WO1991007958A1 - Pharmaceutical preparation-protector of myocardium under ischemia and reperfusion - Google Patents

Abstract

A pharmaceutical preparation as a protector of the myocardium under ischemia and reperfusion consists of an active substance 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone of formula (I) and a pharmaceutical diluent.

Description

 LZΚOTSΤΒΞΗΗY ПΡΞШΙΡΑΤ - ПΡ0ΤЖΤ0Ρ ШΟΚΑΡДΛ ПИΪ ΕГΟ ШШШΙ AND ΡБПЗΡο) 7ΚШ

Area of Technology

The inventive invention is related to the field of medicine 5, and the name of the new treatment is for the treatment of society and society. Prevailing level of technology Ischemic illness of the heart and myocardial infarction is one of the most common diseases. The treatment of myocardial infarction is an actual practice of the problem of cardiology. Pοsκοl- κγ οοΕοvnshνϊ φaκτοροm, οπρedelyagοschiϊνΤ πυοgnοz zhiznι: tsρ :: eτοm zabοlevanii, yavlyaeτsya οbem πορazheniya seρdechnοG 15 muscles οgρanichenie κοnechnyχ ρazmeροv οchaga neκροza yavlyaeτsya vazhneyshshl naπρavleniem τeρaπii οsτροgο inφaρκ- τa miοκaρda. Κ nasτοyaschemu vρemeni dοκazanο, chτο nai- bοlee eφφeκτivnym meτοdοm οgρanicheniya ρazmeροz οsτυο- gο inφaρκτa miοκaρda, πρivοdyaschim κ umenteniga κοli- 20 chesτva οslοzhneny and improve sοκρaτiτelnοy φunκtsii miοκaυda, yavlyaeτsya ρannyaya ρeκanalizatsiya πορazheκnοι: κοροnaρnοy aρτeρii.

Β At the same time, experimental studies have proved the existence of preventable injuries.

25 October, many of which have a potential beneficial effect on the restoration of the business. I found that the benefits of optimizing the treatment of myocardial infarction are many of the reasons associated with the limitation of medical treatment. ^ in experimental studies, a high efficiency is shown to be prevented from reducing the risk of operating conditions. Β parts, it is possible to use calcium antagonists, and agglomerated varapamil; allopurinol; 5 medicinal products (anti-urinary and anti-urea); ibuρροφena; inhibiting lipoxygenase pathway of the acid metabolism metabolism (LE 755s, on the contrary); Metabolism of active acidic acid (superoxide dismutase and catalysis); low level of antioxidants and good for 2, +, and a splenic ion, de- foxam, τοκοφеυοла and gluten; 2-meυκаπτοπροπ-

ΟΗILGLITsIΗa ^(χaiάeϊϊ Y., Biνeϊϊgοu Μ.Α. Κοϊe οG οχueeη gas-άχsaϊv χyu sagsϊχas χgdigu άie ο geοχueeηa-χοη. "G.ΜοΙ.SeΙΙ.

Sagάχο1., Ι984, Ι6: 459-470 ηаηета-ввиве Κ. , Κa ^ χνaga Κ., 0ηχ- koga 8., £а £ аο X., 8а1; οЬ Υ. , ΧΥχχΕΚΕΕегегρег ± ± ± aΙ aηά ϊϊηχχϊϊ οЪвег 1 1 Г Г Г 1 1 1 1 1; οГ вутρ-

-Leave "L'OURGES OF THE HUMAN RESOURCES. ^ ρη. Skhgs. "G. 1988: 684-694

Уегηв 8.ν. , Μχсηае1 3. ^. , Μχв1 ο8 8.Ε. et- aϊ. Genesis χοη ο ЬЬ вχζе οГ χη ГагсЬχοη Шу а11ορиг1; χοη χη -Ыιе χηсететсс-герге-

Giveάsaηχ ^η e е τ-. Cxgsi1a1; χοη, Ι986, 73 - 518-52; ΙлιссЬез

Β.Ε. , Μиϊϊаηе Ε.Μ. LESSOUSEVA aηά χβcЪетχχ--άάάάάάάάάά....... .У .у.... Αηη.Κеν.Ρηaghtas.ΙοχχсοΙ. 1986,26: 201-224

Keener Φ.Z. , Κagan Β.B. , Golubeva Ι.ΙЗ. Warning of stress and hyperactive injuries of a person with the help of an anti-oxidant. Диаυдиология, 1979, 10 8, С.Ι08-Ш;

Μ ^χ vt-ov Z.Ε. , Ρаη1; οηе »G. S., & a11aeLeg Κ.Ρ. et- aϊ. Saηχηe tuοsagάχaϊ geρegGivχοη χgts) yoke: ρgο1; EC1; χοη dy and Ggee gaάχsaϊ vsaνe ^η ββg, Ν-2-tegsaρ ορgορχοηuΙ e ± usχηe. Sagάχονav.sΡagt sοϊ. 1986, 8: 978-988).

And one of these drugs did not find any widespread clinical use of either because of the unavailability of long-term infusion, or because of undesirable inexperience

15 The advantages of the preliminary introduction, which do not correspond to a real clinical situation.

Since there is a need for a 2-methyl-3-pyridyl ester: more or -1,4-optic, which regulates the function of the steam circuit, which inhibits the activity of the substance

20 In case of visceral and ischemic shock, it is also possible to disrupt the detoxification process in the end. The data for limiting this connection to the size of the source are available. - 3 -

πυ ϊ informatively at ми без ыс without using the ρ е на на на at 47 ^ and at 33. sοοτveτsτvenκο πρi administered in dοze 7; x / κg vκuτρibρyushinnο and 2 mg / κg vnuτρiveκκο (Zϋ, Α, 1,148,280; 5ϋ, Α, 9Ι50Ι0; Ιevshι GS, Chuτi sοzdaniya κοmπ- leκsnyχ gemοκορρeκτοροv ιποκa for treatment, and Gemaτοlοgiya τυansφuziοlοgiya, 1986,. ' ^* 12, p.13-18; Levin G.S., Κurumukov Α.G., Κamenetskaya Ts.Ι., Ερmishsha Ο.Α., ΙGnevays Β.B., Drregis Ya.Ya., Experimental Therapy of the infectious disease of the compound, which is an artifical and effective elec- tric element, the Medical Department of Uzbekistan, 1988, 12, 0.56-60).

However, for the time being, it is indicated that a convenient business is not acceptable for research on the territory of the United States. This is due to the fact that the country has a low collective price for this type of animal, which does not exceed 6% of the average salary. Β due to nizκshντ κοllaτeρalnym κροvοτοκοm cheρez 45 MIN κοροnaρnοy οκκlyuzii neκροτizatsii ποdveρgaeτsya all mis- κaρd ishemiziροvashοιτ οblasτi, το esτ without πρimeneniya κοροκaρnοy ρeπeρφuzii in eτi sροκi nevοzmοzhnο πρedοτvρa- τiτ miοκaρda death. Κροme τοgο, ποκazanο, chτο πρi οπ- ρedelenii ρazmzροv shφaρκτa miοκaρda in ποzdnie sροκi in κρys in οπyτaχ without ρeπeυφuzii visible neκυοτichesκaya zο- on umenyπaeτsya on account isτοncheniya sτenκπ levοgο zheludοch- κa in οblasτi shφaρκτa with φορmiροvaκiem anevυizmy, τaκ chτο veschesτva affecting προtsessy Cuts, can give visible variations in size of the road. Geagze Ω. . , V. The Εχsηagά, Κχηe_αa L ^"Υe11οιι Ya.Μ.Τe ha-b:. Aη iηaiχaΙe tοάeϊ Gοg T-ϊιe avvevβteητ- οG -Yιe ρϊιagtasοϊοβχaϊ Ιχtχ-La-χοp οG χηGagsτ βχζe ιG.Μ.S.S.. ., Ι986, Зиρρ1. Ι-20Ι (ΑЬ8-Лг.)

There is a known connection - 2,3,5,6, 8 - pentagroxy-7- ethyl-Ι, 4-factor (a nice pigment of a lot of hedgehogs), having the following structure:

- 4 -

Εдιη ^η Ε. , νа11еηГеϊ8 Κ. Ι Ь η η η η ас ас ± ± ± Ъ Ъ Ъ ас ас χ. -Cηet. Βeg. , Ι94-Ι, Βά, Η.9, δ. Ι5 --Ι598;

ΤЬοтвοη Κ.Η. Зρχηοсηгостез. - Ιη: Κа-ϊϊигϊϊу Οссиггχπе

. - 2 her. - οοηάοη-Κеν Υοгϊс: Αсаά. Ρgevv, Ι97Ι _»Ρ« 57-27

The indicated compound has a bactericidal effect on certain types of young microorganisms and a high anti-oxidative effect, which is beneficial

5 to call ego to stabilize fats and oils to oxidize. The use of the indicated compound in the medical profession, in particular for the treatment of heart-related diseases, is not known.

DISCLOSURE OF INVENTION

10 The inventive drug is a new product and is not described in the literature.

The main task of the invention was to create a cure-free, reliably active, non-invasive patient.

15 denial and, thus, to limit the area of myocardial failure, which does not cause harmful effects, which has a low incidence.

The task was resolved in order to treat myocardial infarction in case of ischemia and reperfusion, including

20 active substance and pharmaceutical diluent, according to the invention, as a matter of fact, the active substance contains 2,3,5,6,8 - there is an effect on the substance:

ο οн

The main dose of the claimed product is a satisfactory average of 25, which is I mg / kg of weight. - 5 -

The claimed products may be used for various medicinal products, for example, medical devices, tablets. According to the invention, the claimed preparation, 5 are used in the form of injectable substances with the contents of the active substance I mg / kg. In order ποvysheniya ρasτvορshlοsτi deysτvugoschegο veschesτva leκaρsτ- venous πρeπaρaτ mοzheτ sοdeρzhaτ veschesτvο, ποvyshagaπee egο ρasτvορshlοsτ, naπυimeρ, κaρbοnaτ naτρiya or gisτi- Yu qui in mοlyaρnοm sοοτnοshenii κ deysτvuτοschemu veschesτvu 2: 1 ι: 6: 1, sοοτveτsτvennο. A pharmaceutical manufacturer of the claimed inventive product is a 0.9% manufacturing unit of a medical device.

The inventors are effective:.: With::: 15 restrictions that are expected to be excluded, which causes a decrease in the source of income of 40; πρeπaυaτ πυedοτvρaschaeτ ρazviτie ρeπeρφuziοnnοgο ποvρezhdeκiya sοsu- disτοgο ρusla inφaρκτ-svyazannοy κοροnaρnοGι aρτeριta and vyzyvaeτ znachiτelnοe uvelicheshe κροvοτοκa therein and τaκzhe 20 sποsοbsτvueτ improve φz ^g nκtsii mnοκaρda nezavisπmο οτ influence ρazmeρy shφaρκτa miοκaρda.

Pρeπaρaτ οbladaeτ nizκοy τοκsichnοsτyο (N) ^ _β sοs- τavlyaeτ besποροdnyχ for mice 148mg / κg for κρys Βisτaρ 87 mg / κg for κροliκοv-chinchilla 125 mg / κg) malοG ρazοvοι 25 and κuρsοvοϋ dοzοπ, bοlshοy τeρaπevτichesκοϊι shiυοτοπ. The а- neprevichnaya shiυοο а is equal to 40.

Κρaτκοe οπisashe cheυτezhey Β further izοbρeτenie ποyasnyaeτsya ποdροbnygl οπi- saniem zayavlyaemοgο πρeπaρaτa sο ssylκami on πυπlagaemye 0 cheρτezhϊά on κοτορyχ: φig.Ι izοbρazhaeτ gρaφichesκοe vyρazhenie summaυnyχ danκyχ πο force change sοκρascheniya (Λ) and naπρyazheniya ποκοya izοliροvannοy mezhyaeludοchκοvοy πeρegοροdκi κυο- liκa (B) Ε κ н н τ τ ле ле ле и и π влиянием влиянием влиянием влиянием влиянием влиянием влиянием влиянием ле κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ κ under the influence of the declared Fig. 2 is a display of physical equipment. The reasons for the release of the disease are: it ischemic and ischemic and ischemic. lack of preparation; Shig. 3 excludes exhaustive waste for 40 weeks of ishelia for 10 minutes; 5 Fig. 4 shows a group dependent on the influence of the size of the liver (left ventricle (Α) and the size of the stomach (B); Fig. 5 excludes a grouper expectation of the expected and actual size of the focus of the failure in the consumer and consumer group; φig.6 izοbρazhaeτ gρaφichesκuyu zavisimοsτ absοlgοτ- nοιϊ eφφeκτivnοsτi zayav.lyaemοgο πρeπaρaτa οτ velichinκ zο- nκ ρisκa (levyGι zheludοcheκ (Λ) and οτnοsiτelnοy ebφeκτiv- 15 nοsτn zayavlyaemοgο πρeπaρaτa οτ uροvnya κοllaτeρ & τιnοgο κροvοτοκa.

The best embodiment of the invention The simplest activity of the claimed preparation has been studied in an experiment on live animals and in a clinic for 20 years.

Βliyanie zayavlyaemοgο πρeπaρaτa on φuΕπstsiοnalnοe sοsτοyanie shοκaρda and vysvοbοzhdenie κρeaτinφοsφοκinazy - maρκeρa ποvρezhdeniya κaρdiοmiοtsiτοv - bylο izuchenο on giποπeρφuziοnnοy mοdeli ischemia miοκaρda and imennο 25 πeρφuziρuemοy cheρez aρτeρshο mezhzheludοchκοvοy πeρegοροd- κe seρdtsa κροliκa, izοliυοvannοy πο mοdiφshschροvannοmu meτοdu Ιangeρa and Bυedi.

Κροliκοv ΙΙΙinshilla (sagltsοv massοy 1, 8-2 κg) anesτe- ziροvali baρbamilοm (30-40 mg / κg vnuτρivennο) vsκρyva- 30 whether gρudnuyu ποlοsτ n vvοdili 40-60 ml κaρdiοπlegichesκο- gο ρasτvορa κοιlnaτnοy τemπeρaτuρy in levyκ zheludοcheκ (sοsτav κaρdiοπlegshesκοgο Mortar in millol / l: 110 ° ССΙ, 16 ° Сϊ, 16 - еСϊ ₂ ; 1.2 ° ССϊ ₂ , 10 ° СΗС0 ₃ , ρΗ = 7.8 πρ and 28 ° С; the gas was not gasified). At this 35th time, we surpassed the estates of the а а ρ а а а а а. After the LONGEST REMAINING, the heart was removed, cut off and the stomachs were placed, the sample was weighed and mixed in the measured chamber. Οbasically π ρ ρ ρ φ φ φ φ------

- 7 -

whether between the two clamps, and the head was connected to the force transducer. Β The mouth of the septic artery entered the kangole and prevented the release of 5 times a weight of 2.2 ml / g of weight. Composition of the product (in mmol / l): 118 ϊаС 6, 6 ΙССϊ, I ΜβСϊ ^, 1,5 CaСι ₂ , 0.435 maΗ ^ θ ^, 24 ΝаΗСΟд, 6 glucose; ρast-in-gas gases were excluded (95 ^ 0, 5% С0); υΗ 7.5 πρи 28 ο С. Ρітм (1 ^~ , 2 Hz) were imposed by means of an electric

10 excursions ended up with an impulse lasting 5 ms, the amplitude of the output voltage was higher. Serious destructive elec- trodes were introduced into the basis of disintegration. At present, during all current experiments, the temperature was 28–0.5 ° С. After the procedure was completed, it was

15 The farm was adapted for I hour. At the same time, the efficiency of the function in э ο на э э э э φ φ φ φ φ γ γ γ γ γ γ γ γ γ γ γ γ γ γ γ γ γ γ γ ,9 γ γ κ. The measured level of adenessa, adenosphysiosis, disability and loss in four of the rooms of the πυυегοοдддддддддддддοο че че че че в че че че в че в в че в в в в в в в в в в в в в в в в в

20 to the end of the adaptation did not practically differ from the other side. Contents of the ergocentric spoilage in the heart of the heart of the heart of the city, the rest of the factory was damaged. With tselyο glgaκοzy removal of sοsudisτοgο ρusla π mezhκleτοchnοgο προsτρan- 5 sτva πeρegοροdκz πeρφuziροvali in τecheshe I min κοnτροl- nygl υasτvοροm not sοdeρzhaschim glgoκοzu, ποsle chegο sκο- ροsτ πeρφuzsh umenshaτgi dο 0.22 ml / g of body weight / min (10 οτ isχοdnοιτ) . Hypothermic disease lasted 40 minutes; then there was an end to the on-line disruption, the initial speed of the infusion was restored to 0. The transgression was reduced within 60 minutes. 3 experiments with the declared devices (in the final concentration of the active substance of 5 μm) were introduced into the facility for 15 minutes before the jam. 3 The same percentage of activity is less expensive than 5% of the experimenter »3 The current is a non-volatile property - 8 -

In order to divide the business environment, it is important to have a quick experience. SUMMARY OF THE EXCESS OF κCreatinphosphine kinases calculated how the sum of all fractions of the specific G: ak-

5 its activity in I ml of efficiency multiplied by the speed of the process. A note of 5 March stated that the incident didn’t affect the force of the cut (Τ), the voltage and the speed of the wheel did not change if there were no further accidents.

10 compresion ρ relaxation.

The aggregate statement of action claimed for the dashamika of changes in force and direct pressure under conditions of ischemia and ρρπ ρ π φ ед ед ед ед на на Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι. Like this, it’s all right.

15 maρnyχ daκnyχ, the claimed πρeπaρaτ (5 τlκΜ) πρaκτichesκι not changed vρemennοgο χοda πadeshya force sοκρascheshya 5 + 2 (η * 6) προτiv + 2 $ (η = 5) οτ isχοdnοy κ 40th shshuτe ishemshϊ, πρedοτvρaschaya ρazviτie ishemichesκοy κοnτρaκτuρy:

146 + 16 $ at 241 + 26 $ at the original voltage

20 ποκο κ 40th minute of the ischemic, υ ^ 0, 0Ι. In case of re-infusion, the claimed reprimand (5 mkΜ) results in a permanent reduction in the strength of the reductions: (72 + 7 after 41 + 4 $; On October 128 + 13, the source is 60th.

25 υеπеυφузиπ). Improvement and restoration of differential parses in the mechanics (maximal speeding up and relaxation + άΤ / ά-и and - άτ / ,τ, ,сс с с с с, сτ / / с с с с с). But, κ 60-З1 minute υ π π уз уз в в в в в в в в в в / άΤ

30 54 + 8, - άΤ / ά-up to 55 + 5 $ οτ original; in experiments, we declined an offer (5 µk ^τ .ϊ) + άΤ / ο, which was restored to 79 + 6 $, υ ^ 0, 0Ι, - ά / д to 77 + 9 $, ρ ^ 0, 0Ι.

There has been an improvement in the outcome of the situation: the degree of satisfaction is greater than that of the current situation.

35 I wandered at the exit to the business group of the opposite. It is for the best part of this application that we have granted a request for refusal to pay for it. - _

to the patient (5 mk), the release of excreted kinases in the erythritis 40 minutes after ischemia was 0.45 + 0.21 weight (weight / min)

5th night of group - 0.78 + 0.10 ΜΕ / g of dry weight / mic (η = 5), ρ ^ .0.01. It also seems to be that the claimed device significantly reduces the cost of an extra load for the initial start-up: 1.57 + 0.5g / min. κοκτυοl-

10th series, Ρ ^ 0, 0Ι. For the sake of payment, the total release of the kinase from the disease and ischemia is available. For 40 minutes of ischemia, it reached 26, 07 + 2, 27 ΜΒ / g of dry weight at the last condition at 14.92 + 3, 58 ΙC / g of dry weight at the speed of the declared case (5); behind

15 10 minutes of treatment 18.17 + 3.70 ΜΞ / g of dry weight π 9, 92 + 1.71 Μ Z / g of dry weight, ρ-s: 0, 0 с, respectively.

On the other hand, a comparison was made with the blocking of the military operation. Βvedenie in πeρφuzaτ veυaπa- sweet Ε κοntsenτρatsii 5x10 ^"Μ κ πρivοdilο πadenshο force

20 reports of the voltage up to 11 + 2 $ output (η = 3) and constant voltage. Cherapamil (0.5 µkΜ) was added to the product for 15 minutes before the start of ischemia and the case for 15 minutes of treatment. More recently, the country was suffering from an inconsequential improvement in the rate of incidence of 5 minutes of ischemia (212 + 28% of the congestion). The restoration of strength was now 60 minutes to a recession of 40 + 5 $ from the source (before introducing the parameter into the case), it also doesn’t do so. 0 Finished, rezamil even with a large concentration, like 5x10 ^" ι, ι in this model, it didn’t have the chance to act.

Like the claimed appliance (5 mk! .Ι) Ε the conditions of the π ρ льн льн π π π ρ е е change the force of reduction, voltage of 5 ο, + άΤ / άϊ; , - άΤ / ά, and also the proximity to the environment is excited when it is protected, its protective effect is apparently not related to the influence on the electrical process. In case of severity of the disease - 10 -

pressure ποd deϊϊsτviem zayavlyaemοgο πρeπaρaτa κe meκya- lοs, ποeτοiu not πρedsτazlyaeτsya vοzmοzhnym οbya ^'sniτ zaschiτny eφφeκτ egο vliyanieιl on κροvοτοκ. Declared to protect the shock of the enemy and to prevent the infusion was tested on the models of the infarction of the disease in the population and the dog.

The myocardial infarction in the inhabitants of the Republic caused a mock for 30 minutes of the descending left of the left artery with the next reaction. The claimed preparation was administered internally for 5 minutes before the external preparation in the dose of 0.3-3, 0 mg / kg. At the end of the day, they used 100 residents of the “chinchilla” mass, weighing 2.5-3 kg. The group, together with the drug, introduced only a little stabilization of the drug (histidine and blood pressure), in addition to that, there was no risk of it. During the course of an emergency after an occlusion, the electrical symptoms of the impairment were evaluated. The pre-dial dial has been detected out of 20 times, and the distribution is disconnected between the disconnected and disconnected plugs. The luminescence of the 8Τ isolate was divided in the other way round, remaining: the maximal tooth κ was 0.04 sec. Was the aggregate segment volume of 50 divided? after 15, 40, 60, 90, 120 π 180 ms after the moment of short-circuiting. The results are expressed in Ι Ι 5-minute meaningful, which was sent for $ 100. Iivοτnyχ zabivazh cheρez 7 cs ^g τοκ ποsle οπeρatsii. The size of the myocardial tract is appreciated by the size of the joint without a collar. For the separation of the size of the casing, the heart was divided into 5 different blocks, which were frozen in dry ice. From each unit, 10 mk cuts were made; in some cases, they activated the dehydrogenase succine in the reaction with the oxygen sync. When this happens, the regular part is worn in purple, and the scruff is not worn out. The public square was cut to the ground, the square occupied by the city; These were divided using the system g / akalysis from the π - Α - I π φ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - section. - II -

We calculated the percentage of the better area from the south. We took into account * the weight of each unit of the seedling and the relative content of the UHE: Ι уб убубοубубуб τκκκ ,Κ,,,,,,,,,,,,, ,π ,ο,, вес, we calculated the weight of the successor in each unit. The results obtained and the introduction of different types of results are shown in Table I.

'! 'a- ο. person ι

Other claims are made on the basis of the size of the vehicle (ρ - ^ - 0,01 πο is the same as κοπτυлемм)

Ρο

Zayavlyaeιlyp chislο zmeυ inωaυκτa πυedιaυaτ κυοli- miοκaυda in -> οτ mτu κg ^"κοv mass miοκaυda levοgο zheludοchκa

March 19 12.40 + 1.17

0, s 12.96 + 2.38

10 7.76 + 1.42 η ο 10 8.67 + 2.07

Ρеρаπаϊνϊил 0.5 10 6.51 + 0.62

Gauge 0.220 10 14.51 + 3.02

Declared D: the dose in the dose of 0.3 mg / kg showed effects on the rate of myocardial infarction. Increasing doses up to 1.0 mg / kg reduced the dose by 40 times compared with the emergency group. A further increase in the dose to 3 lg / kg did not result in an increased protective effect of the drug. Β In connection with this, further use was made of the claimed by us, - 12 -

Equal I: lg / kg, as the therapeutic effect.

The action of a declared treatment for the organic zones of myocardial obstruction in the same time, the model of the experiment 5 is equal to the action of:,. The sample was administered in the form of an external solution in a dose of 0.5 mg / kg. With a lively dietary supplement 0.9-year: fresh water supply to the cold. Variety: the areas for use were only 6.51, and the use was 7.76 for non-refundable terms. An increase in the amount of $ 30 in cases caused an impairment of impaired activity - a transient athero-vascular block of the S-P channel. 15 Infusion of the ли τ τ ли ли κ κ κ г г г г г г г г is limited in size.

Βliyanie ρazlichnyχ dοz πρeπaρaτa κa ποκazaτelπ πυe- κορdialnοgο κaυτiροvaniya tsρedοτavleΕθ in τablitse 2. Βvedenie zayavlyaemοgο πρeπaρaτa in dοze 0.3 mg / κg κe CAUSED 20 valο dοsτοveρnοgο reduction summaρnοgο ποdema οegienτa 8ϊ πο sρavnenigo with ποκazaτelyami κοnτροlnοy gρushsh. Higher doses up to 1-3 mg / kg were available due to a faster, faster total; only κ 90-150 minutes.

Table 2 Influence of different scenarios of introducing a declared device for the electronic device of the indicator for the improvement of the myocardial system (a percentage of the outcome)

End 100 86 + 10 73 + 4 68+ 62 + 7 47 + 5 0,3 00 78 + 15 61 + 16 49 + 1840 + 11 37 + 25 thirteen

Пυ ο д ο τκенπ е τ ab τπгцы ο

The influence of the declared πυеπаυаτа πа υзмэраы from the source of the failure of κ- υοza miοkárda research. This is an exaggeration: the mode of myocardial infarction. This model, in contrast to

5 Industrial () ο κ ли)))) зв ο), you are encouraged to receive this important information, the system is in operation and the system is in operation. On the other hand, I won’t be happy with the development: the system is closed for reimbursement. This is the best option for your patients with the clinic:

10 lessons.

There was a 30-year drive for the user to download the device, but it wasn’t able to get a quick connection (it wasn’t gotten Вен.strong ventilation light: πυοвο-

15 dilas ποd κοnτροlem gazοvοgο sοsτava aρτeρπaτnο: ^":. Κυο- vie for vοsπυοizvedeniya οκκlgοziπ and υeπeρφuzii in bass Seyni πeρedneπ nisχοdyascheGι aρτeρshι isποlzοvalas meτοdi- κa κaροτidnο-κοροnaρnοgο shunτiροvanπya with dvuχsτuπenchaτοg οκκlyuzieG: and ρeπeυφ: ν ^', -zieπ.

20 The distant segment of the previous one is cannulated and parsed, and it is received only by the general public. Ηa πυοτyazheniπ vsegο eκsπeυi- menτa mοniτορiροvalis chasτοτa seυdechnκχ sοκυascheniϊ :, 5 eleκτροκaρdiοgυamma in οτvedenii, sοοτveτsτvuyusche? .. II sτaκ- daρτnοmu, vnuτυshΕseludοchκοvοe, aρτeρiaτnοe n πeρηuziοn- nοe daΕlenie in sπsτeme πeρedneZ nisχοdyascheg aυτeυshι, κο- nechnοe diasτοlichesκοe davτenπe (Ρ) in levοm on the other hand, άρ / ά basal κ :: and the maximum κυοвοτοκ in - 14 -

Descending: arteories. GSροvοτοκ Ε shunτe πeυeκυyvatsya n ⁵ '

? 0 ılpkgt with the following: υ π π ρ з Г Г::: in 4 hours.

Οκκшэзпя: ι υеіпеυ π π π ди ди ди ди ди------------уз э э э э э э э. κ и и и с с ен ен stenosis. ^"Ϊeυez ± δ ιlπι- uτ ishe- iiι: οπρedelyalsya υeτυοgυadny"^{"κοροnaρnyG} κυοvοτοκ.

For visitor gaps ^{, the} visitor’s zone and the end of the trip are subject to the following: νχνο with the following: is there a second exit? Well, the area of the land and not Bychis. The value of the return is calculated on the basis of the return of the income.

The best data on the disclosure of the claims on the source of the source is not. are not shown in table 3.

Τab.shscha 3 Βliyanie zayavlyaenοgο πρeπaυaτa on ρazmeρ inηaυκτa miοκaρda in sοbaκ ^(g υ ^. 0, 05)

Addendum 3

Υ исл Ч Ч исл------:::::: Дв ΙΟ ΙΟ ΙΟ ΙΟ ΙΟ ΙΟ ΙΟ ²

1

I 12 0, 045 + 0.003 15, 0 + 1.6 τ sz

Τροο

± Neg 0, 052 + 0, 00G .0, 0+;, ν_ ⁾ 7 ο, οει + s, οϊ7 ιο, Τ ÷ Ι,

Гр7, тша I - counting; gρuππa 2 - οdnοκρaτnοe vg.edenπe Τ ιιg / κg zayavlyaeτlοgο πρeπaρaτa 5 glπκuτ dο ρeπeρηuznp; group 3 - a two-part introduction on the basis of the preparation of the dose before I гlg / κ? ^-1 cheρez mπnuτ ishemπi 5 and 5: iπ- ^{~ d} τ dο ρe- πeρs ^ή Uzi ::. Thank you: κ ρ ο вы вы """" - - - - - - - - - - - - τ τ из из 5 5 5 5 5 5 5.

Well, it’s obvious that there are 3, groups 2 and 3 did not differ: - it’s great ... the main class of the zone is /

10 levs, the ventricle, the cathedral, and the fortune, and the poor, that is the meaning of the Convention, which is indefinite.

At the same time, the size of the eye is expressed and expressed: the area of the left ventricle is one- and two-

On the 15th, with the introduction, declare that the drug was available more, the chep in S-D: group. Differences in the region were inevitable because of the lack of clarity 2 to 3.

Ηa yiτ.4 πρedsτavleny data ο vliyaniπ ρazιleροg zοκy ρisκa (Α.) And κοllaτeρaιgyιοgο κροvοτοκa (T n ^η. Ρazie-

20 ρy οchaga κeκροza in κοnτροlnοιϊ gυuτshe and πρi πρsh.ιenenii zayavlyaeglοgο πρeπaρaτa. As indicated in Section 4, we declare that you are limited to a part of the infectious disease at all in the case of an unresponsive range. Dependence of the zone of necrosis / left G-ventricle of

25 zοny ρisκa / leByG "zheτudοcheκ: ι zοny κeκροza / zοκg υnsκa οτ κοllaτeρalκοgο κροvοτοκa κοsila lineGιny: .χaρaκτeρ π οshιsyvalas uρaΕnenieι.τ lπκenοy ρegρessιsh: in κοnτροlκοϊ- gρushιe ι zοna neκροza / levyϊ zheludοcheκ = 0.50 zοya ρisκa / left-

30 WAS a ventricle g = 0.94; - 16 -

zone of risk / zone area = 64.6-290, zone of return = -0.9; in experience; sections 2 and 3 of the wish / year: stomach = 0.336, the eye / year same.

5 daughters g = 0.92, and the eye is not in good condition / zone is = 45.0-274, it is called: ����������: g = -0 _; 7Ι. Differences in the availability of resources: availability: available (υ ^ Ο. Οδ).

Χϊщϊϊ χааυа завис завис завис завис зависшшшшш зависшшшш и и и и и и и и и и и κκφκ и κли- с ο с с ссашашашашашашашашашашашашашашашашπашπππππππππππππππππππππ πυυаπππашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашашtingnerless yearsening period-ед-----

The statement in the form of an expression of a plurality: linear is: regressions with the values of the eye / left ventricle and the catarrh of the palate in the sense of independence are independent. For the end of the year, it was the only one that had: the eye of the left / left ': same section 0.62, the area of the left / left: the stomach - 65, 9,

15 kallateralny: κυοΕθΤθκ g = 0.9C (.0.0001).

Finished completely, the size of the area of the left / right ventricle, the complete abnormality of the patient, neglect of the neglect; gρуππе (g ~ = 0.97). On the basis of this, the method was developed.

20 for a quantitative assessment of the effectiveness of the claimed product, which is limited to the size of the infarction. For each lively experimental group, the value of the expected size of the myocardial infarction was calculated (Fig. 5). As shown in Fig. 5, the effect of the claimed product was large.

25 cases have been delivered. The efficiency of the claimed product was estimated at the difference between the actual value and the total cost of the product. -Two indicators of effect were used:

- RESISTANT EFFICIENCY, DISPLAYING, EVERYTHING

30 how many days in fact: the size of the information is less than the usual;

- the absolute effective, indicative of the fact that the left ventricle is very impaired due to the lack of activity: .. that is, it is; useful eφ-

35 facts.

Ιϊssledοzanie zavisπglοsτi eαyeκτivnοsτi zayavlyaemοgο πρeπaρaτa οτ sοsτοyaniya κοροnaρnοgο κροvοοόρascheniya ποκa- zayaο, chτο οτnοsiτelnaya eφφeκτivnοsτ ne zavisiτ οτ ρazmeροv zοny υisκa and absοlyuτnaya eφφeκτivnοsτ πρyaglο

- 17 -

Practical consideration is better than the picture of the search / lebyg: hell, that is to say that there is no reason to forget about the accident.

5 There is, therefore, a large mass of stored Vilnius, which is indicated for the first half of the year. В This means that a negative e-mail will result in an increase in the amount of money that is shown in fig.b. Like, the most erg> - the claimed applicant indicates that it is:

In the United States, the country is located in a separate region of the Republic of Kazakhstan.

Has the effect of the claimed preparation been studied? on πο- κazaτelπ gemοdshιamiκπ (chasτοτa seρdechnnχ with οκρaι enιτι ~ ':, sπsτοlichesκοe pressure Ε levοm ι; eludοchκe).

15 Exclusion of the heart of the heart is not affected by the change in the heart rate of the heart of all parts of the heart. The large introductory introduction of the claimed product, and also did not affect the heart rate, was

20 was liable to tendency (ρ = 0.06) to its loss of life and to the third party during the breakdown.

Οκκlgοziya κοροκaρnοπ aρτeρni πρπvοdila κ ρzzκοmu (in τechenie seκuκd 30) sκizhenπιο sisτοlichesκοgο davlenπya of levοm zheludοchκe κa 10-14 mm ρτ.sτ. ^"Ιa πρeτyazheκiπ vsegο 5 πeρiοda itemshι sisτοlichesκοe pressure levοm zhelu- dοchκe sοχρanyalοs κa eτοι.ι same uροvκe with κ τendepddeGι the Further uglenieniga Β πeρvοy and vτοροy gρuιshaχ ι;. 60- -90 minuτam sisτοlichesκοe davleκie in levοιl zheludοchκe bylο dοsτθΕeρnο snizhenο πο . sρavκeniyu with isχοdnyτ.1 Β 0 τρeτey gρuππe οτlichiya οτ isχοdnοy velπchiκy by.ππ non dοsτοveρnymi Β peρiοd ρeπeροuzip uροveκ sisτοlichesκοgο pressure levοm zheludοchκe in πeρvοG; and vτοροG:. gρuππaχ suschesτzeκnο not menyaπsya, οsτavayas spizheκnym pο sρaΕne- nιpe with isχοdnygli znacheniyamτ :. Β τρeτeι: gρuππe κ mοmenτu 5 ΠΟLΗΟO ρeπeρφuzii sisτοlichesκοe davleκie in levοm zheludοchκe ποvyshalοs πρaκτichesκl dο isχοdnοgο uροvκya _^ οτdi- chayas οτ ποκazaτeleG: πeρvοκ n vτοροy gρuπshι Pοκazaτelι:. κοnechnοgο diasτοlπchesκοgο daΕleκiya in levοm zheludοchκe and ± -

Maximal: fast diastolic sarcopenia

(+ άρ / ЬЬ ШАХ) ια the difference between the others is different,

- Ι Ι Ι κ с ΚΟΌΟ ΚΟΌΟ ди ас ас

(-άο / άЬтаχ) is presented in table 4.

Τ August

Absolute condominium diastolic relaxation (-άρ / т б _т that _α χ _ν χ ΙΟ ' ⁶ ?. G. ΌΤ. СΤ)

Group ли че χ χ χ--τ ен ен ен ен Exclusion, glyc

ЖΪΒΟΤ-: 15 60 90 ΗБΕΧ η

ο> ο 16 20 19 ΙС

2 + 3 16 Λ_ »0 .s 20 20 20

Attachment Table

Гууппа Κοличе- Ιϊсχοд- Сениое πеепеρфузіш.mϊ'Ш STOI naya

LIFE- I Ιδ 30 60 120 Ι4Now ι 10 II 12 13 ΤΔ τ ο

8 23 16 16 17 I? 16 16 Ιδ

2 + 3 9 16? ^D <r 5 r} £ Z οτ ^ Ο ^ ΟΤ ^ Τ ^

Differences with the business group are available ( ^"~ ρ <.0, 05).

Юз κ юз Д Д юз юз Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д Д.

10 The tension of the Empire on it remained available for a long time. ' πο compared with the original. Just by replacing the service in the on-line group, its further reduction, in το - ιε -

TIME κ а BECAUSE OF AN EXPERIENCED GROUP: Is this? ποκazaτel κ ιlο- ιlenτu ποlnοG: ρeπeρsΤguzni πρaκtyachesκπ vοzvρanιaτeya κ isχοd- nοmu uροvnga, οτlichayas οτ znachensh: in isχοdnοι ^': gοuππe. Differ ιττκ ^ / group 2 and 3? The entire current experiment was not noted. Τaκim οbρazο increase maκ- ssh.talnο ^"" sκοροsτi dπasτοlichesκοgο ρasslablenchya ποd deysτviem zayavlyaemοgο πρeπaρaτa iοneτ svideτelsτvοvaτ οb luchg.ιeΗt diasτοlichesκο them: ^'η unκtsshι leΕθgο yaeludο? "- κa?..

There was a learned effect of the claimed drug on the ^α -indicator of the hemodynamics.

Primary pressure in the previous :: downstream: the difference between the pressure is not different. The third quarter is the most recent. s πeρedyae :: nπsχο- dyaschey aρτeρip tsρedsτavleyy τa in the face ^ 5. Chοsκοlκu ποκa- zaτeli maκsimalnοgο κοροnaρnοgο κροvοτοκa vο vτορο: ": π τρeτey gρuππaχ suschesτvennο not οτlichalis, οni bylp οbedineny Sοzdanie κρiτichesκοgο sτenοza πρivοdilο κ decrease maκsimalnοgο κροvοτοκa 50-60. _* . all of the group has a recurrence in the on-line group there was a tendency to further reduce it κ π ο вы вы π π π,,,, and starting from . eρyuzii, κe οτlπchaτyuya οτ isχοdnyχ znacheshsh Ηachinaya with 30-60- !: yggyauτy ρeπeρηuzsh, ρazlichiya between κοnτροlnοO and οπyτnymπ gρzshπaiπ bylπ sτaτichesκi dοsτοveρnymπ Chοκazaτeli vτοροy n τρeτeG:. gρuππ meeζdu sοbοι ^'1 ρazlichayais not.

Table 5

The dynamics of the country in the past: a downward arteration (in me)

Pοκaza- Gρuππa Κοli- ϊsχοd- Sτenοz Ρeπeυyuznya, m_g: τel chesτvο κοe τ _{Τ £} - _{η years,} τπρ _l zhivοτ- ^{χ 10 t? L} - ^1m ^ ^ϋ nyχ

I 2 3 4 5 6 7 D 9 κ D II

АLaximum- τ η τηη sη η ^ r _^ s / g l - "r- ~ ΚΟΌΟ- ^{ιυυ ϋυ} '° ⁶ ^ ^{64 b} ^ ⁵ ' ° in ный ^" ΚΌΟΒΟΤΟΚ .0 -

Further Tab. Δ

10 g

.. - .. h _* . - „g7 ^' 1

ΙLax- 2 ÷ 3 -τ 100 80 e, ("Μ-ϊЗΤ (-.ρ- ^ ^• * - - _" {

:.

Ny basal κο- I 7 100 ο 126 95 95 97 113 98 υοnaυyy "κροvοτοκ 2 + 3 100 87 οΟ ιιο ιz, -ιgZ ^* Ε. Ϊbz- 3? Τ.bs 17

κ ρ- ^ 0.05 s on time: load.:.

When the base unit is in use (Table 5), the unit is not expressive: the value is, at the same time, it is free of charge

5 The growth of the business, which reached the 4th hour of the treatment of $ 1 0 source. Starting from the 30th minute, there are differences in the level of differences between the experienced and experienced customers who are able to achieve good performance. , Им им ρ,,,, ’

The juxtaposition of the myocardium is explained by significant changes in the hemodynamics of the transient arteries, which are included in the incidence of aggression.

the maximum rate of corruption and the disappearance of the reaction of active hyperemia, which indicates that the situation in the country is: regulation

15 vessels of the tune, and, most likely, is the first manifestation of the phenomenon of "ηο-гГϊϊκ". Any other use of this product is not subject to reduction of the maximum volume of purchases; over the course of the whole experiment, the reaction of the reactive was suppressed: it was suppressed, and the basal ones were

20 προgressive increase. Pοsκοlκu gρuιshy zhivοτnyχ not ρazlichalis between sοbοG πο οsnοvnygl ποκazaτelyaιl, οπρedelyayuschigl velichιshu κοροnaυnοgο κροvοτοκa (chasτοτa seρdechnyχ sοκρaschensh-, κοnechnοe diasτοlshιesκοe pressure levοm zheludοchκe, πeρφuziοκnοe pressure) changes

25 κκ ρ на κ ρ в в в::::: ::: :: :: group bus- - 21 -

the claimed action of the drug. Claims in οdnοιϊ gυuππe not οτmechalοs zavisimοsτi ποκazaτele :: κοροpaυ- iοgο κροvοτοκa οτ ρazηeυοv οchaga κeκυοza, chτο svpde- τelsτvueτ ο neποsρedsτvennο: vοzdeιιsτvshι zayavlyaemοgο πυeπaυaτa on sοsudπsτοe υuslο.

Τaκshl οbρazοιl, οdnοκρaτpοe bοlyusnοe vvedenπe za- yavlyaemοgο πρeπaρaτa in dοze I mg / κg 5 ..shnuτ dο υeπeυ- φuzshι yavlyaeτsya eοχοeκτπvny .. ^r - meτοdοm οgρanicheniya υeπeρφu- ziοniοgο ποvρevdeκiya mποκaρda sοbaκ causing umenπeκπe οchaga neκροza 40-45%; The effectiveness of the preparation depends on the individuality of the casualty. κοροκaρnοgο κροvοοb- ρaschenπya (glavnοϊ: deτeρmπnanτnοϊϊ yavlyaeτsya uροven κοlla- τeρainοgο κυοvοτοκa); zayavlyaemκ: πυeπaυaτ πρedοτvυaιτ; ρ- eτ ρazviτie ρeπeυφuziοκnοgο ποzρezdeniya sοsudisτοgο υus- la shιφaρκτ-svyazanpοϊϊ κοροπaρnοGϊ aρτeριsh and vyzyvaeτ zκz- chiτelnοe increase in κροvοτοκa neιϊ and τeκyae sποsοbsτ- vueτ uluchshenshe φunκtsip miοκaρda nezavisimο οτ ΕLGOSHIYA Η °. Sizes of myocardial infarction. The study of the simplest type of testing was performed on 60-year and free mice, 60-τπ π ρ Β Β ве ве ве ве ве ве ве ве ве ве ве б ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве ве. . Znachenπya BΟ ^ ^ ™ ^{"κiχ οκazalΙΙS} 48 + 22, 87 + 15, n + 125 21 mg / κg, sοοτveτsτvennο Τaκshl οbρazοm, zayavlyaemyG: πρeπaρaτ πυi vnuτυπvennο :: vvedenshι eφφeκτivnο πρedοτvρ" aιtsaeτ ρeπeρηuzποκnye ποvυezh- Denia miοκaρda, umenyπaya κοyechnyGι ρazmeρ οchaga failure, improving the skeletal system of the left ventricle and the gastric arteries, results in a low incidence of gastric arteries.

Βeρaπamil πυp vnuτρivennοm introduction οgυanichivaeτ υe- πeρφuziοκnye ποvρezvdeniya τaκ τle eφφeκτivκο, κaκ: v zayav- trolled πρeπaρaτ. Β At the same time, the risk of injury is often neglected due to undesirable effects: ρππenenle we declare πυеπаυата for the sake of limiting υазмеυοв υеπеυ- _ οο

S773I0ΗΞ0 0 ιshοaρκτa ιlποκaρd "πρedποchτiτelκee, che used ποlzοzaκτe veρaπa: .. πla, τaκ κaκ zayavlyaeιlyg πυeπaρaτ not zyzyvaeτ ρazvπτπe not: κe.yaaτelnι: x ποbοchnyχ υeaκtsπ ::.

5 The present material statement is declared by the public - 2, 3, 5,

6, ο - π π π Ι---7 Ι Ι Ι 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4:::::::::::::::::::::::::::::::::::::::::::::::::::::.

THE METHOD OF RADIATION OF MATERIALS FROM EXTREME ORIGINAL SOURCES (freshly recovered or excreted

Yu ιlουsκπχ e: leι_) vκlyuchaeτ a eκsτρaκtsiyu tselezοgο πυο- duκτa ρasτvοροιl 30 ^ -nοy seρnοG: κislοτy in eτπlοvοgl sπiρ- Te, dalneπshuyu "gldκοsτnuιο eκsτρaκtsτgο uκazannοgο veschesτ- Islands of ποluchenποgο υasτvορa χlουοφοριlοιl mixed with ΕΟDΟΙΪ πρi κοι.ιnaτκο" Te .lparotu π. * * * * * * * ο:

15 φορι.ι: the water is equal to 1: 1 π е е л,,, 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1 1 1 1 1 1 1 1 1 1 1 In fact, on the basis of cleanliness, 0.06 ^ 0 is the weight of the original raw materials.

20 Declaration of substance in substance

: .ο? The net is as follows. obobazl.

Digitilevir efiru hydroponically ignites cycling through the prevention of dehydration in vasaclavite, -

25 days 5, & - dpguide-2,3-dial-4, on-the-fly :: I am deactivating Μη0 in the last week ": Η 0, I’ve got 8 days ago, -Ι, 4- on the fact that it is active in the Republic of Kazakhstan and the Republic of Belarus in 90-Ρ5 S, in the United States

30, there was 2, 5, ε-τυigidροxy-3-ethyl-6, 7-screwdriver-4, 4-screwdriver didn’t suppress hydraulic load in the case of 2 operating conditions 5, C-dihydroxy-2-eto-x-ϊ-3-etil-6, 7-di-o-l, 4-n ”

35 Effects of Action. SYSTEMS REAGENTOZ SΗοΟΗ-ΚΡ -

-Α1 _ο 0 πυ and geulpеυауtuре 90-95 С and the resulting тυшелилил- ГГ: these are the goals of the target product that will be deactivated when the process is in progress. C ^ Η-ΝΟ ^ πρ οο - ώ -

70–75 ° C, which gives the target with a glance: output: .. -δ-21 iv.ο. .

Zelav.esh: π е е π ан ан лы лы лы лы лы лы лы......

5 το: _ miοκaρda or nρι_ ποdοzρenιsh on negο in τechenpe suτοκ οτ start zabοlevaniya and τaκκe ιyuch κesτabκlnο "sτeπο- κaρdiκ with vysοκim ρisκοm ρazviτiya inοaρκτa mpοκaρda with .- yavlyaegyash πρeπaρaτ mοzheτ ιτρshlenyaτsya in .ψοbο:.?"^"Ηaρ: ιyade? .tn- garbage:: medical equipment. (solutions, tablets),

10 is preferably in the form of an injectable solution.

The proposed medicinal product for the purpose of delivering this product is subject to 0, all in all, the price is .. ����������������������������� de :: ct-

15 Buietsego substances.

3 links to low: the viability of the business unit for the supply of food for the purchase of a home appliance;

20 6: 1, respectively.

The principle of application is declared: the device is entered into the form in the form of a solution to the first case. On the basis of the manufacturer, the manufacturer uses 0.9 & -nearly discharges of cold water. ? => -

25 the first dose of the drug I Ілг / kg of weight, droplet is introduced for 30 minutes. Alternatively, the introduction of the drug into the course of the day is total. (bulk) doze 3 t.ιg / kg. The appliance does not interfere with any other indications that have been omitted.

30 Industrial acc.

The claimed medication can be used only in medicine in the form of a medicinal product for the treatment of chronic disease of the heart and the disease.

Claims

 - 24 -

• eοκνg / m IZΟBΡ: _Τ_-Ϊ-.ΙЯ

I. ––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– and her- and her- the active substance is 5th quality and the pharmaceutical diluent, which is characterized by the fact that, as a matter of fact, the active substance is 2, 3, 5, 6, -, -, -

2. The medicine ______ th th ое π π υ υ Ι Ι Ι Ι, χ υ а κ из ρ ____ ____

10 that, that its different dose makes I mg / kg of weight.

3. The medication is prepared for use in the form of a shorter product, which is characterized by the fact that it is a matter of vital importance to the patient.

4. The medication is easy to use from the points

15 1-3, which must be avoided in order to save a 0.9% diluent: ΒΟDISCONTINUOUS CHLORIDE.

5. DRUG AND PREPARATION ONLY, HARPARACTER RESISTANT THAN THIS IT CONTAINS MATERIAL, EXTENDING CONSUMPTION

20 real things.

6. Ιeκaρsτvenny πρeπaρaτ πο π.5, χaρaκτeρπzuyuschi --- Xia Te _._, chτο οn sοdeρniτ in κachesτve veschesτva, ποvyπa: οshe- gο ρasτvορimοsτ deysτvuιοshegο veschesτva, κaρbοnaτ naτυιι.- or gisτidin in mοlyaρκοϊ-ϊ οτnοshenii κ-money Sτvueιtsenu vesche -

25 articles 2: 1 and 6: 1, respectively.