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WO1994005301A1 - Compositions destinees au traitement de la dermite, contenant du soufre, de l'acide salicylique et du dimethylsulfone - Google Patents

Compositions destinees au traitement de la dermite, contenant du soufre, de l'acide salicylique et du dimethylsulfone Download PDF

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Publication number
WO1994005301A1
WO1994005301A1 PCT/GB1993/001873 GB9301873W WO9405301A1 WO 1994005301 A1 WO1994005301 A1 WO 1994005301A1 GB 9301873 W GB9301873 W GB 9301873W WO 9405301 A1 WO9405301 A1 WO 9405301A1
Authority
WO
WIPO (PCT)
Prior art keywords
sulphur
salicylic acid
dermatitis
skin
methylsulphonylmethane
Prior art date
Application number
PCT/GB1993/001873
Other languages
English (en)
Inventor
Aws Shakir Mustafa Salim
Original Assignee
Aws Shakir Mustafa Salim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aws Shakir Mustafa Salim filed Critical Aws Shakir Mustafa Salim
Priority to AU49744/93A priority Critical patent/AU4974493A/en
Publication of WO1994005301A1 publication Critical patent/WO1994005301A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof

Definitions

  • Housewife dermatitis is a very common condition which continues to raise considerable interest not only because of the complex mechanisms involved in its development, but also because of the therapeutic challenge it poses.
  • the condition represents the injury inflicted on the skin of the fingers and hands following contact with household detergents, cleansing agents and purifying substances.
  • the dermatitis manifests itself by dryness, roughening, thickening and fissuring of the fingers and hand. Exposure to sunlight for long periods, air pollutants and environmental irritants, promote the dermatitis and enhance its severity.
  • Housewife dermatitis remains a difficult condition to treat and it is, thus, the aim of the present invention to introduce an effective therapy which not only removes the dermatitis but also protects against its recurrence.
  • the mechanism responsible for the development of housewife dermatitis is complex. Although an extensive range of products is available on the market, none is designed to combat the factors behind the development of the dermatitis and none opposes the mediators of skin injury and damage which represent the final common pathway through which irritants such as detergents, produce their adverse skin effects.
  • the present invention aims, therefore, at directly addressing these issues by providing a synergistic composition which not only effectively treats housewife dermatitis and enhances its healing, but also protects against the recurrence of this condition. It follows that application of this invention to the skin improves its condition and maintains its texture and vitality.
  • the invention provides a synergistic composition suitable for use in the treatment of housewife dermatitis, which composition comprises precipitated sulphur with salicylic acid and methylsulphonylmethane.
  • the application of the composition to the skin of the hands has been found in a surprising and very unexpected manner to improve its condition in a number of ways including protection against irritation, maintenance of texture and vitality, and in particular the protection against and treatment of housewife dermatitis. It has also been noted that the composition has the advantageous property of adhesion to the skin thereby affording prolonged contact and enhanced therapeutic delivery. Moreover, the ingredients of the composition interact in a synergistic manner in that the sum of the action of all the ingredients used separately is less than that exhibited by the composition.
  • vasodilator such as menthol in order to further increase the effectiveness of the composition in the skin.
  • the present invention provides a composition of the invention in intimate admixture with a physiologically acceptable carrier, for use in improving the condition of the skin of the hands.
  • the present invention provides a topical formulation comprising a composition of the invention in intimate admixture with a pharmaceutically acceptable vehicle.
  • vehicle should be 'acceptable' in terms of being generally non-deleterious to the skin of the subject being treated and compatible with the other ingredients of the formulation. It will of course be appreciated that certain individuals have significantly more sensitive skins than the average and that in these special cases alternative vehicles to those normally used may need to be tried.
  • Suitable vehicles are well known in the art being noted for example in such standard works as the British Pharmacopoeia and the British National Formulary and include ointment bases and cream bases as well as lotions, pastes, jellies, sprays, aerosols and bath oils.
  • Ointments and creams may contain oleaginous absorption colloidal clays, thickening agents such as gum tragacanth or sodium alginate and other pharmaceutically acceptable accessory ingredients such as humectants, preservatives, buffers and antioxidants which have utility in such formulations.
  • Cream formulations are usually preferred as being most acceptable to the majority of users.
  • a particularly convenient base is one utilizing cetomacrogol, comprising for example 30% w/v cetomacrogol emulsifying ointment (30% w/v cetomacrogol emulsifying wax, 20% w/v liquid paraffin wax, 50% w/v white soft paraffin) in freshly boiled and cooled purified water with for example 0.1% w/v chlorocresol or 0.08% w/v propyl hydroxybenzoate, 0.15% w/v methyl hydroxybenzoate and, 1.5% w/v benzyl alcohol.
  • compositions of the present invention contain at least 0.5% w/w of each of the active ingredients preferably from 1 to 20% w/w, and most preferably from 2 to 10% w/w. These dosage levels do not, however, indicate that the relative ratios of the active ingredients should be identical.
  • compositions of the invention may be administered in a slow release or sustained release topical vehicle so that a prolonged therapeutic effect may be achieved.
  • the frequency of the topical application depends on the indication.
  • a liberal amount of the cream is gently rubbed for a few minutes into the skin of the hands 2 or 3 times a day. It is advisable to leave the evening application overnight to enhance the repair of the skin damage and to stimulate healing.
  • a once daily application suffices. Each application must be washed away with warm water before another one is used. Contact with the eyes and oral consumption must be avoided.
  • compositions should e prepared at a temperature of 25°C.
  • the powder form of the active ingredients is mixed well in a glass or stainless steel container and then the appropriate amount of cetomacrogol 'A' is added and mixed for 10 minutes. When menthol is being used, this should first be finely ground.
  • the composition is allowed to stand for one hour then placed in dark-coloured non-transparent glass containers and stored at temperatures not exceeding 26°C. After preparation the formulation should not be used for at least 12 hours and should not be left for too long exposed to the air or direct sunlight.
  • Example 1 The formulations illustrated in Example 1 may be used 1 to 3 times daily depending on whether the application is being administered for prophylactic or therapeutic reasons.
  • a once daily application is generally recommended.
  • a liberal amount of the cream is spread over the skin of the hands or the area to be treated, and gently rubbed in for a few minutes.
  • a second application is indicated and preferably used in the evening and left overnight.
  • a fresh application should not be used without having washed away the previous one, and this may be done using warm water alone. Treatment may be for a few days or weeks depending on each case and in particular the individual's existing skin condition and requirements.
  • Consecutive females who had been diagnosed to have housewife dermatitis (roughening, thickening and fissuring of the skin of the fingers and hands) were prospectively randomized (by drawing sealed envelopes) on a double blind basis, to treatment with various agents presented in a cetomacrogol 'A' base or with this base alone (control group) , to study the therapeutic effect of their twice daily application for four weeks, as shown in the Table below.
  • Ten females were allocated to each group and the overall age range for the study was 31 to 55 years. A successful therapeutic outcome was judged objectively by observing a complete healing of all the fissuring coupled with a return of the skin texture to its original smoothness.
  • Housewife dermatitis refers to thickening, roughening and fissuring of the skin of the fingers alone or with that of the main part of the hand. Twenty-six females (age range 32 to 55 years - mean 43) randomized to the control group and 24 females (age range 35 to 51 years - mean 42) randomized to the treatment group were fully evaluable. While no beneficial therapeutic effect occurred in the control group, this was realized in all the active therapy group cases (100%) . These women were observed to have acquired complete healing of their skin's fissures and a return of the skin's smoothness and originally normal texture and appearance.
  • the formulations were applied twice daily for ten days onto the shoulders and arms. Each application consisted of a liberal amount of the cream spread over the shoulders and arms then gently rubbed in for a few minutes. Three hours later, the application was washed away with warm water. Physical examination was carried out once every day during the ten days of study. Similarly, standard haematology and biochemistry tests (including liver and urinary function tests, blood glucose, serum amylase and blood gases) with urine examination were performed every day. An electrocardiogram with cardiac enzymes' level estimation were taken every other day. All the therapeutic doses were comfortably tolerated without any apparent allergic or adverse reactions. In addition, no toxicity was produced by any of these doses. It is, consequently, concluded that the formulations described under Example 1 are safe for clinical use in the recommended doses.
  • sulphur with salicylic acid and methylsulphonylmethane components are generally used in similar amounts, by weight, in the synergistic compositions of the invention, other ratios may also be used. Generally there is used a ratio of from 30:1 to 1:10, preferably from 15:1, most preferably from 3:1 to 1:1, by weight.
  • sulphur and salicylic acid may also be varied e.g. between 10:1 and 1:5, preferably 5:1 to 1:1, advantageously approximately

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte à une composition synergique comprenant du soufre et de l'acide salicylique ou un ester ou un sel pharmaceutiquement acceptable de ce dernier, ainsi que du méthylsulfonylméthane. L'invention se rapporte également à son utilisation dans des formulations et des méthodes thérapeutiques et prophylactiques contre la dermite de la ménagère, et permettant de protéger la peau et d'en améliorer l'état.
PCT/GB1993/001873 1992-09-04 1993-09-03 Compositions destinees au traitement de la dermite, contenant du soufre, de l'acide salicylique et du dimethylsulfone WO1994005301A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49744/93A AU4974493A (en) 1992-09-04 1993-09-03 Dermatitis treatment compositions containing sulphur, salicylic acid and dimethylsulphone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929218701A GB9218701D0 (en) 1992-09-04 1992-09-04 Housewife dermatitis treatment
GB9218701.2 1992-09-04

Publications (1)

Publication Number Publication Date
WO1994005301A1 true WO1994005301A1 (fr) 1994-03-17

Family

ID=10721365

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001873 WO1994005301A1 (fr) 1992-09-04 1993-09-03 Compositions destinees au traitement de la dermite, contenant du soufre, de l'acide salicylique et du dimethylsulfone

Country Status (3)

Country Link
AU (1) AU4974493A (fr)
GB (1) GB9218701D0 (fr)
WO (1) WO1994005301A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004105741A1 (fr) * 2003-05-30 2004-12-09 Gianfranco De Paoli Ambrosi Compositions cosmetiques et/ou pharmaceutiques a base de sulphone de dimethyle destinees au traitement et a la prevention d'irritations, d'inflammations et d'erythemes cutanes
RU2336867C2 (ru) * 2003-05-30 2008-10-27 ПАОЛИ АМБРОЗИ Джанфранко ДЕ Композиция для дермального применения, обладающая фотозащитным и антиэритемным действием, содержащая солнечный фильтр и диметилсульфон
EP2269615A1 (fr) * 2003-05-30 2011-01-05 Gianfranco De Paoli Ambrosi Utilisation de diméthyl sulphone dans des formulations de décapage chimique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1012585A (en) * 1963-05-01 1965-12-08 Barnes Hind Lab Inc New compositions for use in acne and like conditions
GB2057263A (en) * 1979-08-30 1981-04-01 Herschler R J Compositions containing methylsulphonylmethane
JPS58198421A (ja) * 1982-05-14 1983-11-18 Reiko Kosaka 皮膚脱色及び皮膚疾患治療用組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1012585A (en) * 1963-05-01 1965-12-08 Barnes Hind Lab Inc New compositions for use in acne and like conditions
GB2057263A (en) * 1979-08-30 1981-04-01 Herschler R J Compositions containing methylsulphonylmethane
JPS58198421A (ja) * 1982-05-14 1983-11-18 Reiko Kosaka 皮膚脱色及び皮膚疾患治療用組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8401, Derwent World Patents Index; Class B05, AN 84-002869 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004105741A1 (fr) * 2003-05-30 2004-12-09 Gianfranco De Paoli Ambrosi Compositions cosmetiques et/ou pharmaceutiques a base de sulphone de dimethyle destinees au traitement et a la prevention d'irritations, d'inflammations et d'erythemes cutanes
JP2006525951A (ja) * 2003-05-30 2006-11-16 デ・パオリ・アムブロスィ、ジアンフランコ 刺激、炎症および皮膚紅斑の治療および予防のための化粧品および／または薬学的組成物
RU2336867C2 (ru) * 2003-05-30 2008-10-27 ПАОЛИ АМБРОЗИ Джанфранко ДЕ Композиция для дермального применения, обладающая фотозащитным и антиэритемным действием, содержащая солнечный фильтр и диметилсульфон
AU2003238687B2 (en) * 2003-05-30 2009-07-02 Gianfranco De Paoli Ambrosi Cosmetic and/or pharmaceutical compositions comprising dimthylsulphone for the cure and prevention of irritation, inflammation and cutaneous erythema
AU2003238687B8 (en) * 2003-05-30 2009-08-06 Gianfranco De Paoli Ambrosi Cosmetic and/or pharmaceutical compositions comprising dimthylsulphone for the cure and prevention of irritation, inflammation and cutaneous erythema
EP2269615A1 (fr) * 2003-05-30 2011-01-05 Gianfranco De Paoli Ambrosi Utilisation de diméthyl sulphone dans des formulations de décapage chimique

Also Published As

Publication number Publication date
AU4974493A (en) 1994-03-29
GB9218701D0 (en) 1992-10-21

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