US10485597B2 (en) 2003-03-31 2019-11-26 DePuy Synthes Products, Inc. Remotely-activated vertebroplasty injection device
US8333773B2 (en) * 2003-03-31 2012-12-18 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
AU2012201924B2 (en) * 2003-04-23 2015-06-18 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
US9072828B2 (en) 2003-04-23 2015-07-07 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
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WO2004094823A3 (fr) * 2003-04-23 2005-02-03 Biovalve Technologies Inc Pompe hydraulique d'administration de medicaments sur de longues durees
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